Cell separating and screening device
By designing a moving frame and drive system in the screening device, convenient replacement of the screening screen and prevention of clogging are achieved, solving the problems of fixed and unreplaceable screening screens and easy clogging in the prior art, thus improving the efficiency and ease of operation of cell separation.
Patent Information
- Application Number
- CN202423008495.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-06
- Publication Date
- 2025-11-21
- Estimated Expiration
- 2034-12-06
AI Technical Summary
The sieves in existing cell separation and screening devices are fixed and cannot be replaced individually, and are prone to clogging, which affects cell separation efficiency.
A device comprising a screening box, a moving frame, a screening box, a limiting frame, a mounting frame, and a screening screen is designed. The screening screen can be easily replaced through a bidirectional lead screw and a drive gear system, and clogging is prevented by vibration driven by a motor.
It enables convenient replacement of the sieve and prevents clogging, improving the efficiency of cell separation and the ease of operation.
Smart Images
Figure CN223576447U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to cell separation screening technical field, more specifically, it relates to a cell separation screening device. BACKGROUND
[0002] T cells are an important part of the human immune system, responsible for recognizing and attacking foreign substances, and T cell proliferation is very important in immunotherapy. Cell proliferation is an important life characteristic of living organisms, and T cells proliferate in a division manner. After T cells proliferate, the sizes of the cells are different, and a cell separation screening device is needed to separate and screen the cells according to the sizes of the cells. In the use process of the existing cell separation screening device, a screening net is usually used to separate and screen the cells, and the screening net is usually fixedly arranged in the device, so that the screening net cannot be replaced individually, which makes the maintenance of the entire device very inconvenient. Secondly, in the use process of the existing cell separation screening device, the screening net is prone to blockage during the separation and screening process, which affects the effective separation of the cells and significantly reduces the working efficiency of the entire device for efficiently screening the cells. SUMMARY
[0003] (I) Technical problem solved
[0004] In view of the problems existing in the prior art, the utility model provides a cell separation screening device to solve the technical problem that the screening net is usually fixedly arranged in the device and cannot be replaced individually in the use process of the existing cell separation screening device mentioned in the background art.
[0005] (II) Technical scheme
[0006] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: a cell separation screening device, comprising a screening box, a movable frame is movably arranged in the screening box, a screening box is arranged on the movable frame, the number of the screening boxes is three, a limiting frame is fixedly arranged on the screening box, an installation frame is movably arranged on the upper end of the limiting frame, a screening net is fixedly arranged in the installation frame, a U-shaped driving chamber is arranged in the installation frame, a bidirectional lead screw is rotatably arranged in the driving chamber, two fixed plates are threadedly arranged on the bidirectional lead screw, two insertion rods are fixedly arranged on one side of each fixed plate, one end of the insertion rod is inserted into the installation frame, a handle is rotatably arranged on one side of the screening box, one end of the handle extends into the driving chamber and is fixedly provided with a driving bevel gear, the driving bevel gear is connected with a driven bevel gear in a meshing mode, the driven bevel gear is fixedly arranged on the bidirectional lead screw, and two limiting rods are arranged on the two sides of the movable frame.
[0007] The utility model is further provided with two limiting rods on the same side, one end of the two limiting rods penetrates through the screening box and is fixedly provided with a limiting plate, and the limiting rods are limited.
[0008] The utility model further provides for, the two limit rods of one side of mobile frame respectively active sleeve set up first spring, first spring setting between mobile frame and screening box, convenient for pushing mobile frame.
[0009] The utility model further provides for, one side of screening box fixedly equipped with motor, motor drive end fixedly equipped with convex wheel, convenient for pushing limit board.
[0010] The utility model further provides for, the gyroscopic wheel is rotationally equipped with gyro wheel, convenient for reducing the friction of convex wheel.
[0011] The utility model further provides for, three installation grooves of cooperation of screening box are provided on mobile frame, one side of mobile frame is formed six fixed chambers to recess inward, mobile board is rotationally equipped in each fixed chamber, two second springs are fixedly connected between mobile board and fixed chamber, convenient for mobile board removal.
[0012] The utility model further provides for, one side of mobile board fixedly equipped with plug -in block, one end of plug -in block is inserted into screening box, one end of plug -in block fixedly equipped with push plate, push plate extends to the outside of fixed chamber, convenient for fixed screening box.
[0013] The utility model further provides for, one side of screening box is hingedly equipped with box door, convenient for taking out after screening cell.
