Controllable microsphere wrapping system
By combining the first and second drug-loaded microspheres and encapsulating them with a nano-silica layer, the problems of low loading efficiency and unstable release caused by drug particle accumulation are solved, achieving adjustable drug concentration and improved release effect.
Patent Information
- Application Number
- CN202423268340.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2034-12-30
AI Technical Summary
In existing microsphere encapsulation technologies, drug particles accumulate inside the microspheres, forming voids. This leads to reduced drug loading efficiency and unstable release rates, affecting bioavailability.
An adjustable microsphere encapsulation system is adopted, which utilizes a combination structure of a first drug-loaded microsphere and a second drug-loaded microsphere. Drug particles are injected through a filling port and coated with a nano-silica layer on the outside to form a structure similar to a drug-loaded microsphere. The amount of drug encapsulation can be adjusted to enhance the loading and release effect.
This system achieves an improvement over existing technologies, enabling adjustable drug concentration at the site of action, enhanced loading capacity and release effect, and meeting diverse clinical needs.
Smart Images
Figure CN223716059U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to microsphere wrapping technical field, especially in a kind of adjustable microsphere wrapping system. BACKGROUND
[0002] In recent years, the development of drug delivery system is concerned, it can accurately send drug to pathological site, reduce the side effect of drug and improve curative effect.And in drug delivery system, drug-loaded microsphere is a common drug carrier, by controlling the release rate and target delivery of drug, microsphere wrapping technology can optimize drug effect and reduce side effect improve the stability and bioavailability of drug.In the future, microsphere wrapping technology will play a more important role in medicine, biotechnology and agriculture and other fields.
[0003] In the current microsphere wrapping drug technology application, when the wrapping amount of drug reaches certain limit value, drug particles will be accumulated in the microsphere, which leads to the formation of cavity.The existence of these cavities not only reduces the drug loading efficiency of microsphere, but also may affect the release rate and bioavailability of drug in vivo.Therefore, the utility model provides a kind of adjustable microsphere wrapping system to solve the problems raised in the above background technology. UTILITY MODEL CONTENT
[0004] The utility model aims at providing a kind of adjustable microsphere wrapping system, second drug-loaded microsphere is filled with different number of first drug-loaded microsphere according to the need, by changing its size target specific tissue or organ, can increase the concentration of drug in the action site.Drugs are injected through filling port at the cavity of second drug-loaded microsphere and first drug-loaded microsphere, and the wrapping layer wrapped outside second drug-loaded microsphere can form a structure similar to a drug-loaded microsphere, to enhance the loading capacity and release effect of drug, and the drug wrapping amount can be appropriately adjusted according to actual needs, so that drug-loaded microsphere can better adapt to drug release requirements.
[0005] To achieve the above object, provide a kind of adjustable microsphere wrapping system, including first drug-loaded microsphere and second drug-loaded microsphere, the first drug-loaded microsphere is equipped with drug inside, the first drug-loaded microsphere is equipped in the inside of second drug-loaded microsphere, the inside of second drug-loaded microsphere is also equipped with drug, and the filling port is formed on the side of second drug-loaded microsphere, and the wrapping layer is arranged on the outside of second drug-loaded microsphere.
[0006] According to the adjustable microsphere wrapping system, the wrapping layer is at least one layer.
[0007] According to the adjustable microsphere wrapping system, the first drug-loaded microsphere and second drug-loaded microsphere are both gelatin microspheres.
[0008] According to the adjustable microsphere wrapping system, the wrapping layer is nanosilica layer.
[0009] The utility model has the following beneficial effects:
[0010] Compared with the prior art, the adjustable microsphere wrapping system, the first drug-loaded microsphere as the basic drug-loaded microsphere can deliver the medicine wrapped in the interior. The second drug-loaded microsphere as the drug-loaded microsphere with a larger size is filled with different numbers of the first drug-loaded microspheres according to the requirement, and by changing the size, the second drug-loaded microsphere can target specific tissues or organs and increase the concentration of the medicine at the action site. The medicine is injected through the filling port at the hollow of the second drug-loaded microsphere and the medicine particles are accumulated in the interior of the second drug-loaded microsphere, as close as possible to the wrapping limit and keeping the dispersibility of the substances in the microsphere. At the same time, the wrapping layer wrapped outside the second drug-loaded microsphere can form a structure similar to a drug-loaded microsphere to enhance the loading capacity and release effect of the medicine. At the same time, the wrapping amount of the medicine can be adjusted according to the actual requirement, so that the drug-loaded microsphere can better adapt to the requirement of the medicine release and meet the requirement of the medicine delivery in different clinical requirements.
[0011] The additional aspects and advantages of the utility model will be partially given in the following description, partially become obvious from the following description, or be understood through the practice of the utility model. BRIEF DESCRIPTION OF DRAWINGS
[0012] The utility model will be further explained in combination with the drawings and embodiments;
[0013] Figure 1 The first drug-loaded microsphere and the medicine structure schematic view of the utility model one kind adjustable microsphere wrapping system;
[0014] Figure 2 The second drug-loaded microsphere and the medicine structure schematic view of the utility model one kind adjustable microsphere wrapping system;
[0015] Figure 3 The utility model one kind adjustable microsphere wrapping system Figure 2 Another state structure schematic view;
[0016] Figure 4 The utility model one kind adjustable microsphere wrapping system Figure 2 The enlarged structure schematic view of A in the middle of the utility model.
