Cryopreservation device

Abstract

The embodiment of the utility model belongs to the technical field of low-temperature storage equipment, and particularly relates to a cryopreservation device. According to the cryopreservation device disclosed by the embodiment of the invention, the storage cavity is arranged to store the sample; and by arranging the cache cavity, the sample is operated. And the cache cavity communicates with the storage cavity through the second taking and placing opening, and a sample taking and placing mechanism, a scanning mechanism, a pipe picking mechanism and a transfer table are arranged in the cache cavity. The sample taking and placing mechanism is configured to input or output a sample box through the first taking and placing opening. The transfer table is located below the pipe picking mechanism, the transfer table is configured to drive the sample box to move in the horizontal plane so as to transfer the sample box among the sample taking and placing mechanism, the second taking and placing opening, the scanning mechanism and the pipe picking mechanism, the sample box transfer structure in the cache cavity is simplified, and the compactness of the structure in the cache cavity can be improved; moreover, the sample boxes do not need to be transferred among a plurality of transfer structures, so that the transfer efficiency of the sample boxes is improved.

Description

Technical Field

[0001] This application relates to the field of low-temperature storage equipment technology, and more particularly to a cryopreservation device. Background Technology

[0002] To maintain the long-term viability of biological tissues such as stem cells, blood, and immune cells, samples are usually stored in sample tubes, and then sample boxes containing multiple sample tubes are stored in cryopreservation devices.

[0003] Cryopreservation devices are typically constructed with a storage chamber and an operating chamber. The storage chamber stores the samples, while the operating chamber is used for sample transfer, scanning, and selection. The operating chamber usually contains a sample transfer structure to facilitate sample movement. In related technologies, multiple sample transfer structures are required to move samples across multiple stations, resulting in a complex structure. Utility Model Content

[0004] This application provides a cryopreservation device in which a transfer station within the buffer chamber is configured to transfer samples between multiple workstations, and the structure is simple.

[0005] In a first aspect, embodiments of this application provide a cryopreservation device, which includes:

[0006] The enclosure assembly is constructed as follows:

[0007] The storage cavity is configured to store sample boxes;

[0008] A buffer cavity is disposed on the side of the storage cavity;

[0009] The first access port is configured to connect the buffer cavity to the outside atmosphere;

[0010] The second access port connects the storage cavity and the cache cavity;

[0011] The sampling mechanism is configured to input the sample box into the buffer cavity through the first sampling port, or to output the sample box from the buffer cavity;

[0012] A scanning mechanism is installed within the buffer cavity, and the scanning mechanism is configured to scan information of the sample tubes within the sample box;

[0013] A tube-picking mechanism is installed within the buffer cavity; the tube-picking mechanism is configured to move vertically upwards and downwards; the tube-picking mechanism is configured to pick up sample tubes from the sample box;

[0014] A transfer platform is installed inside the buffer cavity and located below the tube picking mechanism; the transfer platform is configured to move the sample box in a horizontal plane to transfer the sample box between the sample taking and placing mechanism, the second taking and placing port, the scanning mechanism and the tube picking mechanism; wherein, the horizontal plane is perpendicular to the vertical direction.

[0015] The cryopreservation device of this application embodiment stores samples by providing a storage cavity and operates on the samples by providing a buffer cavity. The buffer cavity is connected to the storage cavity through a second pick-and-place port, and is equipped with a sample pick-and-place mechanism, a scanning mechanism, a tube picking mechanism, and a transfer platform. The sample pick-and-place mechanism is configured to input the sample box into the buffer cavity through the first pick-and-place port, or to output the sample box from the buffer cavity. In this application embodiment, the transfer platform is located below the tube picking mechanism and is configured to move the sample box in a horizontal plane to transfer the sample box between the sample pick-and-place mechanism, the second pick-and-place port, the scanning mechanism, and the tube picking mechanism, thereby realizing the movement of the sample box between multiple stations, simplifying the sample box transfer structure within the buffer cavity, and thus simplifying the structure within the buffer cavity.

[0016] This application embodiment utilizes a single transfer station to achieve the transfer of sample boxes between four locations. The structure is simple and helps to improve the compactness of the internal structure of the buffer cavity. Moreover, it eliminates the need to transfer sample boxes between multiple transfer structures, thereby improving the transfer efficiency of sample boxes.

[0017] In some embodiments of this application, the transfer station includes:

[0018] A first moving mechanism is configured to form a receiving portion for accommodating the sample box; the first moving mechanism is configured to drive the sample box to move in one direction within the horizontal plane.

[0019] A rotating mechanism, the output end of which is connected to the first moving mechanism; the rotating mechanism is configured to drive the first moving mechanism to rotate about a rotating axis; the rotating axis is perpendicular to the horizontal plane.

[0020] The transfer platform in this embodiment drives the sample box to move along one direction of the horizontal plane by setting a first moving mechanism, and drives the first moving mechanism to rotate around a rotation axis by setting a rotating mechanism, thereby causing the sample box to rotate in any direction on the horizontal plane. Through the cooperation of the first moving mechanism and the rotating mechanism, the sample box is driven to move in any direction on the horizontal plane, which facilitates the transfer of the sample box between the sample picking and placing mechanism, the second picking and placing port, the scanning mechanism, and the tube picking mechanism.

[0021] In some embodiments of this application, the first moving mechanism includes:

[0022] The base is connected to the output end of the rotating mechanism;

[0023] A receiving member is slidably mounted on the base, the receiving member being configured to form the receiving portion;

[0024] A first actuator is mounted on the base; the first actuator is connected to the receiving member and is configured to drive the receiving member to slide relative to the base.

[0025] In this embodiment, the first moving mechanism provides driving force for the movement of the sample box by setting a first driver, accommodates the sample box by using a receiving member, and provides an installation position for the first driver and the receiving member by setting a base. The first driver drives the receiving member to slide relative to the base, thereby causing the sample box to slide in one direction in the horizontal plane.

[0026] In some embodiments of this application, an elastic member is provided on the base, and the elastic member is configured to elastically contact the sample box in a direction perpendicular to the sliding of the receiving member;

[0027] The accommodating member is provided with a limiting member, which is configured to limit the position of the sample box along the sliding direction of the accommodating member when the elastic member is in elastic contact with the sample box;

[0028] The tube-picking mechanism is configured to pick a selected sample tube from the sample box when the elastic member and the limiting member restrict the position of the sample box.

[0029] In this embodiment, an elastic member is provided on the base to elastically contact the sample box, thereby limiting the position of the sample box along the sliding direction perpendicular to the receiving member; a limiting member is provided on the receiving member, which contacts the sample box, thereby limiting the position of the sample box along the sliding direction of the receiving member. Thus, by using the elastic member and the limiting member to limit the position of the sample box within the receiving member, the accuracy of the tube picking operation is ensured.

[0030] Furthermore, in this embodiment, the first driver drives the limiting member to move through the receiving member, so that the sample box switches between the limiting position and the unlocking position, eliminating the need for an additional driver and simplifying the structure of the transfer table. Specifically, in the limiting position, the elastic member and the limiting member restrict the position of the sample box within the receiving member; in the unlocking position, the elastic member and the limiting member separate from the sample box.

[0031] In some embodiments of this application, the rotating mechanism includes:

[0032] The mounting components are located below the base;

[0033] A second driver is mounted on the mounting member; the output end of the second driver is fixedly connected to the base, and the second driver is configured to drive the base to rotate about the rotation axis.

[0034] In some embodiments of this application, the rotating mechanism provides driving force for the rotation of the first moving mechanism by setting a second driver, and provides a mounting position for the second driver by setting a mounting component, so that the second driver can drive the entire first moving mechanism to rotate around the rotation axis through the base.

