Novel human nasal cavity upper drug delivery device

Abstract

The utility model discloses a novel human nasal cavity upper portion dosing device, which belongs to the technical field of medical instruments and comprises a J-shaped dosing device, the J-shaped tip of the dosing device is provided with a dosing outlet, a dosing assembly and a dosing pipeline communicated with the dosing assembly are arranged in the dosing device, and the dosing pipeline is communicated with the dosing assembly. One end of the dosing pipeline extends out of the dosing outlet, a connecting base is detachably connected to the dosing outlet, an air bag is fixedly installed on the connecting base, a connecting opening is formed in the end, away from the connecting base, of the air bag, and the connecting opening can be fixedly connected to the end, extending out of the dosing outlet, of the dosing pipeline in a sleeved mode. An air inflation assembly used for inflating the air bag is arranged in the dosing device, and the air inflation assembly inflates the air bag so that the air bag can be expanded to drive the dosing pipeline to extend into the nasal cavity. The medicine delivery device can effectively deliver medicine to an olfaction area, and has the advantages of being easy to operate, small in irritation to the nasal cavity of a patient and the like.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to a novel human nasal cavity upper part dosing device. BACKGROUND

[0002] In recent years, intranasal drug delivery as a promising approach to improve the therapeutic efficacy of neurological diseases has attracted great interest. Transnasal-brain drug delivery provides a unique and direct route to the brain, which can bypass the blood-brain barrier and offer potential solutions to challenges associated with traditional drug delivery strategies. It can deliver therapeutic drugs, such as arginine vasopressin, angiotensin II, insulin and oxytocin, directly to the brain, showing promise in various neurological diseases. Intranasal drug delivery has the advantages of fast onset, increased drug bioavailability, reduced systemic adverse reactions and enhanced brain targeting. In addition, relatively high bioavailability, low risk of injury during application and non-invasive self-administration can help improve cost-effectiveness and patient compliance.

[0003] More and more studies have confirmed that drugs delivered to the olfactory region of the upper nasal cavity can be absorbed more quickly and extensively compared to those delivered to the lower nasal cavity, and in addition, the olfactory region is the main area of drug absorption in the transnasal-brain drug delivery route. Due to the complexity of the nasal cavity structure, traditional nasal spray pumps can only deliver drugs to the front and lateral sides of the nasal cavity, and less than 3% of the dose can reach the olfactory region, which seriously affects the efficiency of transnasal-brain drug delivery. Other intranasal drug delivery devices, such as nasal drops, require patients to be in a suitable body position during drug delivery, which also limits the use of such devices. Currently, some intranasal drug delivery products, such as Vianase™, Optinose Opt-Powder™ and Impel POD, have been developed abroad, and they show significantly more dose reaching the olfactory region after drug delivery. However, the effectiveness of Vianase™ has not been confirmed in large-sample studies, and Optinose Opt-Powder™ and Impel POD require users to exhale from the mouth to provide power, which can force the soft palate to close and reduce the dose of drugs reaching the lungs, but many patients with reduced lung function or cognitive impairment may have difficulty using the device correctly.

[0004] In view of the complexity of the nasal cavity structure and the necessity of drug delivery to the olfactory region in transnasal-brain drug delivery, we designed a new intranasal drug delivery device. It can effectively deliver drugs to the olfactory region, while also having the advantages of simple operation and less irritation to the nasal cavity of patients. SUMMARY

[0005] Therefore, the novel human nasal cavity upper part drug delivery device aims at the complexity of nasal cavity structure and the necessity of olfactory region drug delivery in nasal-brain drug delivery, can effectively deliver drugs to the olfactory region, and has the advantages of simple operation, less stimulation to the patient's nasal cavity and the like.

