Horizontal cell vibration receiving platform

Abstract

The utility model discloses a cell horizontal vibration receiving platform, and relates to the technical field of biomedical cell vibration research, a cell placing area in the platform is a plurality of cell culture dish fixing grooves arranged on a horizontal vibration table; a standard sensor and a detected sensor are arranged in the cell placement area; the standard sensor is located above the horizontal vibration table, and the tested sensor is located above the horizontal vibration table and is adjacent to the standard sensor; the vibration generating device comprises a motor and an eccentric wheel; the motor adjusts the rotating speed through the control system and drives the eccentric wheel to generate vibration of different frequencies and amplitudes. The eccentric wheel is connected with the horizontal vibration table through a transmission rod; the control system comprises a control panel and a control circuit; a frequency adjusting button, an amplitude adjusting button and a display screen are arranged on the control system; the frequency adjusting button and the amplitude adjusting button are used for adjusting the frequency and the amplitude of the motor; the display screen is used for displaying the current vibration parameters of the horizontal vibration table. The application can reduce the damage and displacement probability of cells.

Description

Technical Field

[0001] This application relates to the field of biomedical cell vibration research technology, and in particular to a cell-level vibration platform. Background Technology

[0002] In the field of biomedical research, the mechanisms by which cells respond to various physical stimuli have always been a hot topic of interest for scientists. Vibration, as a ubiquitous physical stimulus, has a profound impact on cell proliferation, differentiation, and gene expression. However, current tools for studying cell vibration have many shortcomings, which has spurred the need for the development of novel cell-level vibration platforms.

[0003] Specifically, traditional cell vibration platforms lack precision in controlling vibration parameters. Cells exhibit highly specific responses to vibration frequency and amplitude; even minute changes can lead to significant deviations in experimental results. However, existing platforms typically struggle to achieve highly precise adjustment of vibration frequency and amplitude, limiting the ability to conduct in-depth research into the mechanisms of cellular vibration responses. Furthermore, maintaining cell stability during vibration and ensuring a suitable environment for cell survival is also a critical challenge. In traditional platforms, the fixation methods of cell culture dishes are less than ideal; vibration can easily cause cell displacement, damage, or even death, severely impacting the accuracy and reliability of experimental results. Utility Model Content

[0004] The purpose of this application is to provide a cell-level vibration platform that can precisely control vibration parameters while ensuring cell stability during vibration.

[0005] To achieve the above objectives, this application provides the following solution:

[0006] In a first aspect, this application provides a cell-level vibration platform, comprising:

[0007] Cell placement area, vibration generation device, and control system.

[0008] The cell placement area consists of several cell culture dish fixing slots set on a horizontal vibration table; a standard sensor and a sensor to be tested are set in the cell placement area; the standard sensor is located above the horizontal vibration table, and the sensor to be tested is located above the horizontal vibration table and adjacent to the standard sensor.

[0009] The vibration generating device includes a motor and an eccentric wheel; the motor adjusts its speed through a control system and drives the eccentric wheel to generate vibrations of different frequencies and amplitudes; the eccentric wheel is connected to the horizontal vibration table through a transmission rod.

[0010] The control system includes a control panel and a control circuit; the control panel is equipped with a frequency adjustment button, an amplitude adjustment button, and a display screen; the frequency adjustment button and the amplitude adjustment button are used to adjust the frequency and amplitude of the motor; the display screen is used to display the vibration parameters of the current horizontal vibration table.

[0011] According to the specific embodiments provided in this application, the following technical effects are disclosed:

[0012] This application provides a cell horizontal vibration platform, comprising a cell placement area, a vibration generating device, and a control system. The cell placement area is located on a horizontal vibration table and is equipped with multiple cell culture dish holders. Standard sensors and measured sensors are installed within the cell placement area. Both the standard sensors and the measured sensors are located above the horizontal vibration table and are adjacent to each other. The vibration generating device consists of a motor and an eccentric wheel. The motor's rotational speed is adjusted by the control system to generate vibrations of different frequencies and amplitudes. The eccentric wheel is connected to the horizontal vibration table via a transmission rod. The control system consists of a control panel and control circuitry. The control panel includes frequency adjustment buttons, amplitude adjustment buttons, and a display screen. The frequency and amplitude adjustment buttons are used to adjust the motor's frequency and amplitude, while the display screen shows the current vibration parameters of the horizontal vibration table. This design, through the configuration of the cell culture dish holders, effectively reduces cell damage and displacement, ensuring precise motor drive and thus enabling the generation of the desired vibration frequency and amplitude. Attached Figure Description

[0013] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 This is a schematic diagram of a cell-level vibration platform structure provided in an embodiment of this application.

