Bio-drug intermediate synthesis device

Abstract

The utility model relates to the field of biochemical engineering equipment, in particular to a synthesis device for a biological drug intermediate. The utility model provides a biological medicine intermediate synthesis device capable of efficiently mixing and promoting production. The biological medicine intermediate synthesis device comprises a mixing barrel and a rotating shaft, the rotating shaft is rotatably arranged at the top in the mixing barrel, and the top of the rotating shaft penetrates through the barrel wall of the mixing barrel; the inner wall of the mixing barrel is provided with a plurality of semicircular staggered opposite fixing discs, the tops of the fixing discs are sunken inwards, and the bottom of the rotating shaft penetrates through all the fixing discs and extends to the deeper position of the mixing barrel; the side edge of the rotating shaft is provided with a plurality of semicircular staggered opposite rotating discs, the tops and the bottoms of the rotating discs are sunken downwards, and the rotating bottoms are in sliding fit with the tops of the fixed discs; through a reciprocating path manufactured by the rotating disc and the rotating shaft, raw materials can be fully mixed before entering a catalytic reaction, the reaction rate is increased, and the production efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of biochemical equipment, and in particular to a device for synthesizing biopharmaceutical intermediates. Background Technology

[0002] In the production of biopharmaceuticals, the synthesis of intermediates is a crucial step. Pharmaceutical intermediates are essentially chemical raw materials or products used in drug synthesis processes. These chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they meet certain standards, they can be used in drug synthesis. With the continuous improvement of people's living standards and the constant upgrading of pharmaceuticals, the demand for intermediates is increasing. In some existing pharmaceutical intermediate reaction synthesis devices, uneven mixing of pharmaceutical intermediates occurs during the stirring process, resulting in incomplete reactions, low reaction rates, and reduced production efficiency.

[0003] Therefore, there is a need to design a biopharmaceutical intermediate synthesis device that can efficiently mix and promote production. Utility Model Content

[0004] To overcome the drawback of uneven mixing affecting the reaction rate, the technical problem to be solved is to provide a device for the synthesis of biopharmaceutical intermediates that can efficiently mix and promote production.

[0005] The technical solution of this utility model is: a biopharmaceutical intermediate synthesis device, comprising: a base frame and a mixing tank, the mixing tank being installed on the left side of the base frame; a rotating shaft, rotatably mounted at the top of the mixing tank, the top of the rotating shaft penetrating the top wall of the mixing tank; fixed plates, multiple semi-circular staggered fixed plates provided on the inner wall of the mixing tank, the tops of the fixed plates being recessed inwards, the bottom of the rotating shaft extending through all the fixed plates to a deeper position in the mixing tank; and rotating plates, multiple semi-circular staggered rotating plates provided on the side of the rotating shaft, the tops and bottoms of the rotating plates being recessed downwards, the bottom of the rotating plate being connected to the fixed plate. The system includes: a fixed plate with a sliding fit at the top; multiple stirring paddles on the bottom side of the rotating shaft; a first motor on the top of the mixing tank, with the top of the rotating shaft connected to the output shaft of the first motor via a coupling; a catalytic tank on the right side of the base frame; a sand core inside the catalytic tank, with the radius of the sand core equal to the radius of the inner wall of the catalytic tank; an immobilized enzyme block on top of the sand core; a conduit connecting the bottom of the mixing tank and the top of the catalytic tank, the conduit penetrating the bottom wall of the mixing tank and the top wall of the catalytic tank; and a liquid pump in the middle section of the conduit.

[0006] Furthermore, there is a heat exchange mechanism, which specifically includes: integrated heat exchange tubes, with multiple heat exchange tubes penetrating the side wall of the mixing tank on one side. Each heat exchange tube enters the tank and, after passing through the gap between adjacent but not mating rotating and fixed discs, circles half a turn around the rotating axis before penetrating the mixing tank wall. The outlet of each heat exchange tube is connected to the inlet of the heat exchange tube above it; an inlet pipe, with an inlet pipe located at the inlet of the lowest integrated heat exchange tube; an outlet pipe, with an outlet pipe located at the outlet of the highest integrated heat exchange tube; and a spiral heat exchange tube, with a spiral heat exchange tube arranged around the immobilized enzyme block and sand core inside the catalytic tank. The lower end of the spiral heat exchange tube penetrates the mixing tank wall and connects to the inlet pipe, and the upper end of the spiral heat exchange tube penetrates the mixing tank wall and connects to the outlet pipe.

