Body fixing device of rat brain stereotaxic apparatus

Abstract

The utility model discloses a body fixing device for a rat brain stereotaxic apparatus, and relates to the technical field of animal experiments, the body fixing device comprises a bottom plate, the top end of the bottom plate is fixedly connected with a fixing frame, the top end of the fixing frame is rotatably connected with a fixing mechanism, and the fixing mechanism comprises a motor; the device comprises a fixing frame, two fixing blocks are fixedly connected to the top end of the fixing frame, the two fixing blocks are jointly and rotationally connected with a long rod in a sleeving mode, first gears are fixedly connected to the two ends of the two long rods correspondingly, second gears are connected to the outer surfaces of the two first gears in an engaged mode correspondingly, and the opposite ends of the two second gears are jointly and fixedly connected with a connecting rod; the output end of the motor is fixedly connected with one of the second gears, a cover plate is fixedly connected to the outer surface of the long rod, and fixing grooves are formed in the bottom end of the cover plate and the top end of the fixing frame, the device can limit movement of a rat by arranging the fixing mechanism, and therefore the positioning accuracy can be effectively improved.

Description

Technical Field

[0001] This application relates to the field of animal experimental technology, and in particular to a body fixation device for a rat brain stereotaxic apparatus. Background Technology

[0002] Stereotactic techniques for the rat brain are widely used for precise localization of brain damage, stimulation, and electroencephalogram (EEG) recordings, becoming an indispensable tool for studying brain structure and function. Rat stereotactic techniques primarily utilize a stereotactic frame as the localization instrument. By employing a three-dimensional coordinate system defined by certain skull landmarks (such as the anterior and posterior fontanelles, external auditory canal, orbit, and sagittal suture) or other reference points, the location of certain subcortical neural nuclei can be determined. This allows for targeted stimulation, destruction, drug injection, and potential guidance studies without direct visual exposure. It is an important research method in neuroanatomy, neurophysiology, neuropharmacology, and neurosurgery. Therefore, there is an urgent need in the market for a rat brain stereotactic frame fixation device.

[0003] According to announcement number CN 211750141 U, a stereotactic positioning device for rat brain is disclosed. This technology discloses a technical solution that includes "a clamping rod, a crossbeam, a pusher / puller, a first positioning pin, and a second positioning pin. One end of the clamping rod is connected and fixed to the top surface of the crossbeam. The pusher / puller is sleeved on the outside of the crossbeam and slides relative to the crossbeam. The first positioning pin and the second positioning pin are arranged side by side on the bottom surface of the crossbeam. The first positioning pin is fixed to the crossbeam, and the second positioning pin is fixed to the pusher / puller. The second positioning pin slides relative to the first positioning pin under the action of the pusher / puller. This solution can effectively solve the problems existing in the prior art and can also accurately measure the distance between the anterior and posterior fontanelles."

[0004] Regarding the aforementioned technologies, the inventors believe that most existing rat stereotaxic apparatus body fixation devices only rely on two ear rods for fixation. However, fixation by ear rods alone may not completely restrict the rat's subtle movements, especially in experiments requiring high-precision operation, which may affect the accuracy of positioning. Secondly, most existing devices cannot adapt to rats of various sizes. Therefore, if the fixation device needs to be frequently changed to adapt to rats of different sizes during the experiment, it will consume a lot of time and effort and reduce the overall efficiency of the experiment.

[0005] In view of the aforementioned technologies, the inventors believe that a rat brain stereotaxic apparatus body fixation device is needed to solve the above problems. Utility Model Content

[0006] The purpose of this application is to provide a body fixation device for a rat brain stereotaxic apparatus to improve the accuracy of localization and reduce the overall efficiency of the experiment.

