Freezing device for preparing amorphous microneedle freezing preparation

Abstract

The utility model discloses a freezing device for preparing an amorphous microneedle freezing preparation, which comprises a lower die holder and an upper die, the lower die holder and the upper die holder are connected through a hinge mechanism, a groove is arranged on the top surface of the lower die holder, a forming plate is arranged in the groove, the groove is divided into a forming cavity and a freezing cavity by the forming plate, the freezing cavity is positioned below the forming cavity, and the upper die is positioned below the forming cavity. A mounting groove is formed in the bottom face of the lower die base, a vortex tube is arranged in the mounting groove, the cold air output end of the vortex tube is connected with the freezing cavity, cold air exhaust holes are further formed in the side wall of the freezing cavity, an air inlet pipe is fixedly arranged on the side wall of the mounting groove, and the air inlet pipe is communicated with the input end of the vortex tube and the forming cavity. The freezing cavity is formed in the lower die holder, a preparation for preparing the microneedle can be frozen, rapid refrigeration is achieved through the vortex tube, and the preparation speed of the microneedle preparation is increased; a liquid blowing hole and a liquid discharging hole are formed, redundant preparations can be discharged out of the forming cavity, and the prepared microneedle preparations are standard in shape and stable in structure.

Description

Technical Field

[0001] This invention belongs to the field of microneedle formulation preparation technology, and in particular relates to a freezing device for preparing amorphous microneedle cryogenic formulations. Background Technology

[0002] Microneedling is an emerging drug delivery method that uses tiny needles (typically less than 1 millimeter in diameter and ranging in length from tens to hundreds of micrometers) to penetrate the skin's surface and deliver drugs directly to specific layers beneath the skin. This technology can be used to deliver vaccines, therapeutic drugs, or cosmetic products, offering advantages such as improved drug absorption efficiency, reduced side effects, and simplified drug delivery procedures.

[0003] Currently, the preparation of microneedle formulations includes several methods such as solvent casting, etching, jet deposition, electrospinning, and injection molding. However, all of these require pre-fabrication. Although solvent casting can be used for on-site preparation, the preparation process requires drying at room temperature or a suitable temperature to allow the solvent to evaporate completely, which makes the preparation process relatively long.

[0004] Therefore, we need to design a freezing device for preparing cryogenic formulations of amorphous microneedles to solve these problems. Summary of the Invention

[0005] The problem to be solved by this invention is to provide a freezing device for preparing amorphous microneedle cryogenic formulations.

[0006] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows:

[0007] A freezing apparatus for preparing amorphous microneedle cryogenic formulations includes a lower mold base and an upper mold base connected by a hinge mechanism. A groove is provided on the top surface of the lower mold base, and a forming plate is disposed within the groove, dividing the groove into a forming cavity and a freezing cavity. The freezing cavity is located below the forming cavity. A mounting groove is provided on the bottom surface of the lower mold base, and a vortex tube is disposed within the mounting groove. The cold gas output end of the vortex tube is connected to the freezing cavity. Cold gas exhaust holes are also provided on the side wall and the upper surface of the freezing cavity. An air inlet pipe is fixedly installed on the side wall of the tank. The air inlet pipe is connected to the input end of the vortex tube and the molding cavity respectively. The molding cavity is also provided with a drain hole. The molding plate is provided with a number of formulation holes. The upper mold base is provided with a buffer groove. A base plate is detachably installed in the buffer groove. The base plate is provided with a number of mounting holes. A positioning seat is provided in each mounting hole. A support ridge is fixedly installed on the positioning seat. When the upper mold base and the lower mold base are engaged, the support ridges are inserted into the formulation holes one by one. The upper mold base and the lower mold base are locked together by a locking mechanism.

[0008] Preferably, the hinge mechanism includes a lower connecting groove disposed on the lower mold base and an upper connecting groove disposed on the upper mold base. A first connecting rod is hinged to the inner wall of the lower mold base, and a second connecting rod is hinged to the inner wall of the upper mold base. The free ends of the first connecting rod and the second connecting rod are hinged to each other. When the upper mold base and the lower mold base are engaged, the upper mold base and the lower mold base are positioned opposite each other.

