Kit structure

Abstract

The utility model discloses a kit structure which comprises a kit, a kit turntable and a uniform mixing rotating shaft, a plurality of kit mounting hole sites are circumferentially and uniformly arrayed on the kit turntable, and a uniform mixing rotating shaft capable of rotating is arranged at the end part of each kit mounting hole site; the kit comprises a kit body, a solid-phase magnetic particle rotating sleeve, a solid-phase magnetic particle bottle and a reagent bottle, the plurality of reagent bottles are placed in the kit body, the solid-phase magnetic particle rotating sleeve is rotatably mounted at the end part of the kit body, and the solid-phase magnetic particle bottles are fixed in the solid-phase magnetic particle rotating sleeve; a guide positioning structure is arranged at the lower part of the solid-phase magnetic particle rotating sleeve, a plurality of sawteeth are circumferentially arranged at the lower end of the guide positioning structure, and when the kit is placed in the kit mounting hole position, the sawteeth at the lower end of the guide positioning structure are staggered and matched with the sawteeth at the upper part of the uniform mixing rotating shaft. The problem of tooth abutting possibly occurring in gear transmission in the prior art is solved, meanwhile, the reagent bottle is positioned more firmly, and the reagent bottle is prevented from being taken up in the ascending process of the sample adding needle.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of chemiluminescence detection equipment, and particularly relates to a reagent box structure. BACKGROUND

[0002] Chemiluminescence enzyme immunoassay is a common analysis method of a chemiluminescence instrument, and an alkaline phosphatase-labeled antibody or antigen is used; after an immune reaction occurs between the antibody or antigen and a sample to be measured in a reaction system and a solid carrier, a solid-phase coated antibody complex is formed; through enzyme catalysis and decomposition of a substrate, light is emitted; the light intensity is received by a light quantum reading system; meanwhile, a photon counter converts the light signal into an electrical signal and amplifies the electrical signal; the amplified signal is transmitted to a computer data processing system; and the concentration of the measured substance is calculated.

[0003] In the detection process, multiple reagents and solid carriers are needed, and the carrier containing the reagents and the solid carriers needs to be kept stable in position, so that the sampling needle can be lowered from the center of the bottle mouth of the carrier and suck the reagents and the solid carriers. In order to prevent evaporation of the reagents and entry of foreign matter, the bottle cap needs to be screwed on for storage, which not only increases the workload of the operator, but also makes the bottle cap easy to be confused and wrongly installed on other reagent bottles, increasing the risk of cross contamination of the reagents. The evaporation-proof cap is the simplest solution at present, and it is not necessary to install and remove the bottle cap, but during use, the reagent bottle or reagent box needs to be completely fixed to prevent the reagent bottle or reagent box from being lifted due to the friction generated when the sampling needle is separated from the evaporation-proof cap, causing unpredictable accidents.

[0004] The magnetic microparticles in the solid carrier will gradually settle as the static time increases, resulting in different liquid concentrations, and the stability of the number of magnetic microparticles in the solid carrier cannot be guaranteed during the sucking process, so the solid carrier needs to be mixed frequently to ensure that the magnetic microparticles can be uniformly suspended. Usually, a separate stirring rod is used to enter the liquid periodically for mixing, which not only increases the complexity of the structure and the risk of cross contamination, but also causes loss of magnetic microparticles.

[0005] In recent years, with the development of technology, a reagent box that combines the solid carrier and the reagent has appeared. The carrier of the solid carrier is located at the front end or the rear end of the reagent box, a gear that can rotate independently is designed on the carrier of the solid carrier, a spring piece is arranged at the other end, the gear on the carrier is engaged with the gear on the reagent disc, the reagent box rotates together with the reagent disc, and at the same time, the carrier of the solid carrier rotates independently, so that the solid carrier is mixed. However, this kind of reagent box also has inherent defects, for example, the top tooth phenomenon is easy to occur during the engagement of the two gears, at this time, the gear on the carrier needs to be manually rotated to engage with the gear on the reagent disc and then clamped into the spring piece, which increases the operation difficulty, and if the spring piece is not clamped in place, it may also cause jamming, friction noise, stoppage and other unpredictable effects. SUMMARY

[0006] The utility model discloses a kit structure, which solves the technical problems of the prior art.

