Coupling reaction device

Abstract

The utility model belongs to the technical field of coupling reaction, and discloses a coupling reaction device, which comprises a reaction bottle, a plurality of raw material bottles, an inlet valve and a booster pump component, the reaction bottle is used for accommodating a mixed solution, the raw material bottles are used for accommodating a raw material solution, the inlet valve comprises a first outlet and a plurality of first inlets, and the booster pump component is arranged in the reaction bottle. The multiple first inlets are selectively communicated with the first outlet, each first inlet is communicated with the corresponding raw material bottle, the first outlet is communicated with the reaction bottle through the booster pump assembly, and the booster pump assembly can quantitatively pump a raw material solution into the reaction bottle; according to the coupling reaction device, the operation of manually adding various raw material solutions into the reaction bottle can be omitted, and the effects of improving the efficiency and reducing the labor cost are achieved.

Description

TECHNICAL FIELD

[0001] The utility model relates to coupling reaction technical field especially relates to a coupling reaction device. BACKGROUND

[0002] Coupling reaction is the process that two molecules get a molecule through chemical reaction, which can be used not only in organic synthesis, but also widely used in biology, medicine and detection analysis fields.

[0003] At present, coupling reaction needs to add a plurality of raw material solutions by manual mode, which is time-consuming and laborious, and greatly improves the labor cost.

[0004] Therefore, it is urgent to provide a coupling reaction device to solve the above technical problems. UTILITY MODEL CONTENT

[0005] The utility model aims at providing a coupling reaction device, which can save the operation of manually adding a plurality of raw material solutions into a reaction bottle, and has the effects of improving efficiency and reducing labor cost.

[0006] To achieve this purpose, the utility model adopts the following technical solutions:

[0007] The coupling reaction device comprises:

[0008] A reaction bottle and a plurality of raw material bottles, the reaction bottle is used for containing a mixed solution, and the raw material bottles are used for containing raw material solutions;

[0009] An inlet valve, the inlet valve comprises a first outlet and a plurality of first inlets, the plurality of first inlets are selectively communicated with the first outlet, and each first inlet is communicated with a corresponding raw material bottle;

[0010] A booster pump assembly, the first outlet is communicated with the reaction bottle through the booster pump assembly, and the booster pump assembly can quantitatively pump the raw material solution into the reaction bottle.

[0011] Optionally, the coupling reaction device further comprises a detection assembly, the inlet valve further comprises a second inlet, the second inlet and the plurality of first inlets are selectively communicated with the first outlet, the second inlet is communicated with the reaction bottle, the booster pump assembly is communicated with the reaction bottle through the detection assembly, and the detection assembly comprises a conductivity meter and a pH meter which are communicated.

[0012] Optionally, the coupling reaction device further comprises a controller, the inlet valve, the booster pump assembly, the conductivity meter and the pH meter are signal connected with the controller, the controller can control the second inlet and the plurality of first inlets to be selectively communicated with the first outlet, and the controller can also control the start and stop of the booster pump assembly.

[0013] Optionally, the coupling reaction device further comprises a bubble sensor, an outlet valve and a waste liquid bottle, the bubble sensor is arranged in the inlet valve and communicates with the first outlet, the outlet valve comprises a third inlet, a second outlet and a third outlet, the third inlet communicates with the liquid outlet end of the detection assembly, the second outlet communicates with the reaction bottle, and the third outlet communicates with the waste liquid bottle, the bubble sensor and the outlet valve are signal connected with the controller, and the controller can control the second outlet and the third outlet to selectively communicate with the third inlet.

[0014] Optionally, the number of the reaction bottles, the second inlets and the second outlets are multiple and one-to-one corresponding.

[0015] Optionally, the coupling reaction device further comprises a memory and a display, the memory, the display and the controller are signal connected, the memory is used for storing data received by the controller, and the display is used for displaying the data.

[0016] Optionally, the conductance meter is a conductance temperature measuring instrument.

