Nifuratel content liquid chromatography detection device
By designing an automated liquid chromatography detection device for nifuratel content, and using a weighing sensor and flow regulating valve to control the injection volume of dilution medium, the automatic dilution and filtration of nifuratel solution is achieved. This solves the problems of low detection efficiency and accuracy caused by manual operation, and improves the accuracy and efficiency of detection results.
Patent Information
- Application Number
- CN202422917926.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-28
- Publication Date
- 2025-11-07
- Estimated Expiration
- 2034-11-28
AI Technical Summary
In existing technologies, the dilution and filtration processes of nifuratel solution before liquid chromatography detection require manual operation, resulting in low detection efficiency and inaccurate results.
A liquid chromatography detection device for nifuratel content was designed. The device uses a weighing sensor to automatically weigh the solution, combines a small pump and a flow regulating valve to accurately control the injection volume of the dilution medium, and uses an automatic filtration system to achieve solution dilution and filtration.
It improves the accuracy and efficiency of test results, reduces the workload of staff, and ensures the automation and accuracy of the testing process.
Smart Images
Figure CN223526306U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to liquid chromatography detection technical field, concretely is a nifuratel content liquid chromatography detection device. BACKGROUND
[0002] Liquid chromatograph is a kind of instrument using the difference of distribution ratio of mixture between liquid-solid or two immiscible liquids, and the mixture is separated first, and then analyzed and identified, and its separation principle is a physical process, the flow phase carries the compound to be analyzed and other some coexisting substances and flows through chromatographic column, utilizes the different retention time of different substances on stationary phase, and thus peak time is different to reach separation, and retention time can be used for qualitative, and peak height or peak area can be used for quantitative.
[0003] Nifuratel is a specific compound, and its content determination needs high-precision detection method, and liquid chromatography becomes the preferred method for nifuratel content determination due to its high efficiency, rapidness, sensitivity and the like.
[0004] At present, before liquid chromatography detection is carried out to nifuratel solution, the solution usually needs to be diluted and filtered, and this process is often manually completed by staff, reduces detection efficiency, and manual dilution easily leads to inaccurate dilution medium injection amount, and further leads to inaccurate detection result. UTILITY MODEL CONTENT
[0005] The utility model aims at providing a kind of nifuratel content liquid chromatography detection device to solve the problems presented in the above background.
[0006] To achieve the above object, the utility model provides the following technical scheme: a kind of nifuratel content liquid chromatography detection device, including base, the top of the one end of base is fixedly connected with chromatograph body, the top of the other end of base is fixedly connected with working tank, the top of chromatograph body is placed with solvent bottle, the top of solvent bottle is threadedly connected with first pipe cap, the inside of working tank is equipped with first chamber and second chamber, the top of working tank is fixedly connected with medium bottle, the bottom of medium bottle is arranged in the inside of first chamber, and the bottom of medium bottle is communicated with first pipeline.
[0007] As the further preferred of the technical scheme, the inside of first chamber is fixedly connected with small pump, the input end of small pump is communicated first pipeline, the output end of small pump is communicated with second pipeline, one end of second pipeline is communicated with second pipe cap, and the outside of second pipeline is communicated with flow regulating valve.
[0008] As a further preferred of the technical solution, the bottom of the first chamber is fixedly connected with a first placing disc, the inside of the first placing disc is provided with a bearing disc, the bottom of the inside of the first placing disc is fixedly connected with two weighing sensors, and the sensing ends of the two weighing sensors are fixedly connected to the bottom of the bearing disc.
[0009] As a further preferred of the technical solution, the middle of the bottom of the first placing disc is fixedly connected with a rudder machine, the middle of the bearing disc is rotatably connected with a rotating disc through a bearing, and the output end of the rudder machine is fixedly connected to the middle of the bottom of the rotating disc.
[0010] As a further preferred of the technical solution, the top of the rotating disc is fixedly connected with two symmetrically arranged connecting blocks, the opposite sides of the two connecting blocks are fixedly connected with springs, and one end of the spring is fixedly connected with a clamping block.
[0011] As a further preferred of the technical solution, the top of the working box is fixedly connected with a funnel, the bottom of the funnel is arranged in the inside of the second chamber, the bottom of the funnel is threadedly connected with a filter bottle, the side of the filter bottle is fixedly connected with a pipeline interface, the inside of the top of the filter bottle is fixedly connected with a connecting ring, and the top of the connecting ring is provided with a filter membrane.
