Medicine intermediate crystallizing and drying equipment
By designing a crystallization and drying equipment for pharmaceutical intermediates, the problems of handling harmful gases and crystal accumulation during the drying process were solved, achieving efficient drying and high-quality production of pharmaceutical intermediates.
Patent Information
- Application Number
- CN202423181800.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-23
- Publication Date
- 2025-12-09
- Estimated Expiration
- 2034-12-23
AI Technical Summary
The existing equipment produces irritating gases during the drying process, which can cause harm to the human body. Furthermore, the direct discharge of uncrystallized intermediate crystals can cause environmental pollution. In addition, the existing equipment results in uneven accumulation of crystals during the drying process, which affects the quality of the crystallized drug.
A pharmaceutical intermediate crystallization and drying device was designed, including a crystallization component, a collection component, a stirring component, a drying component, and a vibration screening component. The collection component treats harmful gases, the stirring component stirs the mixture evenly, the drying component removes moisture, and the vibration screening component screens the crystals evenly.
It effectively treats harmful gases, reduces the impact on operators, improves drying efficiency and product quality, and avoids pollution and deterioration caused by crystal accumulation.
Smart Images
Figure CN223641355U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of crystallization and drying technology, and more specifically to a crystallization and drying device for pharmaceutical intermediates. Background Technology
[0002] Pharmaceutical intermediates are essential raw materials in the pharmaceutical synthesis process. With the continuous development of the global pharmaceutical industry and the increasing trend of population aging, the demand for pharmaceutical intermediates continues to grow, and the market prospects are broad. Existing equipment may generate irritating gases during the drying process, which may cause certain harm to the human body. Furthermore, if the undried intermediate crystallization liquid is directly discharged, it will result in waste of raw materials and increase production costs. If a large number of crystals accumulate together during drying, some crystals may not dry sufficiently, thus affecting the quality of the crystallized drug. Utility Model Content
[0003] In order to overcome the above-mentioned defects of the prior art, the present invention provides a pharmaceutical intermediate crystallization and drying device to solve the problems existing in the background art.
[0004] This utility model provides the following technical solution: a pharmaceutical intermediate crystallization and drying device, comprising a crystallization component, a collection component, a stirring component, a drying component, and a vibration screening component. The collection component is located at the bottom of the crystallization component, the stirring component is installed at the top of the crystallization component, the drying component is located in the inner cavity of the collection component, and the vibration screening component is installed on one side of the collection component. The vibration screening component includes a fixture, a vibration motor, a vibration disk, a gear, a sieve plate, a rack, a reset block, and a spring. The fixture is fixedly installed on one side of the housing, and the vibration motor is nested inside the fixture. The output shaft of the vibration motor is fixedly sleeved to the vibration disk through a coupling, and a gear is fixedly installed at the bottom of the vibration disk. The sieve plate is movably engaged inside the housing, and a rack is provided on the top of one side of the sieve plate and meshes with the gear. A handle is provided on one side of the sieve plate. The reset blocks are symmetrically sleeved on both sides of the sieve plate, specifically configured as a movable sleeve. The spring is located inside the sieve plate and the reset block.
[0005] Preferably, the crystallization assembly includes a stirring tank, a feed inlet, a gas supply pipe, a connecting pipe, a cooler, and a heater. The feed inlet is located on one side of the top of the stirring tank. One end of the gas supply pipe is fixedly connected to the top of the stirring tank, and the other end of the gas supply pipe is fixedly connected to the connecting pipe. The cooler and the heater are fixedly connected to both ends of the connecting pipe, and the cooler and the heater are installed on one side of the collecting assembly.
[0006] Preferably, the collection assembly includes a housing, a collection box, an exhaust port, and a gas purifier. The housing is located at the bottom of the mixing tank, and the collection box is movably attached to the bottom of the inner cavity of the housing. A handle is provided on one side of the collection box. The exhaust ports are evenly distributed on one side of the housing, and a gas purifier is fixedly installed on one side of the exhaust ports.
[0007] Preferably, the stirring assembly includes a stirring motor, a telescopic rod, a stirring bar, a scraper, and a valve. The stirring motor is fixedly installed on the top of the stirring tank, and the output shaft of the stirring motor is fixedly connected to the telescopic rod through a coupling. The bottom sides of the telescopic rod are symmetrically connected to the stirring bar, and a scraper is fixedly installed on the bottom of the stirring bar. The valve is symmetrically arranged at the bottom of the stirring tank and the top of the shell.