[0017] Optionally, the booster pump assembly comprises full-automatic micro-plunger pumps.

[0018] Optionally, the number of the inlet valves is two, and the number of the full-automatic micro-plunger pumps is four, wherein the liquid inlets of two full-automatic micro-plunger pumps are connected in parallel and communicate with the first outlet of one inlet valve, the liquid inlets of the other two full-automatic micro-plunger pumps are connected in parallel and communicate with the first outlet of the other inlet valve, and the liquid outlets of the four full-automatic micro-plunger pumps are connected in parallel and communicate with the reaction bottle.

[0019] Optionally, the coupling reaction device further comprises a stirring element, and the stirring element is used for stirring the mixed solution in the reaction bottle.

[0020] The utility model discloses beneficial effects:

[0021] The coupling reaction device provided by the utility model is equipped with a reaction bottle, a raw material bottle, an inlet valve and a booster pump assembly, the reaction bottle is used for containing a mixed solution, the raw material bottle is used for containing a raw material solution, the number of the raw material bottles is multiple, the inlet valve comprises a first outlet and multiple first inlets, the multiple first inlets are selectively communicated with the first outlet, each first inlet is communicated with a corresponding raw material bottle, the first outlet is communicated with the reaction bottle through the booster pump assembly, the booster pump assembly can quantitatively pump the raw material solution into the reaction bottle, in actual application, one first inlet is communicated with the first outlet, then the booster pump assembly is started, the raw material solution in the raw material bottle communicated with the first inlet is quantitatively pumped into the reaction bottle, then the communication between the first inlet and the first outlet is disconnected, another first inlet is communicated with the first outlet, the raw material solution in the raw material bottle communicated with the first inlet is quantitatively pumped into the reaction bottle, then the communication between the first inlet and the first outlet is disconnected, and the multiple raw material solutions can be pumped into the reaction bottle by sequentially communicating and disconnecting the corresponding first inlets and the first outlet according to the reaction requirement, the operation of manually adding the multiple raw material solutions into the reaction bottle is saved, and the efficiency is improved and the labor cost is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 It is the principle diagram of the coupling reaction device provided by the utility model.

[0023] In the drawings:

[0024] 110, reaction bottle; 120, raw material bottle; 200, inlet valve; 210, first outlet; 220, first inlet; 230, second inlet; 300, booster pump assembly; 310, full-automatic micro displacement plunger pump; 400, detection assembly; 410, conductance instrument; 420, pH meter; 500, controller; 600, outlet valve; 610, third inlet; 620, second outlet; 630, third outlet; 700, waste liquid bottle; 800, stirring element. DETAILED DESCRIPTION

[0025] The utility model will be further explained in detail in combination with the drawings and examples. It can be understood that the specific examples described here are only used for explaining the utility model, and not limited to the utility model. In addition, it should be noted that, in order to facilitate the description, only the part related to the utility model is shown in the drawings, not all structures.

[0026] In the description of this utility model, unless otherwise explicitly specified and limited, the terms "connected," "linked," and "fixed" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0027] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0028] In the description of this embodiment, the terms "upper," "lower," "right," etc., refer to the orientation or positional relationship shown in the accompanying drawings. They are used only for ease of description and simplification of operation, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. In addition, the terms "first" and "second" are only used for distinction in description and have no special meaning.

[0029] This embodiment provides a coupling reaction device that eliminates the need for manual addition of multiple raw material solutions to the reaction flask, thereby improving efficiency and reducing labor costs.

[0030] Specifically, such as Figure 1 As shown, the coupled reaction apparatus includes a reaction flask 110, a raw material bottle 120, an inlet valve 200, and a booster pump assembly 300. The reaction flask 110 is used to contain a mixed solution, and the raw material bottle 120 is used to contain a raw material solution. There are multiple raw material bottles 120, and the types of raw material solutions in different raw material bottles 120 are different. The inlet valve 200 includes a first outlet 210 and multiple first inlets 220. The multiple first inlets 220 are selectively connected to the first outlet 210. Each first inlet 220 is connected to a corresponding raw material bottle 120. The first outlet 210 is connected to the reaction flask 110 through the booster pump assembly 300, which can pump the raw material solution into the reaction flask 110 in a metered manner.

