Column temperature box plugging structure of liquid chromatogram tandem mass spectrum
By employing a fixing block and limiting structure design in the column temperature chamber of liquid chromatography-tandem mass spectrometry, the problems of loose connection and damage caused by threaded connections are solved, achieving stable fixation of the chromatographic column, improving experimental efficiency and reducing costs.
Patent Information
- Application Number
- CN202422545284.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-21
- Publication Date
- 2025-11-07
- Estimated Expiration
- 2034-10-21
AI Technical Summary
In existing liquid chromatography-tandem mass spectrometry column boxes, the threaded connections require precise alignment and torque application, which can lead to loose connections or damaged threads when frequently changing columns, reducing experimental efficiency and increasing costs.
The design employs a fixing block and limiting structure. The fixing block is inserted into the fixing groove and the limiting structure is used to fix the chromatographic column, avoiding the need for precise alignment of threaded connections. This ensures that the chromatographic column is firmly fixed in the column temperature box and reduces collision damage.
It improves experimental efficiency, reduces experimental costs, ensures a stable connection of the chromatographic column within the column temperature chamber, prevents damage from collisions, and improves sealing and service life.
Smart Images
Figure CN223526308U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to a column temperature box plug -pull structure of liquid chromatography tandem mass spectrometry belongs to column temperature box technical field. BACKGROUND
[0002] Liquid chromatography tandem mass spectrometry column temperature box is a device that can accurately control temperature, it is usually installed between liquid chromatograph and mass spectrometer, is used for wrapping and heating or cooling chromatographic column, makes chromatographic column can carry out the detection of sample under the optimum temperature condition. The plug -pull structure of chromatographic column temperature box mainly is how the mechanism and part of chromatographic column is installed, fixed and disassembled in column temperature box.
[0003] Among them, threaded connection is a kind of widely used connecting mode, it is through setting threaded structure at the interface of chromatographic column and column temperature box, by rotating chromatographic column makes it and column temperature box closely connected, this connecting mode has the advantages of simple structure, connection firm.
[0004] However, in the process of connecting by using threaded connection mode in actual use, since threaded connection needs staff to accurately align thread and apply proper torque to ensure that connection is closely, when chromatographic column needs to be frequently replaced, it can cause connection not closely due to threaded structure damage, so that chromatographic column is not fixed firmly in column temperature box, when column temperature box shakes, collision occurs between chromatographic column and column temperature box inside, causes chromatographic column to be damaged, greatly reduces experimental efficiency and increases experimental cost. UTILITY MODEL CONTENTS
[0005] The utility model wants to solve technical problems in: provide a column temperature box plug -pull structure of liquid chromatography tandem mass spectrometry, it solves the problem in prior art due to threaded connection needs staff to accurately align thread and apply proper torque to ensure that connection is closely, when chromatographic column needs to be frequently replaced, possibly cause connection not closely or threaded structure damage, so that chromatographic column is not fixed firmly in column temperature box, when column temperature box shakes, collision occurs between chromatographic column and column temperature box inside, causes chromatographic column to be damaged, greatly reduces experimental efficiency and increases experimental cost.
[0006] The technical problem to be solved by the utility model is achieved by the following technical scheme: a column temperature box plug-in structure of liquid chromatography tandem mass spectrometry, including column temperature box, the chromatographic column is detachably connected in the column temperature box, the both ends of the chromatographic column are integrally formed with fixed blocks, the top and bottom of the inner wall of the column temperature box are provided with fixed seats, the fixed seats are provided with fixed grooves for the fixed blocks to be clamped in, the middle parts of the fixed blocks and the fixed seats are provided with round holes for the samples to pass through, the top of the column temperature box is provided with a connecting pipe, and the side of the column temperature box is provided with an opening for the connecting pipe to extend out, one end of the connecting pipe is connected with the mass spectrometer and the liquid chromatograph, the other end is connected with the fixed seat at the top, the fixed seat at the bottom is connected with the column temperature box through a fixed pipe, the fixed pipe is fixed on the column temperature box, and the fixed seat is provided with a limiting structure for limiting the fixed blocks to slide out.
