Immunochromatography detection reagent card
By designing an aspiration mechanism consisting of a syringe and a plunger, the problems of leakage and sample blockage when adding sample solution with a dropper were solved, thus achieving simplicity and accuracy in immunochromatographic detection.
Patent Information
- Application Number
- CN202422861375.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-22
- Publication Date
- 2025-12-05
- Estimated Expiration
- 2034-11-22
AI Technical Summary
In existing respiratory immunochromatographic assays, leakage, failure to drip, or no sample is common when adding sample solution using a dropper, affecting the accuracy of the test results.
Design an immunochromatographic assay card comprising a syringe, a plunger, and a test strip. The syringe and plunger form an aspiration mechanism, the test strip is embedded along the length of the plunger, and the sample pad extends from the front end of the plunger. The sample solution is aspirated by the plunger for detection, avoiding leakage and sample blockage during drop addition.
It achieves a simple and convenient testing process, avoids leakage and sample blockage, and improves the accuracy of test results.
Smart Images
Figure CN223637529U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of reagent cards, in particular to an immunochromatographic detection reagent card. BACKGROUND
[0002] With the continuous development and progress of science and technology, the detection technology of medicine is constantly updated. Among them, the immunochromatographic method is a new detection technology that has emerged abroad. The principle of immunochromatography is that specific antibodies are first fixed on a certain zone of a nitrocellulose membrane. When one end of the dry nitrocellulose is immersed in a sample (urine or serum), the sample will move forward along the membrane due to capillary action. When it moves to the region where the antibodies are fixed, the corresponding antigens in the sample will specifically bind to the antibodies. If the sample is stained with immunocolloidal gold or immunoenzyme, the region will show a certain color, thereby realizing specific immunodiagnosis.
[0003] The existing detection often sets the detection tool as a detection card or a reagent kit. Although with the progress of science, the related technology has developed to a certain extent. The immunochromatographic test usually uses a paper strip or a membrane as a solid carrier, and specific antibodies are fixed on the solid phase. After the sample to be tested is combined with the antibody labeled with dye or fluorescent substance, the specific antibodies on the test paper are combined with the target antigen in the sample by adding the sample to the test paper. If the target antigen exists in the sample, it will combine with the specific antibodies on the solid phase to form a complex. This complex moves on the test paper and finally appears at a specific position on the test paper.
[0004] The respiratory tract immunochromatographic detection in the prior art usually uses a reagent card in combination with a tube of lysis solution, and then drops the sample liquid. However, when the sample liquid is added by using a dropper, there may be liquid leakage, the sample liquid may not be dropped, or the sample liquid may not be dropped onto the sample. This affects the accuracy of the detection result. CONTENT OF THE INVENTION
[0005] The present application provides an immunochromatographic detection reagent card to solve the problems of liquid leakage, sample liquid drop, or sample liquid drop not onto the sample when the sample liquid is added by using a dropper.
[0006] To achieve the above-mentioned purpose, the present application provides an immunochromatographic detection reagent card, which comprises a needle cylinder, a plunger and a test strip. The front end of the needle cylinder is provided with a nipple. The plunger is movably arranged in the needle cylinder. The test strip is embedded in the plunger along the length direction of the plunger, and the sample pad of the test strip extends from the front end of the plunger. The material of the needle cylinder is transparent, and the plunger corresponding to the detection area of the test strip is made of transparent material.
[0007] Optionally, the front end of the nipple is provided with a filter screen.
[0008] Optionally, the outer wall of the needle cylinder is provided with scale lines for indicating volume along the length direction of the needle cylinder.
[0009] Optionally, the inside of the nipple is provided with a one-way valve for allowing liquid to flow into the inside of the needle cylinder in one direction.
[0010] Optionally, the nipple is covered with a sealing film or is provided with a sealing cap.
[0011] Optionally, the material of the needle cylinder is polyethylene, polypropylene, polystyrene or polycarbonate.
[0012] Optionally, the plunger comprises a push rod and a rubber plug provided at the front end of the push rod, the rubber plug is in sliding seal with the inner wall of the needle cylinder, the test strip is embedded in the push rod along the length direction of the push rod, and the sample pad of the test strip extends from the front end of the rubber plug.