[0009] This configuration ensures that the upper and lower mold bases can be adjusted to align their outer contours vertically before they are engaged.

[0010] Preferably, the lower mold base is further provided with an air distribution chamber, which is located between the mounting groove and the molding cavity. The side wall of the molding cavity is provided with a plurality of liquid blowing holes. The air distribution chamber is connected to the molding cavity through the liquid blowing holes, and the air inlet pipe is connected to the air distribution chamber.

[0011] This setup allows for gas distribution, preventing excessive local gas flow.

[0012] Preferably, the buffer groove is provided with a positioning hole, the positioning hole is provided with a spring, and the substrate is provided with a positioning post, the positioning post matching the positioning hole.

[0013] This configuration provides a downward thrust to the substrate, allowing the positioning seat to be firmly inserted into the formulation hole.

[0014] Preferably, the plurality of formulation holes on the molding plate are arranged in a square array, and a plurality of mounting strips are fixedly provided on the substrate, and the plurality of mounting holes are respectively provided on the plurality of mounting strips. When the upper mold base and the lower mold base are engaged, the plurality of blowing holes are respectively located between two adjacent mounting strips.

[0015] This design facilitates the blowing out of excess liquid from the molding cavity.

[0016] Preferably, the locking mechanism includes a magnetic base embedded in the lower mold base and a connecting plate embedded in the upper mold base. The connecting plate is made of ferromagnetic material, and when the upper mold base and the lower mold base are engaged, the magnetic base and the connecting plate are positioned opposite each other.

[0017] This configuration allows for quick locking and separation of the upper and lower mold bases.

[0018] Preferably, a sealing ring is provided on the lower mold base, and the groove is located inside the sealing ring.

[0019] This design prevents air leakage when the formulation solution is blown out.

[0020] Preferably, a handle is fixedly provided on the upper mold base.

[0021] This design facilitates operation of the upper mold base.

[0022] Preferably, a guide post is fixedly provided on the lower mold base, and a guide hole is provided through the upper mold base. When the upper mold base and the lower mold base are engaged, the guide post is located in the guide hole.

[0023] This design makes it easy to align the upper mold base with the lower mold base.

[0024] Preferably, both the blow hole and the drain hole are located above the molding plate and are not connected to the molding plate.

[0025] This setup ensures that the formulation wells are completely filled with the formulation solution.

[0026] The advantages and positive effects of this utility model are:

[0027] This invention enables the freezing of microneedle formulations by setting a freezing chamber on the lower mold base, and accelerates the preparation speed of microneedle formulations through rapid cooling via vortex tubes; the setting of blowing holes and drain holes enables excess formulations to be discharged from the molding cavity, resulting in microneedle formulations with standardized shapes and stable structures. Attached Figure Description

[0028] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0029] Figure 1 This is a schematic diagram of the upper mold base and lower mold base in the engagement state of this utility model;

[0030] Figure 2 This is a schematic diagram of the upper and lower mold bases in the open state of this utility model;

[0031] Figure 3 This is a schematic diagram of the connection structure between the vortex tube and the freezing chamber of this utility model;

[0032] Figure 4 This is a schematic diagram of the gas distribution chamber and liquid blowing hole structure of this utility model;

[0033] Figure 5 This is a schematic diagram showing the distribution of the positioning holes in this utility model;

[0034] Figure 6 This is a schematic diagram showing the positions of the first and second connecting rods when the upper and lower mold bases of this utility model are opened;

[0035] Figure 7 This is a schematic diagram showing the positions of the first and second connecting rods when the upper and lower mold bases of this utility model are engaged.

[0036] Figure 8 This is a schematic diagram of the cooperation between the positioning post and the spring inside the positioning hole of this utility model;

[0037] Figure 9 This is a schematic diagram showing the position and structure of the molding cavity, freezing cavity, and molding plate of this utility model;

[0038] Figure 10 yes Figure 2 Enlarged view of the structure at point A in the image;

[0039] Figure 11 This is a schematic diagram of the connection structure between the positioning seat and the support ridge of this utility model;

[0040] Figure 12 This is a schematic diagram of the structure in which the formulation of this utility model is frozen on the support ridge.

