Heating device for nucleic acid extraction equipment and nucleic acid extraction equipment

Abstract

The utility model discloses a heating device for nucleic acid extraction equipment and the nucleic acid extraction equipment, and the heating device comprises a movable carrier frame which is provided with an accommodating space which is sunken downwards from the top and is used for partially accommodating a reagent strip of the nucleic acid extraction equipment; the heating piece is arranged at the bottom of the accommodating space and is used for heating the to-be-heated liquid in the reagent strip. The heating device for the nucleic acid extraction equipment and the nucleic acid extraction equipment have the advantages of being compact in layout and beneficial to reducing the size of the nucleic acid extraction equipment.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of nucleic acid extraction equipment, and particularly relates to a heating device for a nucleic acid extraction equipment and the nucleic acid extraction equipment. BACKGROUND

[0002] The nucleic acid extraction equipment (such as a nucleic acid extraction instrument) belongs to the field of molecular detection equipment and is widely applied in various fields such as disease control centers, clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microbial detection, food safety detection, animal husbandry and molecular biology research. The structure and position setting of the heating element for heating the liquid to be heated (such as the mixed liquid of the lysis solution and the sample) and the carrier for placing the reagent strip in the existing nucleic acid extraction equipment are not reasonable, which leads to a large space occupied by the nucleic acid extraction equipment, and the nucleic acid extraction equipment is inconvenient to transport or directly placed in a biological safety cabinet. CONTENT OF THE UTILITY MODEL

[0003] The application aims to provide a heating device for a nucleic acid extraction equipment and the nucleic acid extraction equipment, which have the advantages of compact layout and facilitating the reduction of the volume of the nucleic acid extraction equipment.

[0004] In order to achieve the above-mentioned purpose, the first aspect of the application provides a heating device for a nucleic acid extraction equipment, which comprises:

[0005] A moving carrier, wherein a containing space is formed on the moving carrier and is recessed from the top to the bottom and used for partially containing a reagent strip of the nucleic acid extraction equipment;

[0006] A heating element, which is arranged at the bottom of the containing space and used for heating the liquid to be heated inside the reagent strip.

[0007] In the embodiments of the application, a containing groove is formed on the heating element and recessed from the top to the bottom and used for containing part of the tube body of the reagent strip.

[0008] In the embodiments of the application, the heating element comprises a base portion and a stop portion, the containing groove is formed on the base portion, and the stop portion is arranged at the top of the base portion and can apply a lateral stop action force to the tube body.

[0009] In the embodiments of the application, the side of the stop portion facing the tube body is formed with an arc-shaped wall capable of abutting the outer peripheral wall of the tube body.

[0010] In the embodiments of the application, the nucleic acid extraction equipment further comprises a shaking device, and a probe access opening is further formed on the vertical side wall of the moving carrier and used for allowing a probe portion of the shaking device to extend into the containing space.

[0011] In the embodiments of the application, the heating device further comprises a first heat insulation element embedded on the moving carrier and located below the heating element.

[0012] In the embodiment of the present application, the heating device further comprises a moving guide rail arranged inside the cartridge body of the nucleic acid extraction device, and the moving carrier is movably arranged on the moving guide rail and can move to the outside of the cartridge body.

[0013] In the embodiment of the present application, the heating device further comprises;

[0014] a temperature detection member for detecting the temperature of the heat conduction body of the heating member.

[0015] a temperature protection switch for controlling the heat generation body to stop generating heat when the temperature of the heat generation body of the heating member exceeds a preset temperature.

[0016] In the embodiment of the present application, the heating device further comprises a clamping assembly arranged on the moving carrier and used for clamping the reagent strip.

[0017] The second aspect of the present application provides a nucleic acid extraction device comprising the above-mentioned heating device for the nucleic acid extraction device.

[0018] According to the above technical solution, the heating device comprises a moving carrier and a heating member, the moving carrier is formed with a containing space recessed from the top downward and used for partially containing a reagent strip of a nucleic acid extraction device, and the heating member is arranged at the bottom of the containing space and used for heating a liquid to be heated inside the reagent strip. The heating device has a simple structure, the heating member is arranged at the bottom of the containing space of the moving carrier, the integrated design of the moving carrier and the heating member is realized, the space utilization of the containing space is improved, the liquid to be heated can be heated, the occupied space of the moving carrier and the heating member is reduced, which is conducive to reducing the volume of the heating device and the nucleic acid extraction device, conducive to realizing the miniaturization design of the heating device and the nucleic acid extraction device, and conducive to enabling the nucleic acid extraction device to be directly placed in a biological safety cabinet.

