An on-line filter device for chromatography flow path

Abstract

The application provides an online filtering device for a chromatographic flow path, and relates to the technical field of filtering equipment.The online filtering device comprises an upper connecting piece and a lower connecting piece, the upper connecting piece and the lower connecting piece are connected to form a shell, a cavity is formed in the shell, a filtering filter core is arranged in the cavity, the filtering filter core filters small particles and / or other impurities in a sample, and damage of the small particles and / or the other impurities to an instrument is avoided; a sample inlet channel is arranged in the upper connecting piece, a first connecting thread or a first pipe is arranged in the sample inlet channel, and the upper connecting piece is connected with a liquid chromatograph through the first connecting thread or the first pipe; a sample outlet is arranged in the lower connecting piece, a second connecting thread or a second pipe is arranged in the sample outlet, and the lower connecting piece is connected with an external element through the second connecting thread or the second pipe.The filtering device provided by the application can realize real-time and online filtering of fluid in a chromatographic flow path, and has universal connectivity at the front end and the rear end, so that the universal interchangeability in various liquid chromatograph analysis instruments is met.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of filtering devices, in particular to an online filtering device for a chromatographic flow path. BACKGROUND

[0002] In the field of liquid chromatography analysis, small particles and / or other impurities may enter the sample injection valve along the pipeline and into the mobile phase and analysis sample of the liquid chromatography system due to factors such as wear of the plunger seal, and the tiny impurities are prone to cause blockage of the entire liquid chromatography instrument system, causing the system pressure to rise; or the liquid contains soluble impurities, which may affect the test process when flowing into the instrument, and even damage the instrument.

[0003] The existing online filtering device needs additional pipeline components to assist connection at the front and rear, which is relatively troublesome. CONTENT OF THE UTILITY MODEL

[0004] The application provides an online filtering device for a chromatographic flow path, an upper connecting piece and a lower connecting piece are connected to form a shell, a cavity is formed in the shell, and a filter element is arranged in the cavity; a sample inlet channel is arranged in the upper connecting piece, a first connecting thread or a first pipe is arranged in the sample inlet channel, and the upper connecting piece is connected with a liquid chromatography instrument through the first connecting thread or the first pipe; a sample outlet is arranged in the lower connecting piece, a second connecting thread or a second pipe is arranged in the sample outlet, and the lower connecting piece is connected with an external element through the second connecting thread or the second pipe.

[0005] The application provides an online filtering device for a chromatographic flow path, which comprises an upper connecting piece and a lower connecting piece.

[0006] The upper connecting piece and the lower connecting piece are connected to form a shell, a cavity is formed in the shell, and a filter element is arranged in the cavity.

[0007] The upper connecting piece is provided with a sample inlet channel in communication with the cavity, a first connecting thread or a first pipe is arranged in the sample inlet channel, and the upper connecting piece is connected with a liquid chromatography instrument through the first connecting thread or the first pipe.

[0008] The lower connecting piece is provided with a sample outlet in communication with the cavity, a second connecting thread or a second pipe is arranged in the sample outlet, and the lower connecting piece is connected with an external element through the second connecting thread or the second pipe.

[0009] In an implementation, the first tube is a first rigid capillary or a first flexible capillary, and an end of the first rigid capillary or the first flexible capillary is fixedly arranged in the sample inlet channel of the upper connector;

[0010] The second tube is a second rigid capillary or a second flexible capillary, and an end of the second rigid capillary or the second flexible capillary is fixedly arranged in the sample outlet of the lower connector.

[0011] In an implementation, the upper connector and the lower connector are both in a cylindrical structure, and open ends of the upper connector and the lower connector are oppositely arranged;

[0012] An outer wall of the upper connector is provided with external threads, and an inner wall of the lower connector is provided with internal threads, and the external threads of the upper connector are screwed with the internal threads of the lower connector.

