Automatic reaction system
The automated reaction system solves the safety risks and inaccuracies associated with manual operation, enabling safe and efficient hydrogenation and hydroformylation reactions without human intervention, thus improving reaction accuracy and product purity.
Patent Information
- Application Number
- CN202423289873.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2034-12-30
AI Technical Summary
In existing technologies, hydrogenation and hydroformylation reactions pose safety risks and lack precision due to manual operation.
An automated reaction system is employed, comprising a microfluidic device, a robotic arm module, a gas supply module, and a control module. The robotic arm module moves the reagents, the microfluidic device completes the reaction, the gas supply module provides the reaction gas, and the control module coordinates the operation of each module to ensure that the reaction takes place in an anhydrous and oxygen-free environment.
It enables safe and efficient hydrogenation and hydroformylation reactions without human intervention, reducing safety risks and improving reaction accuracy and product purity.
Smart Images
Figure CN223717101U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the field of chemical reaction, specifically relates to an automatic reaction system. BACKGROUND
[0002] Hydroformylation and hydrogenation are reaction types frequently used in organic synthesis, and are widely used in medicine, pesticide, perfume and material science and many other fields. For example, in the use of drug research and development, hydrogenation is used to synthesize a variety of intermediates and target molecules with pharmacological activity.
[0003] Hydrogenation and hydroformylation are very popular in industrial and laboratory applications, and the completion of hydrogenation and hydroformylation is usually manually operated. However, due to the flammable and explosive gas involved in the above reaction process, improper manual operation can easily cause safety accidents and has safety risks. CONTENT OF THE UTILITY MODEL
[0004] The utility model provides an automatic reaction system, which aims to solve the problem of safety risks in manual operation in the prior art.
[0005] In order to achieve the above purpose, the utility model provides an automatic reaction system, which comprises
[0006] A microfluidic device is configured with a gas supply module for supplying gas, and is used for hydrogenation and hydroformylation reaction;
[0007] A first mechanical arm module is used for moving reagents;
[0008] A control module is signal connected with the first mechanical arm module and the microfluidic module.
[0009] In the scheme, the first mechanical arm module moves the reagents to the inlet of the microfluidic device, the reagents enter the microfluidic device from the inlet of the microfluidic device, and the hydrogenation and hydroformylation reactions are completed in the microfluidic device. The gas supply module configured in the microfluidic device provides gas for the hydrogenation and hydroformylation reactions, ensuring the normal progress of the reactions.
[0010] Preferably, in order to realize the export of reagents from the reagent storage container, the scheme further comprises a liquid separation module, which comprises a liquid separation pump, and is used for guiding the reagents into the preliminary container.
[0011] The scheme realizes the extraction of reagents from the reagent storage container by configuring the liquid separation module, without manual intervention, reducing the manual workload. At the same time, the liquid separation pump can realize the quantitative extraction of reagents, with higher accuracy.
[0012] Preferably, in order to adapt to different kinds of reagents, the liquid separation module is configured with a plurality of liquid separation pumps, each of which corresponds to a different kind of reagent.
[0013] The present solution provides a plurality of liquid separation pumps, each of which corresponds to a different kind of reagent. When different kinds of reagents need to be mixed, different liquid separation pumps work to introduce different kinds of reagents into the preliminary container.
[0014] Preferably, when different kinds of reagents are in the preliminary container, in order to allow the reagents to mix well before the reaction, the present solution further includes a mixing module for accommodating the preliminary container, and the mixing module is used to shake the preliminary container to mix the reagents.
[0015] The present solution mixes the reagents in the preliminary container through the mixing module when different kinds of reagents are in the preliminary container, thereby improving the reaction efficiency and quality of the hydrogenation reaction and the hydroformylation reaction.
[0016] Preferably, in order to achieve mixing of the reagents, the mixing module of the present solution is a mechanical shaker.
[0017] The present solution preferably sets the mixing module as a mechanical shaker, which has a simple structure, stable operation, and good mixing effect on the reagents.
[0018] Preferably, in order to ensure that the reaction is carried out in a controlled environment free of water and oxygen, the present solution further includes a glove box module, and the microfluidic device and the first robotic arm module are installed in the glove box module.