[0031] In actual application, one first inlet 220 is communicated with the first outlet 210, and then the booster pump assembly 300 is started, so that the raw material solution in the raw material bottle 120 communicated with the first inlet 220 is pumped into the reaction bottle 110 in a metered manner, then the communication between the first inlet 220 and the first outlet 210 is disconnected, another first inlet 220 is communicated with the first outlet 210, so that the raw material solution in the raw material bottle 120 communicated with the first inlet 220 is pumped into the reaction bottle 110 in a metered manner, then the communication between the first inlet 220 and the first outlet 210 is disconnected, and the corresponding first inlet 220 and the first outlet 210 are communicated and disconnected in sequence according to the reaction requirement, so that the plurality of raw material solutions can be pumped into the reaction bottle 110, the operation of manually adding the plurality of raw material solutions into the reaction bottle 110 is saved, and the efficiency is improved and the labor cost is reduced.

[0032] In the embodiment, the number of the first inlets 220 and the raw material bottles 120 is eight, and of course in other embodiments, the number of the first inlets 220 and the raw material bottles 120 can also be three, six or ten, etc.

[0033] Optionally, the coupling reaction device further comprises a stirring element 800, and the stirring element 800 is used to stir the mixed solution in the reaction bottle 110, so that the plurality of raw material solutions in the reaction bottle 110 are mixed uniformly. In the embodiment, the stirring element 800 is a magnetic stirrer, and of course in other embodiments, the stirring element 800 can also be a stirring rod, and the stirring is performed manually.

[0034] Optionally, the coupling reaction device further comprises a detection assembly 400, and the inlet valve 200 further comprises a second inlet 230, the second inlet 230 and the plurality of first inlets 220 are selectively communicated with the first outlet 210, the second inlet 230 is communicated with the reaction bottle 110, and the booster pump assembly 300 is communicated with the reaction bottle 110 through the detection assembly 400, the detection assembly 400 comprises a conductivity meter 410 and a pH meter 420 in communication, after the plurality of raw material solutions are pumped into the reaction bottle 110, the communication between all the first inlets 220 and the first outlet 210 is disconnected, the second inlet 230 is communicated with the first outlet 210, the mixed solution in the reaction bottle 110 is pumped to the detection assembly 400, the conductivity of the mixed solution is detected by the conductivity meter 410, and the pH value of the mixed solution is detected by the pH meter, so that the conductivity and the pH value of the mixed solution are obtained. In addition, compared with the prior art in which the mixed solution is manually obtained for detection, the technical scheme provided in the embodiment does not affect the total volume of the mixed solution on the basis of detecting the conductivity and the pH value of the mixed solution, and thus the precision of the coupling reaction can be improved.

[0035] In actual operation, if the conductivity and / or pH value of the mixed solution does not meet the predetermined requirements, the communication between the second inlet 230 and the first outlet 210 can be disconnected, and then one of the plurality of first inlets 220 (hereinafter referred to as the target first inlet 220) is connected to the first outlet 210. The raw material solution (hereinafter referred to as the target raw material solution) in the raw material bottle 120 connected to the target first inlet 220 is pumped into the reaction bottle 110 in a quantitative manner. Then, the communication between the target first inlet 220 and the first outlet 210 is disconnected, and the second inlet 230 is connected to the first outlet 210 again. The mixed solution in the reaction bottle 110 is pumped to the detection assembly 400 again, so that the conductivity meter 410 detects the conductivity of the mixed solution again, and the pH meter detects the pH value of the mixed solution again. Until the conductivity and pH value of the mixed solution meet the predetermined requirements, the communication between the second inlet 230 and all the first inlets 220 and the first outlet 210 is disconnected.