[0041] The annotations in the attached figures are explained as follows:

[0042] 1. Lower mold base; 2. Groove; 3. Formulation hole; 4. Air inlet pipe; 5. Cold air exhaust hole; 6. Drain hole; 7. Sealing ring; 8. Magnetic seat; 9. Lower connecting groove; 10. First connecting rod; 11. Second connecting rod; 12. Upper connecting groove; 13. Upper mold base; 14. Connecting plate; 15. Mounting strip; 16. Mounting hole; 17. Liquid blowing hole; 18. Hot air pipe; 19. Gas distribution chamber; 20. Handle; 21. Guide hole; 22. Base plate; 23. Molding plate; 24. Freezing chamber; 25. Positioning post; 26. Buffer groove; 27. Positioning hole; 28. Molding chamber; 29. ​​Frozen formulation; 30. Spring; 31. Vortex tube; 32. Cold air pipe; 33. Positioning seat; 34. Support ridge; 35. Mounting groove; 36. Guide post. Detailed Implementation

[0043] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0044] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0045] The present invention will be further described below with reference to the accompanying drawings:

[0046] Example 1: As Figures 1-10 As shown, a freezing device for preparing amorphous microneedle cryogenic formulations includes a lower mold base 1 and an upper mold base 13. The lower mold base 1 and the upper mold base 13 are connected by a hinge mechanism. A groove 2 is provided on the top surface of the lower mold base 1, and a forming plate 23 is provided in the groove 2. The forming plate 23 divides the groove 2 into a forming cavity 28 and a freezing cavity 24. The freezing cavity 24 is located below the forming cavity 28. An installation groove 35 is provided on the bottom surface of the lower mold base 1, and a vortex tube 31 is provided in the installation groove 35. The cold air output end of the vortex tube 31 is connected to the freezing cavity 24. A cold air exhaust hole 5 is also provided on the side wall of the freezing cavity 24. The mold plate 24 is provided with a cold air exhaust port 5. An air inlet pipe 4 is fixedly installed on the side wall of the mounting groove 35. The air inlet pipe 4 is connected to the input end of the vortex tube 31 and the molding cavity 28 respectively. The molding cavity 28 is also provided with a drain hole 6. The molding plate 23 is provided with a number of formulation holes 3. The upper mold base 13 is provided with a buffer groove 26. A base plate 22 is detachably installed in the buffer groove 26. The base plate 22 is provided with a number of mounting holes 16. A positioning seat 33 is provided in each mounting hole 16. The depth of the mounting hole 16 does not exceed the length of the positioning seat 33, and the positioning seat 33 is detachably connected to the mounting hole 16. Figure 11 As shown, a support rib 34 is fixedly provided on the positioning seat 33. When the upper mold seat 13 and the lower mold seat 1 are engaged, several support ribs 34 are inserted into the preparation hole 3 in a corresponding manner, and the upper mold seat 13 and the lower mold seat 1 are locked together by a locking mechanism.

[0047] like Figure 2 , Figure 6 and Figure 7 As shown, the hinge mechanism includes a lower connecting groove 9 on the lower mold base 1 and an upper connecting groove 12 on the upper mold base 13. A first connecting rod 10 is hinged to the inner wall of the lower mold base 1, and a second connecting rod 11 is hinged to the inner wall of the upper mold base 13. The free ends of the first connecting rod 10 and the second connecting rod 11 are hinged to each other. When the upper mold base 13 is engaged with the lower mold base 1, the upper mold base 13 and the lower mold base 1 are in opposite positions. This arrangement ensures that the upper mold base 13 and the lower mold base 1 can be adjusted to be aligned vertically before engagement.

[0048] like Figure 4 As shown, the lower mold base 1 is also provided with a gas distribution chamber 19, which is located between the mounting groove 35 and the molding cavity 28. Several blow holes 17 are provided on the side wall of the molding cavity 28. The gas distribution chamber 19 is connected to the molding cavity 28 through the blow holes 17. The air inlet pipe 4 is connected to the gas distribution chamber 19. This arrangement can distribute the gas and avoid excessive local gas flow.