[0014] (Three) beneficial effects
[0015] Compared with the prior art, the utility model provides a cell separation screening device, with following
[0016] Beneficial effects:
[0017] 1, through screening box, mobile frame, screening box, limit frame, installation frame, screen, drive chamber, two -way lead screw, fixed plate, plug -in rod, steering wheel, drive bevel gear and driven bevel gear cooperation, can when screen appears damage to it individually replace, and the operation of disassembly replacement is simple, makes the whole device maintenance is very convenient.
[0018] 2, through limit rod, limit board, first spring, motor, convex wheel and gyro wheel cooperation, can when separating and screening cell, screening box drives screen to vibrate, can accelerate the separation and screening of cell, can also avoid the phenomenon that screen appears to be blocked, makes cell can effectively separate, and can improve the work efficiency of cell screening.
[0019] 3. Through the cooperation of the installation groove, the fixed chamber, the moving plate, the second spring, the plug block, the push plate and the box door, the screened box can be quickly disassembled after the cell separation and screening is completed, so that the screened cells are conveniently collected and taken out, and the operation is simple and convenient to use. BRIEF DESCRIPTION OF DRAWINGS
[0020] Figure 1 It is a kind of cell separation and screening device under the whole structure schematic diagram in use state;
[0021] Figure 2 It is a kind of cell separation and screening device under the whole structure schematic diagram in use state;
[0022] Figure 3 It is a kind of cell separation and screening device under the whole structure schematic diagram in use state;
[0023] Figure 4 It is Figure 3 It is
[0024] Figure 5 It is a kind of cell separation and screening device under the whole structure schematic diagram in use state;
[0025] Figure 6 It is Figure 5 It is
[0026] In the figure: 1, screening box;2, moving frame;3, screening box;4, limiting frame;5, installation frame;6, screening net;7, drive chamber;8, double screw;9, fixed plate;10, plug rod;11, handle;12, driving bevel gear;13, driven bevel gear;14, limiting rod;15, limiting plate;16, first spring;17, motor;18, convex wheel;19, roller;20, installation groove;21, fixed chamber;22, moving plate;23, second spring;24, plug block;25, push plate;26, box door. DETAILED DESCRIPTION
[0027] It should be noted that the embodiments and features in the embodiments in the present application can be combined with each other without conflict. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.
[0028] It should be noted that, unless otherwise specified, all technical and scientific terms used in the present application have the same meaning as generally understood by those skilled in the art to which the present application belongs.
[0029] In the utility model, in the case where no opposite statement is made, the orientation such as "upper, lower" is usually for the direction shown in the drawing, or for the vertical, perpendicular or gravity direction; similarly, for the convenience of understanding and description, "left, right" is usually for the left, right shown in the drawing; "inner, outer" refers to the inner, outer relative to the contour of each component itself, but the above orientation words are not used to limit the utility model.
[0030] Please refer to Figures 1-6 A cell separation screening device, including screening box 1, the mobile frame 2 is movably arranged in screening box 1, the screening box 3 is installed on the mobile frame 2, the number of screening box 3 is three, the limiting frame 4 is fixedly arranged on the screening box 3, the mounting frame 5 is movably arranged on the upper end of the limiting frame 4, the screening net 6 is fixedly arranged in the mounting frame 5, the driving chamber 7 of U type is arranged in the mounting frame 5, the bidirectional lead screw 8 is rotatably arranged in the driving chamber 7, two fixed plates 9 are threadedly arranged on the bidirectional lead screw 8, two plug rods 10 are fixedly arranged on one side of each fixed plate 9, one end of the plug rod 10 is inserted into the mounting frame 5, the handle 11 is rotatably arranged on one side of the screening box 3, one end of the handle 11 extends into the driving chamber 7 and is fixedly provided with the driving bevel gear 12, the driven bevel gear 13 is meshingly connected with the driving bevel gear 12, and the driven bevel gear 13 is fixedly arranged on the bidirectional lead screw 8.