[0015] Figure 2 This is an overall appearance view of a cell-level vibration platform provided in an embodiment of this application. Detailed Implementation

[0016] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0017] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, the application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0018] Example 1

[0019] like Figure 1 As shown, this embodiment provides a cell-level vibration platform, including: a cell placement area, a vibration generating device, and a control system.

[0020] The cell placement area consists of several cell culture dish fixing slots set on a horizontal vibration table; a standard sensor and a sensor to be tested are set in the cell placement area; the standard sensor is located above the horizontal vibration table, and the sensor to be tested is located above the horizontal vibration table and adjacent to the standard sensor.

[0021] The vibration generating device includes a motor and an eccentric wheel; the motor adjusts its speed through a control system and drives the eccentric wheel to generate vibrations of different frequencies and amplitudes; the eccentric wheel is connected to the horizontal vibration table through a transmission rod.

[0022] The control system includes a control panel and a control circuit; the control panel is equipped with a frequency adjustment button, an amplitude adjustment button, and a display screen; the frequency adjustment button and the amplitude adjustment button are used to adjust the frequency and amplitude of the motor; the display screen is used to display the vibration parameters of the current horizontal vibration table.

[0023] The cell placement area is located on the horizontal vibration table and features a specially designed cell culture dish fixing groove. This groove is made of a soft, elastic material, such as silicone, which securely holds the cell culture dishes while minimizing the impact of vibration.

[0024] The vibration generating device consists of a high-precision motor and an eccentric wheel. The motor's rotation speed is precisely controlled by a system to drive the eccentric wheel, generating vibrations of various frequencies and amplitudes. The eccentric wheel is connected to the platform surface via a transmission rod, ensuring that the vibration is evenly transmitted to the platform.

[0025] The control system consists of a control panel and control circuitry. The control panel is equipped with frequency and amplitude adjustment buttons and a display screen, allowing operators to intuitively set and monitor vibration parameters. The control circuitry is connected to the motor to ensure precise motor control.

[0026] In some embodiments, such as Figure 1 As shown, the platform dimensions are 375mm × 340mm, containing 6 mounting slots, capable of simultaneously holding 6 125mm × 85mm cell culture plates for cell biology studies with different time groups. The cell placement area contains standard sensors and the sensors to be tested, indicated by circles, used to monitor cell contact parameters.

[0027] In some embodiments, a cell-level resonant platform further includes a precision charge amplifier, a signal conditioner, a power amplifier, and an acquisition controller.

[0028] Specifically, the precision charge amplifier is connected to the output of the standard sensor and is located to the right of the standard sensor. The precision charge amplifier is used to amplify the weak electrical signal received by the standard sensor.

[0029] The signal conditioner is connected to the output of the sensor under test and is located below the precision charge amplifier. The signal conditioner is used to filter interference signals from the horizontal vibration table or other sources.

[0030] The power amplifier is connected to the output of the signal conditioner and is located below the signal conditioner. The power amplifier is used to enhance the strength of the electrical signal output by the signal conditioner.

[0031] The acquisition controller is connected to the output of the power amplifier and is located to the right of the power amplifier. The acquisition controller is used to acquire, process, and store signals from the power amplifier. The output of the acquisition controller is connected to the input of the control system.

[0032] like Figure 2 As shown, the standard sensor is located at the top of the diagram, represented by a small square. The precision charge amplifier is immediately to the right of the standard sensor, represented by a slightly larger rectangle. The sensor under test is located to the right of the standard sensor, represented by a small rectangle. The signal conditioner is located below the precision charge amplifier, represented by a rectangle. The horizontal vibration stage is located next to the signal conditioner, represented by a rectangle, with the cell placement area above it. The power amplifier is located below the signal conditioner, represented by a large rectangle. The acquisition controller is located to the right of the power amplifier, represented by a slightly larger rectangle. The computer and control software are located on the far right, represented by a rectangle, and contain the computer and control software. The temperature control device is located below the horizontal vibration stage.

[0033] The connection relationships between the components of the cell-level vibration platform are as follows:

[0034] The output port of the standard sensor is connected to the input port of the precision charge amplifier. Then, the output port of the precision charge amplifier is connected to the input port of the sensor under test. The output port of the sensor under test is connected to the input port of the signal conditioner. The output port of the signal conditioner is connected to the input port of the power amplifier. Next, the output port of the power amplifier is connected to the input port of the acquisition controller. Finally, the output port of the acquisition controller is connected to the input port of the computer and control software.

[0035] The specific components and their interactions are shown below:

[0036] The standard sensor detects the input signal and converts it into an electrical signal. The precision charge amplifier amplifies the weak electrical signal received from the standard sensor, making it easier for subsequent equipment to process and measure. The sensor under test (SUT) receives and measures the amplified electrical signal to monitor physical quantities such as displacement and acceleration. The signal conditioner filters out signals from the horizontal vibration table or other interference sources, ensuring only useful signals are transmitted to subsequent equipment. The horizontal vibration table serves as the cell placement area, where the signal conditioner suppresses interference from other sources. The power amplifier further amplifies the electrical signal to drive the acquisition controller or other subsequent equipment. The acquisition controller acquires, processes, and stores the signal from the power amplifier, potentially including data conversion and formatting functions. The computer and control software receive the data from the acquisition controller, perform in-depth analysis, processing, and display, and may provide control signals to adjust system operation.