[0036] In this embodiment, along the flow direction of the solution, the conductivity meter 410 is located upstream of the pH meter 420, that is, the liquid inlet of the conductivity meter 410 is connected to the outlet of the booster pump assembly 300, the liquid outlet of the conductivity meter 410 is connected to the liquid inlet of the pH meter 420, and the liquid outlet of the pH meter 420 is connected to the reaction bottle 110. Of course, in other embodiments, along the flow direction of the solution, the conductivity meter 410 can be located downstream of the pH meter 420, that is, the liquid inlet of the pH meter 420 is connected to the outlet of the booster pump assembly 300, the liquid outlet of the pH meter 420 is connected to the liquid inlet of the conductivity meter 410, and the liquid outlet of the conductivity meter 410 is connected to the reaction bottle 110.

[0037] Further, the coupling reaction device further comprises a controller 500, the inlet valve 200, the booster pump assembly 300, the conductance meter 410 and the pH meter 420 are signal connected with the controller 500, the controller 500 can control the second inlet 230 and the plurality of first inlets 220 to selectively communicate with the first outlet 210, the controller 500 can also control the start and stop of the booster pump assembly 300, the conductance meter 410 and the pH meter 420 transmit the detected conductivity and pH value to the controller 500, the controller 500 controls the on-off between the target first inlet 220 and the second inlet 230 and the first outlet 210, until the conductivity and pH value of the mixed solution are adjusted to the predetermined requirements. It should be pointed out that the above-mentioned controller 500 control method is the prior art in the art, for example, the target conductivity value, the target pH value and the calculation formula for adjusting the conductivity value and the pH value are input in the controller 500 in advance, the conductance meter 410 transmits the detected actual conductivity value to the controller 500, the controller 500 compares the actual conductivity value with the target conductivity value, the pH meter 420 transmits the detected actual pH value to the controller 500, the controller 500 compares the actual pH value with the target pH value, when there is a difference between the actual conductivity value and the target conductivity value, and / or, there is a difference between the actual pH value and the target pH value, the controller 500 obtains the type and the amount of the target raw material solution to be added into the reaction bottle 110 according to the calculation formula, and then the controller 500 controls the target first inlet 220 to communicate with the first outlet 210, so that the target raw material solution is quantitatively pumped into the reaction bottle 110.

[0038] Of course, in other embodiments, the selection of the target first inlet 220 from the plurality of first inlets 220 can also be determined by artificial selection, and then the target raw material solution is quantitatively pumped into the reaction bottle 110.

[0039] Optionally, the conductance meter 410 is a conductance temperature meter, which can measure the temperature of the raw material solution and the mixed solution on the one hand, and can have a temperature compensation function on the other hand, so as to improve the detection accuracy of the conductance meter 410. It should be pointed out that the specific principle and method of temperature compensation of the conductance temperature meter are the prior art in the art, which will not be described here.

[0040] The detection range of the pH meter 420 provided in the embodiment is 0-14, the detection accuracy is ±0.1 pH unit, the temperature compensation of the pH meter 420 can automatically correct the change of the pH value with temperature, and the stability is 0.1 pH unit / 10 hours.