[0031] In the embodiment, the screening box 1 is provided with a feed hopper at the upper end, cells needing to be separated and screened are placed into the screening box 1 from the feed hopper, the screening nets 6 on the three screening boxes 3 are used to intercept cells of different sizes, so that the cells are screened and collected in the screening boxes 3, and the separation and screening of the cells are completed. When the screening net 6 is damaged, the handle 11 is rotated, the handle 11 drives the driving bevel gear 12 to rotate, the driving bevel gear 12 drives the driven bevel gear 13 to rotate, the driven bevel gear 13 drives the bidirectional lead screw 8 to rotate, and the two fixed plates 9 move in the direction of separation due to the two opposite threaded zones on the bidirectional lead screw 8, the fixed plate 9 drives the plug rod 10 to move, so that the plug rod 10 is separated from the mounting frame 5, the mounting frame 5 is pushed upward, the mounting frame 5 drives the screening net 6 to be disassembled, and the replaced screening net 6 can be installed in the opposite direction.
[0032] Please refer to Figures 1-6As an embodiment of the vibration of the screening net 6: two limiting rods 14 are arranged on the two sides of the moving frame 2 respectively, one end of the two limiting rods 14 on the same side penetrates through the screening box 1 and is fixedly provided with a limiting plate 15, the two limiting rods 14 on one side of the moving frame 2 are movably sleeved with a first spring 16 respectively, the first spring 16 is arranged between the moving frame 2 and the screening box 1, one side of the screening box 1 is fixedly provided with a motor 17, the driving end of the motor 17 is fixedly provided with a convex wheel 18, and the convex wheel 18 is rotatably provided with a roller 19.
[0033] Specifically, the motor 17 is started, the motor 17 drives the convex wheel 18 to rotate, the roller 19 is arranged at the protruding part of the convex wheel 18, when the roller 19 rotates to contact the limiting plate 15, with the rotation of the convex wheel 18, the roller 19 pushes the limiting plate 15, the roller 19 rotates to reduce the friction between the roller 19 and the limiting plate 15, the limiting plate 15 drives the moving frame 2 to move through the limiting rod 14, the first spring 16 is compressed, the moving frame 2 drives the installed screening box 3 and the screening net 6 to move, when the convex wheel 18 drives the roller 19 to separate from the limiting plate 15, under the pushing of the first spring 16, the limiting rod 14, the limiting plate 15, the moving frame 2, the screening box 3 and the screening net 6 move back to the original position, and the operation is repeated, so that the screening net 6 vibrates back and forth, thereby quickly separating and screening the cells and preventing the screening net 6 from being blocked.
[0034] Please refer to Figures 1-6 As an embodiment of the disassembly of the screening box 3: three installation grooves 20 matched with the screening box 3 are arranged on the moving frame 2, one side of the moving frame 2 is inwardly recessed to form six fixed chambers 21, a moving plate 22 is movably arranged in each fixed chamber 21, two second springs 23 are fixedly connected between the moving plate 22 and the fixed chamber 21, an insertion block 24 is fixedly arranged on one side of the moving plate 22, one end of the insertion block 24 is inserted into the screening box 3, a push plate 25 is fixedly arranged at one end of the insertion block 24 and extends to the outside of the fixed chamber 21, and a box door 26 is hingedly arranged on one side of the screening box 1.
[0035] Specifically, when the cells need to be taken out after the cell screening is completed, the box door 26 is opened, the two push plates 25 are pushed, the push plate 25 drives the moving plate 22 to move, the second spring 23 is compressed, the moving plate 22 drives the insertion block 24 to move, the insertion block 24 is separated from the screening box 3, the screening box 3 is pulled out of the installation groove 20, and the screening box 3 drives the installation frame 5, the screening net 6 and the screened cells to move out.
[0036] In summary, when the whole device is used:
[0037] When in the state of needing to separate and screen cells, the upper end of the screening box 1 is provided with a feeding hopper, and the cells needing to be separated and screened are placed into the screening box 1 from the feeding hopper, and cells of different sizes are intercepted by the screening mesh 6 on the three screening boxes 3, so as to screen them. At the same time, the motor 17 is started, the motor 17 drives the convex wheel 18 to rotate, the roller 19 is arranged at the protruding part of the convex wheel 18, when the roller 19 rotates to contact the limiting plate 15, with the rotation of the convex wheel 18, the roller 19 pushes the limiting plate 15, the roller 19 rotates to reduce the friction between the limiting plate 15, the limiting plate 15 drives the moving frame 2 to move through the limiting rod 14, the first spring 16 is compressed, the moving frame 2 drives the installed screening box 3 and screening mesh 6 to move, when the convex wheel 18 drives the roller 19 to separate from the limiting plate 15, under the pushing of the first spring 16, the limiting rod 14, the limiting plate 15, the moving frame 2, the screening box 3 and the screening mesh 6 move back to the original position, so as to repeat the operation, so that the screening mesh 6 vibrates back and forth, so as to quickly separate and screen the cells, and prevent the screening mesh 6 from being blocked. The screened cells are intercepted in the screening box 3 by the screening mesh 6 for collection.
