Microchannel continuous flow reactor for drug synthesis

Abstract

The utility model provides a microchannel continuous flow reactor for medicine synthesis, which comprises a turn-back cooling water tank, a base is arranged on a bearing frame fixedly arranged above the turn-back cooling water tank, a plurality of reactor main bodies are transversely arranged on the base, the plurality of reactor main bodies are communicated with a liquid outlet channel and a liquid inlet channel, and the liquid outlet channel and the liquid inlet channel are communicated with each other. The liquid inlet channel is communicated with the output end of the circulating pump equipment through a communicating pipe, and the input end of the circulating pump equipment is communicated with the turn-back cooling water tank; according to the utility model, high-efficiency management of drug synthesis reaction heat is realized. According to the design, the S-shaped bent sinking folded plate and the S-shaped bent upper sinking folded plate are utilized, the flowing path and the heat dissipation area are increased, and the heat dissipation efficiency is greatly improved. Meanwhile, the fan on the cooling top plate accelerates cooling, so that the reaction fluid is stable. The combination of the turn-back openings and the folded plates forms a complete transverse turn-back flow channel, and the problem of insufficient cooling is avoided. The structure is compact, space is saved, and installation and maintenance are convenient.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of drug synthesis, especially relates to a microchannel continuous flow reactor for drug synthesis. BACKGROUND

[0002] The microchannel continuous flow reactor used in the field of drug synthesis, as a cutting-edge chemical reaction device integrating microchannel technology and continuous flow chemical principles, provides a highly efficient, safe, and controllable reaction platform for drug synthesis processes. To effectively manage the large amount of heat released during the reaction, the device is equipped with a precise cooling system. This system ingeniously places the reaction unit between the inlet and outlet water channels and uses the heat exchange plates connected in parallel to quickly remove the reaction heat using liquid cooling technology, thereby ensuring the safe and stable operation of the reaction fluid within the reaction plate.

[0003] However, in traditional designs, there is a potential problem: the heat-carrying liquid, after leaving the reactor and entering the water tank, may be pumped back into the water inlet pipeline of the heat exchange system again due to insufficient cooling, affecting the cooling efficiency. To address this challenge, the industry has introduced an innovative continuous flow reactor design, as described in Chinese Utility Model Patent CN 220803169U.

[0004] The drug synthesis microchannel continuous flow reactor described in this patent attempts to use the natural flow power of the liquid in the liquid discharge channel as a power source to drive the impeller to rotate, and then use the impeller to stir the liquid in the water tank to achieve the purpose of mixing and cooling, preventing the high-temperature liquid from being pumped repeatedly. However, this design still has significant shortcomings: due to the coincidence of the impeller and the stirrer axis, combined with the resistance of the surrounding liquid, the power generated by the liquid is difficult to efficiently drive the impeller to rotate quickly. This limitation not only affects the rotational freedom of the impeller, but also further increases the difficulty of the stirrer achieving high-speed rotation and driving the liquid to form a complex turbulent flow pattern, thereby weakening the cooling effect of the stirrer.

[0005] Therefore, it is necessary to invent a microchannel continuous flow reactor for drug synthesis. UTILITY MODEL CONTENTS

[0006] To solve the above technical problems, the utility model provides a microchannel continuous flow reactor for drug synthesis, which comprises a return cooling water tank, a bearing frame, a base, a reactor main body, a liquid outlet channel, a liquid inlet channel, a communication pipe and a circulating pump device. The base is installed on the bearing frame fixedly installed above the return cooling water tank, and a plurality of reactor main bodies are installed horizontally on the base. The reactor main bodies are connected to the liquid outlet channel and the liquid inlet channel. The liquid inlet channel is connected to the output end of the circulating pump device through the communication pipe, and the input end of the circulating pump device is connected to the return cooling water tank.

[0007] Preferably, the return cooling water tank comprises a tank box, a partition, a sinking baffle, a sinking baffle and a return port, the tank box is fixedly installed with a bearing frame above, a circulating pump device is fixedly installed outside the tank box, and a water outlet is arranged in communication with the input end of the circulating pump device, at least three partition plates are fixedly installed inside the tank box, and a plurality of sinking baffles and sinking baffles are installed, and the tank box and each partition plate have the return port.

[0008] Preferably, the partition plate and the tank box have a liquid channel, and a plurality of liquid channels form a complete transverse return flow channel in combination with the return port.

[0009] Preferably, the sinking baffle and the sinking baffle are installed at the liquid channel position, the sinking baffle and the sinking baffle are both serpentine bending structures, and the sinking baffle and the sinking baffle are alternately arranged in the liquid channel.