[0007] The utility model solves the technical issues by adopting the following technical scheme:

[0008] A kit structure comprises a kit, a kit turntable and a mixing shaft, a plurality of kit mounting hole positions are uniformly arranged in a circle on the kit turntable, each kit mounting hole position is provided with a mixing shaft capable of self-rotation at the end thereof, the kit comprises a kit body, a solid-phase magnetic particle rotating sleeve, a solid-phase magnetic particle bottle and a reagent bottle, a plurality of reagent bottles are placed in the kit body, the solid-phase magnetic particle rotating sleeve is rotatably installed at the end of the kit body, and the solid-phase magnetic particle bottle is fixed in the solid-phase magnetic particle rotating sleeve, the lower part of the solid-phase magnetic particle rotating sleeve is provided with a guide positioning structure, a plurality of sawteeth are arranged in a circle at the lower end of the guide positioning structure, and when the kit is placed in the kit mounting hole position of the kit turntable, the sawteeth at the lower end of the guide positioning structure are staggered with the sawteeth at the upper part of the mixing shaft.

[0009] Further, the upper end of the left and right sides of the kit body is respectively provided with an ear wing capable of being elastically deformed, the ear wing is provided with an upper positioning block, the lower end of the ear wing is provided with a lower positioning block, the upper end of the rear side of the kit body is provided with a rear positioning block, each mounting position in the kit body is provided with a bottle body positioning ring, the inner wall is respectively provided with a bottle body positioning rib on both sides, and the bottle body positioning rib is located between the adjacent two mounting positions.

[0010] Further, the sidewall of the kit body is provided with a barcode area and an information identification area, the barcode area is used for pasting a barcode, and the information identification area is used for pasting an information mark.

[0011] Further, the kit turntable is provided with an upper limiting step and a lower limiting step on both sides of each kit mounting hole position, when the kit is placed in the kit mounting hole position, the lower positioning block of the kit body is located on the lower limiting step, and the upper positioning block is clamped into the lower side of the upper limiting step.

[0012] Further, the upper part of the outer wall of the solid-phase magnetic particle rotating sleeve is provided with a first step and a second step, the middle part is provided with a third step and a fourth step, the first step and the fourth step are used for limiting the solid-phase magnetic particle rotating sleeve in the kit body, and the second step and the third step are used for ensuring smooth rotation of the solid-phase magnetic particle rotating sleeve.

[0013] Further, the inner wall of the solid-phase magnetic particle rotating sleeve is provided with a guide limiting block and a fixing rib, and the guide limiting block and the fixing rib are matched with the solid-phase magnetic particle bottle.

[0014] Compared with the prior art, the utility model has the advantages and positive effects that:

[0015] 1. The front end of the kit is provided with a solid-phase magnetic particle rotating sleeve, a solid-phase magnetic particle bottle is fixed in the solid-phase magnetic particle rotating sleeve, a guide positioning structure at the lower part of the solid-phase magnetic particle rotating sleeve is provided with a sawtooth, the upper part of the mixing shaft is also provided with a sawtooth, and the solid-phase magnetic particle rotating sleeve is circumferentially fixed by the sawtooth when being sleeved on the mixing shaft, so that the top tooth phenomenon caused by gear transmission in the prior art is avoided, and manual intervention is not required.

[0016] 2. The upper ends of the two sides of the kit are respectively provided with ear wings capable of being elastically deformed, the kit can be placed in a kit mounting hole on a kit turntable by pinching the ear wings with hands, and the ear wings can be clamped into the kit turntable by releasing elastic potential energy, so that the fixation between the kit and the kit turntable is realized. The kit and the kit turntable are fixed in front, back, left, right, up and down directions, the positioning accuracy of the center positions of the reagent bottles is ensured, and the reagent bottles are prevented from being lifted by the friction force generated between the sampling needle and the evaporation prevention cover during the lifting process of the sampling needle.