[0038] When in the state of needing to take out the cells after separation and screening, the box door 26 is opened, the corresponding two push plates 25 are pushed, the push plate 25 drives the moving plate 22 to move, the second spring 23 is compressed, the moving plate 22 drives the plug block 24 to move, so that the plug block 24 is separated from the screening box 3, the screening box 3 is pulled out, so that the screening box 3 moves out of the installation slot 20, and the screening box 3 drives the installation frame 5, the screening mesh 6 and the cells after separation and screening to move out.
[0039] When in the state of needing to replace the screening mesh 6, when the screening mesh 6 is damaged, the handle 11 is rotated, the handle 11 drives the driving bevel gear 12 to rotate, the driving bevel gear 12 drives the driven bevel gear 13 to rotate, the driven bevel gear 13 drives the bidirectional lead screw 8 to rotate, and the two fixed plates 9 move in the direction of separation due to the two threads with opposite directions on the bidirectional lead screw 8, the fixed plate 9 drives the plug rod 10 to move, so that the plug rod 10 is separated from the installation frame 5, the installation frame 5 is pushed upward, so that the installation frame 5 drives the screening mesh 6 to be disassembled, and the replaced screening mesh 6 can be installed in the opposite direction.
[0040] In all the above-mentioned solutions, the connection between the two components can be selected according to the actual situation, such as welding, bolt and nut connection, bolt or screw connection or other known connection mode, which will not be described here. In the above, whenever there is a fixed connection, welding is preferred. Although the embodiments of the utility model have been shown and described, those skilled in the art can understand that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.
Claims
1. A cell separation and screening device, comprising a screening box (1), characterized in that: The screening box (1) is equipped with a movable frame (2), and a screening box (3) is installed on the movable frame (2). There are three screening boxes (3). A limiting frame (4) is fixed on the screening box (3). An installation frame (5) is movably installed on the upper end of the limiting frame (4). A sieve screen (6) is fixed inside the installation frame (5). A U-shaped drive chamber (7) is provided inside the installation frame (5). A bidirectional lead screw (8) is rotatably installed inside the drive chamber (7). Two fixing plates (9) are threaded on the bidirectional lead screw (8). Two insert rods (10) are fixedly provided on one side of each fixed plate (9). One end of the insert rod (10) is inserted into the mounting frame (5). A rotatable handle (11) is provided on one side of the screening box (3). One end of the rotatable handle (11) extends into the drive chamber (7) and is fixedly provided with a drive bevel gear (12). The drive bevel gear (12) is meshed with a driven bevel gear (13). The driven bevel gear (13) is fixedly provided on the bidirectional lead screw (8). Two limit rods (14) are provided on both sides of the moving frame (2).
2. The cell separation and screening device according to claim 1, characterized in that: Both of the limiting rods (14) on the same side have a limiting plate (15) fixedly installed at one end through the screening box (1).
3. The cell separation and screening device according to claim 2, characterized in that: The two limiting rods (14) on one side of the movable frame (2) are respectively equipped with first springs (16), and the first springs (16) are arranged between the movable frame (2) and the screening box (1).
4. The cell separation and screening device according to claim 3, characterized in that: A motor (17) is fixedly provided on one side of the screening box (1), and a convex wheel (18) is fixedly provided on the driving end of the motor (17).
5. The cell separation and screening device according to claim 4, characterized in that: Rollers (19) are rotatably mounted on the convex wheel (18).
6. A cell separation and screening device according to any one of claims 1 or 2, characterized in that: The movable frame (2) is provided with three mounting slots (20) that cooperate with the screening box (3). One side of the movable frame (2) is recessed inward to form six fixed chambers (21). Each fixed chamber (21) is provided with a movable plate (22). Two second springs (23) are fixedly connected between the movable plate (22) and the fixed chamber (21).
7. The cell separation and screening device according to claim 6, characterized in that: A plug (24) is fixedly provided on one side of the movable plate (22). One end of the plug (24) is inserted into the screening box (3). A push plate (25) is fixedly provided on one end of the plug (24). The push plate (25) extends to the outside of the fixed chamber (21).
8. The cell separation and screening device according to claim 7, characterized in that: The screening box (1) is hinged to a door (26) on one side.