[0019] Other features and advantages of the embodiments of the present application will be described in detail in the following specific embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0020] The accompanying drawings are included to provide a further understanding of the embodiments of the present application, and constitute a part of the specification, and are used to explain the embodiments of the present application together with the following specific embodiments, but do not constitute a limitation on the embodiments of the present application. For those skilled in the art, other drawings can be obtained from the structures shown in the drawings without creative labor. In the drawings:

[0021] Figure 1 is a structural schematic view of the heating device and the reagent strip in the embodiment of the present application;

[0022] Figure 2 This is a first-view structural schematic diagram of the heating device in an embodiment of this application;

[0023] Figure 3 This is a second-view structural schematic diagram of the heating device in an embodiment of this application;

[0024] Figure 4 This is a schematic diagram of the structure of the movable carrier and heating element in the embodiments of this application;

[0025] Figure 5 This is a partial structural diagram of the mobile carrier in an embodiment of this application;

[0026] Figure 6 This is a schematic diagram of the reagent strip structure in an embodiment of this application;

[0027] Figure 7 This is a schematic diagram of the nucleic acid extraction device in the embodiments of this application;

[0028] Figure 8 This is a schematic diagram of the nucleic acid extraction device (without reagent strips) in an embodiment of this application.

[0029] Explanation of reference numerals in the attached figures

[0030] 1-Moving carrier; 101-Accommodation space; 102-Probe inlet / outlet; 103-First clearance notch; 104-Second clearance notch; 105-First partition; 106-Second partition; 107-Guide wall; 2-Reagent strip; 201-Connector; 202-Tube body; 3-Heating element; 301-Accommodation groove; 302-Base; 303-Stop; 304-Arc-shaped wall; 305-Heat conductor; 4-Oscillating device; 401-Probe; 5-First heat insulation element; 6-Moving guide rail; 7-Clamping assembly; 701-First clamping element; 702-Second clamping element; 703-First connector; 704-Second connector; 8-Drive mechanism; 9-Second heat insulation element; 11-Control circuit board; 12-Leak-proof cover; 13-Pushing part. Detailed Implementation

[0031] The specific embodiments of this application will be described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are for illustration and explanation only and are not intended to limit this application.

[0032] This application provides a novel heating device for nucleic acid extraction equipment, such as... Figures 1-4 As shown, the heating device includes:

[0033] The mobile carrier 1 has a recessed space 101 formed on it, which is recessed from top to bottom and is used to partially accommodate the reagent strip 2 of the nucleic acid extraction device;

[0034] The heating member 3 is arranged at the bottom of the accommodation space 101 and is used for heating the liquid to be heated inside the reagent strip 2.

[0035] Specifically, the nucleic acid extraction device in the embodiment can be a nucleic acid extractor, and the reagent strip 2 includes an integrated connector 201 and a plurality of tube bodies 202, and the plurality of tube bodies 202 are distributed along a straight line at intervals. Before nucleic acid extraction, the operator places the reagent strip 2 (the plurality of tube bodies 202 are loaded with different types of solutions, such as a mixed solution of lysate and sample, buffer, eluent, etc.) in the accommodation space 101 of the moving carrier 1, and after the reagent strip 2 is placed in place, the heating member 3 can heat the mixed solution of lysate and sample (i.e. the liquid to be heated) in the tube body 202, which helps to release nucleic acid from cells in the sample more quickly, laying a foundation for subsequent nucleic acid extraction. The heating device in the embodiment has a simple structure, and the heating member 3 is arranged at the bottom of the accommodation space 101 of the moving carrier 1, realizing integrated design of the moving carrier 1 and the heating member 3, improving the space utilization of the accommodation space 101, which can heat the liquid to be heated, so that the nucleic acid can be cracked in a heated cracking manner, and also reduces the overall space occupied by the moving carrier 1 and the heating member 3, which is conducive to reducing the volume of the heating device and the nucleic acid extraction device, and is conducive to realizing the miniaturization design of the heating device and the nucleic acid extraction device, and can enable the nucleic acid extraction device to be directly placed in a biological safety cabinet.

[0036] In an embodiment of the present application, the nucleic acid extraction device further includes a shaking device 4, and the vertical side wall of the moving carrier 1 further forms a probe access opening 102 for the probe part 401 of the shaking device 4 to extend into the accommodation space 101.