[0012] As a further preferred of the technical solution, the bottom of the filter bottle is communicated with a third pipeline, one end of the third pipeline is communicated with a third pipe cap, the inside of the second chamber is fixedly connected with a second placing disc, the inside of the second chamber is fixedly connected with a vacuum pump, the air inlet end of the vacuum pump is communicated with a fourth pipeline, and one end of the fourth pipeline is communicated with the pipeline interface.
[0013] As a further preferred of the technical solution,
[0014] The utility model provides a kind of nifurtoil content liquid chromatography detection device, with the following beneficial effects:
[0015] (1) the utility model discloses a weighing sensor is weighed to nifurtoil solution, obtains the injection diluent quality, and then small pump is automatically injected diluent medium, during this period, flow regulating valve monitors diluent medium injection amount according to injection proportion, reaches specified injection amount, and flow regulating valve and small pump are closed, to accurately inject specified amount of diluent medium, ensure that detection result is accurate.
[0016] (2) the utility model can automatically dilute and filter nifurtoil solution, reduce labor intensity of staff, improve detection efficiency. DRAWINGS
[0017] Figure 1 It is the whole structure schematic view of the utility model;
[0018] Figure 2 It is the first chamber internal structure schematic view of the utility model;
[0019] Figure 3 It is the A place structure amplification schematic view of the utility model;
[0020] Figure 4 It is the second chamber internal structure schematic view of the utility model;
[0021] Figure 5 It is the filter bottle structure schematic view of the utility model.
[0022] In the drawing: 1, base; 2, chromatograph body; 3, working box; 4, solvent bottle; 5, first pipe cap; 6, first chamber; 7, second chamber; 8, medium bottle; 9, first pipeline; 10, small pump; 11, second pipeline; 12, second pipe cap; 13, flow regulating valve; 14, first placing disc; 15, bearing disc; 16, weighing sensor; 17, rudder machine; 18, rotating disc; 19, connecting block; 20, spring; 21, clamping block; 22, hopper; 23, filter bottle; 24, third pipeline; 25, third pipe cap; 26, second placing disc; 27, vacuum pump; 28, fourth pipeline; 29, connecting ring; 30, filter membrane; 31, pipeline interface. DETAILED DESCRIPTION
[0023] The technical scheme in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model.
[0024] The utility model provides technical scheme: as Figure 1 、 Figure 2 And Figure 3 Indicated, in the embodiment, a furazolidone content liquid chromatography detection device, including base 1, the top of one end of base 1 is fixedly connected with chromatograph body 2, the model of chromatograph body 2 is 1260HPLC, the top of the other end of base 1 is fixedly connected with working box 3, the top of chromatograph body 2 is placed with solvent bottle 4, the top of solvent bottle 4 is threadedly connected with first pipe cap 5, the inside of working box 3 is provided with first chamber 6 and second chamber 7, the top of working box 3 is fixedly connected with medium bottle 8, diluent is stored in medium bottle 8, the bottom of medium bottle 8 is arranged in the inside of first chamber 6, and the bottom of medium bottle 8 is communicated with first pipeline 9, solvent bottle 4 can be removed from first pipe cap 5, first pipe cap 5 is connected with the corresponding pipeline of chromatograph body 2, to make chromatograph body 2 extract furazolidone solution in solvent bottle 4 to carry out detection.
[0025] The bottom of the first chamber 6 is fixedly connected with a first placing disc 14, the inside of the first placing disc 14 is provided with a bearing disc 15, the bottom of the inside of the first placing disc 14 is fixedly connected with two weighing sensors 16, the sensing end of the two weighing sensors 16 is fixedly connected to the bottom of the bearing disc 15, when the nitrofurazone solution is diluted, the beaker is taken to add the nitrofurazone solution, then the beaker is placed on the bearing disc 15, the weighing sensor 16 weighs the nitrofurazone solution, so that the dilution medium is injected according to the proportion of the total amount of the nitrofurazone solution.
