Cubic bone tissue engineering scaffold capable of being spliced

Abstract

The utility model relates to the technical field of bone tissue engineering supports, and discloses a splicable cubic bone tissue engineering support which comprises a main body, clamping grooves are formed in the top end of the interior of the main body, movable grooves are formed in one sides of the clamping grooves, connecting blocks are fixed to the two sides of the bottom end of the main body, shaft bodies are installed in the assembling blocks, and the shaft bodies are connected with the clamping grooves. Limiting rings are movably arranged on the outer side walls of the shaft bodies correspondingly, and mounting holes are formed in the two ends of the interiors of the limiting rings correspondingly. By arranging the splicing blocks, the clamping grooves, the limiting blocks, the limiting rings and other assemblies, when the main bodies are used, the splicing blocks and the clamping grooves in the two main bodies can be clamped together according to actual needs, and the main bodies are spliced through clamping and limiting between the limiting blocks and the limiting rings; the main body can reach the required height for use, so that the main body can adapt to different forms of bone defects, and the purpose of personalized treatment is achieved.

Description

Technical Field

[0001] This utility model relates to the field of bone tissue engineering scaffold technology, and in particular to a splicable cubic bone tissue engineering scaffold. Background Technology

[0002] Bone tissue possesses a certain capacity for self-healing, but when the size of the defect exceeds a critical threshold, bone defect healing and functional recovery must be intervened clinically. Autologous bone grafting, allogeneic bone grafting, and vascularized fibular grafting are currently common methods for treating large bone defects. While these methods have achieved some clinical efficacy, autologous bone grafting is a "healing through injury" approach that sacrifices healthy bone tissue, and its limited availability severely restricts its clinical application. Allogeneic or xenogeneic bone grafting also faces risks such as immune rejection and infection. Therefore, developing effective alternatives to autologous bone grafts and establishing novel strategies for bone defect repair are urgent clinical challenges.

[0003] With the continuous development of biomaterials science and additive manufacturing technology, bone tissue engineering is expected to replace natural bone grafts and become a feasible solution to the challenges of bone defect treatment. Scaffolds can fill the defect site and provide mechanical support in the early stages of bone defect treatment, while also providing structural support for cells and guiding the ingrowth of new tissue. Utility Model Content

[0004] The purpose of this invention is to provide a splicable cubic bone tissue engineering scaffold to solve the problems mentioned in the background art.

[0005] This utility model discloses a splicable cubic bone tissue engineering scaffold, comprising a main body. The top of the main body is provided with a slot, and one side of the slot is provided with a movable groove. Connecting blocks are fixed on both sides of the bottom of the main body, and splicing blocks are fixed at the bottom of the connecting blocks. A limiting block is fixed on one side of the splicing block, and the top of the limiting block is provided with a limiting groove. Assembly blocks are fixed on the top of both sides of the main body. A shaft is installed inside the assembly block. A limiting ring is movably provided on the outer wall of the shaft, and mounting holes are provided at both ends of the limiting ring.

[0006] This invention relates to a splicable cubic bone tissue engineering scaffold, wherein the cross-section of the splicing block is smaller than the cross-section of the slot, and the splicing block and the slot form an interlocking structure.

[0007] This invention relates to a splicable cubic bone tissue engineering scaffold, wherein the cross-section of the limiting ring is larger than the cross-section of the limiting block, and the limiting ring and the limiting block form an interlocking structure.

[0008] This invention relates to a splicable cubic bone tissue engineering scaffold, wherein the splicing blocks are arranged in four sets, and the four sets of splicing blocks are symmetrically distributed about the central axis of the main body.

[0009] This utility model discloses a splicable cubic bone tissue engineering scaffold, wherein the interior of the main body is uniformly provided with holes, the interior of the main body is uniformly fixed with a first small beam, the first small beam is uniformly fixed with a second small beam and a third small beam, and the surface of the main body is uniformly provided with rough particles.

[0010] This invention relates to a splicable cubic bone tissue engineering scaffold, wherein a plurality of first, second, and third trabeculae are provided, and the plurality of first, second, and third trabeculae are distributed at equal intervals inside the main body.

[0011] This utility model discloses a splicable cubic bone tissue engineering scaffold, wherein a fixing plate is fixed on both sides of the main body, a retaining ring is fixed on one side of the fixing plate, and a retaining hole is provided inside the retaining ring. A reinforcing rod is movably installed inside the retaining hole, and a locking sleeve is movably installed at the upper and lower ends of the outer side wall of the reinforcing rod, and a threaded sleeve is fixed on the inner side wall of the locking sleeve.

[0012] This utility model discloses a splicable cubic bone tissue engineering scaffold, wherein the upper and lower ends of the outer wall of the reinforcing rod are uniformly provided with external threads, and the reinforcing rod and the threaded sleeve form a threaded connection.

[0013] The present invention provides a splicable cubic bone tissue engineering scaffold that differs from existing technologies in that it not only allows for splicing between scaffolds, but also facilitates the ingrowth of osteoblasts and the infiltration of angiogenic cells, and achieves more stable splicing between bone tissue engineering scaffolds.