[0037] Specifically, the oscillation device 4 in the embodiment can be an ultrasonic oscillation device arranged on the side of the mobile carrier 1 where the probe access opening 102 is located. The ultrasonic oscillation device is provided with a retractable probe part 401 for outputting ultrasonic waves. When ultrasonic oscillation is needed, the probe part 401 is driven to extend and protrude into the accommodation space 101 from the probe access opening 102, so that the probe part 401 can abut against the reagent strip 2 in the accommodation space 101, and the probe part 401 transmits ultrasonic waves to the reagent strip 2 to perform ultrasonic oscillation on the solution inside the reagent strip 2, so that the nucleic acid in the solution is subjected to ultrasonic lysis. Further, when the nucleic acid is subjected to ultrasonic lysis, the solution (i.e., the liquid to be heated) inside the reagent strip 2 is heated by using a heating device, which is beneficial to further improving the effect and efficiency of nucleic acid lysis. After the ultrasonic oscillation is completed, the probe part 401 is driven to retract and exit from the probe access opening 102 to the accommodation space 101. In the embodiment, the arrangement of the probe access opening 102 on the mobile carrier 1 enables the nucleic acid in the solution inside the reagent strip 2 to be subjected to ultrasonic lysis, and also enables the nucleic acid to be subjected to ultrasonic lysis as the main method and heating lysis as the auxiliary method, thereby increasing the lysis method of the nucleic acid and expanding the application range of the nucleic acid extraction equipment.

[0038] In an embodiment of the present application, the heating member 3 is formed with an accommodation groove 301 recessed from top to bottom and used for accommodating part of the tube body 202 of the reagent strip 2. After the reagent strip 2 is placed, the bottom of the tube body 202 falls into the accommodation groove 301. The arrangement of the accommodation groove 301 reduces the shaking of the tube body 202 inside the accommodation space 101, improves the stability of the tube body 202 after being placed, and is beneficial to improving the heating and nucleic acid extraction effect.

[0039] In an embodiment of the present application, the contour of the accommodation groove 301 is consistent with the contour of the bottom wall of the tube body 202. This arrangement can not only avoid stress concentration on the bottom of the tube body 202 and protect the tube body 202, but also improve the uniformity of heating and further improve the heating effect of the liquid to be heated.

[0040] In an embodiment of the present application, the number of heating members 3 is multiple. The multiple heating members 3 include a first heating member for heating the lysis liquid and a second heating member for heating the elution liquid. Further, in the embodiment, the number of second heating members is one, the number of first heating members is multiple, and the multiple first heating members are integrated. The second heating member and the first heating member are distributed at intervals in the length direction of the reagent tube carrier 1.

[0041] In an embodiment of the present application, the heating member 3 includes a base part 302 and a stop part 303. The accommodation groove 301 is formed on the base part 302, and the stop part 303 is arranged on the top of the base part 302 and can exert a lateral stop force on the tube body 202.

[0042] Specifically, in the embodiment, the first heating member and the second heating member are both formed with the base portion 302, the first heating member is provided with the stop portion 303 (the second heating member is not provided with the stop portion 303), and the nucleic acid extraction device further comprises a shaking device 4 for shaking the liquid to be heated in the tube body 202, the shaking device 4 applies a shaking force to the tube body 202 heated by the first heating member from a side away from the stop portion 303, when the shaking device 4 performs the shaking operation, the stop portion 303 plays a role of stopping the tube body 202, and the shaking force and the lateral stopping force are located at opposite radial sides of the tube body 202, so that the setting of the stop portion 303 can further enhance the stability of the tube body 202 when it is shaken, and is beneficial to improving the shaking effect.

[0043] In an embodiment of the present application, the stop portion 303 is formed with an arc-shaped wall 304 capable of abutting against the outer circumferential wall of the tube body 202 on a side facing the tube body 202, and the setting of the arc-shaped wall 304 can make the force applied to the tube body 202 more uniform when the tube body 202 contacts the stop portion 303, so as to avoid damage of the tube body 202 due to concentrated force.

[0044] In an embodiment of the present application, the heating member 3 comprises a heat-conducting body 305 and a heat-generating body (not shown in the figure), the heat-generating body is used for emitting heat, the heat-conducting body 305 is connected with the heat-generating body and is used for transferring heat from the heat-generating body to the liquid to be heated, and the base portion 302 and the stop portion 303 are both formed on the heat-conducting body 305. Further, in the embodiment, the heat-conducting body 305 is made of aluminum alloy, which has the advantages of low cost and fast heat conduction, and effectively guarantees the heating effect of the heating member 3 on the liquid to be heated.

[0045] In an embodiment of the present application, the heating device further comprises a first heat insulation member 5 embedded in the moving carrier 1 and located below the heating member 3.

[0046] Specifically, in the embodiment, the material of the moving carrier 1 can be aluminum alloy, which has the advantages of light weight and low cost, and the setting of the first heat insulation member 5 can insulate the heat of the heating member 3, so as to avoid damage of other components connected with the moving carrier 1 due to the heat transfer of the heating member 3, and is beneficial to prolonging the service life of the heating device and the nucleic acid extraction device. Further, the height of the top surface of the first heat insulation member 5 is greater than or equal to the height of the bottom wall of the accommodating space 101, and in the case that the height of the top surface of the first heat insulation member 5 is greater than the height of the bottom wall of the accommodating space 101, the first heat insulation member 5 will not interfere with the tube body 202 beside the heating member 3 on the reagent strip 2.

[0047] In an embodiment of the present application, as shown in FIG. 6, the heating device further comprises a second heat insulation member 6 embedded in the moving carrier 1 and located below the heating member 3. Figure 5As shown, the heating device further comprises a second heat insulation member 9 arranged below the first heat insulation member 5 and used for upwardly pressing against the first heat insulation member 5. Specifically, the lower portion of the second heat insulation member 9 in the embodiment is further provided with other components (such as a control circuit board), and the arrangement of the second heat insulation member 9 can further avoid the downward transmission of heat of the heating member 3, thereby protecting the components below the second heat insulation member 9.

[0048] In an embodiment of the present application, as shown in Figure 5 As shown, the heating device further comprises a leakage-proof cover plate 12 arranged below the second heat insulation member 9. Specifically, the control circuit board 11 is used for controlling the heating device, and the leakage-proof cover plate 12 is arranged between the second heat insulation member 9 and the control circuit board 11. The arrangement of the leakage-proof cover plate 12 can avoid the solution accidentally leaked from the reagent strip 2 from downwardly penetrating through the bottom wall of the containing space 101 to drop onto the control circuit board 11, thereby providing good protection for the control circuit board 11 and further improving the use reliability of the heating device.

[0049] In an embodiment of the present application, the heating device further comprises a moving guide rail 6, and the moving guide rail 6 is arranged inside a bin body of the nucleic acid extraction device. The moving carrier 1 is movably arranged on the moving guide rail 6 and can move to the outside of the bin body.

[0050] Specifically, the bin body is formed with an ejection opening, and the moving guide rail 6 is arranged inside the bin body (not shown in the figure) and aligned with the ejection opening. The nucleic acid extraction device further comprises a driving mechanism 8 drivingly connected with the moving carrier 1. Under the driving action of the driving mechanism 8, the moving carrier 1 can move to the outside of the bin body through the ejection opening. The above arrangement can make the moving carrier 1 move to the outside of the bin body when it is necessary to place or replace the reagent strip 2. In this case, the moving carrier 1 and the driving mechanism 8 are stably and firmly connected together and will not be tilted, thereby facilitating the operator to directly place the reagent strip 2 into the containing space 101 or take the reagent strip 2 out of the containing space 101, without the need to first move the moving carrier 1 out of the bin body and then take the reagent strip 2 off the moving carrier 1, thereby improving the convenience of installation or replacement of the reagent strip 2 and being beneficial to improving the efficiency of nucleic acid extraction.

[0051] Further, the heating device further comprises a bin door which is reversibly arranged on the bin body and located at the position of the ejection opening, as shown in Figure 4As shown, the mobile carrier 1 is further provided with a pushing part 13 on the vertical side wall of the mobile carrier 1 towards the side of the door, which is used to apply a pushing force to the door. Specifically, the pushing part 13 protrudes from the vertical side wall of the mobile carrier 1 towards the side of the door, and when the mobile carrier 1 moves out of the bin with the reagent strip 2, the pushing part 13 contacts the door first and applies a pushing force to the door with the continuous movement of the mobile carrier 1, so that the door can be flipped relative to the bin body under the action of the pushing force and the ejection opening is exposed, thereby enabling the mobile carrier 1 and the reagent strip 2 to be smoothly ejected from the bin and avoiding the situation that the door is difficult to be pushed open.