[0019] The present solution installs the microfluidic device and the first robotic arm module in the glove box module. Therefore, whether the first robotic arm module moves the reagents or the reagents complete the reaction in the microfluidic device, the entire process is in a controlled environment free of water and oxygen. This ensures that the air-sensitive hydrogenation reaction and hydroformylation reaction can be carried out safely and efficiently.
[0020] Preferably, after the reagents complete the reaction in the microfluidic device, in order to accommodate the products after the reaction, the present solution further includes a sample bottle for accommodating the products after the reaction.
[0021] In the present solution, after the reagents complete the reaction in the microfluidic device, the reagents flow out of the microfluidic device and are then accommodated in the sample bottle. The sample bottle stores the products after the reaction, avoiding leakage of the products to the outside.
[0022] Preferably, in order to improve the purity of the products after the reaction, the sample bottle of the present solution is provided with a filter for filtering the products after the reaction.
[0023] The product after reaction in the scheme enters a sample bottle through a filter. The sample bottle can remove by-products and unreacted substances in the reaction, thereby improving the purity of the final product.
[0024] To avoid cross contamination, the filter in the scheme is preferably a disposable filter. By providing a disposable filter, cross contamination between different reagents and different reaction products is avoided, which helps to ensure the purity of the reaction.
[0025] Preferably, to move the product after reaction, the scheme further comprises a second robotic arm module for moving the product after reaction.
[0026] The scheme moves the product after reaction by configuring a second robotic arm, reducing the manual operation process and reducing the workload of manual operation. At the same time, it is also beneficial to reduce the risk brought by manual operation.
[0027] Preferably, to quickly and accurately detect the purity and concentration of the product and provide detailed data support for experimental results, the scheme further comprises a high-performance liquid chromatograph for detecting the product after reaction.
[0028] In the scheme, the high-performance liquid chromatograph is configured to detect the product after reaction by the high-performance liquid chromatograph when the reaction is completed, and determine the purity and concentration of the product.
[0029] The automatic reaction system disclosed in the scheme has the beneficial effects that the movement of reagents is performed by a robotic arm, and the reaction is completed by a microfluidic device. The reaction process does not require manual intervention, and the safety risks brought by manual operation are avoided. BRIEF DESCRIPTION OF DRAWINGS
[0030] Figure 1 The schematic diagram of the automatic reaction system in Example 1.
[0031] Figure 2 The schematic diagram of the automatic reaction system in Example 2.
[0032] The reference signs include: a liquid separation module 1, a mixing module 2, a microfluidic device 3, a first robotic arm module 4, a gas supply module 5, a glove box module 6, a high-performance liquid chromatograph 7, and a second robotic arm module 8. DETAILED DESCRIPTION
[0033] In order to make the purpose, technical scheme and advantages of the embodiments clearer, the utility model is further described in detail below in combination with the drawings and embodiments. When the following description refers to the drawings, identical numbers in different drawings represent identical or similar elements unless otherwise indicated. The implementations described in the following example embodiments do not represent all implementations consistent with the present disclosure. Instead, they are merely examples of apparatuses and methods consistent with some aspects of the present disclosure as detailed in the appended claims.
[0034] In the present disclosure, the orientation words such as "inner" and "outer" are defined according to the contour of the corresponding parts themselves unless otherwise stated. The terms such as "first" and "second" used in the present disclosure are used to distinguish one element from another element, and do not have sequentiality and importance. Embodiment 1
[0035] Basically as shown in the accompanying Figure 1 The present disclosure is directed to an automated reaction system for realizing automated hydroformylation and hydrogenation reactions, solving the problems of safety risks and poor accuracy caused by manual operation in the prior art.
[0036] The present automated reaction system specifically comprises a liquid separation module 1, a mixing module 2, a microfluidic device 3, a first mechanical arm module 4, a glove box module 6, a high-performance liquid chromatograph 7 and a control module.
[0037] The control module in the present embodiment can be a control module in the prior art, such as an industrial computer module or a single-chip microcomputer module, etc. The liquid separation module 1, the mixing module 2, the microfluidic device 3, the first mechanical arm module 4 and the glove box module 6 are in signal communication with the control module, and the above modules are controlled to work cooperatively by the control module.
