Rapid detection paper chip

Abstract

The utility model discloses a paper chip for rapid detection, which relates to the technical field of experimental detection and comprises a paper base material, a waterproof frame is fixed on the inner side of the paper base material, a first preprocessing module and a detection module are respectively arranged at two ends of the inner side of the waterproof frame, and three second preprocessing modules are arranged between the first preprocessing module and the detection module. A first flow guide channel is connected between each second pretreatment module and the first pretreatment module, a second flow guide channel is connected between each second pretreatment module and the detection module, and a plurality of drainage channels are arranged on the outer side of the detection module in an array mode; the ends, away from the detection module, of the multiple liquid discharging channels are connected with the residue discharging module. According to the paper chip for rapid detection provided by the utility model, the flowing speed of the sample liquid is effectively improved by further guiding the sample liquid and providing additional driving force, so that the sample liquid can flow to the detection module more rapidly, and the detection efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to experimental detection technical field especially, and it is a kind of paper chip of rapid detection. BACKGROUND

[0002] Microfluidic paper chip is a new microfluidic analysis technology platform, with low cost, simple production, convenient to carry and other advantages, has great application prospect in clinical diagnosis, food quality control and environmental monitoring and other application fields.The paper chip made by traditional method cannot resist organic solvents such as anhydrous ethanol, acetone and isopropyl alcohol, thus limiting the detection application of paper chip.

[0003] For example, Chinese utility model patent (CN209215389U) discloses a kind of paper chip of rapid detection, which is described as follows: by selecting the way of double hydrophobic region, separating pretreatment process and detection process and a series of improvements, overcoming the defects of traditional microfluidic, reducing the transfer loss of sample between different regions, ensuring the stability and accuracy of detection results.

[0004] When using the above-mentioned paper chip for detection, the liquid flow speed cannot be improved when the sample is transferred between different regions, although the stability of the detection results is ensured, but the detection efficiency cannot be improved, therefore, the present application provides a kind of paper chip of rapid detection. UTILITY MODEL CONTENT

[0005] Therefore, it is necessary to provide a kind of paper chip of rapid detection to solve the above technical problems, by setting the heating circuit outside the three first flow guide grooves to heat the sample liquid when passing through the first flow guide grooves, cooperating with the electrophoresis circuit arranged outside the three second flow guide grooves and the structural design of the second flow guide grooves, to facilitate further guiding the sample liquid and providing additional driving force, effectively improving the flow speed of the sample liquid, so that the sample liquid can flow to the detection module faster to improve the detection efficiency, and relax the standard requirements of sample liquid input amount, the excess sample liquid is guided through the liquid discharge groove to be received by the excess sample liquid receiving module to avoid pollution.

[0006] To solve the above technical problems, the utility model adopts the technical scheme as follows:

[0007] A kind of paper chip of rapid detection is applied to dopamine detection.

[0008] The paper chip comprises a paper base material, a waterproof frame is fixed to the inner side of the paper base material, a first pretreatment module and a detection module are arranged at the two ends of the inner side of the waterproof frame respectively, three second pretreatment modules are arranged between the first pretreatment module and the detection module, a first flow guide groove is arranged between each second pretreatment module and the first pretreatment module, a second flow guide groove is arranged between each second pretreatment module and the detection module, a plurality of liquid discharge grooves are arranged on the outer side of the detection module, a residual discharge module is arranged at the end of the liquid discharge groove away from the detection module, the outer side of the residual discharge module is attached to the inner side of the waterproof frame, and a hydrophobic layer is arranged on the top of the paper base material.

[0009] As a preferred embodiment of the paper chip for rapid detection provided by the utility model, a cover top plate is arranged at the upper end of the paper base material, and a water absorption bottom plate is arranged at the lower end of the paper base material.

[0010] As a preferred embodiment of the paper chip for rapid detection provided by the utility model, a sample feeding port is arranged in the inner side of one end of the cover top plate, and the sample feeding port is located at the upper end of the first pretreatment module.

[0011] As a preferred embodiment of the paper chip for rapid detection provided by the utility model, a viewing port is arranged in the inner side of the other end of the cover top plate, a light transmission plate is arranged in the inner side of the viewing port, the light transmission plate is fixed to the cover top plate, and the viewing port is located at the upper end of the detection module.

[0012] As a preferred embodiment of the paper chip for rapid detection provided by the utility model, heating circuits are arranged on the outer sides of the three first flow guide grooves.

[0013] As a preferred embodiment of the paper chip for rapid detection provided by the utility model, electrophoresis circuits are arranged on the outer sides of the three second flow guide grooves.