[0008] Preferably, the drying assembly includes a wind turbine, blades, and heating rods. The wind turbine is nested in the inner wall of one side of the housing, and the output shaft of the wind turbine is fixedly connected to the blades via a coupling. The heating rods are symmetrically installed on the top of the inner cavity of the housing.
[0009] The technical effects and advantages of this utility model are as follows:
[0010] This invention, by incorporating a collection component and a drying component, facilitates the handling of harmful gases generated during the crystallization and drying process of pharmaceutical intermediates, reduces the impact of irritating odors and harmful gases on operators, improves the working environment, and allows for the recycling and reuse of uncrystallized intermediate crystals.
[0011] This invention, by incorporating a collection component and a vibration screening component, facilitates the uniform and even distribution of crystals above the sieve plate, thereby improving the drying efficiency and product quality of pharmaceutical intermediates and preventing contamination and deterioration caused by improper manual operation, which could affect the quality of the crystallized drug. Attached Figure Description
[0012] Figure 1 This is a schematic diagram of the overall structure of this utility model.
[0013] Figure 2 This is a schematic diagram of the overall structure and some cross-sectional views of the present invention.
[0014] Figure 3 For the present utility model Figure 2 Schematic diagram of structure A in the middle.
[0015] Figure 4 For the present utility model Figure 2 Schematic diagram of structure B in the middle.
[0016] The attached figures are labeled as follows: 1. Crystallization assembly; 101. Stirring tank; 102. Feed inlet; 103. Gas supply pipe; 104. Connecting pipe; 105. Refrigerator; 106. Heater; 2. Collection assembly; 201. Shell; 202. Collection box; 203. Exhaust port; 204. Gas purifier; 3. Stirring assembly; 301. Stirring motor; 302. Telescopic rod; 303. Stirring rod; 304. Scraper; 305. Valve; 4. Drying assembly; 401. Wind turbine; 402. Blade; 403. Heating rod; 5. Vibrating screening assembly; 501. Fixer; 502. Vibrating motor; 503. Vibrating plate; 504. Gear; 505. Screen plate; 506. Rack; 507. Reset block; 508. Spring. Detailed Implementation
[0017] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings. In addition, the morphology of each structure described in the following embodiments is merely illustrative. The pharmaceutical intermediate crystallization drying equipment involved in this utility model is not limited to the structures described in the following embodiments. All other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.
[0018] Reference Figure 1-4 This utility model provides a pharmaceutical intermediate crystallization and drying device, including a crystallization component 1, a collection component 2, a stirring component 3, a drying component 4, and a vibration screening component 5. The collection component 2 is located at the bottom of the crystallization component 1, the stirring component 3 is installed at the top of the crystallization component 1, the drying component 4 is located in the inner cavity of the collection component 2, and the vibration screening component 5 is installed on one side of the collection component 2.
[0019] The crystallization assembly 1 includes a stirring tank 101, a feed inlet 102, a gas supply pipe 103, a connecting pipe 104, a cooler 105, and a heater 106. The feed inlet 102 is located on the top side of the stirring tank 101. One end of the gas supply pipe 103 is fixedly connected to the top of the stirring tank 101, and the other end of the gas supply pipe 103 is fixedly connected to the connecting pipe 104. The cooler 105 and the heater 106 are fixedly connected to both ends of the connecting pipe 104. The cooler 105 and the heater 106 are installed on one side of the collection assembly 2, which is beneficial for providing hot air and cold air to the interior of the stirring tank 101 through the cooler 105 and the heater 106, so as to realize the evaporation and crystallization of the drug intermediate.
[0020] The collection component 2 includes a housing 201, a collection box 202, an exhaust port 203, and a gas purifier 204. The housing 201 is located at the bottom of the mixing tank 101, and the bottom of the inner cavity of the housing 201 is movable to receive the collection box 202. A handle is provided on one side of the collection box 202. The exhaust ports 203 are evenly distributed on one side of the housing 201, and the gas purifier 204 is fixedly installed on one side of the exhaust ports 203. This facilitates the collection box 202 to collect the uncrystallized drug liquid, and the gas generated during crystallization and drying is purified and discharged through the exhaust ports 203 and the gas purifier 204.