[0026] The inside of the first chamber 6 is fixedly connected with a small pump 10, the model of the small pump 10 is F40P1-CP8DA-MJ4, the input end of the small pump 10 is communicated with the first pipeline 9, the output end of the small pump 10 is communicated with the second pipeline 11, one end of the second pipeline 11 is communicated with the second pipe cap 12, and the outside of the second pipeline 11 is communicated with the flow regulating valve 13, the model of the flow regulating valve 13 is HK-62-H15, the second pipe cap 12 is connected with the beaker, and then the small pump 10 is started, the small pump 10 draws the dilution medium in the medium bottle 8 through the first pipeline 9, and then the dilution medium is delivered to the beaker through the second pipeline 11, during which the flow regulating valve 13 monitors the injection amount of the dilution medium according to the injection proportion, and when the specified injection amount is reached, the flow regulating valve 13 and the small pump 10 are closed, so that the specified amount of dilution medium is accurately injected.
[0027] The middle of the bottom of the first placing disc 14 is fixedly connected with a rudder 17, the middle of the bearing disc 15 is rotatably connected with a rotating disc 18 through a bearing, the output end of the rudder 17 is fixedly connected to the middle of the bottom of the rotating disc 18, after the dilution medium is injected, the second pipe cap 12 is removed, and the rudder 17 is started, the rudder 17 drives the rotating disc 18 to rotate, so that the beaker is rotated to accelerate the fusion of the nitrofurazone solution and the dilution medium.
[0028] The top of the rotating disc 18 is fixedly connected with two symmetrically arranged connecting blocks 19, the opposite sides of the two connecting blocks 19 are fixedly connected with springs 20, one end of the spring 20 is fixedly connected with a clamping block 21, when the beaker is placed on the rotating disc 18, the clamping block 21 is pressed, the spring 20 is compressed, and the spring 20 exerts a counterforce to clamp the beaker through the clamping block 21, so that the beaker is prevented from being thrown out when the rotating disc 18 rotates.
[0029] As Figure 4 and Figure 5As shown, the top of the working box 3 is fixedly connected with a hopper 22, the bottom of the hopper 22 is arranged in the second chamber 7, the bottom of the hopper 22 is threadedly connected with a filter bottle 23, the side of the filter bottle 23 is fixedly connected with a pipe interface 31, the inside of the top of the filter bottle 23 is fixedly connected with a connecting ring 29, the top of the connecting ring 29 is mounted with a filter membrane 30, the filter membrane 30 is divided into water system filter membrane and organic system filter membrane, the filter bottle 23 is unscrewed from the hopper 22, and then the filter membrane 30 is directly laid on the connecting ring 29, so that the filtering work can be started.
[0030] The bottom of the filter bottle 23 is communicated with a third pipe 24, one end of the third pipe 24 is communicated with a third pipe cap 25, the inside of the second chamber 7 is fixedly connected with a second placing disc 26, the inside of the second chamber 7 is fixedly connected with a vacuum pump 27, the air inlet end of the vacuum pump 27 is communicated with a fourth pipe 28, one end of the fourth pipe 28 is communicated with the pipe interface 31, the beaker is taken off from the turntable 18, the solvent bottle 4 is taken off from the first pipe cap 5, the solvent bottle 4 is connected with the third pipe cap 25, then the diluted solution is poured into the hopper 22, the vacuum pump 27 is started, the vacuum pump 27 is communicated with the pipe interface 31 through the fourth pipe 28, the filter bottle 23 is vacuumized, the diluted solution is filtered into the inside of the filter bottle 23 under the change of air pressure, and then enters the solvent bottle 4 through the third pipe 24, after the filtering is completed, the solvent bottle 4 is connected with the first pipe cap 5 again, and the chromatograph body 2 is started, so that the analysis of liquid chromatography can be started.