[0007] Furthermore, there is a balancing mechanism, which specifically includes: a gas storage cylinder, located on one side of the catalytic converter; a second motor, located at the top of the gas storage cylinder; a lead screw, rotatably located inside the gas storage cylinder, with the output shaft of the second motor connected to the lead screw via a coupling; a sealing plate, slidingly located inside the gas storage cylinder, with the sealing plate threadedly engaged with the lead screw; multiple limiting protrusions, evenly spaced inside the gas storage cylinder, which slidably engage with the sealing plate; and a connecting pipe, located on the outside of the gas storage cylinder near the top, penetrating the gas storage cylinder wall and extending through the side wall of the catalytic converter near the top.

[0008] Furthermore, it also includes: an air inlet pipe, which is installed at the top of the mixing barrel and penetrates the barrel wall; an air pump, which is installed on the outside of the mixing barrel, with the air inlet pipe located at one end outside the mixing barrel and connected to the air pump inlet; and an air outlet pipe, which is installed at the bottom of the mixing barrel and penetrates the barrel wall, with the air outlet pipe located at one end outside the mixing barrel and connected to the air pump outlet.

[0009] Furthermore, it also includes: an electrically controlled three-phase valve, with an electrically controlled three-phase valve installed at the top and bottom of the mixing tank, the outlet end of which penetrates through the wall of the mixing tank; a pH sensor, with a pH sensor installed at the top and bottom of the mixing tank, the pH sensor being connected to the electrically controlled three-phase valve via a wire that penetrates through the wall of the mixing tank; and storage tanks, with the inlet end of the electrically controlled three-phase valve connected to two storage tanks, which respectively store acidic and alkaline pH adjusters.

[0010] The present invention has the following advantages: 1. The reciprocating path created by the rotating disk and the fixed disk, as well as the increase in path disorder by the air pump, can make the raw materials fully mixed before entering the catalytic tank, thereby increasing the reaction rate and improving production efficiency.

[0011] 2. By maintaining the reaction system at the required temperature through a heat exchange mechanism, the enzyme blocks can catalyze at a suitable temperature, increasing the reaction rate and improving production efficiency. Attached Figure Description

[0012] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0013] Figure 2 This is a partial three-dimensional cross-sectional view of the mixing tank and rotating shaft of this utility model.

[0014] Figure 3 This is a three-dimensional structural diagram of the components of this utility model, such as the rotating shaft, stirring paddle, and rotating disk.

[0015] Figure 4 This is a three-dimensional cross-sectional view of the heat exchange mechanism and catalytic tank of this utility model.

[0016] Figure 5 This is an exploded three-dimensional view of the immobilized enzyme block and sand core of this utility model.

[0017] Figure 6 This is a three-dimensional cross-sectional view of the components of this utility model, such as the gas storage cylinder and the sealing plate.

[0018] Figure 7 This is a three-dimensional cross-sectional view of the mixing tank and air pump components of this utility model.

[0019] Figure 8 This is a three-dimensional structural diagram of the pH sensor and electrically controlled three-phase valve components of this utility model.