[0038] The glove box module 6 in the present embodiment can be a glove box device in the prior art. The glove box module 6 forms a controlled environment free of water and oxygen inside, ensuring that the reaction is not interfered by the external environment and that the experiment is carried out under safe and efficient conditions. The surface of the glove box module 6 is provided with detectors such as a humidity sensor and an oxygen monitor. The humidity sensor and the oxygen monitor can monitor the humidity and oxygen inside the glove box, ensuring that the reaction is carried out in a water-free and oxygen-free environment.
[0039] The glove box module 6 in the present embodiment is internally provided with the liquid separation module 1, the mixing module 2, the microfluidic module and the first mechanical arm module 4. The modules cooperate with each other to ensure that the entire experiment is completed in a water-free and oxygen-free controlled environment.
[0040] The liquid separation module 1 in the embodiment specifically includes a plurality of pump bodies, for example, liquid separation pumps. The specific number of liquid separation pumps can be set according to the actual use scene. For example, 2, 3, 4 or 5 liquid separation pumps can be set. Each liquid separation pump is matched with different types of reagents, that is, the inlet of the liquid separation pump can be in communication with the reagent container. When the liquid separation pump works, the liquid separation pump can draw out the reagent in the reagent container and guide the reagent into the preliminary container. The preliminary container is a common glass bottle or glass cup, which is used to contain reagents and mix reagents.
[0041] The liquid separation module 1 in the embodiment is in a signal connection state with the control module, and works under the control of the control module to ensure that the reagent drawn into the preliminary container is of a predetermined proportion to meet the needs of the reaction.
[0042] It should be noted that in order to ensure that various different reagents can be loaded into the preliminary container, the first mechanical arm module 4 can be used to move the preliminary container so that the preliminary container moves to the outlet of different liquid separation pumps in turn. Then, different liquid separation pumps can load different reagents into the corresponding preliminary container. Alternatively, in some embodiments, the outlets of a plurality of liquid separation pumps can be all arranged at the same position, and then the first mechanical arm module 4 places the preliminary container at the position, and different liquid separation pumps load different reagents into the preliminary container.
[0043] The first mechanical arm module 4 in the embodiment is installed in the interior of the glove box module 6, and includes at least one mechanical arm, the specific number of which can be set as needed, for example, the first mechanical arm module 4 can include two, three or four mechanical arms, etc. The mechanical arm can be a six-axis mechanical arm in the prior art. The mechanical arm can clamp the corresponding object (for example, the preliminary container) to move the object to the corresponding position.
[0044] It should be noted that the first mechanical arm module 4 in the embodiment is in a signal connection state with the control module, and the control module controls the mechanical arm in the first mechanical arm module 4 to work at a predetermined time and accurately places the object at the corresponding position. For example, when the reaction is needed, the control module can control the mechanical arm to grab the preliminary container so that the preliminary container receives different types of reagents. Then, after the reagents are completely loaded into the preliminary container, the control module controls the mechanical arm to move the preliminary container.
[0045] The mixing module 2 in the embodiment is also installed inside the glove box module 6. After the primary container is filled with different types of reagents, the first robotic arm module 4 can place the primary container on the mixing module 2. The mixing module 2 is specifically preferably a mechanical shaker, and the mechanical shaker can be used to place the primary container. After the primary container is placed on the mechanical shaker, the mechanical shaker can drive the primary container to shake, and the mechanical shaker can mix the reagents in the primary container. The mechanical shaker in the embodiment is preferably a mechanical shaker in the prior art.
[0046] It should be noted that the mechanical shaker in the embodiment is in signal connection with the control module. The mechanical shaker is controlled by the control module to work and stop.
[0047] After the reagents in the primary container are mixed on the mixing module, the mechanical arm in the first robotic arm module 4 moves the primary container after mixing, so that the primary container is moved to the inlet of the microfluidic device 3. The sample injection needle configured on the microfluidic device 3 can realize the absorption of the mixed reagents into the inside of the microfluidic device 3. The mixed reagents perform hydrogenation reaction or hydroformylation reaction in the microfluidic device 3.
[0048] When the mixed reagents perform reaction in the microfluidic device 3, in order to ensure the normal progress of the hydrogenation reaction or the hydroformylation reaction, the microfluidic device 3 in the embodiment is in communication with the gas supply module 5. The gas supply module 5 can supply gas to the inside of the microfluidic device 3, so that the hydrogenation reaction or the hydroformylation reaction can be performed normally. The gas supply module 5 is specifically a gas cylinder, and the gas cylinder stores the gas used for reaction.