[0013] Alternatively, an outer wall of the upper connector is provided with internal threads, and an inner wall of the lower connector is provided with external threads, and the internal threads of the upper connector are screwed with the external threads of the lower connector.

[0014] In an implementation, the chromatographic flow path online filtering device further comprises a sealing ring;

[0015] The upper connector and the lower connector clamp the sealing ring, the sealing ring is coaxial with the sample inlet channel, and the filter element is arranged in the sealing ring.

[0016] In an implementation, a middle part of a bottom end of the upper connector is provided with an upper groove, the sealing ring is inserted into the upper groove, and a diameter of the sealing ring is equal to or smaller than an inner diameter of the upper groove.

[0017] Alternatively, an inner wall of a top end of the lower connector is provided with a lower groove, the sealing ring is inserted into the lower groove, and a diameter of the sealing ring is equal to or smaller than an inner diameter of the lower groove.

[0018] In an implementation, a depth of the upper groove is smaller than a thickness of the sealing ring, after the sealing ring is inserted into the upper groove, a top part of the sealing ring is located in the upper groove, and a bottom part of the sealing ring is located outside the upper groove.

[0019] Alternatively, a depth of the lower groove is smaller than the thickness of the sealing ring, after the sealing ring is inserted into the lower groove, a bottom part of the sealing ring is located in the lower groove, and a top part of the sealing ring is located outside the lower groove.

[0020] In an implementation, the chromatographic flow path online filtering device further comprises a sealing column;

[0021] The sealing column is arranged in the cavity, and the sample inlet channel, the sealing column, the filter cartridge and the sample outlet are coaxially arranged;

[0022] The upper connector and the lower connector clamp the sealing column and the filter cartridge, one end of the sealing column abuts against the filter cartridge, and the other end of the sealing column abuts against the upper connector or the lower connector.

[0023] In a feasible implementation, the sealing column comprises an inner ring body and an outer ring body, the outer wall of the inner ring body is sleeved with the outer ring bodies, and the upper connector and the lower connector clamp the inner ring body and the outer ring body;

[0024] The inner ring body is provided with a granular filler, one end of the sealing column abuts against the filter cartridge, and the other end of the sealing column abuts against the upper connector or the lower connector.

[0025] In a feasible implementation, a first clamping groove is arranged in the middle of the bottom end of the upper connector, and a second clamping groove is arranged in the inner wall of the top end of the lower connector;

[0026] The end of the sealing ring away from the sealing column is inserted into the first clamping groove or the second clamping groove, and the end of the sealing column away from the sealing ring is inserted into the second clamping groove or the first clamping groove.

[0027] In a feasible implementation, a polygonal slot is arranged in the bottom end of the lower connector, and the polygonal slot is in communication with the sample outlet;

[0028] A connecting screw is arranged in the polygonal slot, the connecting screw is internally provided with a through hole, the second pipe is penetrated through the connecting screw, and the connecting screw is connected with an external instrument.

[0029] The upper connector and the lower connector are connected to form a shell, a cavity is formed in the shell, a filter cartridge is arranged in the cavity, small particles and / or other impurities in a sample are filtered through the filter cartridge, and the small particles and / or other impurities are prevented from damaging an instrument;

[0030] A sample inlet channel is arranged in the upper connector, a first connecting thread or a first pipe is arranged in the sample inlet channel, the upper connector is connected with a liquid chromatograph through the first connecting thread or the first pipe; a sample outlet is arranged in the lower connector, a second connecting thread or a second pipe is arranged in the sample outlet, and the lower connector is connected with an external element through the second connecting thread or the second pipe. The filter provided in the application can realize real-time and online filtering of fluid in a chromatographic flow path, and has universal connectivity at the front end and the rear end to meet the universal interchangeability in various liquid chromatograph instruments. Attached Figure Description

[0031] Figure 1 This is a schematic diagram of the structure of the first online filtration device for chromatographic flow path provided in this application;

[0032] Figure 2 This is a schematic diagram of the structure of the second type of online filtration device for chromatographic flow path provided in this application;

[0033] Figure 3 This is a schematic diagram of the structure of the third type of online filtration device for chromatographic flow path provided in this application;

[0034] Figure 4 This is a schematic diagram of the structure of the fourth type of online filtration device for chromatographic flow path provided in this application;

[0035] Figure 5 This is a schematic diagram of the structure of the fifth type of online filtration device for chromatographic flow path provided in this application;

[0036] Figure 6 This is a schematic diagram of the structure of the sixth type of online filtration device for chromatographic flow path provided in this application;

[0037] Figure 7 This is a schematic diagram of the structure of the seventh type of online filtration device for chromatographic flow path provided in this application;

[0038] Figure 8 This is a schematic diagram of the structure of the eighth type of online filtration device for chromatographic flow path provided in this application;

[0039] Figure 9 This is a schematic diagram of the structure of the ninth type of online filtration device for chromatographic flow path provided in this application;

[0040] Figure 10 yes Figure 9 Front view sectional view.

[0041] Explanation of reference numerals in the attached figures:

[0042] 10 - Upper connector; 20 - Lower connector; 30 - Filter element; 40 - First fitting; 50 - Second fitting; 60 - Sealing ring; 70 - Sealing post; 80 - Connecting screw;

[0043] 11-Inlet channel; 12-First connecting thread; 13-Upper groove; 14-First clamping groove; 21-Outlet; 22-Second connecting thread; 23-Lower groove; 24-Second clamping groove; 25-Polygonal slot; 41-First rigid capillary; 42-First flexible capillary; 51-Second rigid capillary; 52-Second flexible capillary; 71-Inner ring; 72-Outer ring. Detailed Implementation

[0044] In order for those skilled in the art to better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described in the following with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor should be within the scope of protection of the present application.

[0045] A liquid chromatograph is an instrument used to separate and analyze different components in a mixture. It uses a liquid as the mobile phase, which is delivered to the chromatographic column by a high-pressure pump. The sample interacts with the stationary phase in the chromatographic column, and different components have different partition coefficients between the stationary phase and the mobile phase, thereby achieving separation.

[0046] Liquid chromatographs have the advantages of high separation efficiency, high sensitivity and high selectivity, and are widely used in the fields of chemistry, biology, medicine, environment, etc. It can be used to analyze various compounds such as small organic molecules, biological macromolecules, drugs, pesticides, food additives, etc.

[0047] A liquid chromatograph generally consists of a liquid delivery system, a sample injection system, a chromatographic column, a detector and a data processing system, etc. The liquid delivery system is responsible for providing a stable mobile phase; the sample injection system introduces the sample into the chromatographic column; the chromatographic column is the core component of separation; the detector is used to detect the separated components; and the data processing system processes and analyzes the detection signals. Different types of liquid chromatographs have different characteristics and application ranges, such as high-performance liquid chromatographs (HPLC), ultra-high-performance liquid chromatographs (UPLC), etc.

[0048] When using a liquid chromatograph, it is necessary to select appropriate chromatographic columns, mobile phases and detection methods according to specific analysis requirements, and to calibrate and maintain the instrument to ensure the accuracy and reliability of the analysis results. The existing online filtering device needs to be connected with screws before and after, which is more troublesome.

[0049] The online filtering device for chromatographic flow path provided by the present application is provided with a sample injection channel in the upper connecting piece, a first connecting thread or a first pipe is arranged in the sample injection channel, and the upper connecting piece is connected with the liquid chromatograph through the first connecting thread or the first pipe; a sample outlet is arranged in the lower connecting piece, a second connecting thread or a second pipe is arranged in the sample outlet, and the lower connecting piece is connected with external elements through the second connecting thread or the second pipe. The filter provided by the present application realizes real-time and online filtering of the fluid in the chromatographic flow path, and has universal connectivity at the front and rear ends to meet the universal interchangeability in various liquid chromatography instruments.

[0050] The specific structure of the online filtering device for chromatographic flow path provided by the present application will be described in detail below with reference to the drawings.

[0051] Reference Figures 1-5 As shown, this application provides an online filtration device for chromatographic flow paths, including an upper connector 10 and a lower connector 20;

[0052] The upper connector 10 and the lower connector 20 are connected to form a housing. A cavity is formed inside the housing. The cavity is a closed cavity. A filter element 30 is provided inside the cavity. The filter element 30 includes a sieve plate, filter disc and / or filter membrane and / or particulate packing, etc. The filter element 30 is used to filter small particles and / or other impurities in the sample.

[0053] The upper connector 10 is provided with an injection channel 11 that communicates with the cavity. The injection channel 11 is provided with a first connecting thread 12 or a first pipe fitting 40. The upper connector 10 is connected to the liquid chromatograph through the first connecting thread 12 or the first pipe fitting 40.

[0054] The lower connector 20 is provided with a sample outlet 21 that communicates with the cavity. The sample outlet 21 is provided with a second connecting thread 22 or a second pipe fitting 50. The lower connector 20 is connected to external components through the second connecting thread 22 or the second pipe fitting 50.

[0055] Furthermore, the first tube 40 is a first rigid capillary 41 or a first flexible capillary 42, and the end of the first rigid capillary 41 or the first flexible capillary 42 is fixed in the sample inlet channel 11 of the upper connector 10.

[0056] The second tube 50 is a rigid capillary tube 51 or a flexible capillary tube 52, with the end of the rigid capillary tube 51 or the flexible capillary tube 52 fixed inside the sample outlet 21 of the lower connector 20.

[0057] Specifically, such as Figure 2 As shown, a first rigid capillary 41 is provided in the sample inlet channel 11 of the upper connector 10, and a second rigid capillary 51 is provided in the sample outlet 21 of the lower connector 20; Figure 3 As shown, a first connecting thread 12 is provided in the sample inlet channel 11 of the upper connector 10, and a second connecting thread 22 is provided in the sample outlet 21 of the lower connector 20; as Figure 4 As shown, a first connecting thread 12 is provided in the sample inlet channel 11 of the upper connector 10, and a second flexible capillary tube 52 is provided in the sample outlet 21 of the lower connector 20; Figure 5 As shown, a first flexible capillary tube 42 is provided in the sample inlet channel 11 of the upper connector 10, and a second connecting thread 22 is provided in the sample outlet 21 of the lower connector 20; the connector and the tube body have multiple combination methods.

[0058] The hard capillary tube 41 or the flexible capillary tube 42 is adapted to the connection requirement of the instrument in various use environments, reduces the trouble that other filters need to be connected by screws at both ends to be used, and also reduces the generation of dead volume.

[0059] The online filtering device for chromatographic flow path provided by the embodiment of the application comprises an upper connecting piece 10 and a lower connecting piece 20 connected to form a shell, a cavity is formed in the shell, and a filtering element 30 is arranged in the cavity.

[0060] The upper connecting piece 10 is provided with a sample inlet channel 11 in communication with the cavity, the sample inlet channel 11 is provided with a first connecting thread 12 or a first pipe 40, and the upper connecting piece 10 is connected with a liquid chromatograph through the first connecting thread 12 or the first pipe 40.

[0061] Referring to Figures 1-5 In some embodiments, the upper connecting piece 10 and the lower connecting piece 20 are both in a cylindrical structure, and the outer wall of the upper connecting piece 10 and the lower connecting piece 20 is provided with a structure of opposite sides, four sides, six sides or the like for cooperation with assembly and installation tools, and the open ends of the upper connecting piece 10 and the lower connecting piece 20 are oppositely arranged.

[0062] The outer wall of the upper connecting piece 10 is provided with an external thread, and the inner wall of the lower connecting piece 20 is provided with an internal thread, and the external thread of the upper connecting piece 10 is screwed with the internal thread of the lower connecting piece 20.