[0013] Optionally, the rear end of the push rod is integrally formed with a handle, and the handle is provided with a breaking groove at the connection with the push rod.
[0014] Optionally, the plunger comprises a push rod and a plug head integrally formed at the front end of the push rod, the outer peripheral wall of the plug head is in sliding seal with the inner wall of the needle cylinder, the material of the push rod is the same as that of the plug head, the test strip is embedded in the push rod along the length direction of the push rod, and the sample pad of the test strip extends from the front end of the plug head.
[0015] Optionally, the rear end of the push rod is integrally formed with a handle, and the handle is provided with a breaking groove at the connection with the push rod.
[0016] The immunoassay test reagent card provided by the present application has the beneficial effect that, compared with the prior art, the immunoassay test reagent card of the present application forms a suction mechanism by cooperation of the needle cylinder and the plunger, embeds the test strip in the plunger along the length direction of the plunger, and the sample pad of the test strip extends from the front end of the plunger, in use, the lysis / dilution liquid mixed with the sample is sucked into the needle cylinder from the nipple at the front end of the needle cylinder by pulling the plunger backward, the sample pad of the test strip absorbs the lysis liquid mixed with the sample and performs immunoassay detection, the whole detection process is simple and convenient; compared with the way of adding sample by dropping with a dropper, the way of adding sample by suction can avoid the phenomenon of liquid leakage and failure to drop; since the sample pad extends from the front end of the plunger, it can directly contact with the sample liquid sucked into the needle cylinder, and the phenomenon of blocking the sample pad when the sample is thick is reduced. BRIEF DESCRIPTION OF DRAWINGS
[0017] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0018] in:
[0019] Figure 1 This is a schematic diagram of the overall structure of an immunochromatographic assay reagent card shown in one embodiment of this application;
[0020] Figure 2 This is an exploded view of an immunochromatographic assay kit card according to an embodiment of this application;
[0021] Figure 3 This is an exploded view of another immunochromatographic assay kit card shown in one embodiment of this application;
[0022] Figure 4 This is a schematic cross-sectional view of the syringe tip in an immunochromatographic assay reagent card according to an embodiment of this application;
[0023] Figure 5 This is a schematic diagram of the structure of the one-way valve inside the syringe of an immunochromatographic assay reagent card, as shown in one embodiment of this application.
[0024] Explanation of key component symbols:
[0025] 100. Syringe; 111. Nipple; 112. Scale mark;
[0026] 200. Plunger;
[0027] 210. Push rod; 2101. Break groove; 211. Handle;
[0028] 220. Rubber stopper;
[0029] 230. Plug;
[0030] 300. Test strips;
[0031] 400. Filter screen;
[0032] 500. One-way valve;
[0033] 600. Sealing cap. Detailed Implementation
[0034] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings. Preferred embodiments of this application are shown in the drawings. However, this application can be implemented in many other different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a thorough and complete understanding of the disclosure of this application.
[0035] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on or indirectly on that other component. When a component is referred to as being "connected to" another component, it can be directly connected to or indirectly connected to that other component.
[0036] It should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.
[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.
[0038] As described in the background section, existing respiratory immunochromatographic assays often involve adding a reagent card and a lysis buffer vial. However, when using a dropper to add the sample solution, issues such as leakage, failure to dispense the sample solution, or the sample solution not being dispensed can occur, affecting the accuracy of the test results.
[0039] To address the aforementioned problems, embodiments of this application provide an immunochromatographic assay reagent card, such as... Figures 1-2 As shown, the immunochromatographic assay kit includes a syringe 100, a plunger 200, and a test strip 300. The syringe 100 has a nipple 111 at its front end. The plunger 200 is movably disposed inside the syringe 100. The test strip 300 is embedded in the plunger 200 along its length, with the sample pad of the test strip 300 extending from the front end of the plunger 200. The syringe 100 is made of transparent material, making it easy to observe the position of the plunger 200 inside the syringe 100 and the liquid absorption of the sample pad during use. The detection area of the plunger 200 corresponding to the test strip 300 is made of transparent material, making it easy to observe the detection results of the test strip 300.
