Catalytic hydrolysis synthesis device for medical intermediates

Abstract

The utility model relates to a catalytic hydrolysis synthesis device for medical intermediates. The catalytic hydrolysis synthesis device comprises a reaction kettle, wherein a reaction chamber is arranged in the reaction kettle and is used for catalytic synthesis of raw materials of the medical intermediates; the Venturi mixer is arranged on one side of the reaction kettle and is communicated with the feeding end of the reaction kettle, and the Venturi mixer is provided with a mixing chamber for mixing the medical intermediate raw materials. The venturi mixer is arranged as an improved device, reaction raw materials enter the reaction kettle through the venturi tube distributor, and a gas phase and a liquid phase are fully mixed in the venturi mixer in a high-speed and strong-disturbance environment, so that the contact area of the two phases is increased, the mass transfer effect of the gas phase and the liquid phase is enhanced, and the reaction rate is increased. The problem of excessive vibration of the reaction kettle caused by water vaporization due to large boiling point difference of water and oil phases is solved, and the service life of the reaction kettle is prolonged.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the field of medical and chemical equipment, specifically relates to a kind of medical intermediate catalytic hydrolysis synthesis device. BACKGROUND

[0002] Under the action of catalyst, reactant raw materials and water or water vapor reach certain activation energy in hydrolysis reaction process, and the reaction can be started, but the speed of chemical reaction of various fluids such as gas-liquid is influenced by mass transfer intensity, two-phase contact area, reaction form and other factors.

[0003] When the reaction of gas-liquid two-phase is involved, bubble reactor, washing tower or spray tower type reactor is usually used, and such reactor has problems such as uneven gas dispersion, poor gas-liquid reaction effect and slow chemical reaction rate.In actual production, due to uneven gas distribution, the traditional gas distributor cannot completely solve the problem of gas-liquid mass transfer resistance, resulting in low reaction rate and difficult control of reaction process. UTILITY MODEL CONTENT

[0004] In order to solve the technical problems mentioned in the background art, the present application provides a kind of medical intermediate catalytic hydrolysis synthesis device.

[0005] A kind of medical intermediate catalytic hydrolysis synthesis device includes:

[0006] Reaction kettle, reaction chamber is equipped in the reaction kettle for medical intermediate raw material catalytic synthesis;

[0007] Venturi mixer, the Venturi mixer is located at one side of the reaction kettle and is communicated with the feed end of the reaction kettle, and the Venturi mixer is provided with a mixing chamber to mix the medical intermediate raw material.

[0008] Through the above technical solution, the Venturi mixer is set as an improved device, and the reaction raw material enters the reaction kettle through the Venturi tube distributor, so that the gas-liquid two-phase is fully mixed in the high-speed and strong disturbance environment of the Venturi mixer, thereby increasing the two-phase contact area, strengthening the gas-liquid two-phase mass transfer effect and improving the reaction rate. By absorbing the superheated gas phase raw material through the Venturi mixer, the problem of excessive vibration of the reaction kettle caused by the large difference between the boiling points of water and oil is solved, and the service life of the reaction kettle is greatly prolonged.

[0009] Further, the Venturi mixer includes:

[0010] Steam suction pipeline, the steam suction pipeline is located at one side of the Venturi mixer and is communicated with the mixing chamber of the Venturi mixer;

[0011] A catalyst suction pipeline is arranged on the other side of the venturi mixer and communicates with the mixing chamber of the venturi mixer.

[0012] A circulating pump suction pipeline communicates with the mixing chamber of the venturi mixer at one end.

[0013] Further, the catalyst suction pipeline is connected to the catalyst including homogeneous or heterogeneous flow materials such as gas phase, liquid phase, gas-liquid mixed phase, liquid-solid mixed phase and gas-solid mixed phase.

[0014] Further, the catalyst hydrolysis synthesis device for medical intermediates further comprises:

[0015] A steam superheater is arranged on the end of the venturi mixer away from the reaction kettle and communicates with the steam suction pipeline.

[0016] Further, the steam superheater is heated by heat conducting oil with a temperature of 100-300℃.

[0017] Further, the steam superheater further comprises:

[0018] A heating device is arranged at one end of the heat conducting oil inlet to receive heat conducting oil, a cavity containing heat conducting oil is arranged in the heating device, the heating device is heated by heat conducting oil, and the heat conducting oil heating temperature is 100-300℃.

[0019] A steam inlet is arranged at the end of the heating device away from the venturi mixer and communicates with the heating device.