[0035] In some embodiments of this application, the rotating shaft is configured on the base and the rotating shaft is connected to the output terminal of the second driver;

[0036] The projection of the axis of rotation vertically onto the base coincides with the center of the base.

[0037] In some embodiments of this application, the center of the rotating shaft coincides with the center of the base, so that the first moving mechanism maintains good balance during rotation, reducing instability caused by eccentricity; it also helps to improve rotation accuracy, reduce errors caused by eccentricity, and improve the accuracy of the transfer table in transferring sample boxes.

[0038] In some embodiments of this application, the receiving portion is provided with a cutout portion so that the scanning mechanism can scan the information of the sample box through the cutout portion;

[0039] The hollow portion opens at one end along the sliding direction of the receiving member, so that the sample box can enter and exit the receiving portion through the opening.

[0040] Some embodiments of this application provide a cutout in the receiving portion, exposing the bottom of the sample box, which facilitates the scanning mechanism to scan the information of the sample tube at the bottom of the sample box.

[0041] In some embodiments of this application, the hollow portion is provided with an opening so that the sample box can enter and exit the receiving portion through the opening, which facilitates the transfer of the sample box between the receiving member and the sample taking and placing mechanism.

[0042] In some embodiments of this application, the transfer station further includes:

[0043] A second moving mechanism is connected to the rotating mechanism and is configured to drive the rotating mechanism and the first moving mechanism to move along a first direction;

[0044] The second pick-and-place port is located on one side of the transfer platform along the first direction.

[0045] Some embodiments of this application, by setting a second moving mechanism, drive the rotating mechanism and the first moving mechanism to move along a first direction in the horizontal plane, thereby driving the sample box to move along the first direction; on the one hand, it can provide space for the rotating mechanism to drive the first moving mechanism to rotate, and on the other hand, the second moving mechanism increases the moving distance of the sample box along the first direction. When multiple annular rotating cages are set, the transfer table and the transfer robot have sufficient moving distance along the first direction, ensuring that the sample box is smoothly transferred between the transfer table and the transfer robot.

[0046] In some embodiments of this application, the cryopreservation device includes multiple annular rotating cages; the multiple annular rotating cages are arranged coaxially and sequentially arranged inner and outer cages along the radial direction.

[0047] Some embodiments of this application can provide more storage locations by setting up multiple annular rotating cages, which helps to improve the storage utilization rate of the storage cavity.

[0048] Secondly, embodiments of this application provide a cryopreservation device, which includes:

[0049] At least one first enclosure, the first enclosure being constructed to form:

[0050] The storage cavity is configured to store sample boxes;

[0051] A first opening, which is in communication with the storage cavity;

[0052] The second housing is constructed as follows:

[0053] A buffer cavity is disposed on the side of the storage cavity;

[0054] The first access port is configured to connect the buffer cavity to the outside atmosphere;

[0055] At least one second opening, the second opening being configured to communicate with the buffer cavity;

[0056] The second housing is detachably connected to the first housing; when the second housing is connected to the first housing, the second opening is opposite to the first opening to form a second access port connecting the storage cavity and the buffer cavity;

[0057] The buffer cavity is equipped with:

[0058] The scanning mechanism is configured to scan information about the sample tubes within the sample box;

[0059] The tube-picking mechanism is configured to move vertically upwards and downwards; the tube-picking mechanism is configured to pick up sample tubes from the sample box;

[0060] The sampling mechanism is configured to input the sample box into the buffer cavity through the first sampling port, or to output the sample box from the buffer cavity;

[0061] A transfer platform is located below the tube-picking mechanism; the first pick-and-place port, the second pick-and-place port, and the scanning mechanism are arranged on the side of the transfer platform;

[0062] The transfer platform is configured to rotate and move linearly in a horizontal plane to transfer the sample box between the sample taking and placing mechanism, the second taking and placing port, the scanning mechanism, and the tube picking mechanism; wherein the horizontal plane is perpendicular to the vertical plane.

[0063] The cryopreservation device of this application embodiment stores samples by providing a storage cavity and operates on the samples by providing a buffer cavity. The buffer cavity is connected to the storage cavity through a second pick-and-place port, and is equipped with a sample pick-and-place mechanism, a scanning mechanism, a tube picking mechanism, and a transfer platform. The sample pick-and-place mechanism is configured to input the sample box into the buffer cavity through the first pick-and-place port, or to output the sample box from the buffer cavity. In this application embodiment, the transfer platform is located below the tube picking mechanism, and is configured to move the sample box in a horizontal plane to transfer the sample box between the sample pick-and-place mechanism, the second pick-and-place port, the scanning mechanism, and the tube picking mechanism, simplifying the sample box transfer structure within the buffer cavity, and thus simplifying the structure within the buffer cavity.

[0064] This application embodiment utilizes a single transfer station to achieve the transfer of sample boxes between four locations. The structure is simple and helps to improve the compactness of the internal structure of the buffer cavity. Moreover, it eliminates the need to transfer sample boxes between multiple transfer structures, thereby improving the transfer efficiency of sample boxes.

[0065] Furthermore, the box assembly in this application embodiment is provided with a detachably connected first box and a second box, so that the first box and the second box can be separated in an emergency to transfer the sample in the first box, thereby improving the reliability of the cryopreservation device.

[0066] In some embodiments of this application, multiple first boxes are provided, and the multiple first boxes are arranged circumferentially around the second box.

[0067] The second housing is configured to form a plurality of second openings, each second opening being opposite to one of the first openings to form a second loading / unloading port.

[0068] In some embodiments of this application, since the transfer stage is configured to rotate and move linearly in the horizontal plane, it can transport the sample box to multiple positions in any direction on the horizontal plane. This not only allows for more flexible placement of the sample handling mechanism, the second handling port, and the scanning mechanism, but also enables the provision of multiple storage cavities, increasing storage space. Thus, one buffer cavity can be paired with multiple storage cavities, and the transfer stage allows for the transfer of the sample box between the buffer cavity and multiple storage cavities, expanding storage space. Attached Figure Description

[0069] To more clearly illustrate the implementation methods in the embodiments of this application or related technologies, the accompanying drawings used in the description of the embodiments or related technologies will be briefly introduced below. Obviously, the accompanying drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings.

[0070] Figure 1 This is a schematic diagram of the structure of a cryopreservation device provided in some embodiments of this application;

[0071] Figure 2 This is a schematic diagram of the internal structure of a cryopreservation device provided in some embodiments of this application;

[0072] Figure 3 This is a schematic diagram of the internal structure of a cryopreservation device provided in some embodiments of this application;

[0073] Figure 4 A schematic diagram showing the location of a portion of the buffer cavity structure and a sampling mechanism provided in some embodiments of this application;

[0074] Figure 5 This is a schematic diagram showing the location of a portion of the internal structure of the buffer cavity provided in some embodiments of this application;

[0075] Figure 6 This is a schematic diagram showing the location of a portion of the internal structure of the buffer cavity provided in other embodiments of this application;

[0076] Figure 7 Schematic diagrams of the cryopreservation apparatus provided in other embodiments of this application;

[0077] Figure 8 A schematic diagram showing the location of a portion of the internal structure of the buffer cavity provided in some embodiments of this application;

[0078] Figure 9 Schematic diagrams of the cryopreservation apparatus provided in some embodiments of this application;

[0079] Figure 10 This is a schematic diagram of the structure of a transfer station provided in some embodiments of this application;

[0080] Figure 11 Exploded views of a transfer station provided in some embodiments of this application;

[0081] Figure 12 This is a partial structural schematic diagram of a transfer station provided in some embodiments of this application;

[0082] Figure 13 This is a partial structural schematic diagram of a transfer station provided in some embodiments of this application.