[0041] Optionally, the coupling reaction device further comprises a bubble sensor (not shown in the figures), an outlet valve 600 and a waste liquid bottle 700. The bubble sensor is arranged in the inlet valve 200 and communicates with the first outlet 210. The outlet valve 600 comprises a third inlet 610, a second outlet 620 and a third outlet 630. The third inlet 610 communicates with the liquid outlet end of the detection assembly 400. The second outlet 620 communicates with the reaction bottle 110. The third outlet 630 communicates with the waste liquid bottle 700. The bubble sensor and the outlet valve 600 are signal connected with the controller 500. The controller 500 can control the second outlet 620 and the third outlet 630 to selectively communicate with the third inlet 610. If the raw material solution pumped into the reaction bottle 110 contains bubbles, the metering accuracy of the raw material solution will be reduced, which will affect the coupling reaction. To solve the technical problem, the bubble sensor is arranged in the inlet valve 200 in the technical scheme provided in the embodiment, which is used to detect whether the raw material solution in the inlet valve 200 contains bubbles. If the bubble sensor detects that the raw material solution contains bubbles, the controller 500 controls the third outlet 630 of the outlet valve 600 to communicate with the third inlet 610, so that the raw material solution with bubbles in the inlet valve 200 is pumped into the waste liquid bottle 700. If the bubble sensor does not detect that the raw material solution contains bubbles, the controller 500 controls the second outlet 620 of the outlet valve 600 to communicate with the third inlet 610, so that the raw material solution without bubbles in the inlet valve 200 is pumped into the reaction bottle 110. It can be seen that the design solves the problem of pumping the raw material solution with bubbles into the reaction bottle 110, thereby improving the metering accuracy of the raw material solution.

[0042] Optionally, the coupling reaction device further comprises a storage and a display (not shown in the figures). The storage, the display and the controller 500 are signal connected. The storage is used to store the data received by the controller 500. The display is used to display the data. Therefore, the historical data such as the conductivity value, the pH value, the temperature value and the pumping metering can be recorded and consulted, which is convenient for checking the data.

[0043] Optionally, the booster pump assembly 300 comprises a full-automatic micro-plunger pump 310. The flow rate accuracy of the full-automatic micro-plunger pump 310 for pumping solution can reach ±2%, which can realize high-precision quantitative pumping of the raw material solution. In actual use, the full-automatic micro-plunger pump 310 can be controlled by the controller 500 to pump multiple raw material solutions according to the preset time and the preset order, thereby improving the automation effect of the coupling reaction device.

[0044] In other embodiments, the booster pump assembly 300 comprises a booster pump and a flow meter. The liquid inlet or the liquid outlet of the booster pump communicates with the flow meter, so as to detect the flow of the raw material solution, thereby achieving the effect of quantitative pumping of the raw material solution.

[0045] Further, the number of inlet valves 200 is two, and the number of fully automatic micro piston pumps 310 is four, wherein the liquid inlets of two fully automatic micro piston pumps 310 are connected in parallel and communicated with the first outlet 210 of one inlet valve 200, the liquid inlets of the other two fully automatic micro piston pumps 310 are connected in parallel and communicated with the first outlet 210 of the other inlet valve 200, and the liquid outlets of the four fully automatic micro piston pumps 310 are connected in parallel and communicated with the reaction bottle 110 through the conductance instrument 410, the pH meter 420 and the outlet valve 600. The two fully automatic micro piston pumps 310 corresponding to each inlet valve 200 can be pumped in sequence or in turn to achieve the effect of continuous pumping of the solution (for example, when the first fully automatic micro piston pump 310 is started, the second fully automatic micro piston pump 310 is stopped, after the raw material solution in the first fully automatic micro piston pump 310 is completely pumped out, the first fully automatic micro piston pump 310 is stopped, and the second fully automatic micro piston pump 310 is started), which improves the stability of the solution pumping flow and further ensures the accuracy of the total amount of the raw material solution pumped.