[0010] Preferably, the bottom of the sinking baffle is fixed to the inner wall groove bottom of the tank box, the upper part allows liquid flow, the bottom of the sinking baffle is not fixed to the inner wall groove bottom of the tank box, and the bottom end of the sinking baffle allows liquid flow, and the top end does not allow liquid flow.

[0011] Preferably, the liquid flowing in the liquid channel reciprocates up and down through the sinking baffle and the sinking baffle, and the upper end of the sinking baffle is fixed to the cooling top plate.

[0012] Preferably, the cooling top plate is located above the liquid channel in the middle position, that is, below the base, and a plurality of cooling fans are fixedly installed on the cooling top plate.

[0013] Preferably, one of the liquid channels at the two sides of the tank box is in communication with the circulating pump device through the water outlet, and the other liquid channel is provided with a liquid outlet channel above, and the liquid discharged from the liquid outlet channel enters the liquid channel below.

[0014] Compared with the prior art, the utility model has the advantages of:

[0015] The utility model discloses a utility model discloses the utility model discloses through the introduction of the design of the return cooling water tank, realize the efficient management of the drug synthesis reaction heat. The design utilizes the serpentine bending structure of the sinking baffle and the sinking baffle in multiple liquid passages, makes liquid reciprocating flow, significantly increases the flow path and the heat dissipation area, thereby greatly improves the heat dissipation efficiency. Meanwhile, the cooling fan on the cooling top plate further speeds up the cooling speed of the liquid, ensures that the reaction fluid can keep the safe and stable temperature state in the reactor main body. In addition, the ingenious combination of the return port, the sinking baffle and the sinking baffle constitutes a complete transverse return flow channel, optimizes the flow mode of the liquid, effectively avoids the problem that the liquid is pumped in advance due to insufficient cooling in the traditional design, ensures that the liquid can be cooled sufficiently after leaving the reactor.

[0016] The utility model discloses the reactor main body, the return cooling water tank, the bearing frame and the base and other key components are compactly combined together, form a compact structure, easy to install and maintain whole, not only saves the precious space resource, also greatly facilitates the daily maintenance and maintenance work of equipment. More importantly, through efficient heat dissipation and optimized flow mode, the microchannel continuous flow reactor for drug synthesis of the utility model can ensure that the reaction is carried out under the optimum temperature condition, thereby significantly improve the reaction efficiency and product quality. In addition, stable temperature control also effectively prevents the security risk that may be caused by overheating, significantly improves the overall safety performance, provides strong guarantee for the production safety and product quality in the field of drug synthesis. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is the whole structure schematic diagram of the utility model.

[0018] Figure 2 It is the structure schematic diagram of the return cooling water tank of the utility model.

[0019] Figure 3 It is the local section structure schematic diagram of the return cooling water tank of the utility model.

[0020] Figure 4 It is the overhead structure schematic diagram of the water tank box of the utility model.

[0021] In the drawing:

[0022] Return cooling water tank 1, water tank box 11, baffle 12, sinking baffle 13, sinking baffle 14, return port 15, cooling top plate 16, cooling fan 17, bearing frame 2, base 3, reactor main body 4, liquid outlet passage 5, liquid inlet passage 6, communication pipe 7, circulating pump equipment 8. DETAILED DESCRIPTION

[0023] In order to make the person skilled in the art better understand the technical scheme of the present application, the technical scheme in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor should belong to the scope of protection of the present application.

[0024] In the description of the embodiments, it should be noted that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "two ends", "one end", "the other end" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore it cannot be understood as a limitation on the present application. In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance. In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "provided with", "connection" and the like should be understood broadly, for example, "connection" can be fixed connection, can also be detachable connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be the communication between two elements inside. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0025] As shown in the accompanying Figure 1 to the accompanying Figure 4 As shown:

[0026] The micro-channel continuous flow reactor for drug synthesis provided by the present application comprises a return cooling water tank 1, a bearing frame 2, a base 3, a reactor main body 4, a liquid outlet channel 5, a liquid inlet channel 6, a communication pipe 7 and a circulating pump device 8, the bearing frame 2 is fixedly installed above the return cooling water tank 1, the base 3 is installed on the bearing frame 2, a plurality of reactor main bodies 4 are horizontally arranged and installed on the base 3, the plurality of reactor main bodies 4 are communicated with the liquid outlet channel 5 and the liquid inlet channel 6, the liquid inlet channel 6 is communicated with the output end of the circulating pump device 8 through the communication pipe 7, and the input end of the circulating pump device 8 is communicated with the return cooling water tank 1.