[0083] Explanation of reference numerals in the attached figures:

[0084] 10: Sample box; 11: First sample box; 12: Second sample box;

[0085] 20: Storage mechanism; 21: Circular rotating cage; 22: Transfer robot arm;

[0086] 30: Sampling and placement mechanism;

[0087] 40: Tube picking mechanism; 50: Scanning mechanism;

[0088] 60: Transfer station;

[0089] 100: Cabinet assembly; 101: Storage cavity; 102: Buffer cavity; 103: First loading / unloading port; 104: Second loading / unloading port; 110: First cabinet; 111: First cabinet liner; 120: Second cabinet; 121: Second cabinet liner; 122: Display device; 130: First insulation door; 140: Second insulation door;

[0090] 200: Base; 201: Moving channel; 202: First chute;

[0091] 300: First moving mechanism; 310: Receiving component; 311: Receiving part; 312: Hollowed-out part; 313: First slide rail; 320: First driver; 330: First transmission assembly; 331: First gear; 332: First rack;

[0092] 400: Rotating mechanism; 410: Second driver; 420: Mounting component; 421: Second slider; 430: Second transmission assembly; 431: Second gear; 432: Third gear;

[0093] 500: Second moving mechanism; 510: Third drive; 520: Third transmission assembly; 521: Fourth gear; 522: Second rack; 530: Base; 531: Second slide rail;

[0094] 600: Elastic component;

[0095] 700: Limiting component. Detailed Implementation

[0096] To make the objectives, implementation methods and advantages of this application clearer, the exemplary implementation methods of this application will be clearly and completely described below with reference to the accompanying drawings of the exemplary embodiments of this application. Obviously, the described exemplary embodiments are only some embodiments of this application, and not all embodiments.

[0097] It should be noted that the brief descriptions of terms in this application are only for the convenience of understanding the embodiments described below, and are not intended to limit the embodiments of this application. Unless otherwise stated, these terms should be understood in their ordinary and common meaning.

[0098] Furthermore, the terms “comprising” and “having”, and any variations thereof, are intended to cover but not exclusively include, for example, a product or device that includes a series of components is not necessarily limited to those that are explicitly listed, but may include other components that are not explicitly listed or that are inherent to such product or device.

[0099] In the description of this application, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0100] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0101] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0102] Cryopreservation devices are typically constructed with a storage chamber and an operating chamber. The storage chamber stores the samples, while the operating chamber is used for sample transfer, scanning, and selection.

[0103] Sample transfer structures are typically installed within the operating chamber to facilitate sample transfer. In related technologies, multiple sample transfer structures are required to move samples across multiple stations, resulting in complex structures, large installation space requirements, and a large overall footprint for the cryopreservation device. Furthermore, the complex sample transfer structures complicate the transfer control logic between stations, impacting sample transfer efficiency.

[0104] Therefore, this application provides a cryopreservation device in which a transfer stage is provided in the buffer chamber and is configured to move in the horizontal plane, thereby transferring samples between the first sampling port, the second sampling port, the scanning position and the tube picking position. The device has a simple structure and high sample transfer efficiency.

[0105] The first sampling port connects the buffer cavity to the outside atmosphere; the second sampling port connects the buffer cavity to the storage cavity.

[0106] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0107] Combination Figure 1 and Figure 2 Some embodiments of this application provide a cryopreservation device for cryopreserving biological samples.

[0108] The cryopreservation device may include a housing assembly 100, which serves as the external component of the cryopreservation device. The housing assembly 100 not only forms a storage chamber for storing biological samples, but also forms an installation chamber for the cryopreservation device drive components and an operation chamber for forming biological samples.

[0109] In some embodiments, the housing assembly 100 is configured to form a storage cavity 101, which is configured to store a sample box 10. The sample box 10 serves as a container for storing medical materials such as biological samples. In the accompanying drawings of the embodiments of this application, it is shown as a cuboid box, but this is not a limitation on the shape and structure of the sample box 10.

[0110] Reference Figure 2 and Figure 3 The cryopreservation device may include a storage mechanism 20, which is installed in the storage cavity 101 and is used to place the sample box 10.

[0111] The cryopreservation device may include a transfer robot 22, which is installed in the storage cavity 101 to place the sample box 10 on the storage mechanism 20 or to transfer the sample box 10 of the storage mechanism 20 to the outside of the storage cavity 101.

[0112] In some embodiments, the storage mechanism 20 may include an annular rotating cage 21, and the transfer robot 22 may be located at the center of the annular rotating cage 21, which facilitates the improvement of the structural compactness of the cryopreservation device and the improvement of the storage utilization rate in the storage cavity 101.

[0113] The annular rotating cage 21 may include multiple storage racks arranged circumferentially to provide more storage locations.

[0114] The annular rotating cage 21 can be configured to rotate about its axis; the transfer manipulator 22 is configured to move vertically and along a first direction (corresponding to...). Figure 2 The telescopic movement (in the Y-axis direction) and the combination of these two mechanisms can transfer the sample box 10 at any position on the annular rotating cage 21.

[0115] In some embodiments, multiple annular rotating cages 21 may be provided, with the multiple annular rotating cages 21 arranged coaxially and arranged radially inside and outside each other. In this way, not only can the storage capacity of the sample box 10 in the storage cavity 101 be increased, but the structure of the storage mechanism 20 is also compact, which is conducive to improving the space utilization rate in the storage cavity 101.

[0116] exist Figure 2 and Figure 3 In the structure shown, two annular rotating cages 21 are provided. This is only an illustration of the number of annular rotating cages 21, and not a limitation on the number of annular rotating cages 21. Moreover, in Figure 2 and Figure 3 In the diagram, only one storage rack is shown in the annular rotating cage 21. This is for illustrative purposes only and is not a limitation on the number of storage racks.

[0117] Typically, the temperature inside the storage chamber 101 is low, for example, -80°C. If the sample box 10 is transferred directly between the storage chamber 101 and the external environment, the sample box 10 is prone to frost formation; and the large temperature difference is detrimental to the storage quality of the sample and will also cause temperature fluctuations in the storage chamber 101.

[0118] Therefore, in some embodiments, the housing assembly 100 is further configured to form a buffer cavity 102, the storage temperature of which is higher than that of the storage cavity 101. Of course, the storage temperature of the buffer cavity 102 is below zero degrees Celsius. For example, the storage temperature of the buffer cavity 102 is -30°C, -40°C, etc.

[0119] In some embodiments, the cryopreservation device includes two refrigeration systems, one for cooling the storage chamber 101 and the other for cooling the buffer chamber 102. This configuration facilitates precise temperature control of the storage chamber 101 and the buffer chamber 102.

[0120] The buffer cavity 102 is located on the side of the storage cavity 101, thus facilitating sample access. Exemplarily, the buffer cavity 102 is arranged in the storage cavity 101 along a first direction (corresponding to...). Figure 2 On one side of the Y-axis direction. At this time, the transfer robot 22 is configured to move telescopically along the first direction to realize the transfer of the sample box 10 between the buffer cavity 102 and the storage cavity 101.

[0121] The buffer cavity 102 is configured to be optionally connected to the storage cavity 101, allowing the sample cartridge 10 to be transferred between the buffer cavity 102 and the storage cavity 101. This allows for sample handling in the low-temperature environment of the buffer cavity 102, preventing frost buildup on the sample cartridge 10 and thus avoiding interference with sample handling. Furthermore, the sample cartridge 10's movement in and out of the storage cavity 101 via the buffer cavity 102 reduces the impact of sudden temperature changes on sample storage quality and also minimizes the influence on the temperature within the storage cavity 101.