[0046] Optionally, the number of the reaction bottles 110, the second inlets 230, the second outlets 620 and the stirring elements 800 are multiple and one-to-one correspondence, for example, the number of the reaction bottles 110 can be two, three or five, and so on, and then each reaction bottle 110 can carry out coupling reaction respectively. In practical application, usually one coupling reaction needs to be carried out for about eight hours, and in the prior art, one coupling reaction can be carried out per day by manual method. In the technical scheme provided in the embodiment, the coupling reactions in the three reaction bottles 110 can be carried out in turn by the control of the controller 500, and then three coupling reactions can be carried out in turn in twenty-four hours, which greatly improves the reaction efficiency. It should be pointed out that the number of the above-mentioned second inlets 230 can be realized by setting multiple inlet valves 200, that is, each inlet valve 200 is provided with one or more than two second inlets 230, or the number of the inlet valves 200 is one, and multiple second inlets 230 are arranged on the inlet valve 200. It should be pointed out that when the number of the inlet valves 200 is two or more, the above-mentioned second inlets 230 and the multiple first inlets 220 selectively communicate with the first outlet 210 means that in the same inlet valve 200, the second inlet 230 and the multiple first inlets 220 selectively communicate with the first outlet 210. Before carrying out the coupling reaction, it is confirmed that the multiple first inlets 220 are respectively communicated with the corresponding raw material bottles 120, and the liquid inlet pipe connected with the first inlets 220 is inserted into the raw material solution in the raw material bottle 120, so that the pipeline is exhausted of air, and the whole flow path dead volume is about 3ml. Under the power of the booster pump assembly 300, the raw material solution enters the inlet pump from the first inlet 220, and then flows through the booster pump assembly 300, the conductance instrument 410, the pH tester 420 and the outlet valve 600 in turn, and finally flows into the reaction bottle 110 from the second outlet 620 of the outlet valve 600, and multiple raw material solutions are pumped into the reaction bottle 110 by the above-mentioned method. In the process of pumping the raw material solution, if the bubble sensor detects that there are bubbles in the raw material solution, the communication between the third inlet 610 and the second outlet 620 of the outlet valve 600 is disconnected, the communication between the third inlet 610 and the third outlet 630 is conducted, so that the raw material solution with bubbles is pumped into the waste liquid bottle 700, until the raw material solution with bubbles is discharged from the pipeline, the communication between the third inlet 610 and the third outlet 630 is disconnected, and the communication between the third inlet 610 and the second outlet 620 is conducted, and the raw material solution without bubbles is pumped into the reaction bottle 110. Under the stirring action of the stirring element 800, the raw material solution in the reaction bottle 110 is fully mixed to form a mixed solution.Then all the communication between the first inlets 220 and the first outlet 210 is disconnected, the communication between the second inlets 230 and the first outlet 210 is conducted, and the mixed solution in the reaction bottle 110 is pumped from the first inlets 220 into the inlet pump, and then sequentially flows through the booster pump assembly 300, the conductance instrument 410, the pH meter 420 and the outlet valve 600, and finally flows into the reaction bottle 110 from the second outlet 620 of the outlet valve 600. The conductance instrument 410 detects the conductivity of the mixed solution, and the pH meter detects the pH value of the mixed solution. If the actual conductivity value and / or the actual pH value of the mixed solution do not meet the requirements, the controller 500 controls the target first inlet 220 and the first outlet 210 to be conducted, so that the target raw material solution is pumped into the reaction bottle 110 in a quantitative manner, until the actual conductivity value and the actual pH value of the mixed solution meet the requirements, so that the mixed solution in the reaction bottle 110 starts to react. During the reaction process, the booster pump assembly 300 can be started at regular time intervals to pump the reaction solution to the conductance instrument 410 for temperature detection and recording, which facilitates data tracing and checking.

[0047] In practical applications, the inlet valve, the full-automatic micro-plunger pump, the conductance instrument, the pH meter and the outlet valve in the chromatography equipment can be connected in communication, then the plurality of first inlets 220 of the inlet valve 200 are respectively communicated with a corresponding raw material bottle 120, the plurality of second outlets 620 of the outlet valve 600 are respectively communicated with a corresponding reaction bottle 110, and the third outlet 630 of the outlet valve 600 is communicated with the waste liquid bottle 700, so as to obtain the coupling reaction device provided in the embodiment. The automatic condition optimization and process development can be realized by cooperation of hardware and software. Exemplarily, the chromatography equipment can be AKTA avant 150 chromatography equipment, and the control software can be UNICORN software. The signal connection mode of the UNICORN software and the inlet valve, the full-automatic micro-plunger pump, the conductance instrument, the pH meter and the outlet valve in the chromatography equipment is the prior art in the field, which will not be described here.