[0049] like Figure 8 As shown, a positioning hole 27 is provided in the buffer groove 26, and a spring 30 is provided in the positioning hole 27. A positioning post 25 is provided on the substrate 22. The positioning post 25 matches the positioning hole 27. This arrangement can provide a downward pushing force to the substrate 22, so that the positioning seat 33 can be firmly inserted into the preparation hole 3.

[0050] like Figure 2 , Figure 4 and Figure 10 As shown, a number of formulation holes 3 on the molding plate 23 are arranged in a square array. A number of mounting strips 15 are fixedly provided on the substrate 22, and a number of mounting holes 16 are respectively provided on the mounting strips 15. When the upper mold base 13 and the lower mold base 1 are fastened together, a number of blowing holes 17 are respectively located between two adjacent mounting strips 15. This arrangement facilitates the blowing out of excess liquid in the molding cavity 28. After the upper mold base 13 and the lower mold base 1 are fastened together, the mounting strip 15 near the blowing hole 17 can fit against the side wall of the molding cavity 28, while the mounting strip 15 near the drain hole 6 cannot fit against the side wall of the molding cavity 28.

[0051] like Figure 1 and Figure 2As shown, the locking mechanism includes a magnetic seat 8 embedded in the lower mold base 1 and a connecting plate 14 embedded in the upper mold base 13. The connecting plate 14 is made of ferromagnetic material. When the upper mold base 13 and the lower mold base 1 are engaged, the magnetic seat 8 and the connecting plate 14 are positioned opposite each other. This arrangement enables the upper mold base 13 and the lower mold base 1 to be locked and separated quickly.

[0052] like Figure 2 As shown, a sealing ring 7 is provided on the lower mold base 1, and the groove 2 is located inside the sealing ring 7. This arrangement prevents air leakage when the formulation solution is blown out.

[0053] like Figure 1 As shown, a handle 20 is fixedly provided on the upper mold base 13, which facilitates the operation of the upper mold base 13.

[0054] like Figure 2 As shown, a guide post 36 is fixedly installed on the lower mold base 1, and a guide hole 21 is provided through the upper mold base 13. When the upper mold base 13 and the lower mold base 1 are engaged, the guide post 36 is located in the guide hole 21. This arrangement facilitates the alignment of the upper mold base 13 and the lower mold base 1.

[0055] Specifically, the blowing hole 17 and the drain hole 6 are both located above the molding plate 23 and are not connected to the molding plate 23. This arrangement ensures that the formulation holes 3 are filled with the formulation solution.

[0056] The working process of this embodiment is as follows: Before use, the positioning seat 33 needs to be inserted into each mounting hole 16 on the mounting strip 15. Then, the upper mold base 13 is rotated using the handle to open the upper mold base 13 and the lower mold base 1. At this time, the structure of the first link 10 and the second link 11 of the hinge mechanism is as follows. Figure 6 As shown, the operator then installs the substrate 22 onto the upper mold base 13, aligns the positioning pin 25 on the substrate 22 with the positioning hole 27 in the buffer groove 26, and inserts it. The friction between the positioning pin 25 and the positioning hole 27 is used to maintain the connection between the substrate 22 and the upper mold base 13. Then, the prepared formulation solution is poured into the molding cavity 28 until the solution is discharged from the drain hole 6, at which point the addition of the formulation solution is stopped. Next, the upper mold base 13 and the lower mold base 1 are fastened together. During fastening, the hinge structure of the first connecting rod 10 and the second connecting rod 11 is used to position the upper mold base 13 directly above the lower mold base 1 until the guide pin 36 is aligned with the guide hole 21. Then, the upper mold base 13 and the lower mold base 1 are brought closer together until the upper mold base 13 and the lower mold base 1 are in contact. At this time, the structure of the hinge mechanism is as follows. Figure 7 As shown, when the upper mold base 13 and the lower mold base 1 are fastened together, the support ridge 34 on the positioning seat 33 installed on the base plate 22 will enter the preparation hole 3, and at the same time the positioning seat 33 will also be locked into the preparation hole 3 to achieve sealing of the preparation hole 3.