[0122] In some embodiments, combined with Figure 3 and Figure 4 The housing assembly 100 is also configured to form a first pick-and-place port 103, which is configured to connect the buffer cavity 102 and the outside atmosphere, so that the sample box 10 can enter and exit the buffer cavity 102 through the first pick-and-place port 103.

[0123] For example, the first pick-and-place port 103 is located on the side of the buffer cavity 102 away from the storage cavity 101, so that there is enough space to pick up and place the sample box 10 through the first pick-and-place port 103.

[0124] Combination Figure 2 and Figure 3 The cryopreservation device may include a first insulated door 130, which is configured to open or close the first access port 103. The first insulated door 130 can be opened by an operator; alternatively, the first insulated door 130 may be an electric door, opened or closed under the control of the cryopreservation device's controller.

[0125] Among them, Figure 2 In the middle, the first insulation door 130 closes the first loading / unloading port 103; in Figure 3 In the middle, the first heat preservation door 130 is driven to open the first loading and unloading port 103.

[0126] In some instances, the cryopreservation device may include a sample loading mechanism 30, which is configured to input the sample box 10 into the buffer cavity 102 through the first loading port 103, or to output the sample box 10 from the buffer cavity 102.

[0127] For example, the sampling mechanism 30 is configured to vertically lift the sample box 10 to input or output the sample box 10 to the buffer cavity 102 through the first sampling port 103.

[0128] In some embodiments, combined with Figure 4 The housing assembly 100 is also configured to form a second pick-and-place port 104, which connects the buffer cavity 102 and the storage cavity 101. The sample box 10 is transferred between the storage cavity 101 and the buffer cavity 102 through the second pick-and-place port 104.

[0129] Combination Figure 2 The cryopreservation device may include a second insulated door 140, which is configured to open or close the second access port 104. The second insulated door 140 is an electric door, which can be opened or closed under the control of a controller.

[0130] Continue to refer to Figure 1 In some embodiments, the housing assembly 100 includes a first housing 110, which is configured to form a storage cavity 101.

[0131] The first housing 110 may include a first housing shell, which is the exterior component of the first housing 110.

[0132] The first housing 110 may include a first inner chamber 111, which forms a storage cavity 101. The first inner chamber 111 is fixed inside the first housing. A mounting cavity is formed between the first inner chamber 111 and the first housing for mounting other functional components of the cryopreservation device, such as a refrigeration system and drive components.

[0133] The first enclosure 110 may include a first insulation component, which is disposed between the first enclosure shell and the first enclosure liner 111 to insulate the storage cavity 101. The first insulation component includes a foam structure, an insulation board, etc.

[0134] In some embodiments, the housing assembly 100 includes a second housing 120, which is configured to form a buffer cavity 102 and a first access port 103. The second housing 120 is located on the side of the first housing 110. Figure 1 As shown, the second housing 120 is located on one side of the first housing 110 along its longitudinal direction, wherein the longitudinal direction can correspond to... Figure 1 In the Y-axis direction.

[0135] The second housing 120 may include a second housing shell, which is the exterior component of the second housing 120.

[0136] The second housing 120 may include a second inner chamber 121, which forms a buffer cavity 102. The second inner chamber 121 is fixed inside the second housing. A mounting cavity is formed between the second inner chamber 121 and the second housing for mounting other functional components of the cryopreservation device, such as the sample handling mechanism 30.

[0137] The second enclosure 120 may include a second insulation component, which is disposed between the second enclosure shell and the second enclosure liner 121 to insulate the storage cavity 101. The second insulation component includes a foam structure, insulation board, etc.

[0138] Combination Figure 1 In some embodiments, a display device 122 is mounted on the second housing to display the sample's storage information. Currently, the display device 122 may also have touch functionality for ease of operation.

[0139] In some embodiments, the second housing 120 can be detachably connected to the first housing 110. In this way, in the event of a power outage or other emergency, the first housing 110 and the second housing 120 can be detached to allow for emergency transfer of the samples inside the first housing 110, thereby improving the safety of the cryopreservation device.

[0140] In some embodiments, the first housing 110 is further configured to form a first opening, which communicates with the storage cavity 101. The second cavity is further configured to form at least one second opening, which is configured to communicate with the buffer cavity 102. When the second housing 120 is connected to the first housing 110, the first opening and the second opening are opposite to each other and together form a second access port 104.

[0141] Continue to refer to Figure 2 and Figure 3 The buffer chamber 102 serves as the operating chamber of the sample box 10. A tube picking mechanism 40 may be provided in the buffer chamber 102. The tube picking mechanism 40 is configured to pick a set sample tube from the sample box 10, or to place the sample tube in the sample box 10.

[0142] A scanning mechanism 50 may be installed inside the buffer cavity 102. The scanning mechanism 50 is configured to scan the information of the sample tubes inside the sample box 10.

[0143] A transfer station 60 may be installed inside the buffer cavity 102, and the transfer station 60 is configured to transfer the sample box 10.

[0144] In some embodiments, the transfer table 60 is located below the pipe-picking mechanism 40, which is configured to move vertically (corresponding to...). Figure 3 The sample tube is raised and lowered (in the Z-axis direction) to select a set sample tube from the sample box 10 on the transfer table 60.

[0145] The scanning mechanism 50, the sample loading and unloading mechanism 30, and the second loading and unloading port 104 are all located on the side of the transfer table 60, facilitating the transfer table 60 to transfer samples between the scanning station, the first loading and unloading port 103, and the second loading and unloading port 104. For example, the scanning mechanism 50 and the sample loading and unloading mechanism 30 are respectively located on both sides of the transfer table 60 along a second direction, and the second loading and unloading port 104 is located on one side of the transfer table 60 along a first direction. The second direction is perpendicular to the first direction.

[0146] exist Figure 4 In the orientation shown, the scanning mechanism 50 and the sampling mechanism 30 are located on both sides of the transfer table 60 along the X-axis, and the second sampling port 104 is located on one side of the transfer table 60 along the Y-axis.

[0147] In some embodiments, the transfer table 60 is configured to move the sample box 10 in a horizontal plane to transfer the sample box 10 between the sample taking and placing mechanism 30, the second taking and placing port 104, the scanning mechanism 50, and the tube picking mechanism 40.

[0148] The horizontal plane is perpendicular to the vertical direction. The horizontal plane is the plane defined by the first and second directions. Figure 4 In the directions shown, the horizontal plane is the XY plane.

[0149] The transfer table 60 moves the sample box 10 in the horizontal plane, including moving the sample box 10 in a certain direction in the horizontal plane and rotating the sample box 10 in the horizontal plane, that is, rotating around a rotation axis perpendicular to the horizontal plane.

[0150] Thus, the cryopreservation device of this application embodiment, by setting up a transfer platform 60, enables the sample box 10 to be transferred between four stations: scanning, tube picking, sample taking and placing mechanism 30 and second taking and placing port 104. This not only simplifies the structural arrangement within the buffer cavity 102, but also improves the transfer efficiency of the sample box 10.

[0151] exist Figures 1 to 4 In the illustrated structure, the housing assembly 100 includes a first housing 110 as an example. The housing assembly 100 is configured to form a second access port 104.

[0152] In some embodiments, combined with Figure 4 and Figure 5 The first pick-and-place port 103 and the scanning mechanism 50 are located on both sides of the transfer table 60 along the second direction, and the second pick-and-place port 104 is located on one side of the transfer table 60 along the first direction.

