Accurate refrigeration reaction equipment for preparing fludarabine phosphate

Abstract

The utility model discloses accurate refrigeration reaction equipment for preparing fludarabine phosphate, which comprises an inner reaction tank, an outer refrigeration tank sleeved outside the inner reaction tank and a tank cover mounted at the top of the inner reaction tank, and three groups of isolation pipes penetrating through the outer refrigeration tank are arranged on the side surface and the bottom of the outer wall of the inner reaction tank. A high-position main temperature transmitter, a middle-position main temperature transmitter and a low-position main temperature transmitter which are positioned in the isolation pipe are mounted on the tank wall of the reaction inner tank; and an electric throttle valve and a flow transmitter are mounted on the refrigerant fluid input pipe. The temperature is monitored at different heights and different positions on the reaction inner tank at the same time, the monitoring results refer to each other, and the average temperature can be obtained, so that the purpose of reducing the error of the temperature monitoring results is achieved; by arranging the flow transmitter and the electric throttle valve on the refrigerant fluid input pipe, when the required cooling amplitude is small and the actual cooling speed is high, the refrigerant fluid flow is reduced, so that the refrigeration temperature is easier to control, and the effect of improving the temperature control accuracy is achieved.

Description

Technical Field

[0001] This utility model relates to the field of refrigeration reaction vessel technology, specifically a precision refrigeration reaction device for the preparation of fludarabine phosphate. Background Technology

[0002] Fludarabine phosphate is a fluorinated adenine analogue that is metabolized in the body to triphosphates with antitumor activity. It affects the synthesis of DNA, RNA and proteins and inhibits cell growth. It belongs to the nucleoside antimetabolite antitumor drugs.

[0003] In the production and preparation of fludarabine phosphate, it is often necessary to lower the temperature of the reactor to 0-10℃. Most existing jacketed refrigeration reactors cool the inner reactor by introducing refrigerant into the outer refrigeration tank and circulating the refrigerant. The cooling is determined by controlling the flow of the refrigerant. The temperature of the inner reactor is monitored by only one temperature sensor. This method not only causes temperature monitoring errors because the initial temperature inside the inner reactor cannot reach complete equilibrium, but also makes it difficult to control the timing of shutting off the refrigerant due to the gradual temperature change during the refrigeration process, resulting in inaccurate temperature control, which is not conducive to the production and processing of high-quality reagents. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a precision refrigeration reaction device for the preparation of fludarabine phosphate, which solves the problems of temperature monitoring errors and insufficient temperature control in existing jacketed refrigeration reactors for the preparation of fludarabine phosphate.

[0005] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0006] A precision refrigeration reaction apparatus for the preparation of fludarabine phosphate includes an inner reaction tank, a refrigeration outer tank fitted around the inner reaction tank, and a tank cover installed on the top of the inner reaction tank. A speed-regulating motor is installed on the top of the tank cover and is connected to a stirring mechanism inside the inner reaction tank. A refrigerant inlet pipe and a refrigerant outlet pipe are respectively connected to the bottom and top side of the refrigeration outer tank. Multiple vertical thermally conductive isolation fins are fixedly connected at equal intervals along the circumference on the outer wall of the inner reaction tank. The thermally conductive isolation fins are located below the refrigerant outlet pipe. A discharge pipe and a feed pipe are respectively provided on the bottom and top side of the refrigeration outer tank, penetrating the refrigeration outer tank and communicating with the inner reaction tank.

[0007] The outer wall and bottom of the inner reaction tank are provided with three sets of isolation pipes penetrating the outer refrigeration tank. A high-level main temperature transmitter, a medium-level main temperature transmitter, and a low-level main temperature transmitter are installed on the tank wall of the inner reaction tank, located inside the isolation pipes. An electric throttle valve and a flow transmitter are installed on the refrigerant inlet pipe. The high-level main temperature transmitter, the medium-level main temperature transmitter, the low-level main temperature transmitter, and the flow transmitter are all connected to the controller. The controller is connected to the electric throttle valve.

[0008] Preferably, the stirring mechanism includes a vertically mounted stirring shaft and stirring arms and spiral stirring blades mounted on the stirring shaft.