[0037] In summary, this application has the following technical effects:

[0038] 1) This application reduces cell damage and displacement by setting up a special cell culture dish fixation tank design. The silicone material has good elasticity and cushioning properties. When the platform vibrates, the fixation tank can absorb and disperse the vibration energy, reducing the direct impact on the cells, thereby reducing the probability of cell damage and displacement.

[0039] 2) The integration of temperature and humidity control devices in this application is a key technical aspect in providing a suitable cell growth environment. In cell-level vibration experiments, cells not only require precise vibration stimulation but also need to grow in a stable environment. This device can automatically adjust the temperature and humidity of the cell placement area according to the needs of the cells, keeping them within a suitable range, providing good survival conditions for the cells, thereby ensuring the reliability and reproducibility of experimental results.

[0040] 3) This application achieves precise control of vibration parameters by selecting a high-precision motor and a carefully designed eccentric wheel and transmission structure, coupled with an intelligent control system. For example, the control panel in the control system is equipped with frequency and amplitude adjustment buttons and a display screen, allowing operators to intuitively set and monitor vibration parameters. The control circuit can precisely drive the motor, thereby driving the eccentric wheel to generate the required vibration frequency and amplitude.

[0041] 4) The cell-level vibration platform in this application, from the selection of high-precision components for the vibration generation device and the optimization of the control system, to the material and structural innovation of the cell culture dish fixation tank, and the integration of the cell growth environment maintenance device, achieves significant advantages over existing technologies through the synergistic cooperation of various technical aspects. These advantages make the platform more valuable and significant for application in the field of biomedical cell vibration research, providing scientists with more accurate and reliable experimental tools and promoting the in-depth development of cell vibration research.

[0042] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0043] This document uses specific examples to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. In summary, the content of this specification should not be construed as a limitation of this application.

Claims

1. A cell-level vibration platform, characterized in that, include: Cell placement area, vibration generation device, and control system; The cell placement area consists of several cell culture dish fixing slots set on a horizontal vibration table; a sensor and a test sensor are set in the cell placement area; the sensor is located above the horizontal vibration table, and the test sensor is located above the horizontal vibration table and adjacent to the sensor. The vibration generating device includes a motor and an eccentric wheel; the motor adjusts its speed through a control system and drives the eccentric wheel to generate vibrations of different frequencies and amplitudes; the eccentric wheel is connected to the horizontal vibration table through a transmission rod. The control system includes a control panel and a control circuit; the control panel is equipped with a frequency adjustment button, an amplitude adjustment button, and a display screen; the frequency adjustment button and the amplitude adjustment button are used to adjust the frequency and amplitude of the motor; the display screen is used to display the vibration parameters of the current horizontal vibration table.

2. The cell-level vibration platform according to claim 1, characterized in that, The cell culture dish fixation tank is made of silicone.

3. The cell-level vibration platform according to claim 1, characterized in that, It also includes a precision charge amplifier, a signal conditioner, a power amplifier, and a data acquisition controller.

4. The cell-level vibration platform according to claim 3, characterized in that, The precision charge amplifier is connected to the output of the sensor and is located to the right of the sensor; the precision charge amplifier is used to amplify the weak electrical signal received by the sensor.

5. A cell-level vibration platform according to claim 3, characterized in that, The signal conditioner is connected to the output of the sensor under test and is located below the precision charge amplifier; the signal conditioner is used to filter interference signals from the horizontal vibration table.

6. The cell-level vibration platform according to claim 3, characterized in that, The power amplifier is connected to the output of the signal conditioner and is located below the signal conditioner; the power amplifier is used to enhance the strength of the electrical signal output by the signal conditioner.

7. A cell-level vibration platform according to claim 3, characterized in that, The acquisition controller is connected to the output of the power amplifier and is located to the right of the power amplifier; the acquisition controller is used to acquire, process and store signals from the power amplifier; the output of the acquisition controller is connected to the input of the control system.

8. The cell-level vibration platform according to claim 1, characterized in that, It also includes a temperature regulating device; the temperature regulating device is located below the horizontal vibration table.

9. A cell-level vibration platform according to claim 1, characterized in that, The dimensions of the horizontal vibration table are 375mm × 340mm.

10. A cell-level vibration platform according to claim 1, characterized in that, The horizontal vibration table is equipped with six 125mm×85mm cell culture dish fixing slots, with each cell culture dish fixing slot spaced at the same distance.

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