Device for detecting carbon dioxide removal performance of gas-blood exchange membrane for ECCO2R

Abstract

The utility model discloses a device for detecting the carbon dioxide removal performance of a gas-blood exchange membrane for ECCO2R. The device comprises a shell which is internally provided with a membrane wire and a gas-blood exchange membrane assembly, and a gas inlet and a gas outlet of the membrane wire are respectively communicated with a gas inlet and a gas outlet on the shell of the membrane assembly; a container for storing blood; the blood inlet end of the blood pump is connected with the container, the blood outlet end of the blood pump is connected with a blood inlet of the membrane assembly, and the blood pump is used for conveying blood into a cavity of the membrane assembly located on the outer side of the membrane wire and adjusting blood flow; the gas outlet end of the carbon dioxide supply assembly is connected with the gas inlet of the membrane assembly, and the carbon dioxide supply assembly is used for supplying carbon dioxide into membrane filaments and adjusting the carbon dioxide flow; wherein the blood outlet of the membrane component is connected with the container. The device is used for testing the capacity of the membrane lung for removing carbon dioxide in blood, various influence factors can be regulated and controlled in the circulation process, and the applicability is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to a gas blood exchange membrane carbon dioxide removal performance detection device for ECCO2R belongs to membrane performance detection technical field. BACKGROUND

[0002] With the continuous progress of medical science and technology, people's requirements for respiratory support technology are also getting higher and higher. Extracorporeal life support (ECLS) is a life support technology that uses mechanical equipment to provide partial or full cardiopulmonary support for several days to several months for severe cardiopulmonary failure. It is an effective way to reduce the mortality rate of respiratory failure patients. Extracorporeal membrane oxygenation (ECMO) is part of ECLS. In the past few decades, ECMO technology has made significant progress, effectively supporting the respiratory function of some critically ill patients. However, due to the high operating cost and complex operation of ECMO, patients are prone to bleeding and blood trauma, and other accidents, which limits the clinical application of this technology. In order to make up for the shortcomings of ECMO in actual application, extracorporeal carbon dioxide removal technology (ECCO2R) has emerged. Unlike ECMO, ECCO2R uses lower blood flow, smaller circuits, membranes and catheters, and aims to remove carbon dioxide through extracorporeal circulation to help manage acute respiratory failure. Currently, ECCO2R is mainly used for severe exacerbation of chronic obstructive pulmonary disease (COPD) (aiming to reduce intubation rate and mechanical ventilation duration) and moderate ARDS (reducing ventilation load to allow "over-protective" ventilation settings).

[0003] The principle of ECCO2R is based on the innovative expansion of membrane oxygenation technology, which reduces the concentration of carbon dioxide in the blood to maintain acid-base balance. In the normal process of human respiration, the lungs absorb oxygen into the blood while expelling carbon dioxide out of the body. However, when patients suffer from severe respiratory failure or lung disease, lung function is impaired and cannot effectively expel carbon dioxide. At this time, ECCO2R can serve as an auxiliary breathing means to help expel the accumulated carbon dioxide in the body. The ECCO2R system forms a circulation with venous blood flow, introduces blood into an extracorporeal circulation system, and uses a series of specially designed exhaust membranes to remove carbon dioxide from the blood outside the body. The blood after removing carbon dioxide is guided back into the body to complete a cycle. Therefore, one of the main functions of ECCO2R is to help reduce the concentration of carbon dioxide in the blood of patients and reduce the respiratory burden.

[0004] Gas-blood exchange membrane is the core component of membrane oxygenator, which is the barrier between blood and gas and also provides a place for blood oxidation. The common core materials of membrane oxygenator include polypropylene (PP) and poly 4-methyl-1-pentene (PMP). Compared with PP, PMP, as a thermoplastic polyolefin, is used in ECCO2R system due to its good mechanical stability, thermal stability, gas permeability and plasma leakage resistance. In ECCO2R application, the key performance of gas-blood exchange membrane is carbon dioxide removal performance. The CO2 removal in membrane lung mainly depends on the following conditions: under the condition of fixed membrane lung surface area, blood flow and flushing gas flow, membrane lung and blood contact time and membrane material will affect the CO2 removal efficiency. At present, the CO2 removal process in ECCO2R system lacks research, and there is also a lack of detection technology for carbon dioxide removal performance of gas-blood exchange membrane applied to ECCO2R. Practical new content

[0005] The utility model discloses a kind of carbon dioxide removal performance detection devices of gas-blood exchange membrane for ECCO2R, for testing the ability of membrane lung to remove carbon dioxide in blood, in circulation process, various influencing factors can be regulated, and applicability is improved.