[0020] In the attached diagram, the following are the reference numerals: 1-mixing tank, 2-fixed plate, 3-rotating shaft, 4-rotating disc, 5-stirring paddle, 6-first motor, 7-catalytic tank, 8-immobilized enzyme block, 9-sand core, 10-heat exchange mechanism, 1001-liquid inlet pipe, 1002-integrated heat exchange tube, 1003-spiral heat exchange tube, 1004-liquid outlet pipe, 11-balancing mechanism, 1101-gas storage tank, 1102-lead screw, 1103-sealing plate, 1104-second motor, 1105-limiting protrusion, 1106-connecting pipe, 12-gas inlet pipe, 13-gas pump, 14-gas outlet pipe, 15-pH sensor, 16-electrically controlled three-phase valve, 17-liquid storage tank, 18-conduit pipe, 19-liquid pump, 20-base frame. Detailed Implementation

[0021] The embodiments of this utility model will now be described in detail with reference to the accompanying drawings. Example

[0022] like Figures 1 to 5 As shown, this utility model provides a biopharmaceutical intermediate synthesis device, which specifically includes: a base frame 20, a mixing tank 1, a rotating shaft 3, a fixed plate 2, a rotating plate 4, a stirring paddle 5, a first motor 6, a catalytic tank 7, an immobilized enzyme block 8, a sand core 9, a conduit 18, and a liquid pump 19.

[0023] The base frame 20 has a mixing tank 1 installed on the left side. The top of the mixing tank 1 is equipped with a rotating shaft 3, which penetrates the top wall of the mixing tank. Multiple stirring paddles 5 are installed on the bottom side of the rotating shaft 3. The top of the mixing tank 1 is equipped with a first motor 6. The top of the rotating shaft 3 is connected to the output shaft of the first motor 6 through a coupling for mixing drug raw materials.

[0024] The mixing tank 1 has multiple semi-circular staggered fixed disks 2 on its inner wall. The top of the fixed disks 2 is concave inward. The bottom of the rotating shaft 3 extends through all the fixed disks 2 to a deeper position in the mixing tank 1. The side of the rotating shaft 3 has multiple semi-circular staggered rotating disks 4. The top and bottom of the rotating disks 4 are concave downward. The bottom of the rotating disks 4 slides with the top of the fixed disks 2, which is used to pre-mix the drug raw materials fed into the mixing tank 1 to assist subsequent stirring.

[0025] The base frame 20 is equipped with a catalytic tank 7 on the right side. The catalytic tank 7 contains a sand core 9 with a radius equal to the inner wall radius of the catalytic tank 7. An immobilized enzyme block 8 is located on the top of the sand core 9. A conduit 18 connects the bottom of the mixing tank 1 and the top of the catalytic tank 7. The conduit 18 passes through the bottom wall of the mixing tank 1 and the top wall of the catalytic tank 7. A liquid pump 19 is located in the middle of the conduit 18 for subsequent catalytic reactions of the mixed drug raw materials.

[0026] For example, in use, after the raw material enters the mixing tank 1, it is blocked by the complete circle formed by the fixed plate 2 and the rotating plate 4. At this time, the first motor 6 starts to work, driving the rotating shaft 3 and the rotating plate 4 and the stirring paddle 5 on the rotating shaft 3 to rotate. As the rotating plate 4 rotates, a gap appears in the complete circle. After the raw material moves down through this gap, the next gap appears at a position opposite to the previous gap in the horizontal direction about the rotating shaft 3. This cycle continues, and the raw material moves back and forth continuously as it moves down to the bottom of the mixing tank 1. This allows the raw material to collide and mix during its downward movement. Then, under the action of the stirring paddle 5 at the bottom of the tank, the mixing is more thorough. Subsequently, the raw material is pressurized by the liquid pump 19 and enters the catalytic tank 7 through the conduit 18. Under the action of the immobilized enzyme block 8, it reacts at high speed. Then, the product flows out of the catalytic tank 7 through the sand core 9. Under the action of the sand core 9, the immobilized enzyme block 8 is retained in the catalytic tank 7 for recycling. In this way, the raw material can be thoroughly stirred and mixed, and then reacted at high speed under the catalytic action of the recyclable immobilized enzyme block 8, which accelerates the reaction rate and improves production efficiency. Example

