Head-mounted ultrasonic probe and experimental device

By introducing a transducer channel into the head-mounted ultrasound probe, the problem of ultrasound probes being unable to connect to other devices in the prior art is solved, enabling linkage with other devices and making it suitable for observing neuronal activity in conscious small animals.

CN223760254UActive Publication Date: 2026-01-06SHENZHEN BAY LAB
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Patent Information

Application Number
CN202423029052.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-12-09
Publication Date
2026-01-06
Estimated Expiration
2034-12-09

AI Technical Summary

Technical Problem

Existing head-mounted ultrasound probes cannot be connected to other devices after being installed on the head of small animals, making it impossible to observe neuronal activity during the modulation process.

Method used

A head-mounted ultrasonic probe was designed, comprising a base and a transducer. The transducer channel allows the experimental device to contact the target location and enables linkage with other devices.

Benefits of technology

It enables the linkage between the ultrasound probe and other devices, facilitating the observation of neuronal activity during the control process, and is suitable for behavioral studies in conscious small animals.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model relates to the technical field of ultrasonic transducers, in particular to a head-mounted ultrasonic probe and an experimental device. The head-mounted ultrasonic probe comprises a base and a transducer, the base is provided with a base mounting surface, and the base mounting surface is used for mounting the base at a target position on a living body head. The transducer is provided with a transducer channel, and the transducer channel can allow the experimental device to pass through so that the experimental device can make contact with the target position. The energy converter is installed in the base hole, and the end face of one end of the energy converter is a working face used for facing a target position. Due to the fact that the transducer of the head-mounted ultrasonic probe forms the transducer channel in a surrounding mode, after the base is installed on the head of the living body, an experimental device connected with other equipment can be in contact with a target position on the living body after passing through the transducer channel, passing through the transducer and being led out through the first hole opening, and therefore linkage of the ultrasonic probe and the other equipment is achieved. And convenience is provided for observing the activity of neurons in the regulation and control process.
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Description

Technical Field

[0001] This application relates to the field of ultrasonic transducer technology, specifically to a head-mounted ultrasonic probe and experimental setup. Background Technology

[0002] Ultrasound devices can be used for research on nerve stimulation. For ultrasound stimulation of animals, a bulky commercial single-element focused ultrasound transducer is usually used. Due to the large size and weight of this transducer, the probe must be fixed by a corresponding positioning device during use, and the animal being stimulated needs to be anesthetized. It can only be used on animals in an unconscious state and cannot be used for behavioral studies of freely moving small rodents.

[0003] To apply ultrasound transducers to conscious small animals, head-mounted ultrasound probes are currently used to stimulate them. However, most of these head-mounted ultrasound probes, once installed on the animal's head, leave no space to connect other devices, making it impossible to link the ultrasound probe with other devices and thus impossible to observe neuronal activity during the modulation process. Utility Model Content

[0004] This application provides a head-mounted ultrasound probe to improve the current problem that head-mounted ultrasound probes cannot be connected to other devices after being installed on the head of small animals.

[0005] In addition, the purpose of this application is to provide an experimental device using the above-mentioned head-mounted ultrasound probe.

[0006] In a first aspect, one embodiment provides a head-mounted ultrasound probe, comprising:

[0007] The base has a base mounting surface for mounting the base on a target position on the live head; the base has a base hole, one end of which is a first opening on the base mounting surface, and the first opening faces the target position.

[0008] The transducer has a transducer channel; the transducer channel allows an experimental device to pass through so that the experimental device can contact the target position; the transducer is mounted in the base hole; in the extending direction of the transducer channel, one end face of the transducer is a working surface for facing the target position.

[0009] In another embodiment, the transducer is annular and forms the transducer channel.

[0010] In another embodiment, the transducer is plate-shaped, and the transducer channel is a through hole on the transducer.

[0011] In a further embodiment, the head-mounted ultrasound probe includes a transducer housing, the transducer is fixed in the transducer housing, the transducer is fixed in the base hole through the transducer housing, and the transducer housing has a positioning structure inside, the positioning structure contacting the transducer to position the transducer.

[0012] In a further embodiment, the positioning structure includes a positioning protrusion having a positioning surface positioned with the end face of the transducer, the positioning protrusion being an annular protrusion having a notch for the power supply line of the transducer to pass through.

[0013] In a further embodiment, the transducer housing is cylindrical with openings at both ends. The transducer housing has a first housing opening and a second housing opening. The transducer is inserted into the transducer housing through the first housing opening. The transducer housing also has a spare positioning structure. The spare positioning structure and the positioning structure are arranged in the extension direction of the transducer channel. The spare positioning structure has a spare positioning surface. The spare positioning surface is used to contact the end face of the transducer after the transducer is inserted through the second housing opening to position the transducer. The spare positioning surface faces away from the positioning structure.

[0014] In a further embodiment, the transducer is directly fixed in the hole of the base, and the base has a positioning structure; the positioning structure contacts the transducer to position the transducer.

[0015] In another embodiment, the transducer housing is detachably fixed to the base.

[0016] In a further embodiment, the head-mounted ultrasound probe includes a waterproof membrane located on the side of the transducer facing away from the first aperture. A backing layer is formed on the side of the waterproof membrane facing away from the transducer. The waterproof membrane is used to prevent liquid from flowing between the transducer and the backing layer. Alternatively, the head-mounted ultrasound probe includes a protective cover located on the side of the transducer facing away from the first aperture. A backing layer is formed on the side of the protective cover facing away from the transducer.

