CUMS depression modeling device

Abstract

The utility model discloses a CUMS depression modeling device, and relates to the technical field of biomedical research equipment.The CUMS depression modeling device comprises a supporting frame, a horizontal shaking cage frame is installed above the supporting frame, and a power rocker arm is arranged on the side face of the horizontal shaking cage frame; the device can more effectively simulate uncertainty and pressure in human life by setting a combination of horizontal shaking, inclination, illumination and sounding lamp randomization implementation strategy and an electric shock electric stress source, improves the simulation degree of an animal model to depression, ensures the possibility of diversified simulation of test equipment, and improves the test efficiency. Through joint operation of the power supply control box, the internal remote control on-off device and the matched control system, experiment operation is simplified, meanwhile, experiment process data can be set, scientific researchers can accurately evaluate the stress effect and the depression state of an animal model conveniently, the remote control on-off device can carry out a timely blocking test, and the experiment efficiency is improved. The safety and welfare of the experimental animals in the whole process are ensured, and the ethical examination requirements are met.

Description

Technical Field

[0001] This invention relates to the field of biomedical research equipment technology, specifically a CUMS depression modeling device. Background Technology

[0002] Depression is a common mental illness with a complex pathogenesis involving multiple aspects such as genetics, environment, neurobiochemistry, and psychosocial factors, seriously affecting human physical and mental health and quality of life. The construction of animal models is crucial for in-depth research into the pathogenesis of depression and the development of effective treatments. The Chronic Unpredictable Mild Stress (CUMS) model is currently recognized as one of the most effective methods for simulating human depressive symptoms. It continuously exposes experimental animals to a series of unpredictable mild stressors, inducing behavioral and biological changes similar to human depression.

[0003] However, traditional CUMS modeling often relies on manual manipulation to introduce unpredictable mild stressors into animals, such as periodically tilting the cage, applying light stimulation, or horizontally shaking the cage. This manual manipulation presents several problems, including: Uncontrollability: Different researchers may vary the intensity, duration, and frequency of stressors, affecting the consistency of the model. High labor intensity: Researchers need to perform multiple stressor operations regularly and for extended periods, consuming significant manpower. Difficulty in achieving precise stress programs: It is difficult to accurately control the combination and sequence of stressors, hindering standardized research. Summary of the Invention

[0004] The purpose of this invention is to provide a CUMS depression modeling device to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a CUMS depression modeling device, comprising a support frame, a horizontal rocking cage frame mounted above the support frame, a powered rocker arm provided on the side of the horizontal rocking cage frame, an inclined frame fixedly connected above the horizontal rocking cage frame, and an inhibition cage provided above the inclined frame.

[0006] Preferably, a fixed frame is fixedly connected to the upper end of the support frame, a sliding groove is fixedly connected to the upper end of the fixed frame, a slider is slidably connected above the sliding groove, and a movable plate is fixedly connected to the upper end of the slider.

[0007] Preferably, a servo motor is fixedly connected to the side of the mounting bracket. A first cantilever is mounted on the servo motor. A first gear is fixedly connected to one end of the first cantilever. A first card is rotatably connected above the first gear. A second cantilever is rotatably connected to the lower end of the other end of the first card. A first fixing post is fixedly connected to one end of the second cantilever. A second gear is fixedly connected to the other end of the second cantilever. The second gear meshes with the first gear. A second card is rotatably connected to the lower end of the first cantilever. A third cantilever is rotatably connected to the upper end of the second card. The third cantilever is fixed to the side of the mounting bracket by the servo motor. A third gear is fixedly connected to the upper end of one end of the third cantilever. A third card is rotatably connected to the upper end of the third gear. A fourth cantilever is rotatably connected to the lower end of the third card. A second fixing post is fixedly connected to one end of the fourth cantilever. A fourth gear is fixedly connected to the other end of the fourth cantilever. The fourth gear meshes with the third gear. The servo motor is electrically connected to a power control box.