[0027] like Figure 1 and Figure 4As shown, based on Embodiment 1, there is also a heat exchange mechanism 10. The heat exchange mechanism 10 specifically includes an integrated heat exchange tube 1002, an inlet pipe 1001, an outlet pipe 1004, and a spiral heat exchange tube 1003. Multiple heat exchange tubes are provided through the side wall of the mixing tank 1. After entering the tank, each heat exchange tube goes through the gap between the adjacent but not mating rotating disk 4 and the fixed disk 2, circles half a turn around the rotating shaft 3, and then penetrates the wall of the mixing tank 1. The outlet of each heat exchange tube is connected to the heat exchange tube above it. The liquid inlet is connected to the liquid inlet of the lowest heat exchange tube of the integrated heat exchange tube 1002, and the liquid outlet is provided at the liquid outlet of the highest heat exchange tube of the integrated heat exchange tube 1002. The catalytic tank 7 is equipped with a spiral heat exchange tube 1003 surrounding the immobilized enzyme block 8 and the sand core 9. The lower end of the spiral heat exchange tube 1003 penetrates the wall of the mixing tank 1 and is connected to the liquid inlet tube 1001, and the upper end of the spiral heat exchange tube 1003 penetrates the wall of the mixing tank 1 and is connected to the liquid outlet tube 1004.

[0028] After the raw materials enter, the heat exchange liquid enters from the inlet pipe 1001, and then simultaneously enters the integrated heat exchange tube 1002 and the spiral heat exchange tube 1003. Starting from the bottom of the integrated heat exchange tube 1002 and the spiral heat exchange tube 1003, it flows to the top outlet pipe 1004, and then merges and flows out of the outlet pipe 1004. In this way, not only can the required temperature be maintained in the catalytic tank 7, keeping the enzyme activity at a high level, but the raw material temperature can also be adjusted to the required temperature before the raw materials enter the catalytic tank 7, ensuring the temperature stability inside the catalytic tank 7.

[0029] like Figure 1 and Figure 6 As shown, based on Embodiment 1, a balancing mechanism 11 is also provided. The balancing mechanism 11 specifically includes a gas storage cylinder 1101, a second motor 1104, a lead screw 1102, a sealing plate 1103, a limiting protrusion 1105, and a connecting pipe 1106. A gas storage cylinder 1101 is provided on one side of the catalytic tank 7, and a second motor 1104 is provided on the top of the gas storage cylinder 1101. A lead screw 1102 is rotatably provided inside the gas storage cylinder 1101. The output shaft of the second motor 1104 is connected to the lead screw 1102 via a coupling. The rod 1102 is connected, and the gas storage cylinder 1101 is slidably provided with a sealing plate 1103. The sealing plate 1103 is threadedly engaged with the lead rod 1102. Multiple limiting protrusions 1105 are evenly spaced inside the gas storage cylinder 1101. The limiting protrusions 1105 are slidably engaged with the sealing plate 1103. A connecting pipe 1106 is provided on the outside of the gas storage cylinder 1101 near the top of the gas storage cylinder 1101, penetrating the wall of the gas storage cylinder 1101. The connecting pipe 1106 penetrates the side wall of the catalytic converter 7 near the top.

[0030] When the raw material enters the catalytic converter 7 via the liquid pump 19, the second motor 1104 starts, driving the lead screw 1102 to rotate. The sealing plate 1103, with threads that mesh with the lead screw 1102, moves downwards as the screw rotates, its rotational freedom restricted by the limiting protrusion 1105. The upper space of the sealing plate 1103 inside the gas storage cylinder 1101 is connected to the upper part of the catalytic converter 7 via a connecting pipe 1106. As the sealing plate 1103 moves downwards, the increased internal pressure due to the raw material entering the catalytic converter is relieved, allowing for smoother raw material entry. After the raw material has entered... As the product flows out of the catalytic tank 7, the second motor 1104 starts and rotates in the opposite direction to the direction of the raw material entering, driving the lead screw 1102 to rotate and ultimately driving the sealing plate 1103 to move upward, pushing the gas in the gas storage tank 1101 into the catalytic tank 7 to balance the reduced gas pressure inside the tank due to the product flowing out, allowing the product to flow out quickly. In this way, by maintaining the gas pressure balance inside the tank during the raw material entering and the product flowing out through the balancing mechanism 11, the rate of raw material entering the catalytic tank 7 and the rate of product flowing out of the catalytic tank 7 can be accelerated, thereby improving production efficiency.