[0153] In this embodiment, the first pick-and-place port 103 is positioned lower than the transfer stage 60. Therefore, the pick-and-place mechanism 30 is configured to move vertically, allowing the sample box 10 to be transferred from the pick-and-place mechanism 30 to the transfer stage 60. Thus, with the pick-and-place mechanism 30 and the tube-picking mechanism 40 configured to move vertically, the transfer stage 60 only needs to move horizontally to achieve transfer between four positions: two pick-and-place positions, the tube-picking position, and the scanning position. This simplifies the sample transfer structure within the buffer cavity 102.

[0154] Of course, in some embodiments, the position of the first pick-up and drop-off port 103 can be on the same horizontal plane as the platform of the transfer table 60 that accommodates the sample box 10. In this way, the pick-up and drop-off mechanism 30 can push the sample box 10 to the transfer table 60 from the side of the first pick-up and drop-off port 103 away from the transfer table 60. At this time, the pick-up and drop-off mechanism 30 can move in the horizontal plane.

[0155] In other embodiments of this application, multiple first boxes 110 may be provided, and the multiple first boxes 110 are arranged circumferentially around the second box 120.

[0156] The enclosure assembly 100 is configured to form a plurality of second access ports 104, each second access port 104 connecting one of the storage chambers 101 and the cache chamber 102. Thus, the second enclosure 120 is configured to form a plurality of second openings, each second opening opposite one of the first openings to form a second access port 104.

[0157] Combination Figure 6 and Figure 7 In some possible embodiments of this application, two first housings 110 are provided, and the two first housings 110 are respectively arranged on both sides of the second housing 120 along a certain direction. Combined with... Figure 7 Two first boxes 110 are respectively arranged on both sides of the second box 120 along the X-axis. At this time, the first pick-and-place port 103 and the scanning mechanism 50 can be arranged on both sides of the transfer table 60 along the Y-axis. In this way, the two sample pick-and-place positions, the tube picking position, and the scanning position are respectively arranged on the four sides of the transfer table 60, and the transfer space of the sample box 10 is sufficient.

[0158] In this embodiment, a transfer robot 22 disposed within the storage mechanism 20 extends and retracts along the X-axis to transfer the sample box 10 between the storage mechanism 20 and the transfer table 60.

[0159] Combination Figure 8 and Figure 9In some other possible embodiments of this application, three first housings 110 are provided, and the three first housings 110 are respectively arranged on three sides of the second housing 120. The first pick-up and put-away port 103 is provided on the fourth side of the second housing 120 to facilitate sample pick-up and put-away operations. The scanning mechanism 50 can be provided between any two of the four pick-up and put-away ports. The four pick-up and put-away ports mentioned here include three second pick-up and put-away ports 104 and one first pick-up and put-away port 103.

[0160] In this embodiment, the transfer manipulators 22 in the two first boxes 110 arranged along the X-axis extend and retract along the X-axis to transfer the sample box 10 between the storage mechanism 20 and the transfer table 60; the transfer manipulators 22 in the first box 110 arranged along the Y-axis on one side of the transfer table 60 extend and retract along the Y-axis to transfer the sample box 10 between the storage mechanism 20 and the transfer table 60.

[0161] With the above configuration, the transfer platform 60 of this embodiment is configured to rotate and move linearly in the horizontal plane to transfer the sample box 10 between the sampling mechanism 30, the second sampling port 104, the scanning mechanism 50, and the tube picking mechanism 40. This not only allows for more flexible placement of the sampling mechanism 30, the second sampling port 104, and the scanning mechanism 50, but also enables the provision of multiple storage cavities 101, increasing storage space. Thus, one buffer cavity 102 can be paired with multiple storage cavities 101, and the transfer platform 60 can facilitate the transfer of the sample box 10 between the buffer cavity 102 and the multiple storage cavities 101, expanding storage space.

[0162] The specific structure and function of the transfer station 60 in the embodiments of this application are described in detail below with reference to the accompanying drawings.

[0163] Reference Figure 10 and Figure 11 In some embodiments, the transfer station 60 may include a first moving mechanism 300 configured to drive the sample box 10 to move in one direction in the horizontal plane.

[0164] exist Figure 10 and Figure 11 In this configuration, the first moving mechanism 300 is configured to drive the sample box 10 along a second direction (corresponding to...). Figure 10 (Moves along the X-axis).

[0165] Continue to refer to Figure 10 and Figure 11 In some embodiments, the transfer table 60 may include a rotating mechanism 400, the output of which is connected to a first moving mechanism 300; the rotating mechanism 400 is configured to drive the first moving mechanism 300 to rotate about a rotation axis.

[0166] The axis of rotation is perpendicular to the horizontal plane. The axis of rotation is parallel to the vertical plane.

[0167] It should be noted that, in Figure 10 and Figure 11 In the shown orientation, under the action of the rotating mechanism 400, the first moving mechanism 300 is configured to drive the sample box 10 to move along the second direction. The rotating mechanism 400 can also drive the first moving mechanism 300 to rotate, so that the first moving mechanism 300 is configured to drive the sample box 10 to move along the first direction.

[0168] In this embodiment, the rotating mechanism 400 is configured to drive the first moving mechanism 300 to rotate 360° around the rotating axis, so that the first movement can drive the sample box 10 to move in any direction in the horizontal plane, thereby improving the flexibility of the sample box 10 transfer.

[0169] In some embodiments, combined with Figure 12 and Figure 13 The first moving mechanism 300 is configured to form a receiving part 311 for receiving the sample box 10.

[0170] In some embodiments, the first moving mechanism 300 may include a base 200 configured to form a moving channel 201 extending in one direction in a horizontal plane. The sample box 10 is configured to move along the moving channel 201.

[0171] The base 200 is connected to the output end of the rotating mechanism 400, so that the rotating mechanism 400 can drive the base 200 to rotate in the horizontal plane.

[0172] For example, the base 200 includes a base plate and two side plates, the base plate extending in one direction in a horizontal plane; the two side plates are respectively disposed on both sides of the base plate in another direction. The other direction of the base plate is perpendicular to the extension direction of the base plate. Thus, the base plate and the two side plates enclose and form a moving channel 201 extending in the first direction.

[0173] In some embodiments, the first moving mechanism 300 may include a receiving member 310 configured to form a receiving portion 311 to receive the sample box 10. The receiving portion 311 restricts vertical displacement of the sample box 10. The receiving member 310 is slidably mounted on the base 200.

[0174] In some embodiments, the receiving portion 311 has a cutout portion 312 so that the bottom of the sample box 10 is exposed, which facilitates the scanning mechanism 50 to scan the information of the sample tube at the bottom of the sample box 10.

[0175] The cutout portion 312 has an opening at one end along the sliding direction of the receiving member 310, allowing the sample box 10 to enter and exit the receiving portion 311 through the opening. With this configuration, when the sample box 10 is transferred between the receiving member 310 and the transfer robot 22, the support structure on the transfer robot 22 that supports the sample box 10 is located inside the cutout portion 312, thereby realizing the transfer of the sample box 10 between the receiving member 310 and the transfer robot 22.

[0176] For example, combined Figure 4 The sampling mechanism 30 drives the sample box 10 upward so that it is higher than the receiving member 310; then the receiving member 310 is driven to move along the positive X-axis to below the sample box 10; the sampling mechanism 30 drives the sample box 10 downward so that it is transferred onto the receiving member 310; then the receiving member 310 is driven to move along the negative X-axis, away from the sampling mechanism 30. Thus, the sample box 10 on the sampling mechanism 30 is transferred onto the receiving member 310.

[0177] For example, continue to refer to Figure 3 and Figure 4 The receiving member 310 is driven to move along the positive Y-axis, the transfer robot 22 is configured to move along the negative Y-axis, and the transfer robot 22 is located below the receiving member 310; then the transfer robot 22 is configured to rise so that the sample box 10 is transferred onto the transfer robot 22; when the transfer robot 22 moves into the storage cavity 101 along the positive Y-axis, the receiving member 310 is configured to move along the negative Y-axis.