[0009] Preferably, the refrigerant inlet pipe and the refrigerant outlet pipe are located on both sides of the stirring shaft, and the feed pipe and the discharge pipe are symmetrically arranged with respect to the refrigerant outlet pipe and the refrigerant inlet pipe.

[0010] Preferably, the inner reaction vessel is further equipped with a high-level auxiliary temperature transmitter, a middle-level auxiliary temperature transmitter, and a low-level auxiliary temperature transmitter located inside the isolation pipe. The high-level auxiliary temperature transmitter, the middle-level auxiliary temperature transmitter, and the low-level auxiliary temperature transmitter are symmetrically arranged with the high-level main temperature transmitter, the middle-level main temperature transmitter, and the low-level main temperature transmitter, respectively, and the high-level main temperature transmitter is at a 90° angle to the refrigerant output pipe.

[0011] Preferably, the high-level auxiliary temperature transmitter, the middle-level auxiliary temperature transmitter, and the low-level auxiliary temperature transmitter are also connected to the controller signal.

[0012] Preferably, a refrigerant communication gap of 0.5-2 cm is provided between the thermally conductive insulating fin and the inner wall of the refrigeration outer tank.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] This invention, by setting up a high-level main temperature transmitter, a mid-level main temperature transmitter, a low-level main temperature transmitter, a high-level auxiliary temperature transmitter, a mid-level auxiliary temperature transmitter, and a low-level auxiliary temperature transmitter, simultaneously monitors the temperature at different heights and positions on a large reaction vessel. This avoids the loss or error of temperature monitoring signals caused by damage or error of individual temperature transmitters. At the same time, the monitoring results are cross-referenced and the average temperature can be taken, thereby reducing the error of the temperature monitoring results.

[0015] Furthermore, by installing a flow transmitter and an electric throttle valve on the refrigerant inlet pipe, the flow rate of the refrigerant circulation can be adjusted according to the required cooling range and actual cooling rate of the actual monitored temperature. This slows down the cooling rate and adapts to the gradual temperature change inside the reaction tank. By reducing the refrigerant flow rate when the required cooling range is small and the actual cooling rate is fast, it is easier to control the cooling temperature and improve the accuracy of temperature control. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a schematic diagram of the internal structure of this utility model;

[0018] Figure 3 Right sectional view of the installation of the isolation tube and the inner reaction vessel of this utility model;

[0019] Figure 4 This is a top view of the thermally conductive isolation fin corresponding to the high-level main temperature transmitter of this utility model;

[0020] Figure 5 This is a schematic diagram of the control principle of this utility model.

[0021] In the diagram: 1. Inner reaction vessel; 2. Outer refrigeration vessel; 3. Vessel cover; 4. Speed-regulating motor; 5. Stirring mechanism; 501. Stirring shaft; 502. Stirring arm; 503. Spiral stirring blade; 6. Refrigerant inlet pipe; 7. Refrigerant outlet pipe; 8. Thermally conductive insulating fins; 9. Discharge pipe; 10. Feed pipe; 11. Isolation pipe; 12. High-level main temperature transmitter; 13. Mid-level main temperature transmitter; 14. Low-level main temperature transmitter; 15. Electric throttle valve; 16. Flow transmitter; 17. Controller; 18. High-level secondary temperature transmitter; 19. Mid-level secondary temperature transmitter; 20. Low-level secondary temperature transmitter. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] like Figure 1-5As shown, this utility model provides a technical solution: a precision refrigeration reaction device for the preparation of fludarabine phosphate, including an inner reaction tank 1, a refrigeration outer tank 2 sleeved and installed outside the inner reaction tank 1, and a tank cover 3 installed on the top of the inner reaction tank 1. A speed-regulating motor 4 is installed on the top of the tank cover 3. The speed-regulating motor 4 is connected to a stirring mechanism 5 inside the inner reaction tank 1. The stirring mechanism 5 includes a vertically installed stirring shaft 501 and stirring arms 502 and spiral stirring blades 503 installed on the stirring shaft 501. The stirring mechanism 5 can stir horizontally and stir downward to promote the reaction and improve the material flow to help cool down.

[0024] The bottom and top of the outer refrigeration tank 2 are respectively connected to a refrigerant inlet pipe 6 and a refrigerant outlet pipe 7. Multiple vertical thermally conductive isolation fins 8 are fixedly connected at equal intervals along the circumference on the outer wall of the inner reaction tank 1. A refrigerant communication gap of 0.5-2 cm is set between the thermally conductive isolation fins 8 and the inner wall of the outer refrigeration tank 2, which can achieve a relative refrigerant isolation effect and mutual supplementation. The thermally conductive isolation fins 8 are in direct contact with the refrigerant to improve heat exchange and cooling. The thermally conductive isolation fins 8 are located below the refrigerant outlet pipe 7.

[0025] The bottom and top of the outer cooling tank 2 are respectively provided with a discharge pipe 9 and a feed pipe 10 that penetrate the outer cooling tank 2 and are connected to the inner reaction tank 1. The refrigerant input pipe 6 and the refrigerant output pipe 7 are respectively located on both sides of the stirring shaft 501, which promotes the uniform flow of refrigerant in the outer cooling tank 2 and achieves uniform cooling and heat exchange. The feed pipe 10 and the discharge pipe 9 are symmetrically arranged with the refrigerant output pipe 7 and the refrigerant input pipe 6, respectively.

[0026] Three sets of isolation pipes 11, penetrating the outer refrigeration tank 2, are installed on the outer wall and bottom of the inner reaction tank 1. A high-level main temperature transmitter 12, a medium-level main temperature transmitter 13, and a low-level main temperature transmitter 14 are installed on the tank wall of the inner reaction tank 1, located inside the isolation pipes 11. An electric throttle valve 15 and a flow transmitter 16 are installed on the refrigerant inlet pipe 6. The high-level main temperature transmitter 12, the medium-level main temperature transmitter 13, the low-level main temperature transmitter 14, and the flow transmitter 16 are all signal-connected to a controller 17. The controller 17 is signal-connected to the electric throttle valve 15.

[0027] The inner reaction tank 1 is also equipped with a high-level auxiliary temperature transmitter 18, a middle-level auxiliary temperature transmitter 19 and a low-level auxiliary temperature transmitter 20 located inside the isolation pipe 11. The high-level auxiliary temperature transmitter 18, the middle-level auxiliary temperature transmitter 19 and the low-level auxiliary temperature transmitter 20 are symmetrically arranged with the high-level main temperature transmitter 12, the middle-level main temperature transmitter 13 and the low-level main temperature transmitter 14 respectively, and the high-level main temperature transmitter 12 is at a 90° angle to the refrigerant output pipe 7.

[0028] The high-level auxiliary temperature transmitter 18, the middle-level auxiliary temperature transmitter 19, and the low-level auxiliary temperature transmitter 20 are also connected to the controller 17. By using multiple temperature transmitters at different heights and positions for temperature monitoring, not only can the average temperature be used as the monitoring result, making the temperature monitoring more comprehensive and accurate, but they can also act as mutual backups to avoid inaccurate temperature monitoring caused by the failure of individual temperature transmitters.

[0029] Working principle:

[0030] The reaction material is added into the inner reaction tank 1 through the feed pipe 10. The speed-regulating motor 4 drives the stirring mechanism 5 to stir and mix the reaction material to promote the reaction. When cooling is required, the refrigerant is introduced through the refrigerant inlet pipe 6 below. The refrigerant flows from bottom to top between the inner reaction tank 1 and the outer cooling tank 2 and is output from the refrigerant outlet pipe 7 above. The refrigerant circulation cools the inner reaction tank 1. At the same time, the speed-regulating motor 4 and the stirring mechanism 5 can be selectively turned on to increase the heat exchange rate of the inner reaction tank 1 according to actual needs.

[0031] During the above process, the high-level main temperature transmitter 12, the middle-level main temperature transmitter 13, the low-level main temperature transmitter 14, the high-level auxiliary temperature transmitter 18, the middle-level auxiliary temperature transmitter 19, and the low-level auxiliary temperature transmitter 20 simultaneously monitor the temperature at the upper middle, lower middle, and bottom of the inner tank 1, i.e., at different positions from the refrigerant inlet pipe 6. The temperature monitoring results from multiple temperature transmitters can be referenced to each other, avoiding the loss or error of temperature monitoring signals caused by damage or error of individual temperature transmitters. The average temperature monitored is used as the monitoring result, effectively reducing temperature monitoring errors.