[0031] like Figure 1 and Figure 7 As shown, based on Embodiment 1, it further includes an air inlet pipe 12, an air pump 13, and an air outlet pipe 14. An air inlet pipe 12 is provided at the top of the mixing tank 1, penetrating the tank wall. An air pump 13 is provided on the outside of the mixing tank 1. The air inlet pipe 12 is located at one end outside the mixing tank 1 and connected to the air inlet of the air pump 13. An air outlet pipe 14 is provided at the bottom of the mixing tank 1, penetrating the tank wall. The air outlet pipe 14 is located at one end outside the mixing tank 1 and connected to the air outlet of the air pump 13.

[0032] After the raw materials enter, the air pump 13 draws gas from the top of the mixing tank 1 through the air inlet pipe 12 and then discharges it at the bottom of the mixing tank 1, which makes the mixing process of the raw materials in the mixing tank 1 more disordered and the mixing more thorough.

[0033] like Figure 1 and Figure 8 As shown, based on Example 1, it further includes an electrically controlled three-phase valve 16, a pH sensor 15, and a storage tank 17. The top and bottom of the mixing tank 1 are respectively equipped with an electrically controlled three-phase valve 16. The outlet end of the electrically controlled three-phase valve 16 penetrates through the wall of the mixing tank 1. The top and bottom of the mixing tank 1 are respectively equipped with a pH sensor 15. The pH sensor 15 is connected to the electrically controlled three-phase valve 16 by a wire that penetrates through the wall of the mixing tank 1. The inlet end of the electrically controlled three-phase valve 16 is respectively connected to two storage tanks 17, which store acidic and alkaline pH adjusters respectively.

[0034] When the raw material enters the mixing tank 1, the pH sensor 15 measures the pH value of the raw material and transmits the signal to the electronically controlled three-phase valve 16. Upon receiving the signal, the electronically controlled three-phase valve 16 controls the acid-base regulator in the storage tank 17 to enter the mixing tank 1 based on the result measured by the pH sensor 15. The regulator then enters the mixing process along with the raw material, initially adjusting the pH value of the raw material. When the raw material reaches the bottom of the mixing tank 1, the pH sensor 15 at the bottom measures the pH value of the mixed raw material. Upon receiving the signal, the electronically controlled three-phase valve 16 at the bottom controls the acid-base regulator in the storage tank 17 to enter the bottom of the mixing tank 1 based on the result measured by the pH sensor 15, further and more precisely adjusting the pH value of the raw material. In this way, by adjusting the pH value in the mixing tank 1 in two steps, the pH value of the raw material when it reaches the catalytic tank 7 can be precisely controlled, allowing the enzyme block in the catalytic tank 7 to catalyze under suitable acid-base conditions, increasing the reaction rate and improving production efficiency.

[0035] The above description is merely a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the scope of the claims.

Claims

1. A biopharmaceutical intermediate synthesis apparatus, characterized in that, include: The base frame (20) and the mixing tank (1) are installed on the left side of the base frame (20); Rotating shaft (3), the top of the mixing tank (1) is equipped with a rotating shaft (3); The inner wall of the mixing tank (1) is provided with multiple semi-circular staggered fixed discs (2), and the top of the fixed discs (2) is recessed inward; The rotating disk (4) has multiple semi-circular offset rotating disks (4) on the side of the rotating shaft (3), and the top and bottom of the rotating disk (4) are concave downwards; A stirring paddle (5) is provided at the bottom of the rotating shaft (3); The first motor (6) is provided on the top of the mixing tank (1), and the top of the rotating shaft (3) is connected to the output shaft of the first motor (6) through a coupling; Catalytic tank (7) is installed on the right side of the base frame (20); Sand core (9), the catalytic tank (7) is equipped with sand core (9); Immobilized enzyme block (8), the top of the sand core (9) is provided with immobilized enzyme block (8); The bottom of the mixing tank (1) and the top of the catalytic tank (7) are connected by the conduit (18); A liquid pump (19) is installed in the middle section of the conduit (18).

