Rapid freeze-drying device for polypeptide

Abstract

The utility model relates to the technical field of polypeptide freeze-drying, and discloses a quick freeze-drying device for polypeptide, which comprises a box body for supporting the freeze-drying device; the cold air pipe is fixedly connected to the box body and used for conveying cold air, and one end of the cold air pipe is connected with the air conveying end of the refrigerator through a flange plate; the air outlet is formed in the cold air pipe and is used for blowing cold air onto the test tube filled with polypeptide; the rotating mechanism comprises a bottom supporting plate arranged on the box body and is used for supporting the test tubes; the fixing structure comprises a clamping plate arranged on the box body and is used for fixing the test tube, the cylinder is driven by the motor to rotate, so that the test tube can uniformly rotate, cold air can more uniformly act on a polypeptide solution in the test tube, all parts of the solution can be fully cooled, and the cooling effect is improved. And the uniformity and consistency of the freeze-drying effect are improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to polypeptide freeze drying technical field especially, a kind of for polypeptide freeze drying device. BACKGROUND

[0002] With the development of modern biotechnology, various polypeptide drugs appear, polypeptide has huge application value in clinical medicine, since invention solid-phase chemical synthesis polypeptide, the chemical synthesis of various active polypeptides has been greatly developed, but product composition is relatively complex, generally it is several structural similar polypeptide mixtures with target polypeptide as main.

[0003] But in actual polypeptide in test tube polypeptide freeze drying is not convenient to polypeptide test tube before freeze drying is pre-cooling treatment, to cause polypeptide freeze drying efficiency is lower. UTILITY MODEL CONTENT

[0004] The utility model aims at solving the shortcomings in prior art and proposes a kind of for polypeptide freeze drying device.

[0005] To achieve the above object, the utility model adopts the following technical scheme: a kind of for polypeptide freeze drying device, including:

[0006] Box, for supporting freeze drying device;

[0007] Cold air pipe, solidly connected and arranged on the box, for transmitting cold air, and one end of the cold air pipe is connected with the gas inlet of the refrigerator through the flange;

[0008] Air outlet, open and arranged on the cold air pipe, for blowing cold air on the test tube containing polypeptide;

[0009] Rotating mechanism, including bottom support plate arranged on the box, for supporting test tube;

[0010] Fixing structure, including clamping plate arranged on the box, for fixing test tube.

[0011] As a further description of the above technical scheme: the rotating mechanism further includes:

[0012] Cylinder, rotatably connected to the box, for supporting the bottom support plate, and the bottom support plate is solidly connected and arranged on the cylinder;

[0013] Motor, solidly connected and arranged on the bottom of the box, for driving the cylinder to rotate, and one end of the cylinder is solidly connected and arranged on the output end of the motor;

[0014] Receiving cavity one, open and arranged on the box, for accommodating polypeptide test tube during freeze drying;

[0015] Cover plate one, rotationally connected to the box, for opening and closing the containing cavity one;

[0016] Bolt one, threadedly connected to one end of the cover plate one, for fixing the cover plate one, and one end of the bolt one is threadedly connected to the box;

[0017] Disc, fixedly arranged at one end of the cylinder;

[0018] Placement hole, arranged on the disc, for accommodating polypeptide test tubes;

[0019] Bolt two, threadedly connected to the disc, for fixing the polypeptide test tubes in the placement hole.

[0020] As a further description of the above technical solution: the cylinder penetrates the box, the placement hole penetrates the disc, and the containing cavity one penetrates the upper end of the box.

[0021] As a further description of the above technical solution: the placement hole is provided with several groups, the bottom support plate is provided with several groups, and the bolt two is provided with several groups.

[0022] As a further description of the above technical solution: the fixing structure further comprises:

[0023] Containing cavity two, arranged on the box, for accommodating polypeptide test tubes;

[0024] Sliding groove, arranged on the box in the through hole, for limiting the clamping plate, and the clamping plate is slidingly connected to the sliding groove;

[0025] Spring, one end fixedly arranged on one side of the clamping plate, the other end fixedly arranged on the box, for always keeping the clamping plate moving to one side through the spring rebounding effect;

[0026] Cover plate two, rotationally connected to the box, for opening and closing the cover plate two;

[0027] Through hole, arranged on the cover plate two, for discharging gas in the through hole;

[0028] Bolt three, threadedly connected to the cover plate two, for fixing the cover plate two, and one end of the bolt three is threadedly connected to the box;

[0029] Ventilation channel, arranged on the box, for transmitting cold air in the containing cavity one in the through hole.

