Ultrasonic nerve regulation and control treatment device

Abstract

The utility model discloses an ultrasonic nerve regulation and control treatment device which comprises an ultrasonic phased array transmitting system which comprises a phased array driving module and a time-delay transmitting module, and the phased array driving module receives control parameters from an upper computer to drive the time-delay transmitting module to transmit periodic square wave signals corresponding to the control parameters; the phased array probe comprises an ultrasonic transducer array and a probe body, the probe body is provided with a window, a body of the ultrasonic transducer array is configured in the probe body, and a transmitting plane of the ultrasonic transducer array is coupled to the window. And each array element in the ultrasonic transducer array is in signal connection with the delay transmitting module. The control parameters are received from the upper computer to generate periodic square wave signals for driving array elements of the phased array probe, so that an ultrasonic transducer array in the phased array probe can generate modulated ultrasonic waves focusing on a target point location, and ultrasonic non-destructive treatment is carried out on target nervous tissue.

Description

Technical Field

[0001] This utility model relates to the field of ultrasound medical technology, and in particular to an ultrasound neuromodulation therapy device. Background Technology

[0002] Ultrasound waves are highly directional and their energy is easily concentrated, allowing them to penetrate the skin and converge under the skin. In recent years, the application of ultrasound in medicine has expanded beyond medical imaging to include tumor treatment and the treatment of brain diseases. In the treatment of brain diseases such as epilepsy, anxiety, and migraines, short-term ultrasound exposure can modulate ion channels to affect neuronal excitability, thereby influencing brain activity.

[0003] However, there is currently a lack of mature and widely used treatment products on the market. Utility Model Content

[0004] The purpose of this invention is to provide an ultrasonic neuromodulation therapy device that receives control parameters from a host computer to generate periodic square wave signals to drive the array elements of a phased array probe, thereby enabling the ultrasonic transducer array in the phased array probe to generate modulated ultrasonic waves focused on the target point for non-invasive ultrasonic treatment of the target nerve tissue.

[0005] The technical solution provided by this utility model is: an ultrasonic neuromodulation therapy device, comprising:

[0006] An ultrasonic phased array transmitting system includes a phased array driving module and a delayed transmission module. The phased array driving module receives control parameters from a host computer and drives the delayed transmission module to transmit a periodic square wave signal corresponding to the control parameters.

[0007] A phased array probe includes an ultrasonic transducer array and a probe body. The probe body has a window, the body of the ultrasonic transducer array is disposed inside the probe body and the emission plane of the ultrasonic transducer array is coupled to the window, and each element in the ultrasonic transducer array is signal-connected to the delay emission module.

[0008] Preferably, the delayed transmission module includes a pulse delay value register, a pulse width register, a pulse quantity register, a phase-locked loop module, an internal clock, a control signal synchronization signal generator, a pulse delay timing module, a periodic pulse generator, and a pulse quantity control module. The pulse delay value register, pulse width register, and pulse quantity register respectively store the corresponding pulse delay value, pulse width, and pulse quantity from the control parameters issued by the host computer. The phase-locked loop module is connected to the internal clock signal, which provides clock signals to the control signal synchronization signal generator, the pulse delay timing module, the periodic pulse generator, and the pulse quantity control module. The periodic pulse generator generates periodic pulse signals based on the pulse width data. The pulse delay timing module performs delay processing on each pulse according to the value in the pulse delay value register. The control signal synchronization signal generator generates a control signal synchronized with the pulse signal to coordinate the work of each module. The pulse quantity control module monitors the number of transmitted pulses and stops transmission when a preset value is reached, thereby completing the entire transmission sequence.

[0009] Preferably, the ultrasonic phased array transmitting system further includes a converter, the input terminal of which is signal-connected to the output terminal of the delayed transmission module, and the multiple output terminals of the converter are signal-connected to each element of the ultrasonic transducer array in a one-to-one correspondence.

[0010] Preferably, the acoustic field intensity of the ultrasonic transducer array is less than 3 W / cm². 2 The center emission frequency of the ultrasonic transducer array is 2MHz.

[0011] Preferably, the ultrasonic transducer array consists of 16*16 array elements, with a center-to-center spacing of 1.1mm-1.3mm and an element size of 1mm×1mm.

[0012] Preferably, the focusing depth of the ultrasonic transducer array is 10mm-30mm.

[0013] Preferably, the ultrasonic transducer array is a piezoelectric ceramic transducer array, including a matching layer, a piezoelectric layer and a backing layer. The piezoelectric ceramic generates high-frequency vibrations through the inverse piezoelectric effect to produce ultrasonic waves, which are emitted through the matching layer and act on the target object.