[0020] A steam outlet is arranged at the end of the heating device close to the venturi mixer and communicates with the heating device, and the other end communicates with the steam suction pipeline.

[0021] A regulating valve group is arranged between the steam outlet and the steam suction pipeline, and the regulating valve group is automatically controlled by the remote pressure gauge of the steam outlet.

[0022] Further, the steam inlet is further provided with a pressure reducing valve to adjust the steam pressure at the inlet of the steam superheater from 0.6Mpa to 0.05-0.15MPa.

[0023] Further, the reaction kettle further comprises:

[0024] A distributor is arranged at the bottom of the reaction chamber to uniformly disperse the gas-liquid mixture entering the reaction kettle.

[0025] A stirrer is arranged in the reaction chamber and can stir in the axial direction thereof, and the stirrer is arranged above the distributor;

[0026] A steam heating jacket is arranged on the outer circumferential surface of the reaction kettle, and the steam heating jacket is provided with a tail gas outlet, and a condenser is arranged at the tail gas outlet.

[0027] Further, the stirrer is provided with a stirring paddle, and the stirring paddle comprises one of a centrifugal stirring paddle, a propeller stirring paddle, a turbine stirring paddle, an anchor stirring paddle, a frame stirring paddle and a MIG stirring paddle.

[0028] Further, the catalytic hydrolysis synthesis device for the medical intermediate further comprises:

[0029] An external circulating pump is connected to the reaction kettle at one end and connected to the Venturi mixer at the other end.

[0030] An online analysis device is arranged on the bypass of the vertical section of the external circulating pump, and a manual valve for adjusting the bypass flow is arranged on the external circulating pump.

[0031] The beneficial effects of the present application are:

[0032] (1) The Venturi mixer is arranged on the reaction kettle, the reaction liquid enters the Venturi mixer through the circulating pump, is fully mixed with steam and catalyst, and enters the reaction kettle through the distributor, thereby strengthening the gas-liquid two-phase mass transfer and improving the chemical reaction rate.

[0033] (2) The steam superheater is arranged in front of the Venturi mixer, so that the gas phase entering the reaction kettle is not easy to partially condense, thereby avoiding the problem of excessive reaction kettle vibration caused by the large difference between the water and oil two-phase boiling points, and greatly prolonging the service life of the reaction kettle.

[0034] (3) The distributor arranged at the bottom of the reaction kettle is used to introduce steam, which is better than the traditional process of directly adding water at the liquid level of the reaction kettle, and the mixing effect of the two reactants is better, which is conducive to controlling the chemical reaction process. BRIEF DESCRIPTION OF DRAWINGS

[0035] The accompanying drawings, which form a part of this application, are included to provide a further understanding of the application and are incorporated in and constitute a part of this application. The drawings illustrate embodiments of the present application and, together with the description, serve to explain the principles of the present application.

[0036] Throughout the drawings, the same or similar reference numerals are used to represent the same or similar elements. It should be understood that the drawings are schematic, and the elements and elements are not necessarily drawn to scale.

[0037] In the drawings:

[0038] Figure 1 Structure diagram of catalytic hydrolysis synthesis device for pharmaceutical intermediates of an embodiment of the present application.

[0039] Meaning of reference signs:

[0040] 1, reaction kettle; 11, distributor; 12, stirrer; 13, steam heating jacket; 2, venturi mixer; 21, steam suction line; 22, catalyst suction line; 23, circulating pump suction line; 3, steam superheater; 31, heating device; 32, steam inlet; 33, steam outlet; 34, regulating valve group; 4, external circulating pump; 5, online analysis device. DETAILED DESCRIPTION

[0041] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure can be implemented in various forms and should not be interpreted as being limited to the embodiments set forth herein. On the contrary, the embodiments are provided so that the present disclosure can be more thoroughly and completely understood. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0042] It should also be noted that only parts related to the utility model are shown in the drawings for ease of description. The features in the embodiments of the present disclosure can be combined with each other without conflict.

[0043] It should be noted that the concepts of "first", "second", etc. mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not intended to limit the order or interdependence of the functions performed by these devices, modules or units.

[0044] It should be noted that the adjectives "one", "multiple" mentioned in the present disclosure are illustrative and not limiting, and those skilled in the art should understand that unless otherwise explicitly stated in the context, it should be understood as "one or more".

[0045] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.