[0007] The surface of the chromatographic column is marked with an arrow, one end of the arrow is connected with the fixed seat at the bottom downward, and the other end is connected with the fixed seat at the top upward.
[0008] When the chromatographic column is fixed in the column temperature box, first, the staff adjusts the orientation of the chromatographic column according to the prompt of the arrow, clamps the downward fixed block into the fixed groove, and fixes the fixed block in the fixed seat at the bottom by using the limiting structure, at this time, the round hole is aligned with the pipe opening of the fixed pipe. Then, the connecting pipe is extended into the column temperature box from the opening, and the connecting pipe is moved so that the fixed seat at the top is aligned with the fixed block and the fixed block is clamped into the fixed groove, and then the fixed block is fixed in the fixed seat at the top by using the limiting structure, so that the chromatographic column can be fixed in the column temperature box. By the structure of the application, when the chromatographic column is fixed in the column temperature box, since the threaded connection is not required, the staff does not need to accurately align the threads and apply appropriate torque to ensure tight connection, only the fixed block is clamped into the fixed groove and then fixed by using the limiting structure, so that the chromatographic column can be fixed in the column temperature box. When the chromatographic column needs to be frequently replaced, the connection will not be tight due to damage to the threads, so that the chromatographic column is firmly fixed in the column temperature box, and when the column temperature box shakes, the chromatographic column will not collide with the inside of the column temperature box, and the chromatographic column will not be damaged. The experimental efficiency is greatly improved, and the experimental cost is reduced.
[0009] The utility model is further provided with: the limiting structure includes a plurality of convex blocks integrally formed on the outer walls on both sides of the middle part of the fixed block, recesses for the convex blocks to be clamped in are formed on both sides in the fixed groove, and a rotating groove for the convex blocks to rotate and communicate with the recesses is formed in the fixed groove along the circumferential direction.
[0010] By adopting the above technical solution, when it is necessary to fix the fixing block in the fixing seat, the fixing block is first inserted into the fixing groove. During the process of the fixing block being inserted into the fixing groove, the protrusion is aligned and inserted into the groove. When the protrusion moves to the connection between the groove and the rotating groove, the chromatographic column is rotated to make the protrusion inserted into the rotating groove. The rotating groove limits the protrusion, so that the fixing block cannot be removed from the fixing seat, thereby making the chromatographic column stably fixed in the column temperature box.
[0011] The present invention is further configured such that: a sliding plate is slidably disposed in the rotating groove along the vertical direction, and the sliding plate is connected to the bottom wall inside the rotating groove by an elastic element; the sliding plate is provided with a through hole for the fixing block to be inserted; in this embodiment, the elastic element is a spring.
[0012] By adopting the above technical solution, during the process of the operator pressing the protrusion into the rotating groove, as the protrusion moves, one side of the protrusion abuts against one side of the slider. At this time, one end of the fixing block is inserted into the through hole. As the protrusion continues to move towards the bottom of the rotating groove to be fully inserted, the protrusion pushes the slider to move along the rotating groove towards the bottom. The movement of the slider compresses the spring, generating elastic force. After the protrusion is fully inserted into the rotating groove, the force on the protrusion is released, causing the spring to extend and release the elastic force, pushing the slider away from the bottom of the rotating groove. The movement of the slider pushes the protrusion away from the bottom of the rotating groove until the other side of the protrusion abuts against one side of the inner wall of the rotating groove, making the fixing block and the fixing seat tightly connected and fitted, thereby improving the sealing performance of the connection between the chromatographic column and the fixing seat and ensuring that the column temperature box can work normally.