[0008] Preferably, a hydraulic cylinder is fixedly connected above the movable plate, and four sets of hydraulic cylinders are provided. A rotating block is installed above the hydraulic cylinder, and a rotating plate is rotatably connected to the center of the rotating block. A power control box is installed on the upper surface of the center of the movable plate. The power control box has a built-in remote control switch, and the hydraulic cylinder is electrically connected to the power control box.

[0009] Preferably, a support plate is fixedly connected above the rotating plate, a suppression iron frame is fixedly connected above the support plate, a lighting lamp is installed inside the suppression iron frame, a cover slide rail is fixedly connected above the suppression iron frame, a cover is slidably connected above the cover slide rail, a loudspeaker is installed inside the suppression iron frame, the suppression iron frame is electrically connected to a power control box, the lighting lamp is electrically connected to a power control box, and the loudspeaker is electrically connected to a power control box.

[0010] Compared with the prior art, the beneficial effects of the present invention are:

[0011] Highly effective in inducing depressive symptoms: By setting randomized implementation strategies and combinations of electric shock stressors such as horizontal shaking, tilting, lighting, and sound-emitting lights, it is possible to more effectively simulate the uncertainty and stress in human life, improve the simulation degree of depression in animal models, and ensure the possibility of diverse simulations in experimental equipment.

[0012] Easy to operate and accurate data: The experiment is simplified by operating the power control box and the internal remote control switch and the control system. At the same time, experimental data can be set, which makes it easy for researchers to accurately assess the stress effect and the depressive state of animal models.

[0013] Safety Assurance: The remote-controlled switch allows for timely interruption testing, ensuring the safety and welfare of laboratory animals throughout the process and meeting ethical review requirements. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0015] Figure 2 This is a schematic diagram of the horizontal rocking cage structure of the present invention;

[0016] Figure 3 This is a schematic diagram of the power rocker arm structure of the present invention;

[0017] Figure 4 This is a schematic diagram of the tilting frame structure of the present invention;

[0018] Figure 5 This is a schematic diagram of the suppression cage structure of the present invention.

[0019] In the diagram: 1. Support frame; 2. Horizontal rocker cage frame; 201. Fixed frame; 202. Slide groove; 203. Slider; 204. Moving plate; 3. Power rocker arm; 301. Servo motor; 302. First cantilever; 303. First gear; 304. First card; 305. Second cantilever; 306. First fixed column; 307. Second gear; 308. Second card; 309. Third cantilever; 310. Third gear; 311. Third card; 312. Fourth cantilever; 313. Second fixed column; 314. Fourth gear; 4. Inclined frame; 401. Hydraulic cylinder; 402. Rotating block; 403. Rotating plate; 404. Power control box; 5. Suppression cage; 501. Support plate; 502. Suppression iron frame; 503. Lighting lamp; 504. Cage cover; 505. Megaphone; 506. Cage cover slide rail. Detailed Implementation

[0020] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0021] In the description of this invention, it should be noted that the terms "upper," "lower," "inner," "outer," "front end," "rear end," "both ends," "one end," and "the other end," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0022] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Please see Figure 1-5 An embodiment of the present invention provides a CUMS depression modeling device, including a support frame 1, a horizontal rocking cage frame 2 installed above the support frame 1, a powered rocker arm 3 provided on the side of the horizontal rocking cage frame 2, an inclined frame 4 fixedly connected above the horizontal rocking cage frame 2, and an inhibition cage 5 provided above the inclined frame 4.

[0025] Furthermore, a fixed frame 201 is fixedly connected to the upper end of the support frame 1, a slide groove 202 is fixedly connected to the upper end of the fixed frame 201, a slider 203 is slidably connected above the slide groove 202, and a movable plate 204 is fixedly connected to the upper end of the slider 203.