[0057] When the positioning seat 33 enters the formulation hole 3 and moves to the limit position, the upper mold seat 13 will stop moving. Then, the operator turns the knob on the magnetic seat 8. After the knob is turned, the magnetic seat 8 will generate a magnetic force to attract the connecting plate 14. During this process, the positioning seat 33 will push the substrate 22 upward in the opposite direction. The substrate 22 will move into the buffer groove 26. At the same time, the positioning post 25 will also move into the positioning hole 27, and at the same time, the spring 30 will be compressed. The upper mold seat 13 will also fit with the lower mold seat 1. The sealing ring 7 will seal the connection between the molding cavity 28 and the upper mold seat 13.

[0058] Next, the staff connects the air inlet pipe 4 to an external air source. The gas will enter the gas distribution chamber 19 and the vortex pipe 31 along the air inlet pipe 4. The airflow entering the gas distribution chamber 19 will flow out from the liquid blowing hole 17, blowing out the excess preparation solution between the two mounting strips 15 from the liquid drain hole 6. At the same time, the airflow entering the vortex pipe 31 will generate hot air and cold air under the action of the vortex pipe 31. The hot air will be discharged along the hot air pipe 18, and the cold air will enter the freezing chamber 24 along the cold air pipe 32, and discharge the gas in the freezing chamber 24 until the temperature of the freezing chamber 24 drops to below zero and lasts for at least 20 seconds.

[0059] At this time, the temperature of the molding plate 23 will also drop below zero, freezing the formulation solution in the formulation hole 3 onto the support ridge 34. Then, disconnect the air inlet pipe 4 from the air source, and then rotate the knob on the magnetic base 8 in the opposite direction to make the attraction of the magnetic base 8 disappear. Finally, use the handle to lift the upper mold base 13 upward and flip it up, separating the upper mold base 13 from the lower mold base 1 to remove the substrate 22. Figure 12 As shown, the formulation solution is frozen together with the support ridge 34 on the positioning seat 33. The support ridge 34 is encased in the frozen formulation solution and is cone-shaped. After being inserted into the skin, the formulation solution will dissolve and be absorbed by the skin, while the positioning seat 33 and the support ridge 34 can be disinfected and reused.

[0060] In this embodiment, the molding plate 23 is made of aluminum or copper with good thermal conductivity, and the positioning seat 33 and the support rib 34 are made of amorphous material, which is iron-based amorphous alloy, such as Fe71-xB22Y6Mox (1≤x≤10) and Fe60Mg40-xMnx (20≤x≤25), or other amorphous materials with good biocompatibility.

[0061] Among them, the structure of the positioning seat 33, in addition to the following Figure 11 The cylindrical structure shown can also be frustum-shaped, while the support ridge 34 is a thin sheet structure. Due to the characteristics of amorphous material, the thin sheet structure of the support ridge 34 has particularly excellent support capabilities, which can support the frozen preparation 29 and prevent the frozen preparation 29 from detaching from or breaking from the positioning seat 33 during use.

[0062] It should be noted in this embodiment that after the airflow enters the vortex tube 31, the temperature of the low-temperature gas generated by the vortex tube 31 will gradually decrease. During this process, the excess formulation solution in the molding cavity 28 will be blown out first. Although the drain hole 6 is not connected to the molding plate 23, the rapidly flowing airflow will also carry away the formulation solution, which can ensure that all the formulation solution in the molding cavity 28 except for the formulation hole 3 is discharged.

[0063] The above description provides a detailed account of one embodiment of the present invention. However, this description is merely a preferred embodiment and should not be construed as limiting the scope of the present invention. All equivalent variations and improvements made within the scope of the claims of the present invention should still fall within the patent coverage of the present invention.