[0046] Reference Figure 1The embodiment provides a catalytic hydrolysis synthesis device for a medical intermediate, which comprises a reaction kettle 1, wherein a reaction chamber for containing medical intermediate raw materials to perform catalytic hydrolysis synthesis is arranged in the reaction kettle 1, a distributor 11 is arranged at the bottom of the reaction chamber, a stirrer 12 is coaxially arranged above the distributor 11 and can move in the circumferential direction along the axial direction of the stirrer 12, a steam heating jacket 13 is arranged on the outer circumferential surface of the reaction kettle 1, a tail gas outlet is arranged at the upper end of the steam heating jacket 13, and a condenser is arranged at the tail gas outlet.

[0047] A Venturi mixer 2 is arranged on one side of the reaction kettle 1 and is connected with the distributor 11 in the reaction chamber, wherein a mixing chamber is arranged in the Venturi mixer 2 to mix the medical intermediate raw materials, a catalyst suction pipeline 22 is arranged on one side of the Venturi mixer 2, and a steam suction pipeline 21 is arranged on the other side of the Venturi mixer 2.

[0048] One end of the steam suction pipeline 21 is connected with the Venturi mixer 2, the other end is connected with a steam outlet 33 arranged on one side of a steam superheater 3, and an adjusting valve group 34 is arranged on the steam suction pipeline 21 to control the steam inlet rate; the steam superheater 3 is provided with a heating device 31, and the other side of the steam superheater 3 is provided with a steam inlet 32.

[0049] In combination Figure 1 The catalytic hydrolysis synthesis device for the medical intermediate further comprises an external circulating pump 4, one end of the external circulating pump 4 is connected with the kettle bottom of the reaction kettle 1, the other end is connected with a circulating pump suction pipeline 23 arranged on the Venturi mixer 2, the circulating pump suction pipeline 23 is connected with the mixing chamber arranged in the Venturi mixer 2, an online analysis device 5 is further arranged on the bypass of the vertical section of the external circulating pump 4, and a manual valve for adjusting the bypass flow rate is arranged on the online analysis device 5.

[0050] It should be noted that the adjusting valve group 34 is arranged behind the steam inlet 32 pressure reducing valve of the steam superheater 3, the adjusting valve group 34 is connected with the remote pressure gauge of the steam outlet 33 of the steam superheater 3 and is automatically controlled in interlocking mode, and the steam outlet 33 of the steam superheater 3 is provided with a gas flow meter.

[0051] The stirrer 12 in the embodiment is provided with a stirring paddle, and the form of the stirring paddle includes but is not limited to one of a paddle type, a propeller type, a turbine type, an anchor type, a frame type and a MIG type stirring paddle.

[0052] The operation steps of the catalytic hydrolysis synthesis device for the medical intermediate provided in the embodiment include the following steps:

[0053] The liquid raw material to be reacted is delivered by the external circulating pump 4 to the mixing chamber inside the venturi mixer 2, saturated steam from the steam pipe network 0.6 Mpa is decompressed to 0.098 Mpa by the pressure reducing valve in the adjusting valve group 34, and then the steam passes through the steam superheater 3 into the venturi mixer 2 through the adjusting valve group 34, the steam outlet 33 pressure of the steam superheater 3 is controlled not to be higher than 20 kPa, the 200℃ heat conduction oil from the heat conduction boiler passes through the adjusting valve group 34 into the steam superheater 3, the temperature at the steam outlet 33 of the steam superheater 3 is controlled not to be lower than 150℃, the steam in the steam suction line 21 of the venturi mixer 2 and the catalyst in the catalyst suction line 22 are fully mixed, and the gas-liquid mixture passes through the distributor 11 in the reaction kettle 1 into the reaction kettle 1 for reaction. After the online analysis device 5 analyzes that the reaction reaches a certain conversion rate, the external circulating pump 4 can continuously supplement fresh reaction raw material, a part of the reaction liquid automatically overflows out of the material, and a part of the material continues to circulate and react, so as to realize uninterrupted catalytic hydrolysis synthesis reaction.

[0054] The application has been described above in detail with specific reference to exemplary embodiments. It is understood, however, that various modifications and changes can be made to the application described without departing from the scope thereof which is defined by the appended claims. The detailed description and drawings are to be regarded as illustrative in nature and not as restrictive, if any such modifications and variations are made to the application, they are to fall within the scope of the application described herein. Moreover, the background is intended to provide a context for the present technology and should not be taken as an admission that any of the prior art described therein is prior art to the present application or related fields of application.