[0013] The present invention is further configured such that: a plurality of supports for fixing the chromatographic column are provided on the inner wall of the column temperature box, one end of the support is integrally formed on the side wall of the column temperature box, and the other end is provided with a circular groove for the chromatographic column to be inserted, a locking slot is provided on one side of the circular groove, and guide surfaces are provided on both sides of the locking slot.
[0014] By adopting the above technical solution, when it is necessary to fix the chromatographic column more firmly in the column temperature box, simply press the chromatographic column along the guide surface towards the side wall of the column temperature box so that the chromatographic column is inserted into the circular groove, and the chromatographic column can be fixed on the support. At this time, the two ends of the circular groove undergo slight deformation.
[0015] The present invention is further configured such that a sealing ring is slidably fitted onto one end of the fixing block near the chromatographic column.
[0016] By adopting the above technical solution, the sealing ring not only prevents the sample from leaking out of the chromatographic column and affecting the accuracy of the analytical structure, but also prevents external contaminants from entering the interior of the chromatographic column, protecting the internal structure of the column from damage and thus extending the service life of the chromatographic column.
[0017] The utility model further provides for: the one side of column temperature box is detachably connected with box cover, the side wall of column temperature box is equipped with U type groove for the bottom of box cover clamping around, in this embodiment, the box cover material contains magnetism.
[0018] Among them, the inner wall of U type groove is fixed with magnet which is opposite to the magnetism of box cover.
[0019] Through adopting above-mentioned technical scheme, the setting of magnetic box cover makes that the staff can easily realize the opening and closing of box cover, and only needs to pull or push gently to clamp one side of box cover into U type groove. The magnetic box cover can usually keep stable magnetic force for a long time, and ensures the close closing between box cover and box body.
[0020] The utility model discloses the beneficial effect is: when fixing the chromatographic column in the column temperature box, first, the staff adjusts the orientation of chromatographic column according to the prompt of arrow, clamps the downward fixed block into the fixed slot, and fixes the fixed block in the fixed seat at the bottom using the limiting structure, at this time, the round hole is aligned with the pipe orifice of fixed pipe. Subsequently, the connecting pipe is inserted into the column temperature box from the opening, and the connecting pipe is moved so that the fixed seat at the top is aligned with the fixed block and the fixed block is clamped into the fixed slot, and then the fixed block is fixed in the fixed seat at the top using the limiting structure, so that the chromatographic column can be fixed in the column temperature box. By the structure of the application, when fixing the chromatographic column in the column temperature box, since the thread connection is not needed, the staff does not need to accurately align the thread and apply appropriate torque to ensure tight connection. Only need to clamp the fixed block into the fixed slot and then use the limiting structure to fix, can fix the chromatographic column in the column temperature box, and when the chromatographic column needs to be frequently replaced, the connection will not be tight due to damage of the thread, so that the chromatographic column is firmly fixed in the column temperature box. When the column temperature box shakes, the chromatographic column will not collide with the inside of the column temperature box, and will not cause damage to the chromatographic column. Greatly improve the experimental efficiency while reducing the experimental cost. BRIEF DESCRIPTION OF DRAWINGS
[0021] Figure 1 It is the structural schematic diagram of the utility model;
[0022] Figure 2 It is the explosion structural schematic diagram of the column temperature box in the utility model;
[0023] Figure 3 It is the explosion structural schematic diagram of the chromatographic column in the utility model;
[0024] Figure 4 It is the half cut drawing of fixed seat, elastic member and sliding sheet in the utility model;
[0025] Figure 5 It is the structural schematic diagram of magnet, column temperature box and box cover in the utility model;
[0026] Figure 6 It is a structure schematic view of the box cover in the utility model.