[0040] It can be understood that the immunochromatographic test reagent card is matched with the needle cylinder 100 and the plunger 200 to form a suction mechanism. Since the test strip 300 is embedded in the plunger 200 along the length direction of the plunger 200, and the sample pad of the test strip 300 extends from the front end of the plunger 200, when in use, the lysate / diluent mixed with the sample is sucked into the needle cylinder 100 from the nipple 111 at the front end of the needle cylinder 100 by pulling the plunger 200 backward, the sample pad of the test strip 300 absorbs the lysate mixed with the sample and performs immunochromatographic detection, and the whole detection process is simple and convenient to operate.
[0041] The immunochromatographic test reagent card can avoid the phenomenon of liquid leakage and dripping out during the dripping adding process by means of suction sampling. Since the sample pad extends from the front end of the plunger 200 and can directly contact the sample liquid sucked into the needle cylinder 100, the phenomenon of blocking the sample pad when the sample is thick can be reduced.
[0042] Specifically, the needle cylinder 100 is a transparent cylindrical structure, and the rear end is provided with a curled edge for facilitating finger clamping. The needle cylinder 100 and the nipple 111 are integrally formed, and the needle cylinder 100 and the nipple 111 are in communication. The needle cylinder 100 and the nipple 111 can be integrally injection molded by polyethylene (PE), polypropylene (PP), polystyrene (PS) or polycarbonate (PC).
[0043] In one embodiment, as shown in Figures 1-4 the front end of the nipple 111 is provided with a filter screen 400. By arranging the filter screen 400, impurities and foreign matters in the sample liquid can be filtered during the suction process, so as to avoid blocking the nipple 111.
[0044] In one embodiment, as shown in Figures 1-2 the outer wall of the needle cylinder 100 is provided with scale lines 112 for indicating the volume along the length direction of the needle cylinder 100. During the suction process, the amount of the sample drawn can be controlled by observing the scale lines 112, so as to realize quantitative sampling and improve the accuracy of the detection result.
[0045] Specifically, the scale lines 112 can be realized by laser etching or ink printing.
[0046] In one embodiment, as shown in Figure 4 and Figure 5 the inside of the nipple 111 is provided with a one-way valve 500 for allowing liquid to flow into the inside of the needle cylinder 100 in one direction.
[0047] By arranging the one-way valve 500, the excess sample liquid in the needle cylinder 100 can be prevented from flowing out from the nipple 111 after the detection is completed, so as to avoid pollution.
[0048] In one embodiment, as shown in Figure 2As shown, the nipple 111 is covered with a sealing film (not shown in the figure), or a sealing cap 600 is sleeved on the nipple 111. The opening of the nipple 111 is sealed by the sealing film or the sealing cap 600, so as to avoid foreign matters or water vapor from entering the inside of the needle cylinder 100 during transportation and before use, and to avoid contamination of the test strip 300.
[0049] In some embodiments, as shown in Figures 1-2 As shown, the plunger 200 includes a push rod 210 and a rubber plug 220 arranged at the front end of the push rod 210, the rubber plug 220 is in sliding sealing with the inner wall of the needle cylinder 100, the test strip 300 is embedded in the push rod 210 along the length direction of the push rod 210, and the sample pad of the test strip 300 extends from the front end of the rubber plug 220.
[0050] It can be understood that the plunger 200 in the embodiments of the present application is composed of two parts of the push rod 210 and the rubber plug 220. Specifically, the push rod 210 can be formed by injection molding of transparent medical plastic, and the cross section can be circular or square, as long as the cross section size is greater than the cross section size of the test strip 300, and the length of the push rod 210 is greater than the length of the test strip 300. The rubber plug 220 is made of medical rubber, and the outer dimension is slightly larger than the inner diameter of the needle cylinder 100, so as to form a sliding sealing with the inner wall of the needle cylinder 100.
[0051] In some specific embodiments, as shown in Figures 1-2 As shown, the rear end of the push rod 210 is integrally formed with a handle 211, and a breaking groove 2101 is arranged at the connection between the handle 211 and the push rod 210. The handle 211 and the push rod 210 are broken at the breaking groove 2101 after detection, so as to avoid repeated use.