[0014] Compared with the prior art, the utility model has the following beneficial effects:

[0015] The paper chip for rapid detection provided by the utility model is convenient for heating the sample liquid when the sample liquid passes through the first flow guide groove through the heating circuits arranged on the outer sides of the three first flow guide grooves, the electrophoresis circuits arranged on the outer sides of the three second flow guide grooves and the structural design of the second flow guide groove facilitate further flow guiding of the sample liquid and provide additional driving force, effectively improve the flow speed of the sample liquid, make the sample liquid flow to the detection module faster, thereby improving the detection efficiency, and relax the standard requirements of the sample liquid input amount, and the excess sample liquid is conveniently received by the residual discharge module through the flow guiding of the liquid discharge groove, thereby avoiding pollution. BRIEF DESCRIPTION OF DRAWINGS

[0016] In order to more clearly illustrate the scheme in the utility model, the following will be a simple introduction to the drawings needed to be used in the embodiment description, obviously, the following description of the drawings is some embodiments of the utility model, for those skilled in the art, without creative labor, according to these drawings, other drawings can also be obtained.

[0017] Figure 1 The overall structure schematic diagram of the paper chip for rapid detection provided by the utility model is shown in the figure.

[0018] Figure 2 The structure schematic diagram of the paper chip paper base material outside provided by the utility model is shown in the figure.

[0019] Figure 3 The structure schematic diagram of the paper chip paper base material inside provided by the utility model is shown in the figure.

[0020] Figure 4 The structure schematic diagram of the water-proof frame inside of the paper chip for rapid detection provided by the utility model is shown in the figure.

[0021] The figure mark is explained as follows:

[0022] 1, paper base material; 2, hydrophobic layer; 3, water-proof frame; 4, first pretreatment module; 5, first flow guide channel; 6, second pretreatment module; 7, second flow guide channel; 8, detection module; 9, liquid discharge channel; 10, residual discharge module; 11, cover top plate; 12, sample injection port; 13, viewing port; 14, light transmission plate; 15, water absorption bottom plate. Specific implementation

[0023] As described in the background art, when the above-mentioned paper chip is used for detection, the liquid flow speed cannot be improved when the sample is transferred between different areas, although the stability of the detection result is ensured, but the detection efficiency cannot be improved.

[0024] In order to solve this technical problem, the utility model provides a paper chip for rapid detection, which is applied to dopamine detection.

[0025] The paper chip for rapid detection comprises a paper base material 1, a water isolation frame 3 is fixed to the inner side of the paper base material 1, a first pretreatment module 4 and a detection module 8 are arranged at the two ends of the inner side of the water isolation frame 3 respectively, three second pretreatment modules 6 are arranged between the first pretreatment module 4 and the detection module 8, a first flow guide groove 5 is arranged between each second pretreatment module 6 and the first pretreatment module 4, a second flow guide groove 7 is arranged between each second pretreatment module 6 and the detection module 8, a plurality of liquid discharge grooves 9 are arranged in an array on the outer side of the detection module 8, a residual discharge module 10 is arranged at the end of the plurality of liquid discharge grooves 9 away from the detection module 8, the outer side of the residual discharge module 10 is attached to the inner side of the water isolation frame 3, and a hydrophobic layer 2 is arranged on the top of the paper base material 1.

[0026] The paper chip for rapid detection provided by the utility model is convenient for heating the sample liquid when the sample liquid passes through the first flow guide groove 5 through the heating circuit arranged on the outer side of the three first flow guide grooves 5, cooperates with the electrophoresis circuit arranged on the outer side of the three second flow guide grooves 7 and the structural design of the second flow guide groove 7, is convenient for further guiding the sample liquid and providing additional driving force, effectively improves the flow speed of the sample liquid, makes the sample liquid flow to the detection module 8 faster, thereby improving the detection efficiency, relaxes the standard requirement of the sample liquid input amount, and the excess sample liquid is conveniently received by the residual discharge module 10 through the flow guidance of the liquid discharge groove 9, thereby avoiding pollution.

[0027] It should be noted that the embodiments in the utility model and the features and technical solutions in the embodiments can be combined with each other without conflict.

[0028] It should be noted that: similar labels and letters represent similar items in the following drawings, therefore, once an item is defined in one drawing, it does not need to be further defined and explained in the subsequent drawings.