[0030] As a further description of the above technical solution: the clamping plate is provided with eight groups, and each two groups of the clamping plate fix a group of test tubes.

[0031] As a further description of the above technical solution: the clamping plate is provided with eight groups, and each two groups of the clamping plate fix a group of test tubes.

[0032] The utility model has the following beneficial effects:

[0033] 1、 the utility model discloses, through the motor drive cylinder rotation, make test tube can rotate evenly, to make the cold wind can more evenly act on the polypeptide solution in test tube, ensure that each part of solution can get sufficient cooling, improve the uniformity and consistency of freeze drying effect.

[0034] 2、 the utility model discloses, through the recycling of cold wind, while freeze drying to a group of test tubes, utilize the polypeptide of extra cold wind to another group of test tubes and carry out precooling, shorten the preparation time before formal freeze drying, thereby improve the freeze drying efficiency of whole body significantly. BRIEF DESCRIPTION OF DRAWINGS

[0035] Figure 1 It is a sectional view for polypeptide quick freeze drying device that the utility model proposes;

[0036] Figure 2 It is a partial structure schematic view for polypeptide quick freeze drying device that the utility model proposes;

[0037] Figure 3 It is a structure schematic for polypeptide quick freeze drying device that the utility model proposes Figure 1 ;

[0038] Figure 4 It is a structure schematic for polypeptide quick freeze drying device that the utility model proposes Figure 2 .

[0039] LEGEND:

[0040] 1, box;2, cold air pipe;3, air outlet;401, containing cavity one;402, cover plate one;403, bolt one;404, motor;405, cylinder;406, bottom support plate;407, disc;408, placing hole;409, bolt two;501, containing cavity two;502, air duct;503, cover plate two;504, through hole;505, bolt three;506, sliding slot;507, spring;508, clamping plate. DETAILED DESCRIPTION

[0041] The technical scheme in the embodiments of the utility model will be described clearly and completely below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the utility model.

[0042] Embodiment 1:

[0043] With reference to the drawings Figures 1 to 4 The utility model provides a kind of for polypeptide freeze-drying device, including the box body 1 for supporting freeze-drying device and fixedly connected arrangement on box body 1, for transmission cold gas, and the one end of cold air pipe 2 is connected with the gas end of refrigerating device through flange plate and the air outlet 3 of opening arrangement on cold air pipe 2, for blowing cold gas on the test tube with polypeptide, box body 1 includes rotating mechanism, including the bottom support plate 406 of arrangement on box body 1, for supporting test tube;

[0044] It needs to be explained that the cold air pipe 2 is through the box body 1, and the air outlet 3 is through the cold air pipe 2, and the air outlet 3 is provided with several groups.

[0045] As a preferred implementation form, the rotating mechanism further includes: a cylinder 405 rotatably connected to the box body 1 for supporting the bottom support plate 406, and the bottom support plate 406 is fixedly arranged on the cylinder 405; a motor 404 fixedly arranged at the bottom of the box body 1 for driving the cylinder 405 to rotate, and one end of the cylinder 405 is fixedly arranged on the output end of the motor 404; a receiving cavity one 401 arranged on the box body 1 for accommodating polypeptide test tubes during freeze-drying; a cover plate one 402 rotatably connected to the box body 1 for opening and closing the receiving cavity one 401; a bolt one 403 threadedly connected to one end of the cover plate one 402 for fixing the cover plate one 402, and one end of the bolt one 403 is threadedly connected to the box body 1; a disc 407 fixedly arranged at one end of the cylinder 405; a placing hole 408 arranged on the disc 407 for accommodating polypeptide test tubes; and a bolt two 409 threadedly connected to the disc 407 for fixing polypeptide test tubes in the placing hole 408.