[0006] To achieve the above object, the utility model provides the following technical scheme:

[0007] The utility model provides a novel human nasal cavity upper part drug delivery device, including the dosing device, the dosing device sets up J shape, is equipped with the dosing outlet at the J shape tip of dosing device, be equipped with dosing assembly and dosing pipeline communication with dosing assembly in dosing device, dosing pipeline one end extends out dosing outlet setting, the dosing outlet can detachably connect with the connecting base, the connecting base is fixedly installed with air bag, the air bag is equipped with the connecting port away from the connecting base end, the connecting port can be connected in the dosing pipeline extension dosing outlet end fixed, be equipped with the inflation assembly for the air bag inflation in dosing device, the inflation assembly can make the air bag inflation to drive dosing pipeline to extend to the nasal cavity in the air bag.

[0008] Further, the dosing assembly includes a storage bag one arranged in the dosing device, the storage bag one is communicated with a storage bag two through a one-way valve, the storage bag one is slidably installed with an extrusion plate, sliding the extrusion plate can make the liquid medicine in the storage bag one flow into the storage bag two, the dosing device is provided with a first sliding groove communicated with the storage bag two, the first sliding groove is connected with a dosing button through a first spring, the storage bag two is communicated with the dosing pipeline, and pressing the dosing button can make the liquid medicine in the storage bag two be inhaled through the dosing pipeline.

[0009] Further, a sliding knob is slidably installed on the dosing device shell, the sliding knob is fixedly connected with the extrusion plate through a connecting rod, a dosage scale is arranged on one side of the sliding knob on the dosing device shell, and the sliding knob can control the dosage according to the dosage scale.

[0010] Further, the connecting base is provided with an inflation channel communicated with the inflation assembly and the air bag, and the inflation assembly can inflate the air bag through the inflation channel.

[0011] Further, a second sliding groove is arranged on the dosing device, the inflation assembly includes an inflation button slidably installed in the second sliding groove, the second sliding groove is provided with an inflation pipeline in communication, and the inflation pipeline is provided in communication with the inflation channel.

[0012] Further, the J-shaped tip of the administration device is provided with a positioning block, the positioning block is internally provided with a through hole in communication with the inflation pipeline, the connecting base is provided with a connecting hole matched with the positioning block, and the connecting base is sleeved on the positioning block through the connecting hole to form an inflation passage through the through hole.

[0013] Further, the administration pipeline extends out of the administration outlet end and is fixedly connected with a baffle, and the diameter of the baffle is greater than that of the administration outlet.

[0014] The beneficial effects of the present application are as follows:

[0015] The present application can effectively deliver drugs to the olfactory region, and has the advantages of simple operation, less stimulation to the nasal cavity of the patient, etc.

[0016] The other advantages, objects and features of the present application will be described in the following specification, and are obvious to those skilled in the art or can be taught by those skilled in the art from the practice of the present application. The objects and other advantages of the present application can be achieved and obtained by the following specification. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to make the objects, technical solutions and beneficial effects of the present application clearer, the present application provides the following drawings for illustration:

[0018] Figure 1 The present application is a whole structure sectional view;

[0019] Figure 2 The present application is an administration device structure schematic view;

[0020] Figure 3 The present application is a structure sectional view of the air bag traction mechanism when the air bag is retracted;

[0021] Figure 4 The present application is a structure sectional view of the air bag traction mechanism when the air bag is inflated;

[0022] Figure 5 The present application is an installation sectional view of the extrusion plate.

[0023] The drawings are marked as follows: a dosing device 1, a first medicine storage bag 101, a second medicine storage bag 102, a first sliding groove 103, a first spring 104, a dosing button 105, a dosing pipeline 106, a dosing outlet 107, a baffle 108, a positioning block 109, a through hole 110, a gas bag traction mechanism 2, a base 201, a gas bag 202, an inflation channel 203, a connecting port 204, a connecting hole 205, an inflation assembly 3, a second sliding groove 301, an inflation button 302, a second spring 303, an inflation pipeline 304, a pressing plate 4, a connecting rod 401, a sliding knob 402. DETAILED DESCRIPTION