[0027] In the figure: 1, column temperature box; 2, chromatographic column; 3, fixed block; 4, fixed seat; 5, fixed groove; 6, round hole; 7, connecting pipe; 8, fixed pipe; 9, opening; 10, mass spectrometer; 11, liquid chromatograph; 12, conduit; 13, arrow; 14, lug; 15, recess; 16, rotating groove; 17, sliding sheet; 18, elastic member; 19, through hole; 20, support; 21, round groove; 22, guide surface; 23, sealing ring; 24, box cover; 25, U-shaped groove; 26, magnet; 27, bayonet. DETAILED DESCRIPTION
[0028] In order to make the technical means, creation characteristics, purposes and effects of the utility model easy to understand, the utility model is further described below in combination with specific drawings.
[0029] As shown in Figure 1 , Figure 2 and Figure 3 , a column temperature box 1 plug-in structure of liquid chromatography tandem mass spectrometry includes a column temperature box 1, a chromatographic column 2 is detachably connected in the column temperature box 1, the fixed block 3 is integrally formed at both ends of the chromatographic column 2, the fixed seat 4 is arranged at the top and bottom of the inner wall of the column temperature box 1, the fixed groove 5 for the fixed block 3 to be clamped is formed on the fixed seat 4, the round hole 6 for the sample to pass through is formed in the middle of the fixed block 3 and the fixed seat 4, the connecting pipe 7 is arranged at the top of the column temperature box 1, the opening 9 for the connecting pipe 7 to extend out is formed on one side of the column temperature box 1, one end of the connecting pipe 7 is connected with the mass spectrometer 10 and the liquid chromatograph 11, the other end is connected with the fixed seat 4 at the top, the fixed seat 4 at the bottom is connected with the column temperature box 1 through the fixed pipe 8, the fixed pipe 8 is fixed on the column temperature box 1, and the limiting structure for limiting the fixed block 3 to slide out is arranged on the fixed seat 4.
[0030] Among them, the mass spectrometer 10 is placed on one side of the column temperature box 1, the liquid chromatograph 11 is fixed on the top of the mass spectrometer 10, the mass spectrometer 10 and the chromatograph are connected through the conduit 12, and one end of the connecting pipe 7 extending out of the column temperature box 1 is connected with the conduit 12.
[0031] In addition, the surface of the chromatographic column 2 is marked with the arrow 13, one end of the arrow 13 downward is connected with the fixed seat 4 at the bottom, and the other end upward is connected with the fixed seat 4 at the top.
[0032] When the chromatographic column 2 is to be fixed in the column oven 1, first, the staff adjusts the orientation of the chromatographic column 2 according to the prompt of the arrow 13, inserts the downward fixing block 3 into the fixing groove 5, and fixes the fixing block 3 in the fixing seat 4 at the bottom by using the limiting structure, at this time, the round hole 6 is aligned with the pipe opening of the fixing pipe 8. Then, the connecting pipe 7 is inserted into the column oven 1 from the opening 9, and the connecting pipe 7 is moved so that the fixing seat 4 at the top is aligned with the fixing block 3 and the fixing block 3 is inserted into the fixing groove 5, and then the fixing block 3 is fixed in the fixing seat 4 at the top by using the limiting structure, so that the chromatographic column 2 can be fixed in the column oven 1. Through the structure of the present application, when the chromatographic column 2 is fixed in the column oven 1, since it is not screwed, the staff does not need to accurately align the threads and apply appropriate torque to ensure tight connection, but only needs to insert the fixing block 3 into the fixing groove 5 and then fix it by using the limiting structure, so that the chromatographic column 2 can be fixed in the column oven 1, and when the chromatographic column 2 needs to be frequently replaced, the connection will not be tight due to damage to the threads, so that the chromatographic column 2 is firmly fixed in the column oven 1, when the column oven 1 shakes, the chromatographic column 2 will not collide with the inside of the column oven 1, and will not cause damage to the chromatographic column 2, greatly improving the experimental efficiency while reducing the experimental cost.