[0055] More specifically, although illustrative embodiments of the application have been described herein, the present application is not limited to these embodiments, but includes any and all embodiments having modifications, omissions, combinations (for example, of individual features of the embodiments), adaptations and / or alterations as would be appreciated by those skilled in the art based on the foregoing detailed description of the application. The limitations in the claims are to be interpreted broadly based on the language employed in the claims and not limited to specific examples described in the foregoing detailed description, which examples are to be considered illustrative and not exclusive. Any steps listed in any method or process claim can be executed in any order and are not limited to the order in which they are listed in the claims. Accordingly, the scope of the application should be determined solely by the appended claims and legal equivalents thereof, and not by the foregoing description or any examples described therein.

Claims

1. A catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates, characterized in that, include: A reaction vessel (1) is provided with a reaction chamber for the catalytic synthesis of pharmaceutical intermediate raw materials; Venturi mixer (2) is located on one side of the reactor (1) and connected to the feed end of the reactor (1). The Venturi mixer (2) is provided with a mixing chamber for mixing the pharmaceutical intermediate raw materials.

2. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 1, characterized in that, The Venturi mixer (2) includes: Steam intake pipe (21) is located on one side of the Venturi mixer (2) and is connected to the mixing chamber of the Venturi mixer (2); Catalyst intake line (22) is located on the other side of the Venturi mixer (2) and is connected to the mixing chamber of the Venturi mixer (2); A circulating pump suction line (23) is provided, one end of which is connected to the mixing chamber of the Venturi mixer (2).

3. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 2, characterized in that, The catalyst introduced into the catalyst intake pipe (22) includes homogeneous or heterogeneous flowing substances such as gas phase, liquid phase, gas-liquid mixture, liquid-solid mixture, and gas-solid mixture.

4. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 2, characterized in that, The catalytic hydrolysis synthesis apparatus for the pharmaceutical intermediates also includes: A steam superheater (3) is located at the end of the Venturi mixer (2) away from the reactor (1) and is connected to the steam intake pipe (21).

5. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 4, characterized in that, The steam superheater (3) is heated by heat transfer oil with a temperature of 100-300℃.

6. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 5, characterized in that, The steam superheater (3) also includes: A heating device (31) is provided, one end of which is connected to a heat transfer oil inlet to receive heat transfer oil. The heating device (31) is provided with a chamber for containing heat transfer oil. The heating device (31) is heated by heat transfer oil, and the heating temperature of the heat transfer oil is 100-300℃. Steam inlet (32), the steam inlet (32) is located at the end of the heating device (31) away from the Venturi mixer (2) and is connected to the heating device (31); Steam outlet (33), steam inlet (32) is located at one end of the heating device (31) near the Venturi mixer (2) and connected to the heating device (31), and the other end is connected to the steam intake pipe (21); A regulating valve assembly (34) is located between the steam outlet (33) and the steam intake pipe (21). The regulating valve assembly (34) and the steam outlet (33) are automatically controlled by a remote pressure gauge.

7. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 6, characterized in that, The steam inlet (32) is also equipped with a pressure reducing valve to adjust the steam pressure at the inlet of the steam superheater (3) from 0.6 MPa to 0.05-0.15 MPa.

8. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 1, characterized in that, The reactor (1) also includes: Distributor (11), which is located at the bottom of the reaction chamber to uniformly disperse the gas-liquid mixture entering the reaction vessel (1); A stirrer (12) is disposed in the reaction chamber and is capable of circumferential stirring along its axial direction. The stirrer (12) is disposed above the distributor (11). A steam heating jacket (13) is provided on the outer circumferential surface of the reactor (1) and the steam heating jacket (13) is provided with a tail gas outlet, and a condenser is installed at the tail gas outlet.

9. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 8, characterized in that, The agitator (12) is equipped with an agitator blade, which includes one of the following: centrifugal agitator blade, propulsion agitator blade, turbine agitator blade, anchor agitator blade, frame agitator blade, and MIG agitator blade.

10. The catalytic hydrolysis synthesis apparatus for pharmaceutical intermediates according to claim 1, characterized in that, The catalytic hydrolysis synthesis apparatus for the pharmaceutical intermediates also includes: An external circulation pump (4) is provided, one end of which is connected to the reactor (1) and the other end of which is connected to the Venturi mixer (2). An online analysis device (5) is provided on the bypass of the vertical section of the external circulation pump (4), and the external circulation pump (4) is provided with a manual valve for adjusting the bypass flow.

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