[0017] 3. The utility model has the advantages of convenient use, simple installation, reliable use, supporting online real-time mixing, evaporation prevention, combination use of multiple reagent bottles, saving of mold manufacturing and maintenance cost and the like. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 is the overall structure schematic view of the utility model;

[0019] Figure 2 is the installation schematic view of the kit and the mixing shaft of the utility model;

[0020] Figure 3 is the structure schematic view of the kit of the utility model;

[0021] Figure 4 is the structure schematic view of the other bottle body of the utility model;

[0022] Figure 5 is the structure schematic view of the kit body of the utility model;

[0023] Figure 6 is the top view of the kit body of the utility model;

[0024] Figure 7 is the schematic view of the ear wing of the kit before being clamped into the kit turntable of the utility model;

[0025] Figure 8 is the schematic view of the ear wing of the kit after being clamped into the kit turntable of the utility model;

[0026] Figure 9 is the sectional view of the kit along the length direction of the utility model;

[0027] Figure 10It is a structure schematic view of the solid-phase magnetic micro-particle rotating sleeve of the utility model;

[0028] Figure 11 It is a top view of the solid-phase magnetic micro-particle rotating sleeve of the utility model;

[0029] Figure 12 It is an explosion view of the solid-phase magnetic micro-particle bottle of the utility model;

[0030] Figure 13 It is a top view of the reagent box turntable of the utility model;

[0031] Figure 14 It is a partial sectional view of the reagent box turntable of the utility model;

[0032] Figure 15 It is an assembly schematic view of the reagent box turntable and the reagent box of the utility model;

[0033] Mark explanation: 100, reagent box; 200, reagent box turntable; 300, mixing rotating shaft;

[0034] 101, reagent box body; 102, solid-phase magnetic micro-particle rotating sleeve; 103, solid-phase magnetic micro-particle bottle; 104, reagent bottle; 105, other bottle body;

[0035] 1011, ear wing; 1012, upper positioning block; 1013, lower positioning block; 1014, anti-skid band; 1015, rear positioning block; 1016, bar code area; 1017, information identification area; 1018, solid-phase magnetic micro-particle rotating sleeve mounting hole; 1019, bottle body positioning ring; 1020, bottle body positioning rib; 1021, first step; 1022, second step; 1023, third step; 1024, fourth step; 1025, gear; 1026, guide positioning structure; 1027, guide limiting block; 1028, fixing rib; 1031, solid-phase magnetic micro-particle bottle body; 1032, sealing film; 1033, anti-evaporation cover; 1034, recess;

[0036] 201, reagent box mounting hole; 202, upper limiting step; 203, lower limiting step. DETAILED DESCRIPTION

[0037] The technical scheme of the utility model will be described in detail below in combination with specific embodiments and drawings, but the protection scope of the application is not limited by this.

[0038] The utility model provides a reagent box structure (see Figures 1-15), including a kit 100, a kit turntable 200, and a mixing shaft 300; the kit turntable 200 has a plurality of kit mounting holes 201 arranged in a uniform circle, and each kit mounting hole 201 is provided with a mixing shaft 300 at the end, when the kit 100 is placed in the kit mounting hole 201, the solid-phase magnetic micro-particle rotating sleeve 102 of the kit 100 cooperates with the mixing shaft 300, and the rotation of the solid-phase magnetic micro-particle rotating sleeve 102 is realized through the mixing shaft 300, and the rotation of the solid-phase magnetic micro-particle bottle 103 is realized.

[0039] As shown in Figure 3 , 4 The kit 100 includes a kit body 101, a solid-phase magnetic micro-particle rotating sleeve 102, a solid-phase magnetic micro-particle bottle 103, and a reagent bottle 104; a plurality of reagent bottles 104 are placed in the kit body 101, the solid-phase magnetic micro-particle rotating sleeve 102 is rotatably installed in the solid-phase magnetic micro-particle rotating sleeve mounting hole 1018 at the front end of the kit body 101, and the solid-phase magnetic micro-particle bottle 103 is located in the solid-phase magnetic micro-particle rotating sleeve 102; the solid-phase magnetic micro-particle rotating sleeve mounting hole 1018 has a certain draft angle, which facilitates the installation of the solid-phase magnetic micro-particle rotating sleeve 102.