[0052] In some specific embodiments, as shown in Figure 3 As shown, the plunger 200 includes a push rod 210 and a plug head 230 integrally formed at the front end of the push rod 210, the outer peripheral wall of the plug head 230 is in sliding sealing with the inner wall of the needle cylinder 100, the material of the push rod 210 is the same as that of the plug head 230, the test strip 300 is embedded in the push rod 210 along the length direction of the push rod 210, and the sample pad of the test strip 300 extends from the front end of the plug head 230.
[0053] It can be understood that the plunger 200 in the embodiments of the present application is a whole body with the same material, and the piston component is omitted. The plug head 230 at the front end of the push rod 210 has the function of the piston, and can form a good sliding sealing with the inner wall of the needle cylinder 100.
[0054] Specifically, the push rod 210 and the plug head 230 can be integrally formed by injection molding of transparent medical plastic.
[0055] In some specific embodiments, the rear end of the push rod 210 is integrally formed with the handle 211, and a breaking groove 2101 is arranged at the connection between the handle 211 and the push rod 210, so that the handle 211 and the push rod 210 can be broken after detection, thereby avoiding repeated use.
[0056] The technical features of the above embodiments can be combined in any manner. In order to make the description simple, all possible combinations of the technical features in the above embodiments are not described, but as long as the combinations of the technical features do not exist, they should be considered as the scope of the description.
[0057] The above embodiments only express several implementation manners of the present application, and the description is relatively specific and detailed, but it should not be understood as a limitation on the scope of the application. It should be pointed out that for ordinary skilled persons in the art, several modifications and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the appended claims.
Claims
1. An immunochromatographic test reagent card, characterized by, The application relates to a syringe (100), a plunger (200) and a test strip (300), the front end of the syringe (100) is provided with a nipple (111), the plunger (200) is movably arranged in the syringe (100), the test strip (300) is embedded in the plunger (200) along the length direction of the plunger (200), and the sample pad of the test strip (300) extends from the front end of the plunger (200), the material of the syringe (100) is transparent, and the plunger (200) is made of transparent material corresponding to the detection area of the test strip (300).
2. The immuno-chromatographic test reagent card according to claim 1, characterized by, The front end of the nipple (111) is provided with a filter screen (400).
3. The immunochromatographic test reagent card according to claim 1, characterized by, The outer wall of the syringe (100) is provided with scale lines (112) for indicating the volume along the length direction of the syringe (100).
4. The immunochromatographic test reagent card according to claim 1, characterized by, The inside of the nipple (111) is provided with a one-way valve (500) for allowing liquid to flow into the inside of the syringe (100) in one direction.
5. The immuno-chromatographic test reagent card according to claim 1, characterized by, The nipple (111) is covered with a sealing film, or a sealing cap (600) is arranged on the nipple (111).
6. The immunochromatographic test reagent card according to claim 1, wherein The material of the syringe (100) is polyethylene, polypropylene, polystyrene or polycarbonate.
7. The immunochromatographic test reagent card according to any one of claims 1 to 6, characterized by, The plunger (200) comprises a push rod (210) and a rubber plug (220) arranged at the front end of the push rod (210), the rubber plug (220) is in sliding sealing with the inner wall of the syringe (100), the test strip (300) is embedded in the push rod (210) along the length direction of the push rod (210), and the sample pad of the test strip (300) extends from the front end of the rubber plug (220).
8. The immunochromatographic test reagent card according to claim 7, characterized by, The rear end of the push rod (210) is integrally formed with a handle (211), and a breaking groove (2101) is arranged at the connection between the handle (211) and the push rod (210).
9. The immunochromatographic test reagent card according to any one of claims 1 to 6, characterized by, The plunger (200) comprises a push rod (210) and a plug head (230) integrally formed at the front end of the push rod (210), the outer peripheral wall of the plug head (230) is in sliding sealing with the inner wall of the syringe (100), the material of the push rod (210) is the same as that of the plug head (230), the test strip (300) is embedded in the push rod (210) along the length direction of the push rod (210), and the sample pad of the test strip (300) extends from the front end of the plug head (230).
10. The immuno-chromatographic test reagent card according to claim 9, characterized by, The rear end of the push rod (210) is integrally formed with a handle (211), and a breaking groove (2101) is arranged at the connection between the handle (211) and the push rod (210).