[0049] In the embodiment, the gas and the reagents complete the hydrogenation reaction or the hydroformylation reaction in the microfluidic device 3. After the reaction is completed, the reaction product flows out of the microfluidic device 3 through the pipeline, and the pipeline extends to the outside of the glove box module 6, so as to ensure that the reaction product flows out of the glove box module 6.
[0050] After the reaction product flows out of the pipeline, the reagent directly flows into the sample bottle. The sample bottle can be a glass bottle. At the same time, the embodiment preferably configures a disposable filter at the mouth of the sample bottle. After the reaction product flows out of the microfluidic module, the reagent is filtered by the disposable filter, and then the reagent is contained in the sample bottle.
[0051] In the embodiment, a second robotic arm module 8 is configured outside the glove box module 6. The second robotic arm module 8 also includes at least one mechanical arm. The mechanical arm can be a six-axis mechanical arm. After the reagent is contained in the sample bottle, the mechanical arm takes away the disposable filter, and then the mechanical arm seals the sample bottle.
[0052] It should be noted that in this embodiment, the second robotic arm module 8 and the control module are in a signal connection state. After the microfluidic device 3 completes the reaction, the control module can control the second robotic arm module 8 to seal the sample vial and remove it.
[0053] In this embodiment, a high-performance liquid chromatograph (HPLC) 7 is also installed outside the glove box. After the sample is placed inside the sample vial, the robotic arm in the second robotic arm module 8 places the sample vial into the HPLC 7. The HPLC 7 then detects the products after the reaction.
[0054] The following detailed description illustrates the specific implementation method: A dispensing pump draws the reagent from the reagent container and into a preliminary container. The preliminary container is moved to a mixing module 2 by a robotic arm, where the reagents are mixed. After mixing in the preliminary container, the robotic arm moves the container to a microfluidic device 3. A hydrogenation or hydroformylation reaction is completed in the microfluidic device 3. After the reaction is completed in the microfluidic device 3, the reaction product flows out. The reaction product is contained inside a sample vial. After the reagent is loaded into the sample vial, the robotic arm seals the vial, and the vial is then inserted into the high-performance liquid chromatograph 7 for analysis. Example 2
[0055] The difference between this embodiment and Embodiment 1 is that, as Figure 2 As shown, in this embodiment, after the reagent is filled into the sample vial, the operator can manually remove the sample vial and manually seal it. After the sample vial is sealed, it is manually placed into the high-performance liquid chromatograph 7 (HPLC 7) for analysis of the reagent inside the sample vial.
[0056] The above descriptions are merely embodiments of this utility model, and common knowledge regarding specific structures and characteristics is not elaborated upon here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the structure of this utility model, and these should also be considered within the scope of protection of this utility model. These modifications will not affect the effectiveness of the implementation of this utility model or the practicality of the patent. The scope of protection claimed in this application shall be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.
Claims
1. An automated reaction system, characterized by: The microfluidic device is configured with a gas supply module for supplying gas, and is used for hydrogenation reaction and hydroformylation reaction; A first mechanical arm module is used for moving reagents; A control module is in signal connection with the first mechanical arm module and the microfluidic module. A liquid distribution module is further included, which comprises a liquid distribution pump and is used for guiding reagents into a preliminary container.
2. The automated reaction system of claim 1, wherein: The liquid distribution module is configured with a plurality of liquid distribution pumps, each of which corresponds to a different kind of reagent.
3. The automated reaction system of claim 2, wherein: A mixing module is further included, which is used for accommodating the preliminary container and is used for shaking the preliminary container to mix the reagents.
4. The automated reaction system of claim 2 or 3, wherein: The mixing module is a mechanical shaker.
5. The automated reaction system of claim 4, wherein: A glove box module is further included, and the microfluidic device and the first mechanical arm module are installed in the glove box module.
6. The automated reaction system of claim 1, wherein: A sample bottle is further included, which is used for accommodating the product after reaction.
7. The automated reaction system of claim 1, wherein: The sample bottle is configured with a filter, which is used for filtering the product after reaction.
8. The automated reaction system of claim 7, wherein: A second mechanical arm module is further included, which is used for moving the product after reaction.
9. The automated reaction system of claim 1, wherein: A high-performance liquid chromatograph is further included, which is used for detecting the product after reaction.
10. The automated reaction system of claim 1, wherein: