Exosome concentration equipment for exosome carrying medicine

Abstract

The utility model provides exosome concentration equipment for exosome medicine carrying, which relates to the field of concentration equipment and comprises an operation box, a sealing cover is arranged at the top of the operation box, a fixing frame is arranged in an inner cavity of the operation box, a filter screen is fixedly connected to an inner cavity of the fixing frame, a motor is fixedly connected to the top of the sealing cover, and the motor is fixedly connected to the bottom of the operation box. A positioning mechanism is arranged in an inner cavity of the operation box; the operation box and the sealing cover are arranged, the sealing cover is used for sealing the top of the operation box, so that a closed operation space is provided for concentration operation, the fixing frame is arranged and used for fixing the filter screen, the motor can drive the fixing frame and the filter screen to rotate, so that sample extraction work is facilitated, and the positioning mechanism is arranged, so that the sample extraction efficiency is improved. The device has the advantages that the fixing frame can be conveniently mounted, the fixing frame can be conveniently detached and cleaned, accordingly, exosome residues in the device can be effectively reduced, and the influence of the residues on the quality of follow-up produced finished products can be prevented.

Description

Technical Field

[0001] This utility model belongs to the field of concentration equipment, specifically an exosome concentration device for exosome-loaded drugs. Background Technology

[0002] Exosome drug delivery is an emerging drug delivery technology that utilizes exosomes as drug delivery carriers. Exosomes are tiny membrane vesicles secreted by cells, containing cellular proteins, lipids, and RNA. They can transmit information between cells through body fluids and have certain biocompatibility and targeting properties. Exosome concentration equipment is a specialized device used to separate and concentrate cellular exosomes. These devices play a key role in exosome drug delivery research, effectively extracting and concentrating exosomes from body fluid samples to provide sufficient exosome quantities for subsequent drug loading and application.

[0003] According to application number 202321631277.5, an exosome separation and concentration device is disclosed, including a separation and concentration device body, a discharge port, and a fixed cylinder. The fixed cylinder is provided at the top of the separation and concentration device body, and the discharge port is provided on one side of the fixed cylinder. The separation and concentration cylinder is provided inside the fixed cylinder. The inner wall of the separation and concentration cylinder is provided with a disassembly structure. The outer side of the separation and concentration cylinder is provided with a through hole. Limiting structures are provided on both sides of the separation and concentration cylinder. A motor is provided inside the separation and concentration device body. A control panel is provided on one side of the front end of the separation and concentration device body. This comparative case, by setting a limiting structure, makes the separation and concentration cylinder more stable when rotating. Therefore, by using the combination of the limiting rod and the roller groove, the separation and concentration cylinder can be limited, making the separation and concentration cylinder more stable when rotating, thereby improving the limiting effect.

[0004] This comparative case effectively solved the problem that centrifuge tubes are prone to positional displacement during rotation, leading to tube detachment and failure of exosome raw material separation and concentration. However, the device is structurally robust and cannot be disassembled for cleaning, which can leave liquid residue inside, affecting the purity of subsequent exosome concentration.

[0005] In summary, this invention provides an exosome concentration device for exosome-loaded drugs to solve the above problems. Utility Model Content

[0006] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0007] An exosome drug delivery and exosome concentration device includes an operating box, a sealing cover on the top of the operating box, a fixing frame inside the operating box, a filter screen fixedly connected to the inner cavity of the fixing frame, a motor fixedly connected to the top of the sealing cover, a positioning mechanism inside the operating box, the positioning mechanism including a support ring disposed between the operating box and the sealing cover, a fixing ring movably connected to the inner cavity of the support ring via a bearing, the top of the fixing frame being fixedly connected to the bottom of the fixing ring, and a connecting plate fixedly connected to the inner cavity of the fixing ring.

[0008] Furthermore, in this utility model, the top of the connecting plate is provided with a positioning groove, the output shaft of the motor passes through the inner cavity of the operating box and is connected to a positioning block, the output shaft of the motor is movably connected to the inner wall of the sealing cover through a bearing, and the bottom of the positioning block extends into the inner cavity of the positioning groove and engages with the inner cavity of the positioning groove.

[0009] Furthermore, in this utility model, through holes are provided around the top of the support ring, and positioning posts are fixedly connected around the top of the operation box. The top of the positioning post extends into the inner cavity of the through hole and is movably connected to the inner cavity of the through hole. Positioning holes are provided around the bottom of the sealing cover, and the top of the positioning post engages with the inner cavity of the positioning hole.

[0010] Furthermore, in this utility model, a base is fixedly connected to the bottom of the operation box, and support legs are fixedly connected to both sides of the base, with a base plate fixedly connected to the bottom of the support legs.

[0011] Furthermore, in this utility model, a discharge pipe is fixedly connected to the front of the operation box, and a control valve is provided on the surface of the discharge pipe.

[0012] Furthermore, in this utility model, a fixing frame is fixedly connected to the top of the motor, the bottom of the fixing frame is fixedly connected to the top of the sealing cover, and a lifting rod is fixedly connected to the top of the fixing frame.

[0013] Beneficial effects: This utility model has the following beneficial effects:

[0014] This invention features an operating box and a sealing cover. The sealing cover seals the top of the operating box, providing a closed operating space for concentration operations. A fixing frame is used to fix the filter screen, and a motor drives the fixing frame and filter screen to rotate for sample extraction. A positioning mechanism facilitates the installation of the fixing frame and allows for its disassembly and cleaning, effectively reducing exosome residue inside the equipment and preventing residues from affecting the quality of subsequent finished products. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the main structure of this utility model;

[0016] Figure 2 This is a schematic diagram of the main structure of the control box of this utility model;

[0017] Figure 3 This is a schematic diagram of the separation state of the control box and the sealing cover of this utility model;

[0018] Figure 4 This is a schematic diagram of the main structure of the fixed frame of this utility model.

[0019] In the picture:

[0020] 1. Control box; 2. Sealing cover; 3. Fixing frame; 4. Filter screen; 5. Motor; 6. Positioning mechanism; 601. Support ring; 602. Fixing ring; 603. Connecting plate; 604. Positioning groove; 605. Positioning block; 606. Through hole; 607. Positioning column; 608. Positioning hole; 7. Base; 8. Support leg; 9. Base plate; 10. Discharge pipe; 11. Fixing frame; 12. Lifting rod. Detailed Implementation

[0021] To better understand the technical content of this utility model, specific embodiments are described below in conjunction with the accompanying drawings. Various aspects of this utility model are described in this disclosure with reference to the accompanying drawings, which illustrate numerous illustrative embodiments. The embodiments of this disclosure are not necessarily defined to include all aspects of this utility model. It should be understood that the various concepts and embodiments described above, as well as those described in more detail below, can be implemented in any of many ways, because the concepts and embodiments disclosed in this utility model are not limited to any particular implementation. Furthermore, some aspects of this utility model can be used alone or in any suitable combination with other aspects disclosed in this utility model.

[0022] Example 1

[0023] like Figure 1-4 As shown, this is the first embodiment of the present invention. This embodiment provides an exosome concentration device for exosome-loaded drugs, including an operation box 1. The top of the operation box 1 is provided with a sealing cover 2. The inner cavity of the operation box 1 is provided with a fixing frame 3. The inner cavity of the fixing frame 3 is fixedly connected with a filter screen 4. The top of the sealing cover 2 is fixedly connected with a motor 5. The inner cavity of the operation box 1 is provided with a positioning mechanism 6. The positioning mechanism 6 includes a support ring 601, which is disposed between the operation box 1 and the sealing cover 2. The inner cavity of the support ring 601 is movably connected to a fixing ring 602 through a bearing. The top of the fixing frame 3 is fixedly connected to the bottom of the fixing ring 602. The inner cavity of the fixing ring 602 is fixedly connected with a connecting plate 603.

[0024] like Figure 1-4 As shown, the sealing cover 2 is used to seal the top of the operating box 1, thereby providing a closed operating space for the concentration operation. The fixing frame 3 is used to fix the filter screen 4. The motor 5 can drive the fixing frame 3 and the filter screen 4 to rotate so as to carry out sample extraction. The positioning mechanism 6 plays a role in facilitating the installation of the fixing frame 3, so as to disassemble and clean the fixing frame 3, thereby effectively reducing the exosome residue inside the equipment and preventing the residue from affecting the quality of the subsequent finished products.

[0025] Example 2

[0026] Reference Figure 3 and 4 This is the second embodiment of the present invention, which is based on the previous embodiment.

[0027] In this embodiment, the top of the connecting plate 603 is provided with a positioning groove 604, the output shaft of the motor 5 passes through the inner cavity of the operating box 1 and is connected to the positioning block 605. The output shaft of the motor 5 is movably connected to the inner wall of the sealing cover 2 through a bearing, and the bottom of the positioning block 605 extends into the inner cavity of the positioning groove 604 and engages with the inner cavity of the positioning groove 604.

[0028] The support ring 601 has through holes 606 around its top. The operation box 1 has positioning pins 607 fixedly connected around its top. The top of the positioning pins 607 extends into the inner cavity of the through holes 606 and is movably connected to the inner cavity of the through holes 606. The sealing cover 2 has positioning holes 608 around its bottom. The top of the positioning pins 607 engages with the inner cavity of the positioning holes 608.

[0029] like Figure 3 and 4 As shown, after the positioning pin 607 passes through the through hole 606 and is inserted into the inner cavity of the positioning hole 608, the sealing cover 2 and the support ring 601 can be positioned, thereby fixing the operating box 1, the sealing cover 2 and the support ring 601. The fixing ring 602 is used to support the fixing frame 3. Since the inner cavity of the fixing ring 602 and the support ring 601 are movably connected by a bearing, after the positioning block 605 is inserted into the inner cavity of the positioning groove 604, the support ring 601 and the fixing ring 602 can be positioned, so that the output shaft of the motor 5 can drive it to rotate, thereby driving the fixing frame 3 and the filter screen 4 to rotate.

[0030] Example 3

[0031] Reference Figure 1 and 3 This is the third embodiment of the present invention, which is based on the first two embodiments.