[0048] The coupling reaction device provided in the embodiment can add the raw material solution into the reaction bottle 110 in a timed, quantitative and constant speed manner; the temperature value, the conductivity value and the pH value of the reaction solution and the mixed solution can be detected on line, and the sample solution after detection can return to the reaction bottle 110, so that the detection does not affect the total amount of the solution; the detected data can be recorded in real time and can be traced and viewed.

[0049] Embodiment Two

[0050] The embodiment provides a coupling reaction device, and the differences between the embodiment and the previous embodiments will be mainly described below, and the same parts will not be described here.

[0051] In the embodiment, the number of the reaction bottle 110 and the outlet valve 600 is one, the outlet valve 600 is a three-way valve, the number of the raw material bottle 120 is thirteen, the number of the inlet valve 200 is two, and the inlet valve 200 is an eight-way valve, one of the two eight-way valves has one second inlet 230, one first outlet 210 and six first inlets 220, the other of the two eight-way valves has one first outlet 210 and seven first inlets 220, thus, the two inlet valves 200 have thirteen first inlets 220 in common, the thirteen first inlets 220 are communicated with corresponding one of the raw material bottles 120 respectively, the raw material solutions in the thirteen raw material bottles 120 are different, thus, the thirteen different raw material solutions can be pumped to the reaction bottle 110.

[0052] Embodiment three

[0053] The embodiment provides a coupling reaction device, and mainly describes differences between the embodiment and the foregoing embodiments, and the same parts are not described again.

[0054] In the embodiment, the number of the reaction bottle 110 is three, the number of the raw material bottle 120 is eleven, the number of the outlet valve 600 is one, and the outlet valve 600 is a five-way valve, the outlet valve 600 has one third inlet 610, one third outlet 630 and three second outlets 620, the number of the inlet valve 200 is two, and the inlet valve 200 is an eight-way valve, one of the two eight-way valves has one second inlet 230, one first outlet 210 and six first inlets 220, the other of the two eight-way valves has two second inlets 230, one first outlet 210 and five first inlets 220, thus, the two inlet valves 200 have eleven first inlets 220 in common, the eleven first inlets 220 are communicated with corresponding one of the raw material bottles 120 respectively, the raw material solutions in the eleven raw material bottles 120 are different, thus, the eleven different raw material solutions can be pumped to the reaction bottle 110, and the three reaction bottles 110 can perform three different coupling reactions, and the three different coupling reactions can be performed in a specified order under the control of the controller 500.

[0055] Obviously, the above embodiments of the utility model are only for clearly illustrating the utility model, and are not the limitation of the embodiments of the utility model. For the ordinary skilled in the art, various obvious changes, re-adjustment and replacement can be made without departing from the protection scope of the utility model. Here, all the embodiments need not and can not be exhausted. Any modification, equivalent replacement and improvement made in the spirit and principle of the utility model should be included in the protection scope of the utility model claim.

Claims

1. A coupling reaction apparatus, characterized by, The coupling reaction device comprises: a reaction bottle (110) for containing a mixed solution and a plurality of raw material bottles (120) for containing raw material solutions; an inlet valve (200) comprising a first outlet (210) and a plurality of first inlets (220) selectively communicating with the first outlet (210), each of the first inlets (220) respectively communicating with a corresponding one of the raw material bottles (120); a booster pump assembly (300) through which the first outlet (210) communicates with the reaction bottle (110), the booster pump assembly (300) being capable of pumping the raw material solutions into the reaction bottle (110) in a metered manner.