[0006] To achieve the above object, the technical scheme adopted by the utility model is as follows:

[0007] A kind of carbon dioxide removal performance detection device of gas-blood exchange membrane for ECCO2R, comprising:

[0008] Membrane assembly, membrane filament is installed in the shell, for gas-blood exchange, and the gas inlet of membrane filament, gas outlet are connected with the gas inlet, gas outlet on the shell of membrane assembly respectively;

[0009] Container, for storing blood;

[0010] Blood pump, blood inlet end is connected with container, blood outlet end is connected with the blood inlet of membrane assembly, for transporting blood to the cavity of membrane assembly located in the outside of membrane filament and adjusting blood flow;

[0011] Carbon dioxide supply assembly, gas outlet end is connected with the gas inlet of membrane assembly, for supplying carbon dioxide to membrane filament and adjusting carbon dioxide flow;

[0012] Wherein, the blood outlet of membrane assembly is connected with container.

[0013] Preferably, membrane filament is PMP, PP or PES material.

[0014] Preferably, carbon dioxide supply assembly includes carbon dioxide supplier and flow regulating valve installed on connecting pipeline between the gas outlet end of carbon dioxide supplier and the gas inlet of membrane assembly.

[0015] Preferably, the carbon dioxide supply is a carbon dioxide cylinder filled with carbon dioxide.

[0016] Preferably, the system further comprises a nitrogen supply assembly, the outlet end of which is connected to the gas inlet of the membrane assembly, for supplying nitrogen into the membrane filament and adjusting the flow of nitrogen.

[0017] Preferably, the nitrogen supply assembly comprises a nitrogen supply and a flow regulating valve installed on the connecting pipe between the outlet end of the nitrogen supply and the gas inlet of the membrane assembly.

[0018] Preferably, the nitrogen supply is a nitrogen cylinder filled with nitrogen.

[0019] Preferably, a sampling pipe is installed on the connecting pipe between the outlet end of the blood pump and the blood inlet of the membrane assembly, and on the connecting pipe between the blood outlet of the membrane assembly and the container, and a valve is installed on the sampling pipe.

[0020] Preferably, the shell of the membrane assembly is made of transparent glass.

[0021] Preferably, the blood inlet of the shell of the membrane assembly is arranged close to the gas outlet, and the blood outlet is arranged close to the gas inlet.

[0022] The beneficial effects of the present application are as follows:

[0023] The system is easy to install and test, and has little damage to blood during the test process. In the circulation process, various influencing factors (including gas and blood flow, etc.) can be controlled, improving the applicability and effectively testing the ability of the membrane lung to remove carbon dioxide from blood. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 Figure 1 is a schematic diagram of the connection of the carbon dioxide removal performance detection device of the gas-blood exchange membrane;

[0025] Figure 2 Figure 5 is the data of the change of the oxygen partial pressure of blood with time in the carbon dioxide removal performance test of Example 1;

[0026] Figure 3 Figure 6 is the data of the bicarbonate content of blood in the carbon dioxide removal performance test of Example 1;

[0027] Figure 4 Figure 7 is the data of the pH value of blood in the carbon dioxide removal performance test of Example 1;

[0028] Figure 5 Figure 8 is the data of the oxygen saturation of blood in the carbon dioxide removal performance test of Example 1.

[0029] The meanings of the main reference signs in the drawings are as follows:

[0030] 1. Container, 2. Blood pump, 3. Membrane module, 4. Carbon dioxide supply, 5. Nitrogen supply, 6. Flow control valve, 7. Sampling tube, 8. Valve. Detailed Implementation

[0031] The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0032] This embodiment provides a device for detecting the carbon dioxide removal performance of the gas exchange membrane in ECCO2R, such as... Figure 1 As shown, the assembly includes a container 1, a blood pump 2, a membrane module 3, a carbon dioxide supply component, and a nitrogen supply component. The membrane module 3 has a gas inlet and a gas outlet at its top and bottom ends, respectively. A blood inlet is formed on the lower part of one sidewall, and a blood outlet is formed on the upper part of the other sidewall. Membrane fibers are installed inside the membrane module 3 for gas-blood exchange, and the gas inlets and outlets of the membrane fibers are connected to the gas inlet and gas outlet of the membrane module 3, respectively. The membrane module 3's shell is made of transparent glass; the membrane fibers are made of PMP, PP, or PES material; in Example 1, PMP material was selected.