[0027] Further, the return cooling water tank 1 comprises a water tank box 11, a partition plate 12, a sinking baffle 13, an upper sinking baffle 14 and a return port 15, wherein the water tank box 11 serves as an overall frame, and a bearing frame 2 is fixedly installed above the water tank box 11 and used for supporting key components such as the reactor main body 4. In addition, a circulating pump device 8 is also fixedly installed outside the water tank box 11, and a water outlet is arranged in communication with an input end of the circulating pump device 8 to realize the circulating flow of the liquid. Inside the water tank box 11, at least three partition plates 12 are fixedly installed, and the partition plates 12 and the water tank box 11 jointly form a plurality of liquid channels. Each liquid channel is provided with a return port 15 between adjacent partition plates 12, and the return ports 15 combine with the liquid channels to form a complete transverse return flow channel. This design enables the liquid to repeatedly return and flow in the plurality of channels, greatly increasing the flow path and the heat dissipation area.

[0028] Further, in the liquid channels, a plurality of sinking baffles 13 and upper sinking baffles 14 are respectively arranged. The baffles are all in a serpentine bending structure and are arranged in an alternating transverse manner in the liquid channels. The bottom of the sinking baffle 13 is fixed to the inner wall groove bottom of the water tank box 11, and the liquid is allowed to flow freely above the sinking baffle 13. The bottom of the upper sinking baffle 14 is not fixed to the inner wall groove bottom of the water tank box 11, and the liquid is also allowed to flow at the bottom end of the upper sinking baffle 14, but the liquid is not allowed to pass through at the top end of the upper sinking baffle 14. This design enables the liquid to constantly change the flow direction and flow rate during the flow process, thereby realizing a more efficient heat dissipation effect.

[0029] Further, in order to further improve the heat dissipation efficiency, the utility model also arranges a cooling top plate 16 above the middle position of the water tank box 11. The cooling top plate is located below the base 3 and is fixedly installed with a plurality of cooling fans 17. The cold air generated by the cooling fans 17 passes through the gap of the cooling top plate 16 to blow the liquid below, thereby further accelerating the heat dissipation speed of the liquid channel above. At the same time, the presence of the cooling top plate 16 also plays a role in stabilizing the liquid level and preventing the liquid from splashing out.

[0030] Further, at the two sides of the water tank box 11, one liquid channel is in communication with the circulating pump device 8 through the water outlet, and the other liquid channel is provided with a liquid outlet channel 5 above. After the liquid in the reactor main body 4 is heat-exchanged, the liquid is discharged into the liquid channel below through the liquid outlet channel 5. Subsequently, the liquid is repeatedly folded and flows back under the action of the circulating pump device 8, and is then pumped back into the reactor main body 4 after being cooled, thereby forming a complete circulating flow system. This design not only ensures the continuous cooling and heat dissipation effect of the liquid, but also improves the stability and reliability of the entire reaction system.

[0031] The working principle is as follows: firstly, the circulating pump device 8 pumps the internal liquid through its output end into the communication pipe 7. The communication pipe 7 serves as a transmission medium to guide the liquid to the liquid inlet channel 6. The liquid inlet channel 6 then distributes the liquid to each reactor body 4 for heat exchange.

[0032] In the reactor body 4, the liquid absorbs the heat generated by the reaction, causing its temperature to rise. In order to ensure that the reaction is carried out within the appropriate temperature range, the liquid with heat needs to be guided out through the liquid outlet channel 5.

[0033] The liquid outlet channel 5 discharges the liquid into the liquid channel directly below it, which is located inside the sink box 11. At this time, the liquid begins to enter the cooling process of the return cooling sink 1. In the liquid channel, the liquid first encounters the downward folding plate 13. The downward folding plate 13 guides the liquid to flow upward with its serpentine bending structure, and in the process, increases the flow path and heat dissipation area of the liquid.

[0034] Subsequently, the liquid continues to flow and encounters the upward folding plate 14. Unlike the downward folding plate 13, the bottom of the upward folding plate 14 is not fixed to the inner wall groove bottom of the sink box 11, and the bottom end allows the liquid to flow, but the top end prevents the liquid from passing through. This design allows the liquid to change direction again when flowing through the upward folding plate 14, further increasing the heat dissipation effect.

[0035] In the liquid channel, the downward folding plate 13 and the upward folding plate 14 appear in an alternating transverse arrangement, so that the liquid repeatedly flows up and down in multiple channels. This complex flow pattern not only greatly increases the heat dissipation area of the liquid, but also helps to break the temperature stratification in the liquid and improve the overall mixing effect.