[0014] This utility model discloses a splicable cubic bone tissue engineering scaffold. It is equipped with splicing blocks, slots, limiting blocks, and limiting rings. When using the main body, the splicing blocks and slots of two main bodies can be engaged together according to actual needs. The main body is spliced ​​by the engagement and limiting between the limiting blocks and the limiting rings, so that the main body can reach the required height for use. Thus, the main body can adapt to different shapes of bone defects and achieve the purpose of personalized treatment.

[0015] This utility model discloses a splicable cubic bone tissue engineering scaffold. By setting holes with a pore diameter of 300μm, it can help osteoblasts grow in and angiogenic cells infiltrate. At the same time, by setting a first trabeculae, a second trabeculae, and a third trabeculae inside the main body, it is conducive to osteoblasts crawling and replacing bone formation.

[0016] This utility model discloses a splicable cubic bone tissue engineering scaffold. It is equipped with components such as retaining rings, reinforcing rods, locking sleeves, and fixing plates. After multiple main bodies are spliced ​​together, the reinforcing rods in the above-mentioned components can be engaged with the fixing plates on both sides of the main body. Then, the reinforcing rods are locked by the locking sleeves, thereby making the splicing between the main bodies more stable and less prone to loosening with the increase of use time, resulting in better performance.

[0017] The following description, in conjunction with the accompanying drawings, further illustrates a splicable cubic bone tissue engineering scaffold according to this utility model. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a splicable cubic bone tissue engineering scaffold according to the present invention;

[0019] Figure 2 This is a frontal partial cross-sectional view of a splicable cubic bone tissue engineering scaffold according to the present invention.

[0020] Figure 3 for Figure 2 A magnified view of a section at point A in the middle;

[0021] Figure 4 This is a frontal cross-sectional view of the first small beam in a splicable cubic bone tissue engineering scaffold according to the present invention.

[0022] The markings in the diagram are as follows: 1-Main body; 2-Hole; 3-Fixing plate; 4-Mounting hole; 5-Locking sleeve; 6-Connecting block; 7-Assembly block; 8-Snap ring; 9-Reinforcing rod; 10-Snap hole; 11-Threaded sleeve; 12-Limiting groove; 13-Limiting block; 14-Limiting ring; 15-Shaft; 16-Assembly block; 17-Snap groove; 18-Movable groove; 19-First small beam; 20-Second small beam; 21-Third small beam; 22-Rough particles. Detailed Implementation

[0023] The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0024] Example

[0025] like Figures 1-4As shown, the present invention discloses a splicable cubic bone tissue engineering scaffold comprising a main body 1. A slot 17 is provided at the top of the main body 1, and a movable groove 18 is provided on one side of each slot 17. Connecting blocks 6 are fixed to both sides of the bottom of the main body 1, and splicing blocks 7 are fixed to the bottom of each connecting block 6. A limiting block 13 is fixed to one side of each splicing block 7, and a limiting groove 12 is provided at the top of each limiting block 13. Assembly blocks 16 are fixed to the top of both sides of the main body 1. A shaft 15 is installed inside each assembly block 16. The shaft 15 has an outer... Each side wall is movably provided with a limiting ring 14, and each end of the limiting ring 14 is provided with a mounting hole 4. The cross-section of the splicing block 7 is smaller than the cross-section of the slot 17, and the splicing block 7 and the slot 17 form an engaging structure. The cross-section of the limiting ring 14 is larger than the cross-section of the limiting block 13, and the limiting ring 14 and the limiting block 13 form an engaging structure, making the splicing between the two main bodies 1 more stable. There are four sets of splicing blocks 7, and the four sets of splicing blocks 7 are symmetrically distributed about the central axis of the main body 1, making the splicing between the two main bodies 1 tighter.

[0026] like Figure 2 and Figure 3 As shown, insert the splicing block 7 at the bottom of the first main body 1 into the slot 17 at the top of the second main body 1, so that the first main body 1 and the second main body 1 are engaged together. Then, flip the limiting rings 14 on both sides of the second main body 1 in sequence so that they are engaged into the limiting grooves 12 inside the limiting block 13 and engaged together, so that the two sets of main bodies 1 can be spliced ​​together.

[0027] The interior of the main body 1 is uniformly provided with holes 2. The interior of the main body 1 is uniformly fixed with first small beams 19. The second small beams 20 and third small beams 21 are uniformly fixed between the first small beams 19. The surface of the main body 1 is uniformly provided with rough particles 22. There are several first small beams 19, second small beams 20 and third small beams 21. The several first small beams 19, second small beams 20 and third small beams 21 are distributed at equal intervals inside the main body 1, forming multiple scaffolds inside the main body 1, which is conducive to osteoblasts crawling and replacing bone formation.