[0052] In an embodiment of the present application, the heating device further comprises;

[0053] a temperature detection member for detecting the temperature of the heat-conducting body 305 of the heating member 3;

[0054] a temperature protection switch for controlling the heating body to stop heating when the temperature of the heating body of the heating member 3 exceeds a preset temperature.

[0055] Specifically, the temperature detection member (not shown in the figure) can be a temperature sensor and is arranged inside the heat-conducting body 305 of the heating member 3, and the arrangement of the temperature detection member is conducive to improving the accuracy of the temperature control of the liquid to be heated and improving the efficiency of the nucleic acid lysis. The temperature protection switch (not shown in the figure) is arranged on the heating body of the heating member 3 and is in communication connection with the heating body, which can directly detect the temperature of the heating body and can also control the heating body to stop heating when the temperature of the heating body exceeds a preset temperature, so as to form an overheat protection, avoid the structure damage of the reagent strip 2 due to the high temperature of the reagent strip 2, and also avoid the volatilization of the solution to be heated due to the high temperature of the solution to be heated and cause environmental pollution.

[0056] In an embodiment of the present application, the heating device further comprises a clamping assembly 7 arranged on the mobile carrier 1 and used to clamp the reagent strip 2.

[0057] Specifically, one side of the mobile carrier 1 is formed with a first avoiding gap 103, the other side of the mobile carrier 1 is formed with a second avoiding gap 104 opposite to the first avoiding gap 103, the first avoiding gap 103 and the second avoiding gap 104 are both through along the length direction of the mobile carrier 1 and both communicate with the accommodating space 101, the mobile carrier 1 has a first partition 105 between the first end of the first avoiding gap 103 and the first end of the second avoiding gap 104, and has a second partition 106 between the second end of the first avoiding gap 103 and the second end of the second avoiding gap 104. The clamping assembly 7 comprises a first clamping piece 701, a second clamping piece 702, a first connecting piece 703, a second connecting piece 704, a first elastic piece (not shown in the figure) and a second elastic piece (not shown in the figure), the first clamping piece 701 is arranged at the position of the first avoiding gap 103, the second clamping piece 702 is arranged at the position of the second avoiding gap 104, one end of the first connecting piece 703 is connected with the first clamping piece 701, the other end of the first connecting piece 703 (such as a bolt) passes through the first partition 105 and is connected with the second clamping piece 702, one end of the second connecting piece 704 (such as a bolt) is connected with the first clamping piece 701, the other end of the second connecting piece 704 passes through the second partition 106 and is connected with the second clamping piece 702, the accommodating space 101 is between the first clamping piece 701, the second clamping piece 702, the first partition 105 and the second partition 106; the first elastic piece can be a spring and is sleeved outside the first connecting piece 703, one end of the first elastic piece abuts against the first clamping piece 701, and the other end of the first elastic piece abuts against the first partition 105, the second elastic piece can be a spring and is sleeved outside the second connecting piece 704, one end of the second elastic piece abuts against the first clamping piece 701, and the other end of the second elastic piece abuts against the second partition 106, when the first elastic piece and the second elastic piece are compressed or restored to the original state, the first clamping piece 701, the second clamping piece 702, the first connecting piece 703 and the second connecting piece 704 can move as a whole relative to the mobile carrier 1 (the moving direction is the width direction of the mobile carrier 1).

[0058] Further, the side wall of the accommodation space 101 near the second clamping piece 702 is formed with a guide wall 107 for guiding the reagent strip 2. When the operator installs the reagent strip 2, the reagent strip 2 can more easily enter the accommodation space 101 under the guidance of the guide wall 107. Then the operator continues to apply a downward force to the reagent strip 2. Under the action of the force, the reagent strip 2 continues to move downward. In the process of the downward movement of the reagent strip 2, a pushing force is applied to the second clamping piece 702 in a direction away from the first clamping piece 701. The first clamping piece 701, the second clamping piece 702, the first connecting piece 703 and the second connecting piece 704 move as a whole in the direction of the second clamping piece 702. The first elastic piece and the second elastic piece are compressed. After the reagent strip 2 is moved into position, the second clamping piece 702 continuously applies a pushing force to the reagent strip 2 under the elastic force of the first elastic piece and the second elastic piece. The second clamping piece 702 and the vertical side wall of the accommodation space 101 away from the second clamping piece 702 jointly clamp the reagent strip 2 to further enhance the stability of the reagent strip 2 after installation, which is conducive to further improving the oscillation effect on nucleic acid.