[0033] When the chromatographic column 2 is to be disassembled from the column oven 1, first, the limiting structure is released to limit the fixing block 3 at the top, then the connecting pipe 7 is pulled away from the chromatographic column 2, so that the fixing block 3 is separated from the fixing seat 4 at the top along the fixing groove 5, then the limiting structure is released to limit the fixing block 3 at the bottom, and the chromatographic column 2 is moved away from the fixing pipe 8, so that the fixing block 3 at the bottom is pulled out of the fixing seat 4 at the bottom along the fixing groove 5, so that the chromatographic column 2 can be disassembled from the column oven 1, which is very convenient.
[0034] As shown in Figure 3 and Figure 4 , the limiting structure includes a plurality of protrusions 14 integrally formed on the outer walls on both sides of the middle part of the fixing block 3, the fixing groove 5 is provided with a recess 15 on both sides for the protrusions 14 to be inserted, and the inside of the fixing groove 5 is provided with a rotating groove 16 for the protrusions 14 to rotate and communicate with the recess 15 in the circumferential direction.
[0035] When the fixing block 3 needs to be fixed in the fixing seat 4, first, the fixing block 3 is inserted into the fixing groove 5, in the process of inserting the fixing block 3 into the fixing groove 5, the protrusions 14 are aligned and inserted into the recess 15, when the protrusions 14 move to the communication between the recess 15 and the rotating groove 16, the chromatographic column 2 is rotated, so that the protrusions 14 are inserted into the rotating groove 16, the limiting of the protrusions 14 by the rotating groove 16 makes the fixing block 3 unable to separate from the fixing seat 4, so that the chromatographic column 2 is stably fixed in the column oven 1.
[0036] When the chromatographic column 2 needs to be removed, the chromatographic column 2 is rotated to move the protruding block 14 out of the rotating groove 16, and when the protruding block 14 moves to the position where the recess 15 is communicated with the rotating groove 16, the fixing block 3 is pulled out of the fixing groove 5, so that the chromatographic column 2 can be easily removed from the column oven 1, and the operation is very convenient.
[0037] As shown in Figure 4 The rotating groove 16 is vertically slidably provided with a sliding sheet 17, the sliding sheet 17 is connected with the bottom wall in the rotating groove 16 through an elastic element 18, the sliding sheet 17 is provided with a through hole 19 for clamping the fixing block 3, and the elastic element 18 is a spring in the embodiment.
[0038] During the process that the staff member clamps the protruding block 14 into the rotating groove 16 by pressing, the protruding block 14 moves to abut against one side of the sliding sheet 17, at this time, one end of the fixing block 3 is clamped into the through hole 19, and when the protruding block 14 continues to move towards the bottom of the rotating groove 16 to be clamped into the rotating groove 16, the protruding block 14 pushes the sliding sheet 17 to move towards the bottom of the rotating groove 16, the movement of the sliding sheet 17 causes the spring to be compressed to generate elastic force. When the protruding block 14 is clamped into the rotating groove 16, the force on the protruding block 14 is removed, the spring is stretched to release the elastic force, the sliding sheet 17 moves away from the bottom of the rotating groove 16, the movement of the sliding sheet 17 pushes the protruding block 14 to move away from the bottom of the rotating groove 16, until the other side of the protruding block 14 abuts against one side of the inner wall of the rotating groove 16, so that the fixing block 3 is closely connected with the fixing seat 4 and is in close contact, thereby improving the sealing performance of the connection between the chromatographic column 2 and the fixing seat 4, and ensuring that the column oven 1 can normally work.
[0039] As shown in Figure 3 The inner wall of the column oven 1 is provided with a plurality of supports 20 for fixing the chromatographic column 2, one end of the support 20 is integrally formed on the side wall of the column oven 1, the other end is provided with a circular groove 21 for clamping the chromatographic column 2, one side of the circular groove 21 is provided with a clamping opening 27, and the two sides of the clamping opening 27 are provided with guide surfaces 22.
[0040] When the chromatographic column 2 needs to be more firmly fixed in the column oven 1, the chromatographic column 2 is pressed along the guide surfaces 22 towards the side wall of the column oven 1 to be clamped into the circular groove 21, so that the chromatographic column 2 is fixed on the support 20, and at this time, the two ends of the circular groove 21 are slightly deformed.