[0178] Reference Figure 12 and Figure 13 In some possible implementations of this application, the accommodating member 310 includes two elongated bodies parallel to the extending direction of the moving channel 201, and the two elongated bodies are arranged at intervals along a direction perpendicular to the extending direction of the moving channel 201. Thus, a hollow portion 312 is formed between the two elongated bodies.

[0179] The first moving mechanism 300 may include a first driver 320, which can be used to provide driving force. The first driver 320 is mounted on the base 200. The first driver 320 is connected to the receiving member 310 and is configured to drive the receiving member 310 to move relative to the base 200 in one direction in the horizontal plane, thereby moving the sample box 10.

[0180] The first moving mechanism 300 may include a first transmission component 330, and the first driver 320 is connected to the receiving member 310 through the first transmission component 330.

[0181] For example, when the first driver 320 is a motor, the first transmission assembly 330 may include a meshing first gear 331 and a first rack 332. The first gear 331 is connected to the output shaft of the first driver 320, and the first rack 332 is fixed to the receiving member 310, extending along the X-axis direction. The first driver 320 drives the receiving member 310 to move along the X-axis direction in the horizontal plane through the first gear 331 and the first rack 332. Since the meshing first gear 331 and the first rack 332 have high transmission efficiency and transmission accuracy, it is beneficial to reduce the driving power requirement of the first driver 320 and to enhance the positional accuracy of the receiving member 310 when sliding, thereby improving the positional accuracy of the sample box 10 when moving.

[0182] For example, when the first driver 320 is a motor, the first transmission assembly 330 may include a first screw and a first nut, with the first nut threadedly connected to the first screw. The first screw is connected to the output shaft of the first driver 320 and extends along the X-axis direction in the horizontal plane; the first nut is fixed to the receiving member 310. The first driver 320 drives the receiving member 310 to move along a first direction through the first screw and the first nut. The threaded transmission engagement of the first screw and the first nut converts the rotation of the first driver 320 into the movement of the receiving member 310 along the first direction, resulting in high transmission efficiency and low transmission noise.

[0183] In some embodiments, a first groove 202 is formed on the base 200. Exemplarily, the first groove 202 is provided on the side plate of the base 200. A receiving member 310 is connected to a first slide rail 313, which is slidably disposed within the first groove 202. Through the cooperation of the first groove 202 and the first slide rail 313, the receiving member 310 is slidably mounted on the base 200, and the first groove 202 and the first slide rail 313 have high linear motion accuracy, which helps to improve the positional accuracy of the sample box 10 in one direction within the horizontal plane.

[0184] Reference Figure 10 and Figure 11 The rotating mechanism 400 may include a second driver 410, which provides driving force for the rotation of the first moving mechanism 300.

[0185] The output terminal of the second driver 410 is fixedly connected to the base 200, thereby causing the sample box 10 to rotate in the horizontal plane by driving the base 200 to rotate. For example, the output terminal of the second driver 410 is connected to the bottom plate of the base 200.

[0186] The rotating mechanism 400 may include a mounting member 420 located below the base 200; a second actuator 410 is mounted on the mounting member 420. In some embodiments, the mounting member 420 may be configured to form a receiving cavity, and the second actuator 410 is mounted within the receiving cavity.

[0187] In some embodiments, the rotating mechanism 400 may include a second transmission component 430, through which the second driver 410 is connected to the base 200.

[0188] For example, the second transmission assembly 430 may include a rotating shaft, a meshing second gear 431, and a third gear 432, with the second gear 431 connected to the output shaft of the second driver 410. The rotating shaft is fixed to the base 200, and the third gear 432 is mounted on the rotating shaft. The second driver 410 drives the second gear 431 to rotate, thereby driving the third gear 432 to rotate, which in turn drives the base 200 and the first moving mechanism 300 to rotate around the rotating shaft.

[0189] In this embodiment of the application, by setting the second transmission component 430, not only can the driving force of the second driver 410 be transmitted, but the installation position of the second driver 410 can also be flexible, and the position of the rotating shaft can be set according to actual needs.

[0190] Of course, the above is not a limitation on the structure of the second transmission assembly 430. For example, the second transmission assembly 430 may include three gears, etc.

[0191] In some embodiments, the vertical projection of the axis of rotation onto the base 200 coincides with the center of the base 200. Specifically, the vertical projection of the axis of rotation onto the base plate of the base 200 coincides with the center of the base plate of the base 200.

[0192] This configuration ensures that the first moving mechanism 300 maintains good balance during rotation, reducing instability caused by eccentricity; it also helps to improve rotational accuracy, reduce errors caused by eccentricity, and improve the accuracy of the transfer table 60 in transferring the sample box 10.

[0193] Continue to refer to Figure 10 and Figure 11 The transfer table 60 may include a second moving mechanism 500, which is configured to drive the rotating mechanism 400 and the first moving mechanism 300 to move along a first direction (corresponding to the Y-axis direction in 10). A second pick-and-place port 104 is located on one side of the transfer table 60 along the first direction.

[0194] In this embodiment, a second moving mechanism 500 is provided to drive the rotating mechanism 400 and the first moving mechanism 300 to move along a first direction in the horizontal plane, thereby causing the sample box 10 to move along the first direction. On the one hand, this provides space for the rotating mechanism 400 to drive the first moving mechanism 300 to rotate. On the other hand, the second moving mechanism 500 increases the moving distance of the sample box 10 along the first direction. With a large number of annular rotating cages 21, there is sufficient moving distance between the transfer platform 60 and the transfer robot 22 along the first direction, ensuring that the sample box 10 is smoothly transferred between the transfer platform 60 and the transfer robot 22.

[0195] In some embodiments, the second moving mechanism 500 may include a third driver 510 for providing driving force.

[0196] The third drive 510 can be installed within the mounting component 420, making the structure of the transfer table 60 compact. The third drive 510 can be a motor.

[0197] The second moving mechanism 500 may include a base 530, which is fixed inside the buffer cavity. For example, the base 530 is fixed inside the second housing.

[0198] In some embodiments, the second moving mechanism 500 may include a second screw and a second nut, the second nut being threadedly connected to the second screw. The second screw is connected to the output shaft of the third driver 510 and extends along a first direction; the second nut is fixed to the base 530. The third driver 510 drives the rotating mechanism 400 to move along the first direction via the second screw and the second nut. The threaded engagement of the second screw and the second nut converts the rotation of the third driver 510 into the movement of the rotating mechanism 400 along the first direction, resulting in high transmission efficiency and low transmission noise.

[0199] In other embodiments, the second moving mechanism 500 may be a third transmission component 520, which is connected to the third driver 510 to transmit the driving force of the third driver 510.

[0200] For example, the third transmission component 520 may have a meshing fourth gear 521 and a second rack 522. The fourth gear 521 is connected to the output shaft of the third driver 510, and the second rack 522 is fixed inside the base 530 and extends along the first direction. The third driver 510 drives the rotating mechanism 400 to move along the first direction through the fourth gear 521 and the second rack 522. Since the meshing fourth gear 521 and the second rack 522 have high transmission efficiency and transmission accuracy, it is beneficial to reduce the driving power requirements of the third driver 510 and to enhance the positional accuracy of the rotating mechanism 400 when sliding, thereby improving the positional accuracy of the sample box 10 when moving along the first direction.

[0201] In some embodiments of this application, the second moving mechanism 500 includes a fourth gear 521 and a second rack 522, making the structure of the second moving mechanism 500 compact. Furthermore, the third driver 510 can be mounted together with the second driver 410 within the mounting member 420, which further improves the compactness of the transfer table 60 structure.