[0021] The stirring assembly 3 includes a stirring motor 301, a telescopic rod 302, a stirring bar 303, a scraper 304, and a valve 305. The stirring motor 301 is fixedly installed on the top of the stirring tank 101, and the output shaft of the stirring motor 301 is fixedly connected to the telescopic rod 302 through a coupling. The bottom sides of the telescopic rod 302 are symmetrically connected to the stirring bar 303, and the bottom of the stirring bar 303 is fixedly installed with the scraper 304. The valve 305 is symmetrically arranged at the bottom of the stirring tank 101 and the top of the housing 201, which facilitates the starting of the stirring motor 301. The output shaft of the stirring motor 301 drives the transmission shaft to rotate, and the transmission shaft drives the telescopic rod 302 to rotate, so that the stirring bar 303 and the scraper 304 rotate in the inner cavity of the stirring tank 101 to stir the drug intermediate crystal liquid.
[0022] The drying assembly 4 includes a wind turbine 401, blades 402, and a heating rod 403. The wind turbine 401 is nested in the inner wall of one side of the housing 201, and the output shaft of the wind turbine 401 is fixedly connected to the blades 402 through a coupling. The heating rods 403 are symmetrically installed at the top of the inner cavity of the housing 201. This allows the inner cavity of the housing 201 to be heated by the heating rods 403, after which the wind turbine 401 is started. The output shaft of the wind turbine 401 drives the transmission shaft to rotate, and the transmission shaft drives the blades 402 to rotate to generate wind power, thus drying the moisture in the crystals.
[0023] The vibrating screening assembly 5 includes a fixture 501, a vibrating motor 502, a vibrating plate 503, a gear 504, a screen plate 505, a rack 506, a reset block 507, and a spring 508. The fixture 501 is fixedly installed on one side of the housing 201, and the vibrating motor 502 is nested inside the fixture 501. The output shaft of the vibrating motor 502 is fixedly connected to the vibrating plate 503 via a coupling, and the gear 504 is fixedly installed at the bottom of the vibrating plate 503. The screen plate 505 is movably engaged inside the housing 201, and a rack 506 is provided on the top of one side of the screen plate 505 and meshes with the gear 504. A handle is provided on one side of the screen plate 505, and the reset blocks 507 are symmetrically sleeved on both sides of the screen plate 505. On the side, specifically configured as a movable sleeve, the spring 508 is located inside the sieve plate 505 and the reset block 507, which facilitates the starting of the vibration motor 502. The output shaft of the vibration motor 502 drives the transmission shaft to rotate, and the transmission shaft drives the vibrating disc 503 to rotate. During the rotation of the vibrating disc 503, the gear 504 repeatedly drives the rack 506, causing the sieve plate 505 to move to one side. After the reset block 507 hits the inner wall of the housing 201, it compresses the spring 508. When the gear 504 turns upward, the sieve plate 505 returns to its original position under the action of the spring 508. This process is repeated so that smaller crystals and liquids on the sieve plate 505 fall into the collection box 202 for storage, and suitable crystals are screened for drying.
[0024] The working principle of this utility model:
[0025] First, the crystallization liquid of the drug intermediate is added into the interior of the mixing tank 101 through the feed port 102. The stirring motor 301 is started, and the output shaft of the stirring motor 301 drives the transmission shaft to rotate. The transmission shaft drives the telescopic rod 302 to rotate, so that the stirring rod 303 and the scraper 304 rotate in the inner cavity of the mixing tank 101 to stir the crystallization liquid of the drug intermediate. During stirring, hot air and cold air are supplied to the interior of the mixing tank 101 through the cooler 105 and the heater 106 to achieve the evaporation and crystallization of the drug intermediate. The valve 305 is opened, and the telescopic rod 302 is started to control the scraper 304 to contact the bottom of the inner cavity of the mixing tank 101, so that the crystals and liquid flow down through the valve 305.