Claims

1. A freezing apparatus for preparing amorphous microneedle cryogenic formulations, comprising a lower mold base (1) and an upper mold base (13), characterized in that: The lower mold base (1) and the upper mold base (13) are connected by a hinge mechanism. A groove (2) is provided on the top surface of the lower mold base (1). A forming plate (23) is provided in the groove (2). The forming plate (23) divides the groove (2) into a forming cavity (28) and a freezing cavity (24). The freezing cavity (24) is located below the forming cavity (28). An installation groove (35) is provided on the bottom surface of the lower mold base (1). A vortex tube (31) is provided in the installation groove (35). The cold air output end of the vortex tube (31) is connected to the freezing cavity (24). A cold air exhaust hole (5) is also provided on the side wall of the freezing cavity (24). An air inlet pipe (4) is fixedly provided on the side wall of the installation groove (35). The air inlet pipe (4) is connected to the input end of the vortex pipe (31) and the molding cavity (28) respectively. The molding cavity (28) is also provided with a drain hole (6). The molding plate (23) is provided with a number of formulation holes (3). The upper mold base (13) is provided with a buffer groove (26). The buffer groove (26) is detachably provided with a base plate (22). The base plate (22) is provided with a number of mounting holes (16). Each mounting hole (16) is provided with a positioning seat (33). The positioning seat (33) is fixedly provided with a support rib (34). When the upper mold base (13) and the lower mold base (1) are engaged, the support ribs (34) are inserted into the formulation holes (3) one by one. The upper mold base (13) and the lower mold base (1) are locked together by a locking mechanism.

2. The freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 1, characterized in that: The hinge mechanism includes a lower connecting groove (9) on the lower mold base (1) and an upper connecting groove (12) on the upper mold base (13). A first connecting rod (10) is hinged to the inner wall of the lower mold base (1), and a second connecting rod (11) is hinged to the inner wall of the upper mold base (13). The free ends of the first connecting rod (10) and the second connecting rod (11) are hinged to each other. When the upper mold base (13) is engaged with the lower mold base (1), the upper mold base (13) and the lower mold base (1) are in opposite positions.

3. The freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 1, characterized in that: The lower mold base (1) is also provided with an air distribution chamber (19), which is located between the mounting groove (35) and the molding cavity (28). The side wall of the molding cavity (28) is provided with a plurality of liquid blowing holes (17). The air distribution chamber (19) is connected to the molding cavity (28) through the liquid blowing holes (17). The air inlet pipe (4) is connected to the air distribution chamber (19).

4. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 1, characterized in that: The buffer groove (26) is provided with a positioning hole (27), and a spring (30) is provided in the positioning hole (27). The base plate (22) is provided with a positioning post (25), and the positioning post (25) matches the positioning hole (27).

5. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 3, characterized in that: The formulation holes (3) on the molding plate (23) are arranged in a square array. A plurality of mounting strips (15) are fixedly provided on the substrate (22). A plurality of mounting holes (16) are respectively provided on the plurality of mounting strips (15). When the upper mold base (13) and the lower mold base (1) are engaged, a plurality of blowing holes (17) are respectively located between two adjacent mounting strips (15).

6. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 1, characterized in that: The locking mechanism includes a magnetic seat (8) embedded in the lower mold base (1) and a connecting plate (14) embedded in the upper mold base (13). The connecting plate (14) is made of ferromagnetic material, and when the upper mold base (13) is engaged with the lower mold base (1), the magnetic seat (8) and the connecting plate (14) are positioned opposite each other.

7. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 1, characterized in that: A sealing ring (7) is provided on the lower mold base (1), and the groove (2) is located inside the sealing ring (7).

8. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 1, characterized in that: A handle (20) is fixedly provided on the upper mold base (13).

9. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 2, characterized in that: A guide post (36) is fixedly provided on the lower mold base (1), and a guide hole (21) is provided through the upper mold base (13). When the upper mold base (13) and the lower mold base (1) are engaged, the guide post (36) is located in the guide hole (21).

10. A freezing apparatus for preparing amorphous microneedle cryogenic formulations according to claim 3, characterized in that: The blow hole (17) and the drain hole (6) are both located above the molding plate (23) and are not connected to the molding plate (23).

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