[0063] Alternatively, the outer wall of the upper connecting piece 10 is provided with an internal thread, and the inner wall of the lower connecting piece 20 is provided with an external thread, and the internal thread of the upper connecting piece 10 is screwed with the external thread of the lower connecting piece 20.

[0064] Through screwing of the upper connecting piece 10 and the lower connecting piece 20, the online filtering device for chromatographic flow path can be quickly assembled and disassembled, so that the filtering element 30 and the sealing ring 60 can be replaced.

[0065] As shown in Figure 1 , Figure 2 , Figure 4 and Figure 6 In some embodiments, the online filtering device for chromatographic flow path further comprises a sealing ring 60, and the sealing ring 60 can be a ring made of corrosion-resistant plastic.

[0066] The upper connecting piece 10 and the lower connecting piece 20 clamp the sealing ring 60, thereby ensuring the sealing of the shell. The sealing ring 60 is coaxial with the sample inlet channel 11. The inner diameter of the sealing ring 60 matches the diameter of the filter element 30. The filter element 30 is arranged in the sealing ring 60, thereby facilitating the fixation of the filter element 30.

[0067] Further, the middle part of the bottom end of the upper connecting piece 10 is provided with an upper groove 13. The upper groove 13 is a circular groove. The sealing ring 60 is inserted into the upper groove 13. The diameter of the sealing ring 60 is equal to or smaller than the inner diameter of the upper groove 13.

[0068] After the sealing ring 60 is inserted into the upper groove 13, the top part of the sealing ring 60 is located in the upper groove 13, and the bottom part of the sealing ring 60 is located outside the upper groove 13. The sealing ring 60 and the filter element 30 do not completely enter the upper groove 13, thereby effectively preventing the sealing ring 60 and the filter element 30 from being stuck. The sealing ring 60 and the filter element 30 can be easily removed.

[0069] Alternatively, the inner wall of the top end of the lower connecting piece 20 is provided with a lower groove 23. The lower groove 23 is a circular groove. The sealing ring 60 is inserted into the lower groove 23. The diameter of the sealing ring 60 is equal to or smaller than the inner diameter of the lower groove 23.

[0070] After the sealing ring 60 is inserted into the lower groove 23, the bottom part of the sealing ring 60 is located in the lower groove 23, and the top part of the sealing ring 60 is located outside the lower groove 23. The sealing ring 60 and the filter element 30 do not completely enter the lower groove 23, thereby effectively preventing the sealing ring 60 and the filter element 30 from being stuck. The sealing ring 60 and the filter element 30 can be easily removed.

[0071] Referring to FIGS. 1-3, Figure 7 and Figure 8 In some embodiments, the chromatographic flow path with an online filtration device further comprises a sealing column 70. The sealing column 70 is a column structure with a certain height and thickness.

[0072] The sealing column 70 is used for filtering a sample. The middle part of the sealing column 70 allows the sample to pass through. The sealing column 70 is arranged in the cavity. The sample inlet channel 11, the sealing column 70, the filter element 30, and the sample outlet 21 are coaxially arranged.

[0073] The upper connecting piece 10 and the lower connecting piece 20 clamp the sealing column 70 and the filter element 30. One end of the sealing column 70 abuts against the filter element 30. The other end of the sealing column 70 abuts against the upper connecting piece 10 or the lower connecting piece 20, so as to fix the sealing column 70 and the filter element 30 and allow the filtered sample to pass through.