[0024] As Figures 1-5 shown, the utility model provides a novel human nasal cavity upper part dosing device, include: dosing device 1, dosing device 1 is arranged in J shape, and the J shape tip of dosing device 1 is equipped with dosing outlet 107, dosing device 1 is equipped with dosing assembly and with dosing assembly intercommunication dosing pipeline 106, dosing pipeline 106 one end extends out dosing outlet 107 and is movably arranged, dosing outlet 107 is detachably connected with gas bag traction mechanism 2, gas bag traction mechanism 2 includes the connecting base 201 of setting on dosing outlet 107 and the gas bag 202 of fixed mounting on connecting base 201, connecting base 201 is equipped with with inflation assembly 3 and gas bag 202 all intercommunication inflation channel 203, dosing device 1 is equipped with the inflation assembly 3 for the inflation of gas bag traction mechanism 2, and inflation assembly 3 can be inflated into gas bag 202 through inflation channel 203, the end of gas bag 202 away from connecting base 201 is equipped with connecting port 204, and connecting port 204 is fixedly connected with the end of dosing pipeline 106 extending out dosing outlet 107, and gas bag 202 inflation state can drive dosing pipeline 106 to extend into nasal cavity,

[0025] The drug administration assembly comprises a first drug storage bag 101 arranged in the drug administration device 1, the first drug storage bag 101 is communicated with a second drug storage bag 102 through a one-way valve, the drug administration device 1 is provided with a first sliding groove 103 communicated with the second drug storage bag 102, the first sliding groove 103 is connected with a drug administration button 105 through a first spring 104, the second drug storage bag 102 is connected with a drug administration pipeline 106, one end of the drug administration pipeline 106 is arranged at a drug administration outlet 107, a pressing plate 4 is slidably arranged in the first drug storage bag 101, sliding the pressing plate 4 can make the drug liquid in the first drug storage bag 101 flow into the second drug storage bag 102, and through sliding the pressing plate 4, the quantitative drug administration can be realized, wherein the pressing plate 4 is fixedly connected with a connecting rod 401, one end of the connecting rod 401 extends out of the drug administration device 1 and is fixedly connected with a sliding knob 402, in actual operation, through sliding the sliding knob 402 by an operator, the pressing plate 4 can slide in the first drug storage bag 101, the specific dose of the drug liquid in the first drug storage bag 101 can enter the second drug storage bag 102 through the one-way valve, and pressing the drug administration button 105 can make the drug liquid in the second drug storage bag 102 flow through the drug administration pipeline 106 and be administered intranasally.

[0026] The drug administration device 1 is provided with a second sliding groove 301, the inflation assembly 3 comprises an inflation button 302 slidably arranged in the second sliding groove 301, the inflation button 302 is sealingly connected with the second sliding groove 301, the inflation button 302 is connected with the inner wall of the second sliding groove 301 through a second spring 303, the second sliding groove 301 is communicated with an inflation pipeline 304, one end of the inflation pipeline 304 extends out of the drug administration outlet 107 and is sealingly connected with the inflation channel 203, when the inflation assembly 3 is inflated, the inflation button 302 is pressed, the air bag 202 can be inflated, after the drug administration is completed, the inflation button 302 is released, the inflation button 302 is reset under the action of the second spring 303, and the air bag 202 is retracted.

[0027] In the scheme, when the air bag traction mechanism 2 is connected with the dosing device 1, the connecting base 201 is sleeved on the dosing outlet 107, the connecting base 201 is made of elastic material, can wrap the J-shaped tip of the dosing device 1 and is fixed by friction connection, and the connecting port 204 on the air bag 202 is inserted with the dosing pipeline 106 and is fixed by friction; before dosing, inflation operation needs to be performed: the inflation button 302 is pressed, air in the second sliding groove 301 is injected into the air bag 202 through the inflation pipeline 304, the air bag 202 is inflated to drive the dosing pipeline 106 to extend into the nasal cavity along the air bag 202; when dosing, the one-way valve is arranged between the medicine storage bag one 101 and the medicine storage bag two 102, the liquid medicine in the medicine storage bag one 101 can only flow into the medicine storage bag two 102 in one direction, the structure and principle of the one-way valve are well known to those skilled in the art, and will not be described here, after the liquid medicine in the medicine storage bag one 101 flows into the medicine storage bag two 102, the liquid medicine in the medicine storage bag two 102 is injected into the upper part of the nasal cavity through the dosing pipeline 106 by pressing the dosing button 105.