[0040] The kit 100 further includes other bottle bodies 105; the other bottle bodies 105 can be combined into one reagent bottle cavity by two reagent bottle cavities or three reagent bottle cavities to hold reagents of different capacities, such as diluents. Figure 4 As a form of the other bottle bodies 105, different reagent bottles in different cavities share one kit body 101, which greatly reduces the mold cost and manufacturing, storage, and other costs, and is also conducive to the maintenance cost in the later stage.

[0041] As shown in Figures 5-6As shown, the upper ends of the left and right sides of the reagent kit body 101 are respectively provided with ear wings 1011. The ear wings 1011 not only provide an operating area for the operator to hold and pinch, but also can be elastically deformed to allow the reagent kit body 101 to be inserted into the reagent kit turntable 200. The reagent kit body 101 has elastic release grooves at the front and rear ends of the ear wings 1011, providing space for the ear wings 1011 to release elastic deformation. The middle area of ​​the ear wings 1011 is an anti-slip band 1014 formed by multiple protruding particles to increase friction and prevent slippage when pinching the ear wings 1011. The ear wings 1011 are provided with an upper positioning block 1012, the lower end of the ear wings 1011 is provided with a lower positioning block 1013, and the upper rear end of the reagent kit body 101 is provided with a rear positioning block 1015. The upper positioning block 1012, the lower positioning block 1013, and the rear positioning block 1015 are used to limit the position of the reagent kit 100. To ensure the positional stability of the reagent kit 100 when it is coupled with the reagent kit turntable 200, the reagent kit body 101 has a barcode area 1016 on the rear side and an information recognition area 1017 on the left or right side. The barcode area 1016 can be used to attach barcodes, which are easy for barcode scanners to read the contents of the reagent kit. The information recognition area 1017 can be used to attach information labels of the reagent kit, which are convenient for operators to quickly and clearly identify the relevant information of the reagent kit. Each mounting position inside the reagent kit body 101 is provided with a bottle positioning ring 1019 to limit the reagent bottle 104 from the bottom. Multiple bottle positioning ribs 1020 are provided on both sides of the inner wall of the reagent kit body 101, and the bottle positioning ribs 1020 are located between two adjacent mounting positions to limit the reagent bottle 104 from the side. The bottle positioning rings 1019 and bottle positioning ribs 1020 ensure the accuracy of the position of the reagent bottle 104.

[0042] like Figure 7 , 8 As shown, under normal conditions, the two lugs 1011 form an obtuse angle, and the size of the opening is larger than that of the reagent bottle 104. At the same time, a C-shaped structure is designed at the contact position with the shoulder of the reagent bottle 104 to provide a guiding function for the reagent bottle 104, so that the reagent bottle can be picked up and put down with very little force. At the same time, the C-shaped structure can provide a certain pre-pressure to the reagent bottle to prevent the reagent bottle from detaching from the reagent kit body 101. When the reagent kit 100 is inserted into the working position of the reagent kit turntable 200, the inner wall of the upper limit step 202 of the reagent kit turntable 200 contacts the outer wall of the upper positioning block 1012 of the reagent kit body 101, the two lugs 1011 retract inward, and the C-shaped structure locks the shoulder of the reagent bottle 104 to prevent the friction generated by the sampling needle and the anti-evaporation cap during the upward movement from lifting the reagent bottle 104 or other bottles 105.