[0074] Specifically, the sealing column 70 comprises an inner ring body 71 and an outer ring body 72, the inner ring body 71 can be made of corrosion-resistant plastic, and the outer ring body 72 can be a metal ring body, the outer wall of the inner ring body 71 is sleeved with a plurality of outer ring bodies 72, and the upper connecting piece 10 and the lower connecting piece 20 clamp the inner ring body 71 and the outer ring body 72;

[0075] The inner ring body 71 is provided with a granular filler, the granular filler is wrapped by a filter membrane, one end of the sealing column 70 abuts against the filter element 30, and the other end of the sealing column 70 abuts against the upper connecting piece 10 or the lower connecting piece 20;

[0076] As shown in Figure 8 , the outer wall of the inner ring body 71 is sleeved with two outer ring bodies 72, the two outer ring bodies 72 are vertically arranged; the granular filler is arranged in the inner ring body 71, and the sealing column 70 is arranged at the upper portion of the sealing ring 60, and the granular filler is located at the upper portion of the filter element 30; or as shown in Figure 7 , the sealing column 70 is arranged at the lower portion of the sealing ring 60, and the granular filler is located at the lower portion of the filter element 30.

[0077] The granular filler plays an adsorption role, the granular filler is used for removing non-particle impurities, the upper connecting piece 10 and the lower connecting piece 20 are screwed after being connected, the upper connecting piece 10 and the lower connecting piece 20 clamp the sealing column 70 and the sealing ring 60, and the granular filler and the filter element 30 are fixed while the sealing property of the shell is ensured.

[0078] Further, in some embodiments, a first clamping groove 14 is arranged at the middle of the bottom end of the upper connecting piece 10, a second clamping groove 24 is arranged on the inner wall of the top end of the lower connecting piece 20, and the first clamping groove 14 and the second clamping groove 24 are both circular groove bodies matched with the sealing column 70;

[0079] The end of the sealing ring 60 away from the sealing column 70 is inserted into the first clamping groove 14 or the second clamping groove 24, and the end of the sealing column 70 away from the sealing ring 60 is inserted into the second clamping groove 24 or the first clamping groove 14;

[0080] As shown in Figure 7 , the sealing ring 60 is completely located in the first clamping groove 14, and the top end of the sealing column 70 is located in the first clamping groove 14; as shown in Figure 9 , the sealing ring 60 is completely located in the second clamping groove 24, and the bottom end of the sealing column 70 is located in the second clamping groove 24, so as to improve the stability of the fixation of the sealing column 70 and the sealing ring 60.

[0081] Referring to Figure 9 and Figure 10 , it can be seen that Figure 9 and Figure 10The middle A is an external instrument. In some embodiments, the bottom end of the lower connecting piece 20 is provided with a polygonal slot hole 25, which can be an inner hexagonal slot, an outer hexagonal slot, or other polygonal slots. The polygonal slot hole 25 is in communication with the sample outlet 21.

[0082] The polygonal slot hole 25 is provided with a connecting screw 80. The connecting screw 80 is a general connecting screw. The connecting screw 80 is provided with a through hole in the inside. The pipe 40 penetrates the connecting screw 80. The external thread of the connecting screw 80 is connected with the external instrument.

[0083] When the connecting screw 80 is connected with the next phase instrument, the shell is directly rotated to drive the connecting screw 80 to rotate, thereby being connected with the next phase instrument. When being tightened, the hand feeling is better, and the use is simple and convenient.

[0084] According to the above technical features, the working principle of the online filtering device for chromatographic flow path in the actual application scene is as follows:

[0085] As shown in Figures 1-5 , the upper connecting piece 10 is provided with a sample inlet channel 11. The sample inlet channel 11 is provided with a first connecting thread 12 or a first pipe 40. The upper connecting piece 10 is connected with the liquid chromatograph through the first connecting thread 12 or the first pipe 40. The lower connecting piece 20 is provided with a sample outlet 21. The sample outlet 21 is provided with a second connecting thread 22 or a second pipe 50. The lower connecting piece 20 is connected with the external element through the second connecting thread 22 or the second pipe 50. The front and rear ends of the filter should have general connectivity, which is convenient for connection with the liquid chromatograph equipment to meet the general interchangeability in various liquid chromatograph instruments.