[0007] The rat brain stereotaxic apparatus body fixation device provided in this application adopts the following technical solution:

[0008] A rat brain stereotaxic device body fixation device includes a base plate, a fixing frame fixedly connected to the top of the base plate, a fixing mechanism rotatably connected to the top of the fixing frame, a lifting mechanism slidably connected to the lower inner wall of the fixing frame, the fixing mechanism including a motor, two fixing blocks fixedly connected to the top of the fixing frame, a long rod rotatably sleeved on the two fixing blocks, first gears fixedly connected to both ends of the two long rods, second gears meshing with the outer surfaces of the two first gears, a connecting rod fixedly connected to the opposite ends of the two second gears, the output end of the motor fixedly connected to one of the second gears, a cover plate fixedly connected to the outer surface of the long rod, and fixing grooves formed at the bottom of the cover plate and the top of the fixing frame, the two fixing grooves being mirror-distributed to allow the rat to be fixed through the two fixing grooves.

[0009] By adopting the above technical solution, when it is necessary to fix the rat, first place the rat in the fixing groove at the bottom, then turn on the motor. The motor can drive the second gear to rotate, the second gear can drive the connecting rod to rotate, the connecting rod can drive another second gear to rotate, the two second gears can drive the two first gears to rotate respectively, the two first gears can drive the long rod to rotate, and the long rod can drive the fixing groove on the cover plate to completely cover the rat, so that the four circular grooves on the cover plate can fix the rat's limbs, and then the experiment can be carried out.

[0010] Optionally, the lifting mechanism includes a cylinder, the bottom end of the fixed frame is provided with a rectangular groove, the output end of the cylinder is fixedly connected to a slide rail, the bottom end of the slide rail is slidably connected to the top end of the base plate, the top end of the slide rail is slidably connected to a slider, the top end of the slider passes through the upper inner wall of the rectangular groove and extends into one of the fixed grooves, and a heating plate is fixedly connected to one end of the slider located in one of the fixed grooves, the heating plate being used to maintain the rat's body temperature.

[0011] By adopting the above technical solution, when the rats to be tested are slightly smaller, the cylinder is first turned on. The cylinder can drive the slide to move. Under the action of the long groove and the limiting strip, the slide can drive the slider to rise. The slider can drive the heating plate to rise. When it rises to the appropriate position, the cylinder is turned off. Then the rat can be fixed by the fixing mechanism.

[0012] Optionally, two limiting grooves are provided at both ends of the fixing frame and the cover plate, and the eight limiting grooves are the same size. A through-type experimental groove is provided at the top of the cover plate.

[0013] By adopting the above technical solution, eight limiting slots are used to fix the rat's limbs, and the experimental slot is used for experiments on the rat's brain.

[0014] Optionally, a support plate is fixedly connected to the bottom of the motor, and one end of the support plate is fixedly connected to one end of the fixing frame.

[0015] By adopting the above technical solution to support and fix the motor, the motor can operate more stably.

[0016] Optionally, soft pads are fixedly provided on the inner surfaces of the two fixing grooves and the eight limiting grooves.

[0017] By adopting the above technical solution, it is possible to avoid injury to rats due to their struggles when restraining them.

[0018] Optionally, the bottom end of the cylinder is fixedly connected to the top end of the base plate and located within a rectangular groove.

[0019] By adopting the above technical solution, the cylinder can be effectively fixed, making the cylinder run more smoothly.

[0020] Optionally, the top of the slide rail is provided with an elongated groove, and the top of the slider is fixedly connected with a limiting strip that works in conjunction with the limiting groove.

[0021] By adopting the above technical solution, the device can be effectively prevented from being damaged due to the slider moving out of its motion trajectory.

[0022] Optionally, the outer surface of the heating plate is slidably connected to the inner surface of the lower fixing groove.

[0023] By adopting the above technical solution, the heating plate can be raised and lowered more smoothly.

[0024] In summary, this application includes at least one of the following beneficial technical effects:

[0025] 1. By setting up a fixing mechanism, the device can restrict the movement of rats under the action of the motor driving the cover plate to rotate, and with the action of the four circular grooves, thereby effectively improving the accuracy of positioning.