[0043] like Figures 9-11As shown, the upper part of the outer wall of the solid magnetic particle rotating sleeve 102 is provided with a first step 1021 and a second step 1022, and the middle part is provided with a third step 1023 and a fourth step 1024. The draft angles of the second step 1022, the third step 1023 and the fourth step 1024 are adapted to the draft angle of the solid magnetic particle rotating sleeve mounting hole 1018. The lower edge of the first step 1021 and the upper edge of the fourth step 1024 serve as the upper and lower limiting structures of the solid magnetic particle rotating sleeve 102 in the solid magnetic particle rotating sleeve mounting hole 1018. The outer diameter of the fourth step 1024 is slightly larger than the inner diameter of the lower edge of the solid magnetic particle rotating sleeve mounting hole 1018 by 0.1 to 0.2 mm, so that the fourth step 1024 can pass through the lower edge of the solid magnetic particle rotating sleeve mounting hole 1018 under a certain pressure and prevent it from being pulled out in the opposite direction. The second step 1022 and the third step 1023 are the upper and lower rotating mating surfaces of the solid-phase magnetic particle rotating sleeve 102 and the solid-phase magnetic particle rotating sleeve mounting hole 1018. While ensuring the guiding distance, they reduce unnecessary contact surfaces, thereby reducing friction and allowing the solid-phase magnetic particle rotating sleeve 102 to rotate smoothly within the solid-phase magnetic particle rotating sleeve mounting hole 1018. The inner wall of the solid-phase magnetic particle rotating sleeve 102 is provided with two guide limiting blocks 1027 that mate with the solid-phase magnetic particle bottle 103. Simultaneously, multiple fixing ribs 1028 that are interference-fitted with the solid-phase magnetic particle bottle 103 are provided, ensuring that the solid-phase magnetic particle bottle 103 remains fixed inside the solid-phase magnetic particle rotating sleeve 102. The lower part of the solid-phase magnetic particle rotating sleeve 102 is provided with a gear 1025 or a guide positioning structure 1026, supporting different self-mixing modes. The gear 1025, as a backup solution in this embodiment, can mesh with external gears or racks to achieve online real-time mixing. The bottom of the guide positioning structure 1026 is uniformly provided with multiple serrations around its circumference, and the upper part of the mixing shaft 300 is also provided with the same number of serrations around its four sides. When the solid magnetic particle sleeve 102 falls axially onto the mixing shaft 300, the serrations on the upper part of the mixing shaft 300 and the serrations of the guide positioning structure 1026 are interlocked. With the downward pressing action, the solid magnetic particle sleeve 102 rotates in the solid magnetic particle sleeve mounting hole 1018 until the serrations of the mixing shaft 300 and the serrations of the guide positioning structure 1026 are fully engaged, thereby achieving the fixation between the solid magnetic particle sleeve 102 and the mixing shaft 300.

[0044] like Figure 12 As shown, the solid magnetic microparticle bottle 103 includes a solid magnetic microparticle bottle body 1031, a sealing film 1032, and an anti-evaporation cap 1033; the anti-evaporation cap 1033 and the solid magnetic microparticle bottle body 1031 are provided with a sealing film 1032; the solid magnetic microparticle bottle body 1031 has two grooves 1034; when the solid magnetic microparticle bottle 103 is engaged with the solid magnetic microparticle rotating sleeve 102, the grooves 1034 engage with the guide limiting block 1027 on the inner wall of the solid magnetic microparticle rotating sleeve 102 to fix the solid magnetic microparticle bottle 103 and the solid magnetic microparticle rotating sleeve 102.

[0045] As Figures 13-15 shown, the kit carousel 200 has a plurality of kit mounting holes 201 in a circumferential array, and each kit mounting hole 201 is provided with an upper limiting step 202 and a lower limiting step 203 on both sides, when the operator pinches the ear wings 1011 of the kit body 101, places the kit 100 in the kit mounting hole 201, the lower positioning block 1013 on both sides of the kit body 101 is located on the lower limiting step 203, at this time the operator releases the ear wings 1011, the ear wings 1011 rely on their own elastic deformation to release to both sides, so that the upper positioning block 1012 of the kit body 101 is clamped into the lower side of the upper limiting step 202, completing the fixation of the left and right sides of the kit 100; when the kit 100 cooperates with the kit mounting hole 201, the solid-phase magnetic particle rotating sleeve 102 is axially dropped on the mixing rotating shaft 300, and the center position of the solid-phase magnetic particle bottle 103 is fixed through the sawtooth circumferential cooperation; the rear positioning block 1015 prevents the inclination generated when the kit 100 is taken and placed, and in combination with the center position fixed, the front and rear direction of the kit is fixed. Through the fixation of the front, rear, left, right, upper and lower directions, the positioning accuracy of the center position of each reagent bottle is ensured, and the frictional force generated between the sample adding needle and the evaporation prevention cover during the rising process will not lift the kit. At the same time, the two lower limiting steps 203 of the kit 100 are concave fan-shaped to accommodate the operation space of the operator for taking and placing the kit 100.