[0033] Container 1 is used to store blood; the blood inlet of blood pump 2 is connected to container 1, and the bleeding end is connected to the blood inlet of membrane module 3, which is used to deliver blood into the cavity of membrane module 3 located outside the membrane filament and to regulate blood flow; the bleeding outlet of membrane module 3 is connected to container 1 to form a blood circuit.

[0034] The carbon dioxide supply assembly includes a carbon dioxide supplier 4 and a flow regulating valve 6 installed on the connecting pipe between the outlet of the carbon dioxide supplier 4 and the gas inlet of the membrane module 3. The carbon dioxide supplier 4 is a carbon dioxide cylinder filled with carbon dioxide. The outlet of the carbon dioxide cylinder is connected to the gas inlet of the membrane module 3 for supplying carbon dioxide into the membrane fibers, and the flow regulating valve 6 regulates the carbon dioxide supply flow rate.

[0035] The nitrogen supply assembly includes a nitrogen supply unit 5 and a flow regulating valve 6 installed on the connecting pipe between the outlet of the nitrogen supply unit 5 and the gas inlet of the membrane module 3. The nitrogen supply unit 5 is a nitrogen cylinder filled with nitrogen. The outlet of the nitrogen cylinder is connected to the gas inlet of the membrane module 3 for supplying purging nitrogen into the membrane fibers and regulating the nitrogen flow rate through the flow regulating valve 6.

[0036] Sampling tubes 7 are installed on the connecting pipe between the bleeding end of the blood pump 2 and the blood inlet of the membrane module 3, and on the connecting pipe between the bleeding outlet of the membrane module 3 and the container 1. A valve 8 is installed on the sampling tube 7.

[0037] Working principle:

[0038] During the test, the treated blood is stored in the container 1 and connected to the circuit, pumped into the shell of the membrane module 3 by the blood pump 2, and flows in the membrane module 3 outside the membrane filaments for gas-blood exchange. The carbon dioxide from the gas inlet enters the inner hole of the membrane filaments and exchanges with the blood in the shell of the membrane module 3 to simulate the blood with high carbon dioxide content of the patient. The nitrogen gas is introduced into the inner hole of the membrane filaments and exchanges with the blood in the membrane module 3. The carbon dioxide combined with the blood is discharged through the gas outlet of the membrane module 3. The treated blood is returned to the container 1 through the blood outlet, thereby realizing the circulation process. The blood sample is taken from the sampling tube 7 for detection.

[0039] Example 1

[0040] Fresh anticoagulant animal blood is stored in the container 1, and the circuit is connected to the blood at a flow rate of 10 ml / min. When the blood fills the entire circuit, the blood sample is tested. Figure 1 The circuit is connected to the blood at a flow rate of 10 ml / min. When the blood fills the entire circuit, the blood sample is tested.

[0041] Carbon dioxide gas is introduced, and the blood gas value of the blood is tested every 5 min until the blood gas value meets the blood gas range of the patient's blood, such as the carbon dioxide partial pressure of rabbit blood > 40 mmHg, the bicarbonate content > 25 mmol / L, and the pH value < 7.15.

[0042] Nitrogen gas is introduced, the gas flow rate is set to 150 ml / min, the blood flow rate is maintained at 10 ml / min, the pump is stopped every 5 min to take a sample, and the blood gas value of the blood sample before and after the membrane is tested.