[0017] Legend:
[0018] 1, the first drug-loaded microsphere; 2, medicine; 3, filling port; 4, second drug-loaded microsphere; 5, wrapping layer. DETAILED DESCRIPTION
[0019] The detailed embodiments of the utility model will be described in detail in this part, the preferred embodiment of the utility model is shown in the drawings, the role of the drawings is to supplement the description of the written part with graphics, so that people can intuitively and visually understand each technical feature and overall technical scheme of the utility model, but it cannot be understood as the limitation of the protection scope of the utility model.
[0020] Referring to Figures 1-4 The utility model discloses an adjustable microsphere wrapping system, which comprises a first drug-loaded microsphere 1 and a second drug-loaded microsphere 4, the first drug-loaded microsphere 1 is internally provided with a drug 2, the first drug-loaded microsphere 1 is arranged in the second drug-loaded microsphere 4, the inner side of the second drug-loaded microsphere 4 is also provided with the drug 2, a filling port 3 is formed in one side of the second drug-loaded microsphere 4, and the outer side of the second drug-loaded microsphere 4 is provided with a wrapping layer 5.
[0021] The first drug-loaded microsphere 1 is used as a basic drug-loaded microsphere, and the drug 2 wrapped in the first drug-loaded microsphere 1 can be delivered. The second drug-loaded microsphere 4 is used as a larger drug-loaded microsphere, and different numbers of the first drug-loaded microsphere 1 are filled in the second drug-loaded microsphere 4 according to needs. By changing the size, the second drug-loaded microsphere 4 can target specific tissues or organs, and the concentration of the drug 2 at the action site can be increased. The drug 2 is injected into the hollow part of the second drug-loaded microsphere 4 through the filling port 3, and the drug particles are accumulated in the second drug-loaded microsphere 4, as close as possible to the wrapping limit and maintaining the dispersibility of the substances in the microsphere. At the same time, the wrapping layer 5 wrapped on the outer side of the second drug-loaded microsphere 4 can form a structure similar to a drug-loaded microsphere, so as to enhance the drug loading capacity and release effect. At the same time, the drug wrapping amount can be appropriately adjusted according to actual needs, so that the drug-loaded microsphere can better adapt to the drug release requirements and meet the drug delivery requirements of different clinical needs.
[0022] The wrapping layer 5 is provided as at least one layer, and more layers of the wrapping layer 5 can be provided according to needs. By adjusting the thickness of the wrapping layer 5, the performance of the material can be accurately controlled to meet the needs of different application scenarios.
[0023] The first drug-loaded microsphere 1 and the second drug-loaded microsphere 4 are both gelatin microspheres. The gelatin microsphere is a relatively widely used drug-loaded microsphere, which can stably wrap various drugs 2 and can deliver the drugs 2 to the lesion site through good biocompatibility and degradability.
[0024] The wrapping layer 5 is a nanosilica layer. The nanosilica layer not only has good biocompatibility and stability, but also can effectively protect the core of the microsphere, improve the chemical stability and thermal stability of the core, realize the slow release and targeted delivery of the drug 2, improve the treatment effect and reduce the side effects.
[0025] Working principle: the first drug-loaded microspheres 1 as the basis of drug-loaded microspheres, the drug 2 inside can be carried out drug 2 delivery. And the second drug-loaded microspheres 4 as a larger size of drug-loaded microspheres, the inside according to the needs of different number of first drug-loaded microspheres 1, by changing its size target specific tissue or organ, can increase the concentration of drug 2 in the action site. And in the second drug-loaded microspheres 4 and the first drug-loaded microspheres 1 cavity by filling the mouth 3 injection of drug 2, drug particles accumulation in the second drug-loaded microspheres 4 inside, as close as possible to the limit and keep the dispersion of the material in the microspheres. At the same time, with the wrapping layer 5 wrapped in the second drug-loaded microspheres 4 outside can form similar to a drug-loaded microspheres structure, to enhance the drug load and release effect. At the same time, according to the actual need to adjust the drug amount, so that the drug-loaded microspheres can better adapt to the requirements of drug release, meet the different clinical requirements of drug delivery requirements.
[0026] The above embodiment of the present application is described in detail in combination with the drawings, but the present application is not limited to the above embodiment, and various changes can be made within the knowledge possessed by those skilled in the art in the technical field without departing from the purpose of the present application.
Claims
1. A regulatable microsphere encapsulation system, characterized in that, The application relates to a drug-loaded microsphere, which comprises a first drug-loaded microsphere (1) and a second drug-loaded microsphere (4), the first drug-loaded microsphere (1) is internally provided with a drug (2), the first drug-loaded microsphere (1) is arranged inside the second drug-loaded microsphere (4), the inside of the second drug-loaded microsphere (4) is also provided with the drug (2), a filling opening (3) is arranged on one side of the second drug-loaded microsphere (4), and an outer side of the second drug-loaded microsphere (4) is provided with a wrapping layer (5).
2. The regulatable microsphere encapsulation system of claim 1, wherein, The wrapping layer (5) is provided as at least one layer.
3. The regulatable microsphere encapsulation system of claim 2, wherein, The first drug-loaded microsphere (1) and the second drug-loaded microsphere (4) are both gelatin microspheres.
4. The regulatable microsphere encapsulation system of claim 2, wherein, The wrapping layer (5) is a nano-silicon dioxide layer.