[0046] The working principle and working process of the utility model are:

[0047] The operator pinches the ear wings 1011 of the kit 100, places the kit 100 into any kit mounting hole 201 on the kit carousel 200, so that the lower positioning block 1013 of the kit 100 falls on the lower limiting step 203 of the kit carousel 200, at this time the ear wings 1011 are released, the upper positioning block 1012 relies on its own elastic deformation to automatically clamp into the lower side of the upper limiting step 202 of the kit carousel 200, that is, the placement of the kit 101 is completed. The solid-phase magnetic particle rotating sleeve 102 of the kit 100 rotates in the solid-phase magnetic particle rotating sleeve mounting hole 1018, and finally the sawtooth of the upper part of the mixing rotating shaft 300 cooperates with the sawtooth of the guide positioning structure 1026, and the cooperation of the solid-phase magnetic particle rotating sleeve 102 and the mixing rotating shaft 300 is completed; at this time, the position fixation of the kit 100 on the kit carousel 200 is completed.

[0048] With the rotation of the kit turntable 200, the mixing rotating shaft 300 rotates through the connection gear or swing lever structure, so that the solid-phase magnetic particle rotating sleeve 102 rotates, and then drives the solid-phase magnetic particle bottle 103 to rotate, realizing the online mixing of the solid-phase magnetic particles.

[0049] The utility model is not described in the prior art.

Claims

1. A kit structure comprising a kit, a kit carousel and a mixing shaft; the kit carousel is provided with a plurality of kit mounting holes in a uniform circumferential array, and each kit mounting hole is provided with a mixing shaft capable of self-rotation at the end thereof; characterized in that, The kit comprises a kit body, a solid-phase magnetic particle rotating sleeve, a solid-phase magnetic particle bottle and reagent bottles; the reagent bottles are placed in the kit body, the solid-phase magnetic particle rotating sleeve is rotatably installed at the end of the kit body, and the solid-phase magnetic particle bottle is fixed in the solid-phase magnetic particle rotating sleeve; the lower part of the solid-phase magnetic particle rotating sleeve is provided with a guide positioning structure, and the lower end of the guide positioning structure is provided with a plurality of sawteeth in a circle; when the kit is placed in the kit mounting hole of the kit turntable, the sawteeth at the lower end of the guide positioning structure are staggered with the sawteeth at the upper part of the mixing rotating shaft.

2. The kit structure according to claim 1, characterized in that, The upper end of the left and right sides of the kit body is respectively provided with an ear wing capable of being elastically deformed, the ear wing is provided with an upper positioning block, the lower end of the ear wing is provided with a lower positioning block, and the upper end of the rear side of the kit body is provided with a rear positioning block; each mounting position in the kit body is provided with a bottle body positioning ring, and the inner wall is provided with a bottle body positioning rib on both sides, and the bottle body positioning rib is located between the adjacent two mounting positions.

3. The kit structure according to claim 1 or 2, characterized in that, The sidewall of the kit body is provided with a barcode area and an information identification area, the barcode area is used for pasting a barcode, and the information identification area is used for pasting an information mark.

4. The kit structure according to claim 2, characterized in that, The kit turntable is provided with an upper limiting step and a lower limiting step on both sides of each kit mounting hole; when the kit is placed in the kit mounting hole, the lower positioning block of the kit body is located on the lower limiting step, and the upper positioning block is clamped into the lower side of the upper limiting step.

5. The kit structure according to claim 1, characterized in that, The upper part of the outer wall of the solid-phase magnetic particle rotating sleeve is provided with a first step and a second step, the middle part is provided with a third step and a fourth step, the first step and the fourth step are used for limiting the solid-phase magnetic particle rotating sleeve in the kit body, and the second step and the third step are used for ensuring smooth rotation of the solid-phase magnetic particle rotating sleeve.

6. The kit structure according to claim 1 or 5, characterized in that, The inner wall of the solid-phase magnetic particle rotating sleeve is provided with a guide limiting block and a fixing rib, and the guide limiting block and the fixing rib are matched with the solid-phase magnetic particle bottle.

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