[0029] Embodiment 1:

[0030] Please refer to Figures 1-4 A paper chip for rapid detection comprises a paper base material 1, a water isolation frame 3 is fixed to the inner side of the paper base material 1, in order to conveniently receive and detect the input sample liquid, a first pretreatment module 4 and a detection module 8 are arranged at the two ends of the inner side of the water isolation frame 3 respectively, in order to improve the flow speed of the sample liquid during transfer, thereby improving the detection efficiency, three second pretreatment modules 6 are arranged between the first pretreatment module 4 and the detection module 8, a first flow guide groove 5 is arranged between each second pretreatment module 6 and the first pretreatment module 4, a heating circuit is arranged on the outer side of the three first flow guide grooves 5, a second flow guide groove 7 is arranged between each second pretreatment module 6 and the detection module 8, and an electrophoresis circuit is arranged on the outer side of the three second flow guide grooves 7.

[0031] The first flow guide channel 5 and the second flow guide channel 7 not only effectively reduce the loss of sample liquid during transfer, but also facilitate the flow of sample liquid by the inclined structure of the second flow guide channel 7, and further improve the flow speed of the sample liquid by cooperating with the heating circuit and the electrophoresis circuit, so that the sample liquid can flow to the detection module 8 faster to improve the detection efficiency.

[0032] When the sample liquid is too much, in order to avoid pollution caused by sample liquid overflow, a plurality of liquid discharge channels 9 are arranged on the outer side of the detection module 8, and the ends of the plurality of liquid discharge channels 9 away from the detection module 8 are connected with a residual liquid discharge module 10. The outer side of the residual liquid discharge module 10 is attached to the inner side of the water barrier frame 3. Similarly, the inclined structure of the liquid discharge channel 9 facilitates the flow of excess sample liquid to the residual liquid discharge module 10 for receiving and storage to avoid pollution, thereby relaxing the standard requirement of the sample liquid input amount and effectively simplifying the detection requirement.

[0033] Embodiment 2:

[0034] The rapid detection paper chip provided in embodiment 1 is further optimized, specifically, as shown in Figure 2 The top of the paper substrate 1 is provided with a hydrophobic layer 2, and the upper end of the paper substrate 1 is provided with a cover top plate 11. In order to facilitate the input of sample liquid through the cover top plate 11, a sample input port 12 is formed in the inner side of one end of the cover top plate 11. The sample input port 12 is located at the upper end of the first pretreatment module 4. The lower end of the paper substrate 1 is provided with a water absorption bottom plate 15, so that when sample liquid leaks out, it can be easily absorbed. Further, in order to facilitate the viewing of the detection results of the detection module 8, a viewing port 13 is formed in the inner side of the other end of the cover top plate 11. The inner side of the viewing port 13 is provided with a light transmission plate 14, and the light transmission plate 14 is fixed with the cover top plate 11. The viewing port 13 is located at the upper end of the detection module 8.

[0035] Embodiment 3:

[0036] The rapid detection paper chip provided in embodiment 1 is further optimized. The above-mentioned sample liquid can be a dopamine solution or other solution to be detected. The above-mentioned heating circuit and electrophoresis circuit are existing public power technologies, which are printed by metal ink.

Claims

1. A rapid detection paper chip, characterized in that, The utility model provides a paper substrate (1) is provided with waterproof frame (3) on the inner side, the inner side of waterproof frame (3) is provided with first pretreatment module (4) and detection module (8) respectively on both ends, be provided with three second pretreatment module (6) between first pretreatment module (4) and detection module (8), be connected with first flow guide channel (5) between each second pretreatment module (6) and first pretreatment module (4), be connected with second flow guide channel (7) between each second pretreatment module (6) and detection module (8), the outer side of detection module (8) is provided with a plurality of drainage channel (9) in array, a plurality of drainage channel (9) is connected with residual module (10) and is set up on the one end away from detection module (8), the outer side of residual module (10) is pasted with the inner side of waterproof frame (3), and the top of paper substrate (1) is provided with hydrophobic layer (2).

2. The rapid detection paper chip according to claim 1, characterized in that, The upper end of the paper substrate (1) is provided with a cover top plate (11), and the lower end of the paper substrate (1) is provided with a water absorption bottom plate (15).

3. The rapid detection paper chip according to claim 2, characterized in that, The inside of one end of the cover top plate (11) is provided with a sample pouring port (12), and the sample pouring port (12) is located on the upper end of the first pretreatment module (4).

4. The rapid detection paper chip according to claim 3, characterized in that, The inside of the other end of the cover top plate (11) is provided with a viewing port (13), and the inner side of the viewing port (13) is provided with a light transmission plate (14), and the light transmission plate (14) is fixed with the cover top plate (11), and the viewing port (13) is located on the upper end of the detection module (8).

5. The rapid detection paper chip according to claim 1, wherein, The outer side of each of the three first flow guide channels (5) is provided with a heating circuit.

6. The rapid detection paper chip according to claim 1, wherein, The outer side of each of the three second flow guide channels (7) is provided with an electrophoresis circuit.

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