[0086] When the sample is filtered only by the filter element 30, the upper connecting piece 10 and the lower connecting piece 20 clamp the filter element 30. The filter element 30 is located between the sample inlet channel 11 and the sample outlet 21. The sample flows through the filter element 30 to achieve filtration.

[0087] As shown in Figure 1 , Figure 2 , Figure 4 and Figure 6 , in order to improve the sealing performance of the filtering device, the outer wall of the filter element 30 can be sleeved with a sealing ring 60. The upper connecting piece 10 and the lower connecting piece 20 clamp the sealing ring 60 to achieve sealing. In order to stably fix the sealing ring 60, the bottom end of the upper connecting piece 10 is provided with an upper groove 13. The sealing ring 60 is inserted into the upper groove 13. Alternatively, the inner wall of the top end of the lower connecting piece 20 is provided with a lower groove 23. The sealing ring 60 is inserted into the lower groove 23, so that the sealing ring 60 is stably fixed.

[0088] As shown in Figure 7 and Figure 8As shown, in order to further improve the filtering effect, the cavity is further provided with a sealing column 70, the sealing column 70 is used for filtering the sample, the middle part can allow the sample to pass, the sample inlet channel 11, the sealing column 70, the filtering filter element 30 and the sample outlet 21 are coaxially arranged, the non-particle impurities are removed by the granular filler; and, in order to stably fix the sealing column 70, the bottom end of the upper connecting piece 10 is provided with a first clamping groove 14, the top end of the inner wall of the lower connecting piece 20 is provided with a second clamping groove 24, one end of the sealing column 70 is inserted into the second clamping groove 24 or the first clamping groove 14, and the other end abuts against the sealing ring 60, so that the stability of the sealing column 70 and the sealing ring 60 is improved.

[0089] It is easy to understand that, on the basis of the several embodiments provided in the present application, the skilled in the art can combine, split, recombine and the like to obtain other embodiments, and these embodiments do not exceed the protection scope of the present application.

[0090] The above specific embodiments have further detailed the purposes, technical solutions and beneficial effects of the embodiments of the present application, and it should be understood that the above is only the specific implementation of the embodiments of the present application, and is not used to limit the protection scope of the embodiments of the present application, and any modification, equivalent replacement, improvement and the like made on the basis of the technical solutions of the embodiments of the present application should be included in the protection scope of the embodiments of the present application.

Claims

1. An on-line filter device for chromatography flow paths, characterized by: The upper connecting piece (10) and the lower connecting piece (20) are connected to form a shell, and a cavity is formed in the shell, and a filter cartridge (30) is arranged in the cavity. The upper connecting piece (10) is provided with a sample inlet channel (11) communicating with the cavity, and a first connecting thread (12) or a first pipe (40) is arranged in the sample inlet channel (11), and the upper connecting piece (10) is connected with a liquid chromatograph through the first connecting thread (12) or the first pipe (40). The lower connecting piece (20) is provided with a sample outlet (21) communicating with the cavity, and a second connecting thread (22) or a second pipe (50) is arranged in the sample outlet (21), and the lower connecting piece (20) is connected with an external element through the second connecting thread (22) or the second pipe (50).

2. The online filtering device for chromatographic flow path according to claim 1, wherein: The first pipe (40) is a first hard-state capillary tube (41) or a first flexible capillary tube (42), and the end of the first hard-state capillary tube (41) or the first flexible capillary tube (42) is fixedly arranged in the sample inlet channel (11) of the upper connecting piece (10); The second pipe (50) is a second hard-state capillary tube (51) or a second flexible capillary tube (52), and the end of the second hard-state capillary tube (51) or the second flexible capillary tube (52) is fixedly arranged in the sample outlet (21) of the lower connecting piece (20).