[0036] At the same time, the cooling top plate 16 located above the middle position of the sink box begins to play a role. The cooling top plate is fixedly installed with several cooling fans 17, and the cooling air generated by the cooling fans 17 blows to the liquid below through the gap of the cooling top plate 16, further accelerating the cooling speed of the liquid.

[0037] After sufficient cooling, the liquid is again pumped back by the circulating pump device 8 through the water outlet on one of the two liquid channels at the sides of the sink box 11. At this time, the liquid has completed the complete circulation flow process from the reactor body 4 to the return cooling sink 1 and then to the reactor body 4.

[0038] Under the action of the circulating pump device 8, these cooled liquids are again sent into the communication pipe 7 and the liquid inlet channel 6, and then distributed to each reactor main body 4, providing the medium required for the next round of drug synthesis reaction to cool and exchange heat. This design not only ensures the continuous cooling and heat dissipation effect of the liquid, but also improves the stability and reliability of the whole reaction system, thereby ensuring the efficient and safe operation of the drug synthesis reaction.

[0039] The technical scheme disclosed by the utility model, or the technical scheme inspired by the technical scheme of the utility model by those skilled in the art, designs similar technical schemes, and achieves the above technical effects, which falls within the protection scope of the utility model.

Claims

1. A microchannel continuous flow reactor for pharmaceutical synthesis, characterized by, The utility model provides a kind of reactor, including return cooling water tank (1), bearing frame (2), pedestal (3), reactor main body (4), liquid outlet channel (5), liquid inlet channel (6), communication pipe (7) and circulating pump equipment (8), the bearing frame (2) of return cooling water tank (1) is fixedly installed on the top, and the pedestal (3) is installed on the bearing frame (2), and the reactor main body (4) is installed on the pedestal (3) transversely, and the reactor main body (4) is communicated with liquid outlet channel (5) and liquid inlet channel (6), and the liquid inlet channel (6) is communicated with the output end of circulating pump equipment (8) by communication pipe (7), and the input end of circulating pump equipment (8) is communicated with return cooling water tank (1).

2. A microchannel continuous flow reactor for pharmaceutical synthesis as claimed in claim 1, wherein: The return cooling water tank (1) includes water tank box (11), partition (12), sunken folded plate (13), upper sunken folded plate (14) and return port (15), the bearing frame (2) is fixedly installed on the top of water tank box (11), the circulating pump equipment (8) is fixedly installed on the outside of water tank box (11), and the water outlet is provided and communicated with the input end of circulating pump equipment (8), at least three partition (12) is fixedly installed in water tank box (11), and a plurality of sunken folded plate (13) and upper sunken folded plate (14) are installed, and the water tank box (11) is communicated with each partition (12) and has return port (15).

3. A microchannel continuous flow reactor for the synthesis of a pharmaceutical according to claim 2, wherein: The partition (12) is communicated with water tank box (11) and the liquid channel between water tank box (11), and a plurality of liquid channels form a complete transverse return flow channel in combination with return port (15).

4. A microchannel continuous flow reactor for the synthesis of a pharmaceutical according to claim 3, wherein: The sunken folded plate (13) and upper sunken folded plate (14) are installed in the position of liquid channel, and the sunken folded plate (13) and upper sunken folded plate (14) are serpentine bending structures, and the sunken folded plate (13) and upper sunken folded plate (14) are alternately arranged in the liquid channel.

5. A microchannel continuous flow reactor for the synthesis of a pharmaceutical according to claim 4, wherein: The bottom of sunken folded plate (13) is fixed with the inner wall groove bottom of water tank box (11), and the liquid is allowed to flow above it, and the bottom of upper sunken folded plate (14) is not fixed with the inner wall groove bottom of water tank box (11), and the bottom end of upper sunken folded plate (14) is allowed to flow, and the top end is not allowed to flow.

6. A microchannel continuous flow reactor for the synthesis of a pharmaceutical according to claim 5, wherein: The liquid flowing in the liquid channel reciprocates up and down through the sunken folded plate (13) and upper sunken folded plate (14), and the top end of upper sunken folded plate (14) is fixed with cooling top plate (16).

7. A microchannel continuous flow reactor for the synthesis of a pharmaceutical according to claim 6, wherein: The cooling top plate (16) is located above the liquid channel in the middle position, i.e. below the pedestal (3), and a plurality of cooling fans (17) are fixedly installed on the cooling top plate (16).

8. A microchannel continuous flow reactor for the synthesis of a pharmaceutical according to claim 7, wherein: One of the liquid channels at the most two sides of water tank box (11) is communicated with circulating pump equipment (8) through water outlet, and the upper of another liquid channel is provided with liquid outlet channel (5), and the liquid discharged from liquid outlet channel (5) enters the liquid channel below it.

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