[0041] As shown in Figure 3 The end of the fixing block 3 close to the chromatographic column 2 is slidably sleeved with a sealing ring 23.
[0042] The sealing ring 23 prevents sample from leaking out of the chromatographic column 2, affecting the accuracy of the analysis structure, and good sealing prevents external contaminants from entering the chromatographic column 2, protecting the internal structure of the chromatographic column 2, thereby prolonging the service life of the chromatographic column 2.
[0043] As shown in Figure 5 The side of the column temperature box 1 is detachably connected with a box cover 24, and a U-shaped groove 25 for clamping the bottom of the box cover 24 is formed on the side wall of the column temperature box 1, and in this embodiment, the box cover 24 is magnetic.
[0044] The inner wall of the U-shaped groove 25 is fixed with a magnet 26 opposite to the box cover 24.
[0045] The magnetically attracted box cover 24 enables the worker to easily open and close the box cover 24, and only needs to pull or push to clamp one side of the box cover 24 into the U-shaped groove 25. The magnetically attracted box cover 24 can usually maintain stable magnetic force for a long time, and ensure the tight closure between the box cover 24 and the box body.
[0046] The basic principle, main features and advantages of the present application are shown and described above. Those skilled in the art should understand that the present application is not limited by the above embodiments, and various changes and improvements can be made without departing from the spirit and scope of the present application. These changes and improvements all fall within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalents.
Claims
1. A column oven plug-in structure of liquid chromatography tandem mass spectrometry, comprising a column oven (1), a chromatographic column (2) is detachably connected in the column oven (1), characterized in that: The color spectrum column (2) is provided with fixed blocks (3) at both ends, the top and bottom of the inner wall of the column temperature box (1) are provided with fixed seats (4), the fixed seats (4) are provided with fixed grooves (5) for clamping the fixed blocks (3), the fixed blocks (3) and the fixed seats (4) are provided with round holes (6) for sample passing, the column temperature box (1) is provided with a connecting pipe (7) at the top, one end of the connecting pipe (7) is connected with a mass spectrometer (10) and a liquid chromatograph (11), the other end is connected with the fixed seat (4) at the top, and the fixed seat (4) is provided with a limiting structure for limiting the sliding out of the fixed block (3).
2. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 1, characterized in that: The limiting structure comprises a plurality of protrusions (14) arranged on the outer wall of the fixed block (3), and the fixed groove (5) is provided with a groove (15) for clamping the protrusion (14).
3. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 2, characterized in that: The rotating groove (16) is provided with a sliding piece (17) which slides in the vertical direction.
4. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 3, characterized in that: The sliding piece (17) is connected with the bottom wall inside the rotating groove (16) through an elastic element (18).
5. The plug structure of a column oven (1) for liquid chromatography tandem mass spectrometry according to claim 1, characterized in that: The sliding piece (17) is provided with a through hole (19) for clamping the fixed block (3).
6. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 5, characterized in that: The inner wall of the column temperature box (1) is provided with a plurality of supports (20) for fixing the color spectrum column (2).
7. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 1, characterized in that: One end of the support (20) is fixed on the column temperature box (1), and the other end is provided with a circular groove (21) for clamping the color spectrum column (2).
8. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 1, characterized in that: The fixed seat (4) at the bottom is connected with the column temperature box (1) through a fixed pipe (8), and the fixed pipe (8) is fixed on the column temperature box (1).
9. The column oven plug-in structure for liquid chromatography tandem mass spectrometry according to claim 1, characterized in that: The fixed block (3) is provided with a sealing ring (23) near one end of the color spectrum column (2). One side of the column temperature box (1) is detachably connected with a box cover (24), and the column temperature box (1) is provided with a U-shaped groove (25) around the bottom end for clamping the box cover (24).