[0202] Since both the second driver 410 and the third driver 510 are mounted within the mounting member 420, the output shaft of the second driver 410 is offset from the center of the mounting member 420. Therefore, the rotating mechanism 400 is equipped with a gear transmission set so that its rotation axis is located at the center of the mounting member 420. This improves the stability of the rotating mechanism 400 in supporting the first moving mechanism 300, ensuring balanced force distribution on the rotating mechanism 400 and facilitating the stability of the first moving mechanism 300 in moving the sample box 10.

[0203] In some embodiments, a guide structure is provided between the base 530 and the mounting member 420 to guide the mounting member 420 to move along a first direction.

[0204] For example, a second sliding groove 531 is provided on the base 530, and the second sliding groove 531 extends along the first direction; a second slider 421 is provided on the mounting member 420, and the second slider 421 is slidably mounted in the second sliding groove 531. Through the cooperation of the second sliding groove 531 and the second slider 421, not only can the connection between the mounting member 420 and the base 530 be reliable, but the mounting member 420 can also be slidably mounted on the base 530. Furthermore, the second sliding groove 531 and the second slider 421 have high linear motion accuracy, which is beneficial to improving the positional accuracy of the sample box 10 along the first direction.

[0205] As described above, the transfer station 60 uses the first moving mechanism 300, the rotating mechanism 400 and the second moving mechanism 500 to drive the sample box 10 to transfer between the sample taking and placing mechanism 30, the scanning mechanism 50, the tube picking mechanism 40 and the second taking and placing port 104.

[0206] When the transfer platform 60 drives the sample box 10 to the tube-picking position, the tube-picking mechanism 40 selects the sample tubes inside the sample box 10. Since the tube-picking mechanism 40 has a vertical movement function and a sample tube gripping and releasing function, the transfer platform 60 uses the first moving mechanism 300 and the rotating mechanism 400 to adjust the position of the sample box 10 on the horizontal plane, so that the selected sample tube is located below the tube-picking mechanism 40, allowing the tube-picking mechanism 40 to grip and release the sample tube.

[0207] Therefore, the positioning of the sample box 10 at the tube-picking position is crucial to the accuracy of the tube-picking operation. The limiting structure set on the transfer table 60 is described in detail below with reference to the attached drawings to limit the position of the sample box 10 at the tube-picking position.

[0208] Reference Figure 12 The transfer table 60 may include an elastic member 600 disposed on the base 200. The elastic member 600 is located on one side of the sample box 10 along the first limiting direction and is configured to elastically extend and retract along the first limiting direction. The elastic member 600 is configured to elastically contact the side of the sample box 10 along the first limiting direction to limit the position of the sample box 10 along the first limiting direction.

[0209] The first limiting direction is perpendicular to the sliding direction of the accommodating member 310. Figure 12 In the middle, the first limiting direction is parallel to the Y-axis direction.

[0210] The transfer platform 60 of this application embodiment, by providing an elastic member 600, can not only use the elastic force of the elastic member 600 to limit the position of the sample box 10 along the first limiting direction; but also the elastic force of the elastic member 600 acting on the sample box 10 along the first limiting direction is variable, which is conducive to the smooth movement of the sample box 10 along the extension direction of the moving channel 201.

[0211] The transfer table 60 may include a limiting member 700, which is disposed on the receiving member 310 and moves along a first direction under the drive of the first moving mechanism 300. The limiting member 700 is configured to limit the position of the sample box 10 along a second limiting direction.

[0212] The second limiting direction is parallel to the sliding direction of the receiving member 310. The second limiting direction is perpendicular to the first limiting direction, and the plane defined by the second limiting direction and the first limiting direction is parallel to the horizontal plane. Figure 12 In the middle, the second limiting direction is parallel to the X-axis direction.

[0213] Thus, by setting up the elastic member 600 and the limiting member 700, the transfer table 60 limits the position of the sample box 10 along the first limiting direction and the second limiting direction, ensuring the accuracy of the tube picking operation.

[0214] Furthermore, in this embodiment, elastic member 600 and limiting member 700 are used to limit the position of sample box 10 in the first limiting direction and the second limiting direction, respectively, so that the position limitation in each direction is more accurate and it is beneficial to improve the accuracy of tube picking operation.

[0215] In some embodiments of this application, when the limiting member 700 restricts the position of the sample box 10 along the second limiting direction, the elastic member 600 is configured to elastically contact the sample box 10 along the first limiting direction to restrict the position of the sample box 10 along the first limiting direction.

[0216] Thus, when the first moving mechanism 300 drives the sample box 10 to move along the second limiting direction until the limiting member 700 abuts against the sample box 10, the elastic member 600 abuts against the sample box 10, thereby limiting the position of the sample box 10 in the horizontal plane.

[0217] The tube picking mechanism 40 is configured to pick a set sample tube from the sample box 10 when the elastic member 600 and the limiting member 700 restrict the position of the sample box 10, thus ensuring the accuracy of the tube picking operation.

[0218] like Figure 12 As shown, the first moving mechanism 300 drives the sample box 10 to move within the moving channel 201, thus the moving channel 201 has a picking position and an unlocking position.

[0219] When the first moving mechanism 300 drives the sample box 10 to the tube picking position, the limiting member 700 restricts the sample box 10 to the receiving portion 311 along the second limiting direction, and the elastic member 600 elastically contacts the sample box 10. Then, the tube picking mechanism 40 is configured to pick up a sample tube from the sample box 10.

[0220] When the first moving mechanism 300 drives the sample box 10 to the unlocked position, the elastic member 600 and the limiting member 700 disengage from the sample box 10, thereby releasing the position limitation on the sample box 10.

[0221] Therefore, in this embodiment of the application, as the transfer platform 60 drives the sample box 10 to move along the moving channel 201 using the first moving mechanism 300, it also drives the limiting component to move along the moving channel 201, causing the sample box 10 to move between the picking position and the unlocking position. In other words, the position limiting and unlocking of the sample box 10 are achieved during the movement of the sample box 10 along the extending direction of the moving channel 201, without the need for an additional driving mechanism, which simplifies the structure of the transfer platform 60.

[0222] Typically, during the tube-picking process, the tube-picking mechanism 40 selects a target sample tube from one sample box 10, places the target sample tube into another sample box 10, and finally transfers the sample box 10 to achieve the transfer of the target sample tube. Therefore, the positions of the two different sample boxes 10 need to be defined separately throughout the tube-picking process.

[0223] In some embodiments, two elastic members 600 and two limiting members 700 may be provided to limit the two sample boxes 10 respectively, so as to ensure the accuracy of picking and placing the tube.

[0224] In other embodiments, one elastic member 600 and one limiting member 700 may be provided respectively. The first moving mechanism 300 drives the sample box 10 to move between the tube picking position and the unlocking position, so that the two sample boxes 10 move alternately to the tube picking position to realize the tube picking operation.

[0225] In some embodiments, combined with Figure 13 The accommodating member 310 is configured to form two accommodating portions 311, and the two accommodating portions 311 are respectively located on both sides of the limiting member 700 along the second limiting direction.

[0226] The first moving mechanism 300 is configured to selectively move one of the accommodating portions 311 such that the sample box 10 within the accommodating portion 311 comes into elastic contact with the elastic member 600 and abuts against the limiting member 700.