3. The online filtering device for chromatographic flow path according to claim 1, wherein: The upper connecting piece (10) and the lower connecting piece (20) are both in a cylindrical structure, and the open ends of the upper connecting piece (10) and the lower connecting piece (20) are oppositely arranged; The outer wall of the upper connecting piece (10) is provided with an external thread, the inner wall of the lower connecting piece (20) is provided with an internal thread, and the external thread of the upper connecting piece (10) is screwed with the internal thread of the lower connecting piece (20); Or, the outer wall of the upper connecting piece (10) is provided with an internal thread, the inner wall of the lower connecting piece (20) is provided with an external thread, and the internal thread of the upper connecting piece (10) is screwed with the external thread of the lower connecting piece (20). The online filtering device for chromatographic flow path further comprises a sealing ring (60); 4. The on-line filter device for chromatography flow path according to claim 1, characterized by: The upper connecting piece (10) and the lower connecting piece (20) clamp the sealing ring (60), the sealing ring (60) is coaxial with the sample inlet channel (11), and the filter cartridge (30) is arranged in the sealing ring (60).

5. The online filtering device for chromatographic flow path according to claim 4, wherein: The bottom end of the upper connecting piece (10) is provided with an upper groove (13), the sealing ring (60) is inserted into the upper groove (13), and the diameter of the sealing ring (60) is equal to or smaller than the inner diameter of the upper groove (13). ​ Or, the inner wall of the top end of the lower connector (20) is provided with a lower groove (23), the sealing ring (60) is inserted into the lower groove (23), and the diameter of the sealing ring (60) is equal to or less than the inner diameter of the lower groove (23).

6. The online filter device for chromatography flow path according to claim 5, characterized in that: The depth of the upper groove (13) is less than the thickness of the sealing ring (60), and after the sealing ring (60) is inserted into the upper groove (13), the top of the sealing ring (60) is located in the upper groove (13), and the bottom of the sealing ring (60) is located outside the upper groove (13); Or, the depth of the lower groove (23) is less than the thickness of the sealing ring (60); after the sealing ring (60) is inserted into the lower groove (23), the bottom of the sealing ring (60) is located in the lower groove (23), and the top of the sealing ring (60) is located outside the lower groove (23).

7. The on-line filter device for chromatography flow path according to claim 4, characterized by: The online filter device for chromatography flow path further comprises a sealing column (70); The sealing column (70) is arranged in the cavity, and the sample inlet channel (11), the sealing column (70), the filter element (30) and the sample outlet (21) are coaxially arranged; The upper connector (10) and the lower connector (20) clamp the sealing column (70) and the filter element (30), one end of the sealing column (70) abuts against the filter element (30), and the other end of the sealing column (70) abuts against the upper connector (10) or the lower connector (20).

8. The online filter device for chromatography flow path according to claim 7, characterized in that: The sealing column (70) comprises an inner ring body (71) and an outer ring body (72), the outer wall of the inner ring body (71) is sleeved with a plurality of outer ring bodies (72), and the upper connector (10) and the lower connector (20) clamp the inner ring body (71) and the outer ring body (72); The inner ring body (71) is provided with a particle filler, one end of the sealing column (70) abuts against the filter element (30), and the other end of the sealing column (70) abuts against the upper connector (10) or the lower connector (20).

9. The online filter device for chromatography flow path according to claim 7, characterized in that: The bottom end of the upper connector (10) is provided with a first clamping groove (14), and the inner wall of the top end of the lower connector (20) is provided with a second clamping groove (24); One end of the sealing ring (60) away from the sealing column (70) is inserted into the first clamping groove (14) or the second clamping groove (24), and one end of the sealing column (70) away from the sealing ring (60) is inserted into the second clamping groove (24) or the first clamping groove (14).

10. The online filter device for chromatography flow path according to claim 1, characterized in that: The bottom end of the lower connector (20) is provided with a polygonal slot (25), and the polygonal slot (25) is in communication with the sample outlet (21). The polygonal slot hole (25) is internally provided with a connecting screw (80), the inside of the connecting screw (80) is provided with a through hole, the second pipe fitting (50) penetrates the connecting screw (80), and the connecting screw (80) is connected with external instruments.

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