[0026] 2. By setting up a lifting mechanism, the device can adapt to rats of different sizes by the action of the cylinder driving the heating plate to rise and fall, thereby reducing the time of the entire experimental process and effectively improving the efficiency of the experiment. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the structure of this application.

[0028] Figure 2 This is a cross-sectional schematic diagram of the fixing frame of this application.

[0029] Figure 3This is a schematic diagram of the slider in this application.

[0030] Figure 4 This is a schematic diagram of the cover plate of this application.

[0031] In the diagram, 1. Base plate; 2. Fixing frame; 3. Cover plate; 4. Lifting mechanism; 5. Fixing mechanism; 6. Limiting groove; 11. Long groove; 12. Heating plate; 13. Rectangular groove; 14. Experimental tank; 15. First gear; 16. Motor; 17. Support plate; 18. Connecting rod; 19. Cylinder; 20. Second gear; 21. Slide rail; 22. Slider; 23. Fixing block; 31. Limiting strip; 32. Fixing groove; 33. Long rod; 34. Soft pad. Detailed Implementation

[0032] The following is in conjunction with the appendix Figure 1 - Appendix Figure 4 This application will be described in further detail below.

[0033] Example

[0034] A body fixation device for a rat brain stereotaxic instrument includes a base plate 1, a fixing frame 2 on the upper part of the base plate 1, and a fixing mechanism 5 and a lifting mechanism 4 inside the fixing frame 2.

[0035] The fixing mechanism 5 includes a motor 16, two first gears 15, two second gears 20, and two fixing blocks 23. A support plate 17 is provided at the lower part of the motor 16. One side of the support plate 17 is connected to one side of the fixing frame 2. The output end of the motor 16 is fixedly connected to one of the second gears 20. A connecting rod 18 is provided on the opposite side of the two second gears 20. The connecting rod 18 is rotatably sleeved with the inside of the fixing frame 2. A long rod 33 is provided on the opposite side of the two first gears 15. The outside of the long rod 33 is rotatably sleeved with the two fixing blocks 23. The two sides of the long rod 33 are respectively connected to the two first gears 15. The two first gears 15 are respectively meshed with the two second gears 20.

[0036] A cover plate 3 is provided on one side of the long rod 33. The lower part of the cover plate 3 and the upper part of the fixing frame 2 are both provided with fixing grooves 32 for fixing rats. Two limiting grooves 6 are provided at both ends of the cover plate 3 and both ends of the fixing frame 2 for fixing the limbs of rats. The eight limiting grooves 6 are the same size. A through experimental groove 14 is provided at the upper part of the cover plate 3. The two fixing grooves 32 and the eight limiting grooves 6 are all provided with soft pads 34, which can effectively prevent injury caused by rats struggling.

[0037] The lifting mechanism 4 includes a cylinder 19. A rectangular groove 13 is opened at the lower part of the fixed frame 2. The cylinder 19 is located in the rectangular groove 13 and is connected to the upper part of the base plate 1. A slide rail 21 is slidably connected to the upper part of the base plate 1. A slider 22 is provided at the upper part of the slide rail 21. A long groove 11 is opened at the upper part of the slide rail 21. A limit strip 31 is provided at the lower part of the slider 22. The slide rail 21 and the slider 22 are slidably connected by the long groove 11 and the limit groove 6. The output end of the cylinder 19 is fixedly connected to one side of the slide rail 21.

[0038] The upper part of the slider 22 passes through the rectangular groove 13 and extends into one of the fixed grooves 32. A heating plate 12 is provided at one end of the slider 22 located in the fixed groove 32, and the heating plate 12 is slidably connected to one of the fixed grooves 32.