[0059] When the reagent strip 2 needs to be taken out, the operator applies a pushing force to the first clamping piece 701 in the direction of the second clamping piece 702. The first elastic piece and the second elastic piece are further compressed to move the first clamping piece 701, the second clamping piece 702, the first connecting piece 703 and the second connecting piece 704 as a whole in the direction of the second clamping piece 702 to release the clamping action of the second clamping piece 702 and the vertical side wall of the accommodation space 101 away from the second clamping piece 702 on the reagent strip 2. Then an upward force is applied to the reagent strip 2 to take out the reagent strip 2. The reagent strip 2 can be conveniently taken out, which improves the use convenience and reliability of the heating device.

[0060] Another embodiment of the present application provides a nucleic acid extraction device, which comprises the heating device for the nucleic acid extraction device in the above-described embodiments.

[0061] In the description of the present application, it should be understood that the terms “first” and “second” are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with “first” and “second” can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of “a plurality of” is at least two, for example, two, three, etc., unless otherwise specifically limited.

[0062] In this application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting", "fixing" and the like should be understood in a broad sense, for example, can be fixed connection, can also be detachable connection, or integral; can be mechanical connection, can also be electrical connection or communication with each other; can be directly connected, can also be indirectly connected through an intermediate medium, can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise explicitly limited. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.

[0063] In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "example", "specific example" or "some examples" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples. Furthermore, the skilled in the art can combine and combine the different embodiments or examples described in the present specification and the features of the different embodiments or examples without contradiction.

[0064] Although the embodiments of the present application have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limiting the present application, and those skilled in the art can make changes, modifications, replacements and variations to the above embodiments within the scope of the present application.

Claims

1. A heating device for a nucleic acid extraction apparatus, characterized by, The heating device comprises: a moving carrier (1) having a containing space (101) formed on the moving carrier (1) and recessed from top to bottom and used for partially containing a reagent strip (2) of a nucleic acid extraction device; a heating piece (3) arranged at the bottom of the containing space (101) and used for heating a liquid to be heated inside the reagent strip (2).

2. The heating device for a nucleic acid extraction apparatus according to claim 1, wherein The heating piece (3) has a containing groove (301) formed on the heating piece (3) and recessed from top to bottom and used for containing a part of a tube body (202) of the reagent strip (2).

3. The heating device for a nucleic acid extraction apparatus according to claim 2, wherein The heating piece (3) comprises a base portion (302) and a stop portion (303), the containing groove (301) is formed on the base portion (302), and the stop portion (303) is arranged at the top of the base portion (302) and can apply a lateral stop force to the tube body (202).

4. The heating device for a nucleic acid extraction apparatus according to claim 3, wherein The stop portion (303) has an arc-shaped wall (304) formed on the side of the stop portion (303) facing the tube body (202) and capable of abutting against the outer circumferential wall of the tube body (202).

5. The heating device for a nucleic acid extraction apparatus according to claim 1, wherein The nucleic acid extraction device further comprises a shaking device (4), and the vertical side wall of the moving carrier (1) further has a probe inlet and outlet (102) for allowing a probe portion (401) of the shaking device (4) to extend into the containing space (101).

6. The heating device for a nucleic acid extraction apparatus according to claim 1, wherein The heating device further comprises a first heat insulation piece (5) embedded on the moving carrier (1) and below the heating piece (3).

7. The heating device for a nucleic acid extraction apparatus according to claim 1, wherein The heating device further comprises a moving guide rail (6) arranged inside a storage body of the nucleic acid extraction device, and the moving carrier (1) is movably arranged on the moving guide rail (6) and can move to the outside of the storage body.

8. The heating device for a nucleic acid extraction apparatus according to claim 1, wherein The heating device further comprises: a temperature detecting piece used for detecting the temperature of a heat conducting body (305) of the heating piece (3); a temperature protection switch used for controlling the heat generating body of the heating piece (3) to stop generating heat when the temperature of the heat generating body exceeds a preset temperature.

9. The heating device for a nucleic acid extraction apparatus according to claim 1, wherein The heating device further comprises a clamping assembly (7) arranged on the moving carrier (1) and used for clamping the reagent strip (2).

10. A nucleic acid extraction apparatus, characterized by, The nucleic acid extraction device comprises the heating device for a nucleic acid extraction device according to any one of claims 1-9.

Images