[0014] Preferably, a cable connector is provided on the proximal side of the probe body, and each element of the ultrasonic transducer array is connected to each unit of the converter in the ultrasonic phased array transmitting system via the cable connector.

[0015] Preferably, the cross-section of the probe body perpendicular to its length extension direction is square, and the side length of the square is 2cm-3cm.

[0016] Compared with the prior art, the present invention has the following advantages:

[0017] The ultrasonic neuromodulation therapy device includes an ultrasonic phased array transmitting system and a phased array probe. The ultrasonic phased array transmitting system is used to receive control parameters from the host computer to generate periodic square wave signals to drive the array elements of the phased array probe, thereby enabling the ultrasonic transducer array in the phased array probe to generate modulated ultrasonic waves focused on the target point, and perform non-invasive ultrasonic treatment on the target nerve tissue, such as treating epilepsy, anxiety, migraine, etc. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the ultrasonic neuromodulation therapy device of this utility model;

[0019] Figure 2 This is a schematic diagram of the delayed transmission module of this utility model;

[0020] Figure 3 This is the phased array probe of this utility model;

[0021] Figure 4 This is the phased array probe of this utility model;

[0022] Figure 5 This is a cross-sectional view of the phased array probe of this utility model.

[0023] Explanation of reference numerals in the attached figures:

[0024] 1-Phase array probe; 101-Ultrasonic transducer array; 102-Probe body; 1021-Window; 1022-Elastic fixing hook; 1023-Cable connector. Detailed Implementation

[0025] The following specific examples illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. This utility model can also be implemented or applied through other different specific embodiments, and various details in this specification can be modified or changed based on different viewpoints and applications without departing from the spirit of this utility model. It should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0026] It should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0027] Example

[0028] The technical solution of this embodiment is: an ultrasound neuromodulation therapy device, comprising:

[0029] An ultrasonic phased array transmitting system includes a phased array driving module and a delayed transmission module. The phased array driving module receives control parameters from a host computer and drives the delayed transmission module to transmit a periodic square wave signal corresponding to the control parameters.

[0030] The phased array probe 1 includes an ultrasonic transducer array 101 and a probe body 102. The probe body 102 has a window 1021. The body of the ultrasonic transducer array 101 is disposed inside the probe body 102 and the emission plane of the ultrasonic transducer array 101 is coupled to the window 1021. Each element in the ultrasonic transducer array 101 is signal-connected to the delay transmission module.

[0031] In this embodiment, the ultrasonic neuromodulation therapy device includes an ultrasonic phased array transmitting system and a phased array probe 1. The ultrasonic phased array transmitting system is used to receive control parameters from the host computer to generate periodic square wave signals that drive the array elements of the phased array probe 1, thereby enabling the ultrasonic transducer array 101 in the phased array probe 1 to generate modulated ultrasonic waves focused on the target point, and to perform non-invasive ultrasonic treatment on the target nerve tissue, such as treating epilepsy, anxiety, migraine, etc.

[0032] Preferred, see Figure 2 The delayed transmission module includes a pulse delay value register, a pulse width register, a pulse quantity register, a phase-locked loop module, an internal clock, a control signal synchronization signal generator, a pulse delay timing module, a periodic pulse generator, and a pulse quantity control module. The pulse delay value register, pulse width register, and pulse quantity register respectively store the corresponding pulse delay value, pulse width, and pulse quantity from the control parameters issued by the host computer. The phase-locked loop module is connected to the internal clock signal, which provides clock signals to the control signal synchronization signal generator, the pulse delay timing module, the periodic pulse generator, and the pulse quantity control module. The periodic pulse generator generates periodic pulse signals based on the pulse width data. The pulse delay timing module performs delay processing on each pulse according to the value in the pulse delay value register. The control signal synchronization signal generator generates a control signal synchronized with the pulse signal to coordinate the work of each module. The pulse quantity control module monitors the number of transmitted pulses and stops transmission when a preset value is reached, thereby completing the entire transmission sequence.