[0039] Working principle: When it is necessary to fix the rat, first place the rat in the fixing groove 32 at the bottom, then turn on the motor 16. The motor 16 can drive the second gear 20 to rotate, the second gear 20 can drive the connecting rod 18 to rotate, the connecting rod 18 can drive another second gear 20 to rotate, the two second gears 20 can drive the two first gears 15 to rotate respectively, the two first gears 15 can drive the long rod 33 to rotate, and the long rod 33 can drive the fixing groove 32 on the cover plate 3 to completely cover the rat, so that the four round grooves on the cover plate 3 can fix the rat's limbs, and then the experiment can be carried out.

[0040] When the rats to be tested are slightly smaller, first turn on the cylinder 19. The cylinder 19 can drive the slide 21 to move. Under the action of the long groove 11 and the limiting strip 31, the slide 21 can drive the slider 22 to rise. The slider 22 can drive the heating plate 12 to rise. When it rises to the appropriate position, turn off the cylinder 19. Then the rat can be fixed by the fixing mechanism 5.

[0041] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Identical components are represented by the same reference numerals. Therefore, all equivalent changes made to the structure, shape, and principle of this application should be covered within the scope of protection of this application.

Claims

1. A body fixation device for a rat brain stereotaxic instrument, comprising a base plate (1), characterized in that: The top of the base plate (1) is fixedly connected to a fixing frame (2), the top of the fixing frame (2) is rotatably connected to a fixing mechanism (5), and the lower inner wall of the fixing frame (2) is slidably connected to a lifting mechanism (4). The fixing mechanism (5) includes a motor (16). Two fixing blocks (23) are fixedly connected to the top of the fixing frame (2). The two fixing blocks (23) are rotatably connected to a long rod (33). Both ends of the two long rods (33) are fixedly connected to a first gear (15). The outer surfaces of the two first gears (15) are meshed with a second gear (20). The opposite ends of the two second gears (20) are fixedly connected to a connecting rod (18). The output end of the motor (16) is fixedly connected to one of the second gears (20). The outer surface of the long rod (33) is fixedly connected to a cover plate (3). The bottom end of the cover plate (3) and the top end of the fixing frame (2) are both provided with fixing grooves (32).

2. The body fixation device for a rat brain stereotaxic instrument according to claim 1, characterized in that: The lifting mechanism (4) includes a cylinder (19). A rectangular groove (13) is provided at the bottom end of the fixed frame (2). A slide rail (21) is fixedly connected to the output end of the cylinder (19). The bottom end of the slide rail (21) is slidably connected to the top end of the base plate (1). A slider (22) is slidably connected to the top end of the slide rail (21). The top end of the slider (22) penetrates the upper inner wall of the rectangular groove (13) and extends into one of the fixed grooves (32). A heating plate (12) is fixedly connected to one end of the slider (22) located in one of the fixed grooves (32).

3. The body fixation device for a rat brain stereotaxic instrument according to claim 1, characterized in that: The fixing frame (2) and the cover plate (3) each have two limiting grooves (6) at both ends. The eight limiting grooves (6) are the same size. The top of the cover plate (3) has a through-type experimental groove (14).

4. The body fixation device for a rat brain stereotaxic instrument according to claim 1, characterized in that: The bottom end of the motor (16) is fixedly connected to a support plate (17), and one end of the support plate (17) is fixedly connected to one end of the fixing frame (2).

5. The body fixation device for a rat brain stereotaxic instrument according to claim 1, characterized in that: The inner surfaces of the two fixing grooves (32) and the eight limiting grooves (6) are all fixedly provided with soft pads (34).

6. The body fixation device for a rat brain stereotaxic instrument according to claim 2, characterized in that: The bottom end of the cylinder (19) is fixedly connected to the top end of the base plate (1) and located in the rectangular groove (13).

7. The body fixation device for a rat brain stereotaxic instrument according to claim 2, characterized in that: The top of the slide (21) is provided with a long groove (11), and the top of the slider (22) is fixedly connected with a limiting strip (31) that is used in conjunction with the limiting groove (6).

8. The body fixation device for a rat brain stereotaxic instrument according to claim 2, characterized in that: The outer surface of the heating plate (12) is slidably connected to the inner surface of the lower fixing groove (32).

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