[0032] In this embodiment, a base 7 is fixedly connected to the bottom of the operation box 1, and support legs 8 are fixedly connected to both sides of the base 7. A base plate 9 is fixedly connected to the bottom of the support legs 8.

[0033] The front of the control box 1 is fixedly connected to the discharge pipe 10, and the surface of the discharge pipe 10 is provided with a control valve.

[0034] A fixing bracket 11 is fixedly connected to the top of the motor 5. The bottom of the fixing bracket 11 is fixedly connected to the top of the sealing cover 2. A lifting rod 12 is fixedly connected to the top of the fixing bracket 11.

[0035] like Figure 1 and 3 As shown, the base 7, support legs 8 and bottom plate 9 are used to support the operation box 1 and improve the stability of the operation box 1 during use. The discharge pipe 10 facilitates the discharge of excrement from the operation box 1. The fixing bracket 11 is used to fix the motor 5. The lifting rod 12 facilitates the removal of the sealing cover 2 so that it can be removed from the top of the operation box 1.

[0036] In use, first move the fixed frame 3 to move the support ring 601 to the top of the operating box 1, and insert the positioning pin 607 into the through hole 606. Then add the raw material into the fixed frame 3. After that, move the sealing cover 2 by taking the lifting rod 12 and move the sealing cover 2 to the top of the operating box 1. Slowly move it down so that the positioning block 605 is inserted into the inner cavity of the positioning groove 604 and the positioning pin 607 is inserted into the inner cavity of the positioning hole 608. Then start the motor 5. Since the inner cavity of the fixed ring 602 and the support ring 601 are movably connected by the bearing, after the positioning block 605 is inserted into the inner cavity of the positioning groove 604, the support ring 601 and the fixed ring 602 can be positioned, so that the output shaft of the motor 5 can drive it to rotate, which in turn can drive the fixed frame 3 and the filter screen 4 to rotate, and perform the exosome separation operation.

[0037] All standard parts used in this application can be purchased from the market, and can be customized according to the description and drawings. The specific connection methods of each part adopt conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment adopt conventional models in the prior art. The control method is automatic control through a controller. The control circuit of the controller can be implemented by simple programming by those skilled in the art and is common knowledge in the field. Since this application is mainly used to protect mechanical devices, the control method and circuit connection will not be explained in detail in this application.

[0038] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Those skilled in the art to which this invention pertains can make various modifications and refinements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of this invention shall be determined by the claims.

Claims

1. An exosome drug delivery and exosome concentration device, comprising an operating box (1), characterized in that: The top of the operation box (1) is provided with a sealing cover (2), the inner cavity of the operation box (1) is provided with a fixing frame (3), the inner cavity of the fixing frame (3) is fixedly connected with a filter screen (4), the top of the sealing cover (2) is fixedly connected with a motor (5), the inner cavity of the operation box (1) is provided with a positioning mechanism (6), the positioning mechanism (6) includes a support ring (601), the support ring (601) is disposed between the operation box (1) and the sealing cover (2), the inner cavity of the support ring (601) is movably connected with a fixing ring (602) through a bearing, the top of the fixing frame (3) is fixedly connected to the bottom of the fixing ring (602), and the inner cavity of the fixing ring (602) is fixedly connected with a connecting plate (603).

2. The exosome concentration device for drug delivery via exosomes as described in claim 1, characterized in that: The top of the connecting plate (603) is provided with a positioning groove (604). The output shaft of the motor (5) passes through the inner cavity of the operating box (1) and is connected to the positioning block (605). The output shaft of the motor (5) is movably connected to the inner wall of the sealing cover (2) through a bearing. The bottom of the positioning block (605) extends into the inner cavity of the positioning groove (604) and engages with the inner cavity of the positioning groove (604).

3. The exosome concentration device for drug delivery via exosomes as described in claim 1, characterized in that: The support ring (601) has through holes (606) around its top. The operation box (1) has positioning pins (607) fixedly connected around its top. The top of the positioning pins (607) extends into the inner cavity of the through holes (606) and is movably connected to the inner cavity of the through holes (606). The sealing cover (2) has positioning holes (608) around its bottom. The top of the positioning pins (607) engages with the inner cavity of the positioning holes (608).

4. The exosome concentration device for drug delivery via exosomes as described in claim 1, characterized in that: The bottom of the operation box (1) is fixedly connected to a base (7), and both sides of the base (7) are fixedly connected to support legs (8), and the bottom of the support legs (8) is fixedly connected to a base plate (9).

5. The exosome concentration device for drug delivery via exosomes as described in claim 1, characterized in that: The front of the operation box (1) is fixedly connected to a discharge pipe (10), and a control valve is provided on the surface of the discharge pipe (10).

6. The exosome concentration device for drug delivery via exosomes as described in claim 1, characterized in that: The top of the motor (5) is fixedly connected to a fixing frame (11), the bottom of the fixing frame (11) is fixedly connected to the top of the sealing cover (2), and the top of the fixing frame (11) is fixedly connected to a lifting rod (12).

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