[0028] The scheme has the advantages that the structure is designed, the complexity of the nasal cavity structure and the necessity of the olfactory area dosing in the nasal-brain dosing can effectively deliver the medicine to the olfactory area, and the operation is simple, the nasal cavity stimulation to the patient is small and the like.

[0029] In an embodiment of the utility model, the dosing pipeline 106 extends out the dosing outlet 107 end fixed connection has the baffle 108, the diameter of baffle 108 is greater than the diameter of dosing outlet 107, to prevent dosing pipeline 106 retract to the inside of dosing device 1, cause dosing pipeline 106 is not convenient and air bag 202 connect.

[0030] In an embodiment of the utility model, the J-shaped tip of dosing device 1 is provided with a positioning block 109, a through hole 110 in communication with the inflation pipeline 304 is arranged in the positioning block 109, a connecting hole 205 matched with the positioning block 109 is arranged on the connecting base 201, and the connecting base 201 is sleeved on the positioning block 109 through the connecting hole 205 to form the inflation channel 203.

[0031] In the scheme, the positioning block 109 is arranged to facilitate the alignment of the connecting base 201 with the positioning block 109 through the connecting hole 205, so that the connecting base 201 is positioned and installed at the J-shaped tip of the dosing device 1.

[0032] Finally, it is pointed out that the above preferred embodiments are only used to illustrate the technical scheme of the utility model and not to limit, although the utility model has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined in the claims of the utility model.

Claims

1. A novel device for administering a substance to the upper part of the human nasal cavity, comprising an applicator, characterised in that: The administration device is J-shaped, and a administration outlet is arranged at the J-shaped tip of the administration device.

2. The novel human upper nasal cavity drug delivery device according to claim 1, characterized in that: The administration assembly comprises a first medicine storage bag arranged in the administration device, the first medicine storage bag is communicated with a second medicine storage bag through a one-way valve, an extrusion plate is slidably arranged in the first medicine storage bag, and sliding the extrusion plate can make the medicine liquid in the first medicine storage bag flow into the second medicine storage bag.

3. The novel human upper nasal cavity drug delivery device according to claim 2, wherein: A slide button is slidably arranged on the administration device shell, the slide button is fixedly connected with the extrusion plate through a connecting rod, a medicine amount scale is arranged on one side of the slide button on the administration device shell, and sliding the slide button can control the administration dose according to the medicine amount scale.

4. The novel upper human nasal cavity drug delivery device according to claim 2, wherein: The connecting base is provided with an inflation channel communicated with the inflation assembly and the air bag.

5. The novel upper human nasal cavity drug delivery device according to claim 3, wherein: The administration device is provided with a second sliding groove, the inflation assembly comprises an inflation button slidably arranged in the second sliding groove, the second sliding groove is provided with an inflation pipeline in communication, and the inflation pipeline is provided in communication with the inflation channel.

6. The novel upper human nasal cavity drug delivery device according to claim 4, wherein: The J-shaped tip of the administration device is provided with a positioning block, the positioning block is internally provided with a through hole communicated with the inflation pipeline, the connecting base is provided with a connecting hole matched with the positioning block, and the connecting base is sleeved on the positioning block through the connecting hole to form the inflation channel through the through hole.

7. The novel upper human nasal cavity drug delivery device according to claim 5, wherein: The administration pipeline is fixedly connected with a baffle at the end extending out of the administration outlet, and the diameter of the baffle is greater than that of the administration outlet.

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