[0028] like Figure 1 and Figure 2 As shown, the surface of the main body 1 is uniformly provided with pores 2, the pore diameter of which is 300μm, which can help osteoblasts grow in and angiogenic cells infiltrate inward. At the same time, the first trabeculae 19, the second trabeculae 20 and the third trabeculae 21 are provided inside the main body 1, which is conducive to osteoblasts crawling and replacing bone formation. Furthermore, the surface of the main body 1 is provided with rough particles 22, which is conducive to osteoblast adhesion and proliferation.

[0029] Both sides of the main body 1 are fixed with fixing plates 3, and one side of the fixing plate 3 is fixed with a retaining ring 8. The retaining ring 8 is provided with a retaining hole 10 inside. The retaining rod 9 is movably installed inside the retaining hole 10. The upper and lower ends of the outer wall of the retaining rod 9 are movably installed with locking sleeves 5. The inner side wall of the locking sleeve 5 is fixed with a threaded sleeve 11. The upper and lower ends of the outer wall of the retaining rod 9 are evenly provided with external threads. The retaining rod 9 and the threaded sleeve 11 form a threaded connection, which makes the locking of the retaining rod 9 more stable and makes the splicing between the two main bodies 1 more secure.

[0030] like Figure 3 As shown, after multiple main body 1s are spliced ​​together, a reinforcing rod 9 is taken and inserted into the retaining ring 8 on one side of the first and second main body 1s. The locking sleeve 5 is then threaded together with both ends of the reinforcing rod 9 to limit the position of the reinforcing rod 9, thereby reinforcing the splicing of the first and second main body 1s through the main body 1s.

[0031] Working principle: In use, the main body 1 can be made of materials such as biaxial calcium phosphate, hydroxyapatite, PLGA, and PLA, which have certain degradation properties. When using it, several main bodies 1 are first spliced ​​together according to actual needs. During splicing, the splicing block 7 at the bottom of the first main body 1 is inserted into the slot 17 at the top of the second main body 1. The limiting ring 14 is then flipped to engage with the limiting groove 12 inside the limiting block 13, thus splicing the two sets of main bodies 1 together. Multiple main bodies 1 can be spliced ​​together according to the above operation to meet corresponding usage requirements. After multiple main bodies 1 are spliced ​​together, the reinforcing rod 9 is taken and engaged with the retaining ring 8 on one side of the first and second main bodies 1. The locking sleeve 5 is then threaded together with both ends of the reinforcing rod 9 for positioning. Thus, the splicing of the first and second main bodies 1 is reinforced by the main body 1. In use, the main body 1 provides mechanical support and structural support for cells, guiding the growth of new tissue.

[0032] Although the present invention has been described in detail above with general descriptions and specific embodiments, some modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A splicable cubic bone tissue engineering scaffold, comprising a main body, characterized in that: The main body has a slot at the top and a movable groove on one side of the slot. Connecting blocks are fixed on both sides of the bottom of the main body, and splicing blocks are fixed at the bottom of the connecting blocks. A limit block is fixed on one side of the splicing block, and a limit groove is provided at the top of the limit block. Assembly blocks are fixed at the top of both sides of the main body. A shaft is installed inside the assembly block. A limit ring is movably provided on the outer wall of the shaft, and mounting holes are provided at both ends of the limit ring.

2. The splicable cubic bone tissue engineering scaffold according to claim 1, characterized in that: The cross-section of the splicing block is smaller than the cross-section of the slot, and the splicing block and the slot form an interlocking structure.

3. The splicable cubic bone tissue engineering scaffold according to claim 1, characterized in that: The cross-section of the limiting ring is larger than that of the limiting block, and the limiting ring and the limiting block form an engaging structure.

4. The splicable cubic bone tissue engineering scaffold according to claim 1, characterized in that: The splicing blocks are arranged in four groups, and the four groups of splicing blocks are symmetrically distributed about the central axis of the main body.

5. The splicable cubic bone tissue engineering scaffold according to claim 1, characterized in that: The main body has uniformly arranged holes inside, a first small beam is uniformly fixed inside the main body, a second small beam and a third small beam are uniformly fixed between the first small beams, and rough particles are uniformly arranged on the surface of the main body.

6. The splicable cubic bone tissue engineering scaffold according to claim 5, characterized in that: There are several of the first, second, and third small beams, and these beams are evenly distributed inside the main body.

7. The splicable cubic bone tissue engineering scaffold according to claim 1, characterized in that: Both sides of the main body are fixed with fixing plates, and one side of each fixing plate is fixed with a retaining ring. Each retaining ring has a retaining hole inside, and a reinforcing rod is movably installed inside each retaining hole. Both the upper and lower ends of the outer wall of the reinforcing rod are movably installed with locking sleeves, and the inner side wall of the locking sleeve is fixed with a threaded sleeve.

8. The splicable cubic bone tissue engineering scaffold according to claim 7, characterized in that: The upper and lower ends of the outer wall of the reinforcing rod are uniformly provided with external threads, and the reinforcing rod and the threaded sleeve form a threaded connection.

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