2. The coupling reaction apparatus according to claim 1, wherein The coupling reaction device further comprises a detection assembly (400), the inlet valve (200) further comprises a second inlet (230) selectively communicating with the first outlet (210) together with the plurality of first inlets (220), the second inlet (230) communicating with the reaction bottle (110), the booster pump assembly (300) communicating with the reaction bottle (110) through the detection assembly (400), the detection assembly (400) comprising a conductivity meter (410) and a pH meter (420) in communication.

3. The coupling reaction apparatus according to claim 2, wherein The coupling reaction device further comprises a controller (500), the inlet valve (200), the booster pump assembly (300), the conductivity meter (410) and the pH meter (420) being in signal connection with the controller (500), the controller (500) being capable of controlling the second inlet (230) and the plurality of first inlets (220) to selectively communicate with the first outlet (210), the controller (500) further being capable of controlling the booster pump assembly (300) to start and stop.

4. The coupling reaction apparatus according to claim 3, wherein The coupling reaction device further comprises a bubble sensor, an outlet valve (600) and a waste bottle (700), the bubble sensor being arranged in the inlet valve (200) and communicating with the first outlet (210), the outlet valve (600) comprising a third inlet (610), a second outlet (620) and a third outlet (630), the third inlet (610) communicating with a liquid outlet end of the detection assembly (400), the second outlet (620) communicating with the reaction bottle (110), the third outlet (630) communicating with the waste bottle (700), the bubble sensor and the outlet valve (600) being in signal connection with the controller (500), the controller (500) being capable of controlling the second outlet (620) and the third outlet (630) to selectively communicate with the third inlet (610).

5. The coupling reaction apparatus according to claim 4, wherein The reaction bottle (110), the second inlet (230) and the second outlet (620) are in one-to-one correspondence and each of them is in a plurality.

6. The coupling reaction apparatus according to any one of claims 3 to 5, characterized by The coupling reaction device further comprises a memory and a display, the memory, the display and the controller (500) are signal connected, the memory is used for storing data received by the controller (500), and the display is used for displaying the data.

7. The coupling reaction apparatus according to any one of claims 2 to 5, characterized by The electric conductivity meter (410) is a conductivity temperature measuring instrument.

8. The coupling reaction apparatus according to any one of claims 1 to 5, characterized by The booster pump assembly (300) comprises full-automatic micro-plunger pumps (310).

9. The coupling reaction apparatus of claim 8, wherein The number of the inlet valves (200) is two, and the number of the full-automatic micro-plunger pumps (310) is four, wherein the liquid inlets of two full-automatic micro-plunger pumps (310) are connected in parallel and communicate with the first outlet (210) of one inlet valve (200), the liquid inlets of the other two full-automatic micro-plunger pumps (310) are connected in parallel and communicate with the first outlet (210) of the other inlet valve (200), and the liquid outlets of the four full-automatic micro-plunger pumps (310) are connected in parallel and communicate with the reaction bottle (110).

10. The coupling reaction apparatus according to any one of claims 1 to 5, characterized by The coupling reaction device further comprises a stirring element (800) for stirring the mixed solution in the reaction bottle (110). The coupling reaction device further comprises a memory and a display, the memory, the display and the controller (500) are signal connected, the memory is used for storing data received by the controller (500), and the display is used for displaying the data. The electric conductivity meter (410) is a conductivity temperature measuring instrument. The booster pump assembly (300) comprises full-automatic micro-plunger pumps (310). The number of the inlet valves (200) is two, and the number of the full-automatic micro-plunger pumps (310) is four, wherein the liquid inlets of two full-automatic micro-plunger pumps (310) are connected in parallel and communicate with the first outlet (210) of one inlet valve (200), the liquid inlets of the other two full-automatic micro-plunger pumps (310) are connected in parallel and communicate with the first outlet (210) of the other inlet valve (200), and the liquid outlets of the four full-automatic micro-plunger pumps (310) are connected in parallel and communicate with the reaction bottle (110). The coupling reaction device further comprises a stirring element (800) for stirring the mixed solution in the reaction bottle (110).

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