[0046] As a preferred implementation form, the cylinder 405 is through the box body 1, the placing hole 408 is through the disc 407, and the receiving cavity one 401 is through the upper end of the box body 1.

[0047] As a preferred implementation form, the placing hole 408 is provided with several groups, the bottom support plate 406 is provided with several groups, and the bolt two 409 is provided with several groups.

[0048] Example 2

[0049] Based on example 1, in order to further improve the polypeptide freeze-drying efficiency, a fixing structure is arranged on the box body 1.

[0050] As a preferred implementation form, the fixing structure includes a clamping plate 508 arranged on the box body 1 for fixing the test tube.

[0051] It needs to be explained that one side of the clamping plate 508 is arc-shaped.

[0052] As a preferable implementation, the fixing structure further comprises: a receiving cavity two 501, which is arranged on the box 1 and used for receiving polypeptide test tubes; a sliding groove 506, which is arranged on the box 1 in the through hole 504 and used for limiting the clamping plate 508, and the clamping plate 508 is slidingly connected to the sliding groove 506; a spring 507, which is fixedly arranged on one side of the clamping plate 508 at one end and on the box 1 at the other end, and used for keeping the clamping plate 508 always moving to one side through the rebounding effect of the spring 507; a cover plate two 503, which is rotationally connected to the box 1 and used for opening and closing the cover plate two 503; a through hole 504, which is arranged on the cover plate two 503 and used for discharging gas in the through hole 504; a bolt three 505, which is threadedly connected to the cover plate two 503 and used for fixing the cover plate two 503, and one end of the bolt three 505 is threadedly connected to the box 1; and a ventilation channel 502, which is arranged on the box 1 and used for transmitting cold air in the receiving cavity one 401 to the through hole 504.

[0053] It should be noted that the ventilation channel 502 is provided with two groups, which is used for better transmitting cold air in the receiving cavity one 401 to the through hole 504.

[0054] As a preferable implementation, the clamping plate 508 is provided with eight groups, and each two groups of clamping plates 508 fix a group of test tubes.

[0055] As a preferable implementation, the ventilation channel 502 penetrates the box 1, the through hole 504 penetrates the cover plate two 503, and the through hole 504 penetrates the upper end of the box 1.

[0056] Working principle: in use, first through the flange of cold air pipe 2 one side 2 connected to the output end of the refrigeration equipment, then twist bolt one 403, bolt one 403 through the threaded connection in the cover plate one 402 and box 1 up, in the bolt one 403 one end off the box 1 on when the wrench cover plate one 402 in the box 1 on rotation, then put the polypeptide containing test tube in the placement hole 408, and the bottom of the test tube on the bottom plate 406, then twist bolt two 409 rotation, bolt two 409 through the threaded connection in the disc 407 to one side, in the bolt two 409 one end on the test tube when the test tube complete fixed, then reverse rotation cover plate one 402, in the bolt one 403 reset threaded connection in the box 1 on cover plate one 402 fixed, then twist bolt three 505 rotation, bolt three 505 through the threaded connection in the cover plate two 503 and box 1 up, in the bolt three 505 off the box 1 on when the wrench cover plate two 503 in the box 1 on rotation, then put the test tube to be freeze-dried on two groups of clamping plate 508, through the arc design of clamping plate 508 one side cooperation test tube drive two groups of clamping plate 508 in the sliding groove 506 on the two sides of the slide and compression spring 507, in the test tube in two groups of clamping plate 508 in the middle, through the spring 507 rebounding effect makes the clamping plate 508 on the test tube fixed, then reverse wrench cover plate two 503 on the through hole 504 closed, then reverse twist bolt three 505 reset in the box 1 on cover plate two 503 fixed, then open refrigeration equipment, cold air through the cold air pipe 2 from the air outlet 3 on the test tube, then open the motor 404, motor 404 drive cylinder 405 in the box 1 on rotation, cylinder 405 drive several groups of test tube rotation, so that the cold air can be more evenly on the polypeptide solution in the test tube, to ensure that all parts of the solution can be fully cooled, so as to improve the freeze-drying efficiency, in a group of polypeptide solution in the test tube freeze-drying when the continuous delivery of cold air, cold air through the air duct 502 into the through hole 504 on the clamping plate 508 on another group of test tube precooling, with the air into the excess air through the through hole 504 discharge containing cavity two 501, so as to use the excess cold air on another group of polypeptide test tube precooling, can shorten the preparation time before formal freeze-drying, further improve the overall freeze-drying efficiency.