2. The biopharmaceutical intermediate synthesis apparatus as described in claim 1, characterized in that, There is also a heat exchange mechanism (10), which specifically includes: An integrated heat exchange tube (1002) is provided on one side of the mixing tank (1) through the side wall of the mixing tank (1). After each heat exchange tube enters the tank, it goes around the rotating shaft (3) half a circle along the gap between the adjacent but not matched rotating disk (4) and fixed disk (2) and then passes through the wall of the mixing tank (1). The liquid outlet of each heat exchange tube is connected to the liquid inlet of the heat exchange tube above it. Liquid inlet pipe (1001), the liquid inlet pipe (1001) is provided at the liquid inlet of the lowest heat exchange tube of the integrated heat exchange tube (1002). The liquid outlet pipe (1004) is provided at the liquid outlet of the uppermost heat exchange tube of the integrated heat exchange tube (1002). A spiral heat exchange tube (1003) is provided inside the catalytic tank (7) around the immobilized enzyme block (8) and the sand core (9). The lower end of the spiral heat exchange tube (1003) passes through the wall of the mixing tank (1) and is connected to the liquid inlet pipe (1001). The upper end of the spiral heat exchange tube (1003) passes through the wall of the mixing tank (1) and is connected to the liquid outlet pipe (1004).

3. The biopharmaceutical intermediate synthesis apparatus as described in claim 2, characterized in that, There is also a balancing mechanism (11), which specifically includes: Gas storage tank (1101), gas storage tank (1101) is provided on one side of catalytic tank (7); The second motor (1104) is provided on the top of the gas storage tank (1101). The lead screw (1102) is rotatably installed inside the air storage cylinder (1101), and the output shaft of the second motor (1104) is connected to the lead screw (1102) through a coupling; A sealing plate (1103) is slidably provided inside the air storage cylinder (1101), and the sealing plate (1103) is threadedly engaged with the lead screw (1102); Limiting protrusions (1105): Multiple limiting protrusions (1105) are evenly spaced inside the gas storage cylinder (1101), and the limiting protrusions (1105) slide in cooperation with the sealing plate (1103); A connecting pipe (1106) is provided on the outside of the gas storage cylinder (1101) near the top of the gas storage cylinder (1101) and passes through the wall of the gas storage cylinder (1101). The connecting pipe (1106) passes through the side wall of the catalytic barrel (7) near the top.

4. The biopharmaceutical intermediate synthesis apparatus as described in claim 3, characterized in that, Also includes: An air inlet pipe (12) is provided at the top of the mixing barrel (1) through the wall of the mixing barrel (1). An air pump (13) is provided on the outside of the mixing barrel (1). The air inlet pipe (12) is located outside the mixing barrel (1) and is connected to the air inlet of the air pump (13). An air outlet pipe (14) is provided at the bottom of the mixing tank (1) through the wall of the mixing tank (1). The air outlet pipe (14) is located outside the mixing tank (1) and is connected to the air outlet of the air pump (13).

5. The biopharmaceutical intermediate synthesis apparatus as described in claim 4, characterized in that, Also includes: An electrically controlled three-phase valve (16) is provided at the top and bottom of the mixing tank (1), and the liquid outlet end of the electrically controlled three-phase valve (16) penetrates the tank wall of the mixing tank (1). pH sensor (15) is provided at the top and bottom of the mixing tank (1). The pH sensor (15) is connected to the electrically controlled three-phase valve (16) by a wire, which passes through the wall of the mixing tank (1). The liquid storage tank (17) and the liquid inlet of the electrically controlled three-phase valve (16) are respectively connected to two liquid storage tanks (17), and the liquid storage tanks (17) store acidic and alkaline pH adjusters respectively.

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