[0026] Furthermore, a servo motor 301 is fixedly connected to the side of the mounting bracket 201. A first cantilever 302 is mounted on the servo motor 301. A first gear 303 is fixedly connected to one end of the first cantilever 302. A first card 304 is rotatably connected above the first gear 303. A second cantilever 305 is rotatably connected to the lower end of the other end of the first card 304. A first fixed post 306 is fixedly connected to one end of the second cantilever 305. A second gear 307 is fixedly connected to the other end of the second cantilever 305. The second gear 307 meshes with the first gear 303. A second card 308 is rotatably connected to the lower end of the first cantilever 302. A third cantilever 309 is rotatably connected to the upper end of the second card 308. Arm 309 is fixed to the side of the mounting bracket 201 by a servo motor. A third gear 310 is fixedly connected to the top of one end of the third cantilever 309. A third card 311 is rotatably connected to the top of the third gear 310. A fourth cantilever 312 is rotatably connected to the bottom of the third card 311. A second fixed post 313 is fixedly connected to one end of the fourth cantilever 312. A fourth gear (314) is fixedly connected to the other end of the fourth cantilever 312. The fourth gear (314) meshes with the third gear 310. The servo motor 301 is electrically connected to the power control box 404. The servo motor can drive the cantilever to perform a gentle and continuous horizontal rocking device to simulate the bumpy feeling during transportation and increase the animal's anxiety level.

[0027] Furthermore, a hydraulic cylinder 401 is fixedly connected to the top of the movable plate 204. Four sets of hydraulic cylinders 401 are provided. A rotating block 402 is installed above the hydraulic cylinder 401. A rotating plate 403 is rotatably connected to the center of the rotating block 402. A power control box 404 is installed on the upper surface of the center of the movable plate 204. The power control box 404 has a built-in remote control switch. The hydraulic cylinders 401 are electrically connected to the power control box 404. The hydraulic cylinders 401 can be individually adjusted in height within a certain range to form different angles of tilt, simulating an unstable living environment and increasing the animal's stress response. The power control box 404 is equipped with a central control system that can automatically or manually set the activation sequence, time interval, and intensity of stressors remotely. Simultaneously, it allows for manual monitoring of animal activity and behavioral changes, ensuring the accuracy and reliability of experimental data, facilitating subsequent data analysis, and enabling remote emergency stopping during testing to ensure animal safety.

[0028] Furthermore, a support plate 501 is fixedly connected above the rotating plate 403, and a suppression frame 502 is fixedly connected above the support plate 501. A lighting lamp 503 is installed inside the suppression frame 502. A cover slide rail 506 is fixedly connected above the suppression frame 502, and a cover 504 is slidably connected above the cover slide rail 506. A loudspeaker 505 is installed inside the suppression frame 502. The suppression frame 502 is electrically connected to a power control box 404, and the lighting lamp 503 is electrically connected to the power control box 404. The loudspeaker 505 is electrically connected to the power control box 404. The suppressor frame 502 is equipped with the loudspeaker 505, which can randomly play high-intensity noise, low-frequency vibration sound, etc., to simulate the psychological impact of noise pollution. The suppressor frame 502 can conduct electricity through the power control box 404. The intensity, frequency and duration of the electric shock can be set through the remote central control system to ensure that the stress response is induced within a safe range. The suppressor frame 502 is equipped with a lighting lamp 503, which can simulate strong light stimulation, day and night reversal and flashing light stimulation.

[0029] Working principle:

[0030] First, install the device in a suitable laboratory environment, connect the power supply and related wiring. Then, depending on the number of experimental animals, connect the appropriate number of suppression racks in series. Next, adjust the tilt rack, setting the tilt angle and frequency, such as randomly tilting 3 times every two weeks, with the tilt angle between 30-45°, for 24 hours. Set the amplifier parameters, such as providing 80 dB noise stress 3 times every 2 weeks, for 1-2 hours. Set the electric shock module parameters, such as randomly giving an electric shock once a week, with a shock current of 0.8-2 mA, lasting 20-30 seconds, with a 30-second interval, for 10 shocks. Set the horizontal shaking parameters, such as randomly shaking the cage once a week at 200 rpm for 5 minutes. Set the strong light stimulation parameters, such as randomly irradiating with strong light / day-night reversal / flickering light once a week for 12 hours. Finally, draw experimental conclusions through sample comparison.