[0033] The delayed transmission module described in this embodiment is implemented based on an FPGA. Before operation, the external microcontroller needs to transmit the operating parameters to the FPGA's shift register group via a serial signal. The FPGA converts these parameters into corresponding pulse delay values ​​(t), frequency division coefficients (div), and output pulse counts (N), which are then stored in the corresponding parameter registers. The clock signal generated by the external crystal oscillator is multiplied by the phase-locked loop circuit inside the FPGA to generate a high-frequency clock signal f0 as the reference clock for pulse generation. At this time, the external microcontroller's preset pulse is in an inactive state, the reference clock f0 cannot be transmitted to all pulse generation modules, and all pulse generation modules are in a reset state through internal control signals. The synchronization signal will also remain in a no-signal state. When the microcontroller's preset pulse changes from an inactive state to an active state, the internal control signal enables all pulse generation modules to start working. The reference clock f0, after being divided by (div * di v1) and shaped, serves as the synchronization signal f1 for the pulse output. f1, after being delayed for a specified number of times (pulse delay value), is then divided by a periodic pulse generator (division factor) and output to the pulse quantity control module. The pulse counting module counts the pulses input from the front end; if the count is less than the "output pulse quantity," pulse output f2 is permitted; otherwise, output is prohibited. The above describes the master circuit control. Each system has only one master circuit control circuit; all others are slave circuits. Slave circuits do not have external crystal oscillators or phase-locked loop modules; their clocks originate from the synchronization signal of the master circuit. The "microcontroller preset pulses" of the master and slave circuits must be synchronized, and the "division factor" input to the master and slave circuits must be equal. The output pulse frequency f2 = f0 / (div * di v1), and the output pulse phase φ = (t / div) * 360°.

[0034] Preferably, the ultrasonic phased array transmitting system further includes a converter, the input end of which is signal-connected to the output end of the delayed transmission module, and the multiple output ends of the converter are signal-connected to each element of the ultrasonic transducer array 101 in a one-to-one correspondence.

[0035] Since the transducer used in this embodiment is not a large transducer but an ultrasonic transducer array 101, a converter is configured for the FPGA-based delayed transmission module to convert the transmission sequence output by the FPGA-based delayed transmission module so as to output it to each element of the transducer array. This enables precise control of each element in the transducer array, thereby enabling precise focusing of ultrasonic waves.

[0036] Preferably, the acoustic field intensity of the ultrasonic transducer array 101 is less than 3 W / cm². 2 The center transmission frequency of the ultrasonic transducer array 101 is 2MHz.

[0037] As the transmission frequency at the transducer center increases, the focused acoustic intensity of ultrasound within human tissue increases, but ultrasound attenuation accelerates and the penetration depth decreases. The effective focusing depth of a phased array is within the range of 10mm to 30mm, and the sound field intensity must not be too high, ideally below 3W / cm². 2 To avoid irreversible damage to human tissues, considering the depth of focus and the intensity of sound, the center emission frequency of the ultrasonic phased array transducer selected in this embodiment is 2MHz.

[0038] Preferably, the ultrasonic transducer array 101 consists of 16*16 array elements, with a center-to-center spacing of 1.1mm-1.3mm and an element size of 1mm×1mm.

[0039] The transducer array used in this embodiment is a 16*16 array element. Existing mature phased array cutting technology can achieve a cutting of 0.2mm between adjacent array elements, and the processing cost is reasonable. Therefore, considering the performance of the phased array, the processing technology and the manufacturing cost, the preferred array element center spacing is 1.2mm, and the array element size is 1mm×1mm.

[0040] Preferably, the focusing depth of the ultrasonic transducer array 101 is 10mm-30mm.

[0041] Based on ergonomic considerations, the focusing depth of the ultrasonic transducer array 101 phased array is set to 10mm-30mm. Specifically, the amplitude and frequency of the periodic square wave signal can be adjusted to achieve the adjustment of the focusing depth.

[0042] Preferably, the ultrasonic transducer array 101 is a piezoelectric ceramic transducer array, including a matching layer, a piezoelectric layer and a backing layer. The piezoelectric ceramic generates high-frequency vibrations through the inverse piezoelectric effect to generate ultrasonic waves, which are emitted through the matching layer and act on the target object.

[0043] The ultrasonic transducer array 101 in this embodiment employs a mature piezoelectric ceramic transducer array. The piezoelectric layer is a piezoelectric matrix formed by several piezoelectric elements. To improve the output bandwidth and amplitude response of the ultrasonic transducer elements, a matching layer is added. The matching layer can solve the impedance mismatch problem between the ultrasonic transducer elements and the target object, thereby improving imaging resolution and sensitivity. The backing layer located on the back of the transducer can absorb and scatter unwanted sound waves, reducing sound wave reflection and interference.

[0044] Preferably, the inner wall of the probe body 102 is provided with a plurality of elastic fixing hooks 1022, and the distance from the elastic fixing hooks 1022 to the window 1021 is coupled with the thickness of the ultrasonic transducer array 101.

[0045] The technical solution of this embodiment provides a plurality of elastic fixing hooks 1022 on the inner wall of the probe body 102 for convenient fixing of the ultrasonic transducer array 101.

[0046] Preferably, a cable connector 1023 is provided on the proximal side of the probe body 102, and each element of the ultrasonic transducer array 101 is connected to each unit of the converter in the ultrasonic phased array transmitting system through the cable connector 1023.