[0057] Finally, it should be noted that: the above only for the preferred embodiments of the present application, and not for limiting the present application, although the foregoing detailed description of the present application has been made, for the skilled in the art, it still can be modified, or part of the technical features of the equivalent replacement, within the spirit and principles of the present application, any modification, equivalent replacement, improvement, etc., should be included in the scope of protection of the present application.

Claims

1. A device for rapid lyophilization of a polypeptide, characterized by: The utility model relates to a polypeptide freeze-drying device, including: Box (1) for supporting freeze-drying device, Cold air pipe (2) is fixedly arranged on box (1) for transmitting cold air, and one end of cold air pipe (2) is connected with the gas delivery end of refrigerator through flange, Air outlet (3) is arranged on cold air pipe (2) for blowing cold air on polypeptide test tube, Rotating mechanism, including bottom support plate (406) arranged on box (1) for supporting test tube, Fixing structure, including clamp plate (508) arranged on box (1) for fixing test tube.

2. A device for rapid freeze-drying of polypeptides according to claim 1, characterized in that: The rotating mechanism further includes: Cylinder (405) is rotatably connected on box (1) for supporting bottom support plate (406), and bottom support plate (406) is fixedly arranged on cylinder (405), Motor (404) is fixedly arranged on the bottom of box (1) for driving cylinder (405) to rotate, and one end of cylinder (405) is fixedly arranged on the output end of motor (404), Accommodating cavity one (401) is arranged on box (1) for accommodating polypeptide test tube during freeze-drying, Cover plate one (402) is rotatably connected on box (1) for opening and closing accommodating cavity one (401), Bolt one (403) is threadedly connected on one end of cover plate one (402) for fixing cover plate one (402), and one end of bolt one (403) is threadedly connected on box (1), Disc (407) is fixedly arranged on one end of cylinder (405), Placement hole (408) is arranged on disc (407) for accommodating polypeptide test tube, Bolt two (409) is threadedly connected on disc (407) for fixing polypeptide test tube in placement hole (408).

3. A device for rapid freeze-drying of polypeptides according to claim 2, characterized in that: The cylinder (405) penetrates the box (1), the placement hole (408) penetrates the disc (407), and the accommodating cavity one (401) penetrates the upper end of the box (1).

4. The device for rapid freeze-drying of polypeptides according to claim 3, characterized in that: The placement hole (408) is provided with a plurality of groups, the bottom support plate (406) is provided with a plurality of groups, and the bolt two (409) is provided with a plurality of groups.

5. A device for rapid freeze-drying of polypeptides according to claim 4, characterized in that: The fixing structure further includes: Accommodating cavity two (501) is arranged on box (1) for accommodating polypeptide test tube, Slide groove (506) is arranged on box (1) in through hole (504) for limiting clamp plate (508), and clamp plate (508) is slidably connected on slide groove (506), Spring (507) is fixedly arranged on one side of clamp plate (508) at one end and on box (1) at the other end for always keeping clamp plate (508) moving to one side through the rebounding effect of spring (507), Cover plate two (503) is rotatably connected on box (1) for opening and closing cover plate two (503), Through hole (504) is arranged on cover plate two (503) for discharging gas in through hole (504), Bolt three (505) is threadedly connected on cover plate two (503) for fixing cover plate two (503), and one end of bolt three (505) is threadedly connected on box (1). Ventilation channel (502) is arranged on the box (1) and is used for transmitting the cold air in the containing cavity (401) in the through hole (504).

6. A device for rapid freeze-drying of polypeptides according to claim 5, characterized in that: The clamping plate (508) is provided with eight groups, and each two groups of the clamping plate (508) fix a group of test tubes.

7. A device for rapid freeze-drying of polypeptides according to claim 6, characterized in that: The clamping plate (508) is provided with eight groups, and each two groups of the clamping plate (508) fix a group of test tubes.

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