[0031] The above descriptions are merely embodiments of the present invention, and common knowledge regarding specific structures and characteristics of the solutions is not described in detail here. It will be apparent to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the present invention is defined by the appended claims rather than the foregoing description. Therefore, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A CUMS depression modeling device comprising a support frame (1), characterized in that: The upper part of the support frame (1) is provided with a horizontal swing cage (2), the side of the horizontal swing cage (2) is provided with a power swing arm (3), the upper part of the horizontal swing cage (2) is fixedly connected with an inclined frame (4), and the upper part of the inclined frame (4) is provided with a cage (5).

2. The CUMS depression modeling device according to claim 1, characterized in that: The upper end of the support frame (1) is fixedly connected with a fixed frame (201), the upper end of the fixed frame (201) is fixedly connected with a chute (202), the upper part of the chute (202) is slidably connected with a sliding block (203), and the upper end of the sliding block (203) is fixedly connected with a moving plate (204).

3. The CUMS depression modeling device according to claim 2, characterized in that: The side of the fixed frame (201) is fixedly connected with a servo motor (301), the servo motor (301) is provided with a first cantilever (302), one end of the first cantilever (302) is fixedly connected with a first gear (303), the upper part of the first gear (303) is rotatably connected with a first card (304), the other end of the first card (304) is rotatably connected with a second cantilever (305), one end of the second cantilever (305) is fixedly connected with a first fixed column (306), the other end of the second cantilever (305) is fixedly connected with a second gear (307), the second gear (307) is in gear connection with the first gear (303), the lower part of the first cantilever (302) is rotatably connected with a second card (308), the upper part of the second card (308) is rotatably connected with a third cantilever (309), the third cantilever (309) is fixed to the side of the fixed frame (201) through the servo motor, one end of the third cantilever (309) is fixedly connected with a third gear (310) above, the third gear (310) is rotatably connected with a third card (311) above, the fourth cantilever (312) is rotatably connected with a fourth cantilever (312) below, one end of the fourth cantilever (312) is fixedly connected with a second fixed column (313), the other end of the fourth cantilever (312) is fixedly connected with a fourth gear (314), the fourth gear (314) is in gear connection with the third gear (310), and the servo motor (301) is electrically connected with a power control box (404).

4. The CUMS depression modeling device according to claim 2, characterized in that: The upper part of the moving plate (204) is fixedly connected with a hydraulic cylinder (401), the hydraulic cylinder (401) is provided with four groups, the upper part of the hydraulic cylinder (401) is provided with a rotating clamping block (402), the center of the rotating clamping block (402) is rotatably connected with a rotating piece (403), the center of the moving plate (204) is provided with a power control box (404) on the upper surface, the power control box (404) is provided with a remote control on-off device, and the hydraulic cylinder (401) is electrically connected with the power control box (404).

5. The CUMS depression modeling device according to claim 4, characterized in that: The upper side of the rotating piece (403) is fixedly connected with a support plate (501), the upper side of the support plate (501) is fixedly connected with an inhibition iron stand (502), the inhibition iron stand (502) is internally provided with an illuminating lamp (503), the upper side of the inhibition iron stand (502) is fixedly connected with a cage sliding rail (506), the cage sliding rail (506) is slidably connected with a cage (504) in the upper side, the inhibition iron stand (502) is internally provided with a loudspeaker (505) in the upper side, the inhibition iron stand (502) is electrically connected with a power control box (404), the illuminating lamp (503) is electrically connected with the power control box (404), and the loudspeaker (505) is electrically connected with the power control box (404).

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