[0026] Next, the vibration motor 502 is started. The output shaft of the vibration motor 502 drives the transmission shaft to rotate, and the transmission shaft drives the vibrating plate 503 to rotate. During the rotation of the vibrating plate 503, the gear 504 repeatedly drives the rack 506, causing the sieve plate 505 to move to one side. After the reset block 507 hits the inner wall of the housing 201, it compresses the spring 508. When the gear 504 turns upward, the sieve plate 505 returns to its original position under the action of the spring 508. This process is repeated so that smaller crystals and liquids on the sieve plate 505 fall into the collection box 202 for storage. After screening suitable crystals, the heating rod 403 is turned on to heat the inner cavity of the housing 201. Then, the wind motor 401 is started. The output shaft of the wind motor 401 drives the transmission shaft to rotate, and the transmission shaft drives the blades 402 to rotate to generate wind power, which dries the moisture in the crystals. The gas generated during drying is purified and discharged through the exhaust port 203 and the gas purifier 204.
[0027] Finally, the dried crystals are collected and stored by pulling out the sieve plate 505, and the collection box 202 is pulled out and the crystals and liquid inside are dried again.
[0028] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.
[0029] Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.
[0030] Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A pharmaceutical intermediate crystallization and drying device, comprising a crystallization component (1), a collection component (2), a stirring component (3), a drying component (4), and a vibration screening component (5), wherein the collection component (2) is disposed at the bottom of the crystallization component (1), the stirring component (3) is installed at the top of the crystallization component (1), the drying component (4) is disposed in the inner cavity of the collection component (2), and the vibration screening component (5) is installed on one side of the collection component (2), characterized in that: The vibrating screening assembly (5) includes a fixture (501), a vibrating motor (502), a vibrating plate (503), a gear (504), a sieve plate (505), a rack (506), a reset block (507), and a spring (508). The fixture (501) is fixedly installed on one side of the housing (201), and the vibrating motor (502) is nested inside the fixture (501). The output shaft of the vibrating motor (502) is fixedly connected to the vibrating plate (503) through a coupling, and the vibration... A gear (504) is fixedly installed at the bottom of the disc (503). The sieve plate (505) is movably engaged inside the housing (201). A rack (506) is provided on the top of one side of the sieve plate (505) and meshes with the gear (504). A handle is provided on one side of the sieve plate (505). The reset block (507) is symmetrically sleeved on both sides of the sieve plate (505), specifically configured to be movably sleeved. The spring (508) is provided inside the sieve plate (505) and the reset block (507).
2. The pharmaceutical intermediate crystallization and drying equipment according to claim 1, characterized in that: The crystallization assembly (1) includes a stirring tank (101), a feed inlet (102), a gas supply pipe (103), a connecting pipe (104), a cooler (105), and a heater (106). The feed inlet (102) is located on one side of the top of the stirring tank (101). One end of the gas supply pipe (103) is fixedly connected to the top of the stirring tank (101), and the other end of the gas supply pipe (103) is fixedly connected to the connecting pipe (104). The cooler (105) and the heater (106) are fixedly connected to both ends of the connecting pipe (104), and the cooler (105) and the heater (106) are installed on one side of the collection assembly (2).
3. The pharmaceutical intermediate crystallization and drying equipment according to claim 1, characterized in that: The collection assembly (2) includes a housing (201), a collection box (202), an exhaust port (203), and a gas purifier (204). The housing (201) is located at the bottom of the mixing tank (101), and the bottom of the inner cavity of the housing (201) is movable to receive the collection box (202). A handle is provided on one side of the collection box (202). The exhaust ports (203) are evenly opened on one side of the housing (201), and a gas purifier (204) is fixedly installed on one side of the exhaust port (203).
4. The pharmaceutical intermediate crystallization and drying equipment according to claim 1, characterized in that: The stirring assembly (3) includes a stirring motor (301), a telescopic rod (302), a stirring bar (303), a scraper (304), and a valve (305). The stirring motor (301) is fixedly installed on the top of the stirring tank (101), and the output shaft of the stirring motor (301) is fixedly connected to the telescopic rod (302) through a coupling. The bottom sides of the telescopic rod (302) are symmetrically connected to the stirring bar (303), and the bottom of the stirring bar (303) is fixedly installed with a scraper (304). The valve (305) is symmetrically arranged at the bottom of the stirring tank (101) and the top of the shell (201).
5. The pharmaceutical intermediate crystallization and drying equipment according to claim 1, characterized in that: The drying assembly (4) includes a wind turbine (401), blades (402) and a heating rod (403). The wind turbine (401) is nested in the inner wall of one side of the housing (201), and the output shaft of the wind turbine (401) is fixedly connected to the blades (402) through a coupling. The heating rod (403) is symmetrically installed on the top of the inner cavity of the housing (201).