[0227] exist Figure 12 In the middle, the limiting member 700 is along the second limiting direction (corresponding to Figure 12 The first sample box 11 and the second sample box 12 are placed on either side of the X-axis (in the X-axis direction). Figure 6 In the middle, the first moving mechanism 300 drives the receiving part 311 to move along the first direction, so that the first sample box 11 elastically contacts the elastic member 600, thereby restricting the first sample box 11 along the first limiting direction (corresponding to Figure 12 The position of the first sample box 11 along the second limiting direction is restricted by the Y-axis direction; and the end of the limiting member 700 away from the second sample box 12 abuts against the first sample box 11, thereby restricting the position of the first sample box 11 along the second limiting direction.

[0228] exist Figure 13 In this illustration, the first sample box 11 is not shown to show the structure of the receiving part 311. Figure 13 In the process, the first moving mechanism 300 drives the accommodating part 311 to move along the second limiting direction so that the second sample box 12 comes into elastic contact with the elastic member 600 to limit the position of the second sample box 12 along the first limiting direction; and the end of the limiting member 700 away from the first sample box 11 abuts against the second sample box 12, thereby limiting the position of the second sample box 12 along the second limiting direction.

[0229] In some embodiments of this application, the first moving mechanism 300 drives the first sample box 11 to move along the second limiting direction to the tube-picking position, the limiting member 700 restricts the position of the first sample box 11 along the second limiting direction, and the elastic member 600 restricts the position of the first sample box 11 along the first limiting direction. Then, the tube-picking mechanism selects the target sample tube from the first sample box 11, such as... Figure 12 As shown.

[0230] Then, the first moving mechanism 300 drives the first sample box 11 to move along the second limiting direction to the unlocked position, causing the elastic member 600 and the limiting member 700 to disengage from the sample box 10. Simultaneously, the first moving mechanism 300 drives the second sample box 12 to move along the second limiting direction to the tube-picking position. The limiting member 700 restricts the position of the second sample box 12 along the second limiting direction, and the elastic member 600 restricts the position of the second sample box 12 along the first limiting direction. Then, the tube-picking mechanism places the target sample tube into the second sample box 12, such as... Figure 13 As shown.

[0231] Therefore, the accommodating member 310 of this application embodiment is constructed with two accommodating portions 311, which can simultaneously accommodate two sample boxes 10. The two accommodating portions 311 are respectively located on both sides of the limiting member 700 along the second limiting direction. The first moving mechanism 300 drives the accommodating member 310 to move along the second limiting direction, so that the sample boxes 10 in the two accommodating portions 311 are alternately moved to the tube picking position. This enables the tube picking mechanism to pick a tube from one sample box 10 and place a tube into the other sample box 10. The positioning operation of the two sample boxes 10 is simple and helps to improve the tube picking efficiency.

[0232] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

[0233] For ease of explanation, the above description has been provided in conjunction with specific embodiments. However, the above exemplary discussion is not intended to be exhaustive or to limit the embodiments to the specific forms disclosed above. Various modifications and variations can be obtained based on the above teachings. The selection and description of the above embodiments are for the purpose of better explaining the principles and practical applications, thereby enabling those skilled in the art to better utilize the described embodiments and various different variations of embodiments suitable for specific use considerations.

Claims

1. A cryopreservation device, characterized in that, include: The enclosure assembly (100) includes: The first box (110) is constructed as follows: Storage cavity (101) is configured to store sample box (10); The first opening is connected to the storage cavity (101); The second housing (120) is detachably connected to the first housing (110); the second housing (120) is constructed as follows: A buffer cavity (102) is disposed on the side of the storage cavity (101); The first take-out port (103) is configured to connect the buffer cavity (102) and the outside atmosphere; Multiple second openings; When the second housing (120) is connected to the first housing (110), the second opening is opposite to the first opening and together define the second pick-up and put-out port (104), which connects the buffer cavity (102) and the storage cavity (101). The first box (110) is provided in multiple ways, and the multiple first boxes (110) are arranged circumferentially around the second box (120); each second opening is opposite to one of the first openings to form a second loading and unloading port (104); The sampling mechanism (30) is configured to input the sample box (10) into the buffer cavity (102) through the first sampling port (103), or to output the sample box (10) in the buffer cavity (102); A scanning mechanism (50) is installed in the buffer cavity (102) and is configured to scan information of the sample tubes in the sample box (10); A tube-picking mechanism (40) is installed in the buffer cavity (102); the tube-picking mechanism (40) is configured to move vertically; the tube-picking mechanism (40) is configured to pick up a sample tube from the sample box (10); A transfer table (60) is installed inside a buffer cavity (102) and located below the tube picking mechanism (40); the transfer table (60) is configured to move the sample box (10) in a horizontal plane to transfer the sample box (10) between the sample picking mechanism (30), the second sample picking port (104), the scanning mechanism (50) and the tube picking mechanism (40); wherein the horizontal plane is perpendicular to the vertical direction.

2. The cryopreservation device according to claim 1, characterized in that, The transfer station (60) includes: The first moving mechanism (300) is configured to form a receiving portion (311) for receiving the sample box (10); the first moving mechanism (300) is configured to drive the sample box (10) to move in one direction within the horizontal plane; A rotating mechanism (400) is provided, the output of which is connected to a first moving mechanism (300); the rotating mechanism (400) is configured to drive the first moving mechanism (300) to rotate about a rotating axis; the rotating axis is perpendicular to the horizontal plane.

3. The cryopreservation device according to claim 2, characterized in that, The first moving mechanism (300) includes: The base (200) is connected to the output end of the rotating mechanism (400); The receiving member (310) is slidably mounted on the base (200), and the receiving member (310) is configured to form a receiving portion (311); A first driver (320) is mounted on a base (200); the first driver (320) is connected to a receiving member (310) and is configured to drive the receiving member (310) to slide relative to the base (200).

4. The cryopreservation device according to claim 3, characterized in that, An elastic member (600) is provided on the base (200), and the elastic member (600) is configured to elastically contact the sample box (10) in a direction perpendicular to the sliding direction of the receiving member (310); A limiting member (700) is provided on the receiving member (310). The limiting member (700) is configured to limit the position of the sample box (10) along the sliding direction of the receiving member (310) when the elastic member (600) is in elastic contact with the sample box (10). The tube picking mechanism (40) is configured to pick a set sample tube from the sample box (10) when the position of the sample box (10) is restricted by the elastic member (600) and the limiting member (700).

5. The cryopreservation apparatus according to claim 3, characterized in that, The rotating mechanism (400) includes: Mounting component (420) is located below base (200); A second driver (410) is mounted on a mounting member (420); the output of the second driver (410) is fixedly connected to the base (200), and the second driver (410) is configured to drive the base (200) to rotate about the rotation axis.

6. The cryopreservation apparatus according to claim 5, characterized in that, The rotating shaft is formed on the base (200) and is connected to the output end of the second driver (410); The projection of the axis of rotation vertically onto the base (200) coincides with the center of the base (200).

7. The cryopreservation apparatus according to claim 3, characterized in that, The receiving part (311) is provided with a cutout part (312) so that the scanning mechanism (50) can scan the information of the sample box (10) through the cutout part (312); The cutout portion (312) has an opening at one end along the sliding direction of the receiving member (310) so that the sample box (10) can enter and exit the receiving portion (311) through the opening.

8. The cryopreservation apparatus according to any one of claims 2-7, characterized in that, The transfer station (60) also includes: A second moving mechanism (500) is connected to a rotating mechanism (400), and the second moving mechanism (500) is configured to drive the rotating mechanism (400) and the first moving mechanism (300) to move along a first direction; The second pick-up / drop-off port (104) is located on one side of the transfer table (60) along the first direction.

9. The cryopreservation apparatus according to any one of claims 1-7, characterized in that, The cryopreservation device includes multiple annular rotating cages (21); the multiple annular rotating cages (21) are arranged coaxially and are sequentially inner and outer cages along the radial direction.

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