Detection mixing device
By designing a vibration device with an eccentric wheel and elastic connection, the problem of slow reaction rate between freeze-dried pellets and reagents was solved, achieving rapid and uniform mixing of the reaction liquid and improving the efficiency of nucleic acid amplification reaction.
Patent Information
- Application Number
- CN202422846178.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-21
- Publication Date
- 2025-11-21
- Estimated Expiration
- 2034-11-21
AI Technical Summary
In existing technologies, when lyophilized microspheres react with reagents, the reaction rate is slow under static conditions, making it difficult to quickly complete the nucleic acid amplification reaction.
Design a device for detecting mixing, which uses an eccentric wheel and a circumferentially rotating component that is elastically connected. Through the vibration of a vibrating disk, the reactants are made to oscillate in the horizontal direction, thereby increasing the reaction rate.
The vibration effect of the vibrating device significantly improves the reaction rate, ensures uniform mixing of the reaction liquid, and enhances the efficiency of the nucleic acid amplification reaction.
Smart Images
Figure CN223576442U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of detection kits, in particular to a detection mixing device. BACKGROUND
[0002] In the field of detection kits, a certain specific substance is detected by mixing detection, for example, normal temperature constant temperature nucleic acid rapid detection technology, which relies on recombination enzymes, single-stranded DNA binding proteins, DNA polymerases and specific primers in the system. Under normal temperature constant temperature (37-42 DEG C) conditions, nucleic acid amplification reaction can be quickly completed.
[0003] Generally, the freeze-dried small balls are placed in the reaction tube for reaction, but in the actual reaction process, the reaction of the freeze-dried small balls and the reagent starts from the surface. In the case of static, the reaction is slow at the beginning. CONTENT OF THE INVENTION
[0004] In order to improve the reaction rate in the reaction tube, the present application provides a detection vibration device.
[0005] The detection mixing device provided by the present application adopts the following technical scheme: a detection mixing device, comprising a base and a mounting plate, characterized in that: the base is provided with a containing groove for placing a reaction piece, the lower side of the containing groove is provided with a vibration disc for abutting against the lower end of the reaction piece, the vibration disc comprises a circumferential rotating piece elastically connected to the mounting plate, and an eccentric wheel arranged on the output shaft of the circumferential rotating piece, the rotation axis of the eccentric wheel is parallel to the extension direction of the containing groove.
[0006] By adopting the above technical scheme, when the eccentric wheel is arranged parallel to the containing groove, when the circumferential rotating piece drives the eccentric wheel to rotate, a circumferential swinging effect will be formed in the horizontal direction, and the circumferential rotating piece elastically connected to the base can adapt to the overall vibration amplitude, so that the reaction piece obtains the effect of shaking, so as to improve the reaction rate.
[0007] Preferably, the circumferential rotating piece is a motor, and the eccentric wheel is arranged on the output shaft of the circumferential rotating piece.
[0008] Preferably, a waterproof shell is arranged outside the circumferential rotating piece, and the eccentric wheel is located in the waterproof shell.
[0009] Preferably, a rubber layer is arranged outside the waterproof shell.
[0010] Preferably, the upper side of the rubber layer is provided with a protruding part, the protruding part is embedded into the lower side of the containing groove, and the waterproof shell is located outside the containing groove.
[0011] Preferably, the length of the protruding part extending into the accommodating groove is a, the axial length of the protruding part is b, and a / b is not greater than 0.2.
[0012] Preferably, the lower side of the circumferential rotating member is provided with a floating disc, and the lower side of the floating disc and the mounting plate are provided with floating springs.
[0013] Preferably, the mounting plate is threadedly connected with a guide rod penetrating through the floating disc, the floating spring is sleeved on the guide rod, and the upper end of the guide rod is provided with a limiting block located on the upper side of the floating disc.
[0014] Preferably, the floating disc is provided with a limiting hole for inserting the circumferential rotating member, the diameter of the limiting hole is greater than that of the circumferential rotating member, and the inner wall of the limiting hole is circumferentially provided with an elastic column abutting against the outer wall of the circumferential rotating member.
[0015] In summary, the present application has at least one of the following beneficial technical effects:
[0016] 1. When the eccentric wheel is arranged parallel to the accommodating groove, the circumferential rotating member drives the eccentric wheel to rotate, thereby forming a circumferential swinging effect in the horizontal direction. The circumferential rotating member elastically connected to the base can adapt to the overall vibration amplitude, so that the reaction member obtains a shaking effect, thereby improving the reaction rate.
[0017] 2. By arranging the elastic column in the limiting hole, the circumferential rotating member can move circumferentially in the limiting hole, thereby obtaining a better shaking effect. BRIEF DESCRIPTION OF DRAWINGS
[0018] Figure 1 is a structural schematic view of embodiment 1 of the present application;
[0019] Figure 2 is a structural schematic view of embodiment 2 of the present application;
[0020] Figure 3 is a partial cross-sectional view in embodiment 2 of the present application;
[0021] Figure 4 is Figure 3 is an enlarged schematic view of part A in
[0022] BRIEF DESCRIPTION OF DRAWINGS 100, base; 110, accommodating groove; 111, circumferential rotating member; 112, eccentric wheel; 113, waterproof shell; 114, protruding part; 120, floating disc; 121, floating spring; 122, guide rod; 123, limiting block; 124, limiting hole; 125, elastic column; 126, limiting column; 127, mounting groove; 130, mounting plate. DETAILED DESCRIPTION
[0023] The application will be further described in detail below with reference to the accompanying drawings.