[0047] Since each element of the ultrasonic transducer array 101 needs to be connected to the transducer via a cable, the technical solution of this embodiment includes a cable connector 1023 to ensure structural stability and reliability, facilitating installation. Preferably, the cable connector 1023 is configured as a plug-in structure, enabling rapid assembly and disassembly of both the structure and electrical components.

[0048] Preferably, the cross-section of the probe body 102 perpendicular to its length extension direction is square, and the side length of the square is 2cm-3cm.

[0049] To make the probe body 102 easy to handle and to match the size of the ultrasonic transducer array 101 while facilitating observation of the relative position of the probe body 102 and the target object, the cross-section of the probe body 102 perpendicular to its length extension direction is set to a square of 2cm-3cm, which is compact in size and easy to operate.

[0050] Furthermore, in the description of this application, "proximal" and "distal" are commonly used terms in the medical field. Specifically, "proximal" refers to the end closer to the operator, "proximal face" refers to the end face closer to the operator, "distal" refers to the end farther from the operator, and "distal face" refers to the end face farther from the operator.

[0051] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they shall still fall within the protection scope of the present invention.

Claims

1. An ultrasonic neuromodulation therapy device, characterized in that, include: An ultrasonic phased array transmitting system includes a phased array driving module and a delayed transmission module. The phased array driving module receives control parameters from a host computer and drives the delayed transmission module to transmit a periodic square wave signal corresponding to the control parameters. A phased array probe includes an ultrasonic transducer array and a probe body. The probe body has a window, the body of the ultrasonic transducer array is disposed inside the probe body and the emission plane of the ultrasonic transducer array is coupled to the window, and each element in the ultrasonic transducer array is signal-connected to the delay emission module.

2. The ultrasonic neuromodulation therapy device as described in claim 1, characterized in that, The delayed transmission module includes a pulse delay value register, a pulse width register, a pulse quantity register, a phase-locked loop (PLL) module, an internal clock, a control signal synchronization generator, a pulse delay timing module, a periodic pulse generator, and a pulse quantity control module. The pulse delay value register, pulse width register, and pulse quantity register store the corresponding pulse delay value, pulse width, and pulse quantity from the control parameters issued by the host computer, respectively. The PLL module is connected to the internal clock signal, which provides clock signals to the control signal synchronization generator, the pulse delay timing module, the periodic pulse generator, and the pulse quantity control module, respectively. The periodic pulse generator generates periodic pulse signals based on the pulse width data. The pulse delay timing module performs delay processing on each pulse according to the value in the pulse delay value register. The control signal synchronization generator generates a control signal synchronized with the pulse signal to coordinate the work of each module. The pulse quantity control module monitors the number of transmitted pulses and stops transmission when a preset value is reached, thereby completing the entire transmission sequence.

3. The ultrasonic neuromodulation therapy device as described in claim 2, characterized in that, The ultrasonic phased array transmitting system also includes a converter. The input terminal of the converter is connected to the output terminal of the delayed transmission module, and the multiple output terminals of the converter are connected to each element of the ultrasonic transducer array in a one-to-one correspondence.

4. The ultrasonic neuromodulation therapy device as described in claim 1, characterized in that, The acoustic field intensity of the ultrasonic transducer array is less than 3 W / cm². 2 The center emission frequency of the ultrasonic transducer array is 2MHz.

5. The ultrasonic neuromodulation therapy device as described in claim 4, characterized in that, The ultrasonic transducer array consists of 16*16 elements with a center-to-center spacing of 1.1mm-1.3mm and an element size of 1mm×1mm.

6. The ultrasound neuromodulation therapy device as described in claim 5, characterized in that, The focusing depth of the ultrasonic transducer array is 10mm-30mm.

7. The ultrasonic neuromodulation therapy device as described in claim 1, characterized in that, The ultrasonic transducer array is a piezoelectric ceramic transducer array, including a matching layer, a piezoelectric layer and a backing layer. The piezoelectric ceramic generates high-frequency vibrations through the inverse piezoelectric effect to produce ultrasonic waves, which are emitted through the matching layer and act on the target object.

8. The ultrasonic neuromodulation therapy device as described in claim 1, characterized in that, A cable connector is provided on one side of the probe body near the end, and each element of the ultrasonic transducer array is connected to each unit of the converter in the ultrasonic phased array transmitting system through the cable connector.

9. The ultrasonic neuromodulation therapy device as described in claim 1, characterized in that, The probe body has a square cross-section perpendicular to its length extension direction, and the side length of the square is 2cm-3cm.

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