[0031] The utility model provides a nifuratel content liquid chromatography detection device, specific working principle is as follows: take the beaker and add nifuratel solution, then place the beaker on the turntable 18, the beaker will extrude the clamping block 21 at this time, the clamping block 21 will compress spring 20, and the spring 20 exerts reaction force and makes the clamping block 21 clamp the beaker, and the weighing sensor 16 will weigh nifuratel solution, according to the total amount of nifuratel solution, the diluent medium is injected in proportion, then the second pipe cap 12 is connected with the beaker, and the small -size pump 10 is started again, and the small -size pump 10 extracts the diluent medium in the diluent bottle 8 through the first pipeline 9, and then the diluent medium is delivered to the beaker by the second pipeline 11, during which the flow regulating valve 13 monitors the diluent medium injection amount according to the injection proportion, reaches the specified injection amount, and the flow regulating valve 13 and small -size pump 10 are closed, so as to accurately inject the specified amount of diluent medium, then the second pipe cap 12 is taken down, and the rudder machine 17 is started, and the rudder machine 17 will drive the turntable 18 to rotate, and then the beaker is rotated, so as to accelerate the nifuratel solution and diluent medium fusion, then the filter bottle 23 is screwed off from the hopper 22, and the appropriate filter membrane 30 is directly laid on the connecting ring 29, then the filter bottle 23 is screwed back, then the beaker is taken off from the turntable 18, and the solvent bottle 4 is taken off from the first pipe cap 5, so that the solvent bottle 4 is connected with the third pipe cap 25, then the diluted solution is poured into the hopper 22, and the vacuum pump 27 is started, and the vacuum pump 27 is connected with the pipeline interface 31 through the fourth pipeline 28 and the pipeline interface 31, and the filter bottle 23 is pumped, and the diluted solution is filtered into the inside of the filter bottle 23 under the change of air pressure through the filter membrane 30, and then enters the solvent bottle 4 through the third pipeline 24, after filtering, the solvent bottle 4 is connected with the first pipe cap 5 again, and the chromatograph body 2 is started, and the liquid chromatography analysis can be started.
[0032] Although the embodiments of the utility model have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.
Claims
1. A nifuratel content liquid chromatography detection device comprising a base (1), characterised in that: The top of one end of the base (1) is fixedly connected with a chromatograph body (2), the top of the other end of the base (1) is fixedly connected with a working box (3), the top of the chromatograph body (2) is placed with a solvent bottle (4), the top of the solvent bottle (4) is threadedly connected with a first pipe cap (5), the inside of the working box (3) is provided with a first cavity (6) and a second cavity (7), the top of the working box (3) is fixedly connected with a medium bottle (8), the bottom of the medium bottle (8) is arranged in the inside of the first cavity (6), and the bottom of the medium bottle (8) is communicated with a first pipeline (9).
2. A device for detecting the content of nifuratel by liquid chromatography according to claim 1, characterized in that: The inside of the first cavity (6) is fixedly connected with a small pump (10), the input end of the small pump (10) is communicated with the first pipeline (9), the output end of the small pump (10) is communicated with a second pipeline (11), one end of the second pipeline (11) is communicated with a second pipe cap (12), and the outside of the second pipeline (11) is communicated with a flow regulating valve (13).
3. A device for detecting the content of nifuratel by liquid chromatography according to claim 1, characterized in that: The bottom of the inside of the first cavity (6) is fixedly connected with a first placing disc (14), the inside of the first placing disc (14) is provided with a bearing disc (15), the bottom of the inside of the first placing disc (14) is fixedly connected with two weighing sensors (16), and the sensing end of the two weighing sensors (16) is fixedly connected to the bottom of the bearing disc (15).
4. A device for detecting the content of nifuratel by liquid chromatography according to claim 3, characterized in that: The middle of the bottom of the first placing disc (14) is fixedly connected with a rudder machine (17), the middle of the bearing disc (15) is rotatably connected with a rotating disc (18) through a bearing, and the output end of the rudder machine (17) is fixedly connected to the middle of the bottom of the rotating disc (18).
5. A device for detecting the content of nifuratel by liquid chromatography according to claim 4, characterized in that: The top of the rotating disc (18) is fixedly connected with two symmetrically arranged connecting blocks (19), one side of the two connecting blocks (19) is fixedly connected with a spring (20), and one end of the spring (20) is fixedly connected with a clamping block (21).
6. A device for detecting the content of nifuratel according to claim 1, characterized in that: The top of the working box (3) is fixedly connected with a hopper (22), the bottom of the hopper (22) is arranged in the inside of the second cavity (7), the bottom of the hopper (22) is threadedly connected with a filter bottle (23), the side of the filter bottle (23) is fixedly connected with a pipeline interface (31), the inside of the top of the filter bottle (23) is fixedly connected with a connecting ring (29), and the top of the connecting ring (29) is mounted with a filter membrane (30).
7. A device for detecting the content of nifuratel by liquid chromatography according to claim 6, characterized in that: The bottom of the filter bottle (23) is communicated with a third pipeline (24), one end of the third pipeline (24) is communicated with a third pipe cap (25), the inside of the second cavity (7) is fixedly connected with a second placing disc (26), the inside of the second cavity (7) is fixedly connected with a vacuum pump (27), the air inlet end of the vacuum pump (27) is communicated with a fourth pipeline (28), and one end of the fourth pipeline (28) is communicated with the pipeline interface (31).