[0024] Embodiment 1: a detection mixing device, referring to Figure 1 , comprising a base 100 and a mounting plate 130, the base 100 is provided with a containing groove 110 for placing a reaction member, the containing groove 110 has a vibration disc at the lower side for abutting against the lower end of the reaction member, and the reaction member in this embodiment is a reaction tube body.
[0025] The vibration disc comprises a circumferential rotating member 111 elastically connected to the mounting plate 130, and an eccentric wheel 112 arranged on the output shaft of the circumferential rotating member 111 in an eccentric manner, the rotation axis of the eccentric wheel 112 is parallel to the extension direction of the containing groove 110. In this embodiment, the circumferential rotating member 111 is a motor, and the eccentric wheel 112 is a semi-cylindrical body fixedly connected to the output shaft of the circumferential rotating member 111.
[0026] Since the reaction member has a reaction liquid therein, and in order to enable the vibration disc to better contact with the reaction member, a waterproof shell 113 is arranged outside the motor, and the eccentric wheel 112 is located in the waterproof shell 113. Meanwhile, a rubber layer (not shown in the figure) is arranged outside the waterproof shell 113.
[0027] The rubber layer has a protruding part 114 at the upper side, the protruding part 114 is embedded into the lower side of the containing groove 110, and the waterproof shell 113 is located outside the containing groove 110. The length of the protruding part 114 extending into the containing groove 110 is a, and the axial length of the protruding part 114 is b, a / b is not greater than 0.2. In the containing groove 110, light detection needs to be performed, and the structure of the embedded protruding part 114 can achieve a better light-proof effect.
[0028] Embodiment 2: the difference from embodiment 1 is that, referring to Figure 2 、 Figure 3 , the lower side of the circumferential rotating member 111 is provided with a floating disc 120, and the floating disc 120 has a floating spring 121 between the floating disc 120 and the mounting plate 130. A guide rod 122 is threadedly connected to the mounting plate 130 and penetrates the floating disc 120, the floating spring 121 is sleeved on the guide rod 122, and the guide rod 122 has a limiting block 123 abutting against the upper side of the floating disc 120 at the upper end.
[0029] Referring to Figure 3 、 Figure 4The floating disc 120 has a limiting hole 124 for inserting the circumferential rotating member 111, the diameter of the limiting hole 124 is larger than the circumferential rotating member 111, and the inner wall of the limiting hole 124 has an elastic column 125. The floating disc 120 has a mounting groove 127, and a limiting column 126 is threadedly connected in the mounting groove 127, the elastic column 125 is connected at the end of the limiting column 126, the top of the elastic column 125 is spherical, and it is made of rubber, the top of the elastic column 125 is used for abutting against the outer wall of the circumferential rotating member. The end of the limiting column 126 is kept in the mounting groove 127, and the diameter of the elastic column 125 is smaller than the limiting column 126.
[0030] In this way, in the process of shaking, the circumferential rotating member 111 can also drive the reaction member to make a larger movement in the circumferential direction, the elastic column 125 will be deformed with the circumferential rotating member 111, but in the stable state, it will be located in the middle position under the elasticity of itself. It is worth noting that there is also enough space between the convex part 114 and the inner wall of the accommodating groove 110, even if there is a collision, because the convex part 114 is a rubber body, it will not cause damage due to collision.
[0031] The embodiments of the specific embodiment are the preferred embodiments of the application, and are not limited to the protection scope of the application, so that: any equivalent changes made according to the structure, shape, principle of the application should be covered in the protection scope of the application.
Claims
1. A detection mixing device comprising a base (100) and a mounting plate (130), characterized in that: The base (100) is provided with a containing groove (110) for placing a reaction component, the containing groove (110) has a vibration disc at the lower side for abutting against the lower end of the reaction component, the vibration disc comprises a circumferential rotating member (111) elastically connected to a mounting plate (130), and an eccentric wheel (112) arranged on the output shaft of the circumferential rotating member (111) is eccentric, the rotation axis of the eccentric wheel (112) is parallel to the extending direction of the containing groove (110).
2. The mixing device of claim 1, wherein: The circumferential rotating member (111) is a motor, and the eccentric wheel (112) is arranged on the output shaft of the circumferential rotating member (111).
3. The mixing device of claim 2, wherein: The circumferential rotating member (111) is externally provided with a waterproof shell (113), and the eccentric wheel (112) is located in the waterproof shell (113).
4. The mixing device of claim 3, wherein: The waterproof shell (113) is externally provided with a rubber layer.
5. The mixing device of claim 4, wherein: The rubber layer has a protruding part (114) at the upper side, the protruding part (114) is embedded into the lower side of the containing groove (110), and the waterproof shell (113) is located outside the containing groove (110).
6. The mixing device of claim 5, wherein: The length of the protruding part (114) extending into the containing groove (110) is a, the axial length of the protruding part (114) is b, and a / b is not greater than 0.
2.
7. The mixing device of claim 1, wherein: The circumferential rotating member (111) is provided with a floating disc (120) at the lower side, and the floating spring (121) is arranged between the lower side of the floating disc (120) and the mounting plate (130).
8. The mixing device of claim 7, wherein: The mounting plate (130) is threadedly connected with a guide rod (122) penetrating through the floating disc (120), the floating spring (121) is sleeved on the guide rod (122), and the guide rod (122) has a limiting block (123) located at the upper side of the floating disc (120) at the upper end.
9. The mixing device of claim 8, wherein: The floating disc (120) has a limiting hole (124) for inserting the circumferential rotating member (111), the diameter of the limiting hole (124) is greater than that of the circumferential rotating member (111), and the inner wall of the limiting hole (124) has an elastic column (125) abutting against the outer wall of the circumferential rotating member (111) in the circumferential direction.