[0043] Specifically, Figure 2 The data of the blood oxygen and carbon dioxide partial pressure change over time; as shown in the figure, the carbon dioxide partial pressure of the blood decreases continuously with the extension of the treatment time, which indicates that the carbon dioxide content in the blood decreases, and reflects the better carbon dioxide removal capacity of the measured membrane module. Figure 3 The data of the blood bicarbonate content; as shown in the figure, the bicarbonate content of the blood decreases rapidly with the extension of the treatment time, because the carbon dioxide content in the blood decreases, which in turn leads to a decrease in the amount of carbon dioxide converted into bicarbonate, which verifies the better carbon dioxide removal capacity of the membrane module as described above. Figure 4 The data of the blood pH value; as shown in the figure, the pH value of the blood gradually approaches the standard range of blood from acidity with the extension of the treatment time, because the carbon dioxide content in the blood decreases, which in turn leads to a decrease in the amount of carbon dioxide converted into hydrogen ions, and the acidification of the blood is weakened, which assists in verifying the better carbon dioxide removal capacity of the membrane module as described above. Figure 5The blood oxygen saturation data is shown in the figure. The oxygen saturation of the blood is rapidly increased at first and then gradually maintained at 99% with the increase of the processing time, which indicates that the measured membrane module has not only the excellent carbon dioxide removal capacity but also good oxygenation performance.

[0044] The above only is the preferred embodiment of the present application, it should be pointed out that, for the ordinary skilled in the art, without departing from the principles of the present application, can make a number of improvements and refinements, these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A gas-blood exchange membrane carbon dioxide removal performance detection device for ECCO2R, characterized in that, The application relates to a blood gas exchange device, which comprises: a membrane module, a membrane filament is installed in the shell of the membrane module for gas-blood exchange, and the gas inlet and the gas outlet of the membrane filament are connected with the gas inlet and the gas outlet of the shell of the membrane module respectively; a container for storing blood; a blood pump, the blood inlet end of which is connected with the container, and the blood outlet end of which is connected with the blood inlet of the membrane module, for conveying blood to the cavity of the membrane module outside the membrane filament and adjusting the blood flow; a carbon dioxide supply module, the gas outlet end of which is connected with the gas inlet of the membrane module, for supplying carbon dioxide to the membrane filament and adjusting the carbon dioxide flow; wherein the blood outlet of the membrane module is connected with the container.

2. The device for detecting carbon dioxide removal performance of a gas-blood exchange membrane for ECCO2R according to claim 1, wherein The membrane filament is made of PMP, PP or PES.

3. The device for detecting carbon dioxide removal performance of a gas-blood exchange membrane for ECCO2R according to claim 1, wherein The carbon dioxide supply module comprises a carbon dioxide supply device and a flow regulating valve installed on the connecting pipeline between the gas outlet end of the carbon dioxide supply device and the gas inlet of the membrane module.

4. The device for detecting carbon dioxide removal performance of a gas-blood exchange membrane for ECCO2R according to claim 3, wherein The carbon dioxide supply device is a carbon dioxide cylinder filled with carbon dioxide.

5. The gas-blood exchange membrane carbon dioxide removal performance detection device for ECCO2R according to claim 1, characterized in that, The device further comprises a nitrogen supply module, the gas outlet end of which is connected with the gas inlet of the membrane module, for supplying nitrogen to the membrane filament and adjusting the nitrogen flow.

6. The gas-blood exchange membrane carbon dioxide removal performance testing device for ECCO2R according to claim 5, wherein, The nitrogen supply module comprises a nitrogen supply device and a flow regulating valve installed on the connecting pipeline between the gas outlet end of the nitrogen supply device and the gas inlet of the membrane module.

7. The gas-blood exchange membrane carbon dioxide removal performance testing device for ECCO2R according to claim 6, wherein, The nitrogen supply device is a nitrogen cylinder filled with nitrogen.

8. The gas-blood exchange membrane carbon dioxide removal performance testing device for ECCO2R according to claim 1, characterized in that, Sampling tubes are arranged on the connecting pipeline between the blood outlet end of the blood pump and the blood inlet of the membrane module and on the connecting pipeline between the blood outlet of the membrane module and the container, and valves are installed on the sampling tubes.

9. The gas-blood exchange membrane carbon dioxide removal performance testing device for ECCO2R according to claim 1, characterized in that, The shell of the membrane module is made of transparent glass.

10. The gas-blood exchange membrane carbon dioxide removal performance testing device for ECCO2R according to claim 1, characterized in that, The blood inlet of the shell of the membrane module is arranged close to the gas outlet, and the blood outlet is arranged close to the gas inlet.

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