[0032] Meanwhile, the flow transmitter 16 monitors the flow rate of the refrigerant in the refrigerant inlet pipe 6 in real time. The controller 17, through the monitoring structure, adjusts the opening of the electric throttle valve 15 according to the required cooling range and actual cooling rate of the actual monitored temperature, so as to adjust the flow rate of the refrigerant circulation accordingly. When the required cooling range is small and the actual cooling rate is fast, the refrigerant flow rate is reduced, making it easier to control the cooling temperature, improving the accuracy of temperature control, and thus improving the quality of the product.

[0033] It should be noted that, in this document, terms such as “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A precision refrigeration reaction apparatus for the preparation of fludarabine phosphate, comprising an inner reaction vessel (1), a refrigeration outer vessel (2) fitted onto the outside of the inner reaction vessel (1), and a vessel cover (3) installed on the top of the inner reaction vessel (1), characterized in that: A speed-regulating motor (4) is installed on the top of the tank cover (3). The speed-regulating motor (4) is connected to the stirring mechanism (5) inside the reaction tank (1). The bottom and the top of the side of the refrigeration tank (2) are respectively connected to a refrigerant inlet pipe (6) and a refrigerant outlet pipe (7). Multiple vertical heat-conducting isolation fins (8) are fixedly connected at equal intervals along the circumference on the outer wall of the reaction tank (1). The heat-conducting isolation fins (8) are located below the refrigerant outlet pipe (7). The bottom and the top of the side of the refrigeration tank (2) are respectively provided with a discharge pipe (9) and a feed pipe (10) that penetrate the refrigeration tank (2) and are connected to the reaction tank (1). The outer wall side and bottom of the reaction inner tank (1) are provided with three sets of isolation pipes (11) that penetrate the refrigeration outer tank (2). The tank wall of the reaction inner tank (1) is equipped with a high-level main temperature transmitter (12), a medium-level main temperature transmitter (13) and a low-level main temperature transmitter (14) located inside the isolation pipes (11). An electric throttle valve (15) and a flow transmitter (16) are installed on the refrigerant inlet pipe (6). The high-level main temperature transmitter (12), the medium-level main temperature transmitter (13) and the low-level main temperature transmitter (14) and the flow transmitter (16) are all connected to the controller (17) by signal. The controller (17) is connected to the electric throttle valve (15) by signal.

2. The precision refrigeration reaction apparatus for the preparation of fludarabine phosphate according to claim 1, characterized in that: The stirring mechanism (5) includes a vertically installed stirring shaft (501) and stirring arms (502) and spiral stirring blades (503) installed on the stirring shaft (501).

3. The precision refrigeration reaction apparatus for the preparation of fludarabine phosphate according to claim 2, characterized in that: The refrigerant inlet pipe (6) and refrigerant outlet pipe (7) are located on both sides of the stirring shaft (501), and the feed pipe (10) and discharge pipe (9) are symmetrically arranged with the refrigerant outlet pipe (7) and refrigerant inlet pipe (6).

4. The precision refrigeration reaction apparatus for the preparation of fludarabine phosphate according to claim 3, characterized in that: The inner reaction vessel (1) is also equipped with a high-level secondary temperature transmitter (18), a middle-level secondary temperature transmitter (19), and a low-level secondary temperature transmitter (20) located inside the isolation pipe (11). The high-level secondary temperature transmitter (18), the middle-level secondary temperature transmitter (19), and the low-level secondary temperature transmitter (20) are symmetrically arranged with the high-level main temperature transmitter (12), the middle-level main temperature transmitter (13), and the low-level main temperature transmitter (14), respectively. The high-level main temperature transmitter (12) is at a 90° angle to the refrigerant output pipe (7).

5. The precision refrigeration reaction apparatus for the preparation of fludarabine phosphate according to claim 4, characterized in that: The high-level auxiliary temperature transmitter (18), the middle-level auxiliary temperature transmitter (19), and the low-level auxiliary temperature transmitter (20) are also signal-connected to the controller (17).

6. The precision refrigeration reaction apparatus for the preparation of fludarabine phosphate according to claim 1, characterized in that: A 0.5-2 cm refrigerant communication gap is provided between the thermally conductive insulating fin plate (8) and the inner wall of the refrigeration outer tank (2).

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