[0017] Secondly, one embodiment provides an experimental apparatus, including an ultrasound host and a head-mounted ultrasound probe; the head-mounted ultrasound probe includes:

[0018] The base has a base mounting surface for mounting the base on a target position on the live head; the base has a base hole, one end of which is a first opening on the base mounting surface, and the first opening faces the target position.

[0019] The transducer has a transducer channel; the transducer channel allows an experimental device to pass through so that the experimental device can contact the target position; the transducer is mounted in the base hole; in the extending direction of the transducer channel, one end face of the transducer is a working surface for facing the target position.

[0020] In another embodiment, the transducer is annular and forms the transducer channel.

[0021] In another embodiment, the transducer is plate-shaped, and the transducer channel is a through hole on the transducer.

[0022] In a further embodiment, the head-mounted ultrasound probe includes a transducer housing, the transducer is fixed in the transducer housing, the transducer is fixed in the base hole through the transducer housing, and the transducer housing has a positioning structure inside, the positioning structure contacting the transducer to position the transducer.

[0023] In a further embodiment, the positioning structure includes a positioning protrusion having a positioning surface positioned with the end face of the transducer, the positioning protrusion being an annular protrusion having a notch for the power supply line of the transducer to pass through.

[0024] In a further embodiment, the transducer housing is cylindrical with openings at both ends. The transducer housing has a first housing opening and a second housing opening. The transducer is inserted into the transducer housing through the first housing opening. The transducer housing also has a spare positioning structure. The spare positioning structure and the positioning structure are arranged in the extension direction of the transducer channel. The spare positioning structure has a spare positioning surface. The spare positioning surface is used to contact the end face of the transducer after the transducer is inserted through the second housing opening to position the transducer. The spare positioning surface faces away from the positioning structure.

[0025] In a further embodiment, the transducer is directly fixed in the hole of the base, and the base has a positioning structure; the positioning structure contacts the transducer to position the transducer.

[0026] In another embodiment, the transducer housing is detachably fixed to the base.

[0027] In a further embodiment, the head-mounted ultrasound probe includes a waterproof membrane located on the side of the transducer facing away from the first aperture. A backing layer is formed on the side of the waterproof membrane facing away from the transducer. The waterproof membrane is used to prevent liquid from flowing between the transducer and the backing layer. Alternatively, the head-mounted ultrasound probe includes a protective cover located on the side of the transducer facing away from the first aperture. A backing layer is formed on the side of the protective cover facing away from the transducer.

[0028] According to the head-mounted ultrasound probe of the above embodiment, since the transducer of the head-mounted ultrasound probe has a transducer channel, after the base is installed on the living head, the experimental devices connected to other devices can be brought into contact with the target position on the living body through the transducer channel and the first orifice, thereby realizing the linkage between the ultrasound probe and other devices, and providing convenience for observing the activity of neurons during the control process. Attached Figure Description

[0029] Figure 1 An exploded view of a head-mounted ultrasound probe in one embodiment;

[0030] Figure 2 This is a cross-sectional view of a head-mounted ultrasound probe in one embodiment;

[0031] Figure 3 This is a structural diagram of a head-mounted ultrasound probe using an optical fiber ferrule in one embodiment.

[0032] Figure 4 This is a structural diagram of a head-mounted ultrasound probe using a mini two-photon microscope in one embodiment.

[0033] Figure 5 This is a schematic diagram of a head-mounted ultrasound probe installed on the head of a mouse in one embodiment;

[0034] Figure 6 This is a schematic diagram of the structure of the second type of transducer in one embodiment;

[0035] Figure 7 This is a schematic diagram of the structure of a third type of transducer in one embodiment.

[0036] List of feature names corresponding to the reference numerals in the figure: 100, Head-mounted ultrasound probe; 1, Base; 11, Base mounting surface; 12, Base hole; 13, First opening; 14, Outer protrusion; 2, Transducer; 21, Transducer channel; 22, Working surface; 23, Power supply line; 3, Transducer housing; 31, Positioning structure; 310, Positioning protrusion; 311, Positioning surface; 312, Notch; 32, Backup positioning structure; 321, Backup structure positioning surface; 33, First housing opening; 34, Second housing opening; 4, Protective cover; 41, Protective cover notch; 42, Protective cover through hole; 5, Backing layer; 6, Fiber optic ferrule; 7, Mini two-photon microscope; 8, Mouse.

[0037] Explanation of reference numerals in parentheses in the accompanying drawings: The feature referred to by the reference numerals in parentheses in the accompanying drawings is the feature represented by both the number inside the parentheses and the number outside the parentheses. Detailed Implementation

[0038] The present application will now be described in further detail with reference to the accompanying drawings and specific embodiments. Similar elements in different embodiments are referred to by related similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of the present application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to the present application are not shown or described in the specification. This is to avoid obscuring the core parts of the present application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0039] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0040] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this application, unless otherwise specified, include direct connection, indirect connection, and contact connection (linkage).

[0041] To address the problem that existing head-mounted ultrasound probes cannot allow other devices to simultaneously collect the activity of neurons in a living head, this application provides a head-mounted ultrasound probe that provides a transducer channel for experimental devices via a transducer, facilitating the connection of experimental devices to other equipment.

[0042] In one embodiment, please refer to Figure 1 and Figure 2 The head-mounted ultrasound probe 100 includes a base 1 and a transducer 2. The base 1 has a base mounting surface 11, which is used to mount the base 1 on a target position on a living head. The base 1 has a base hole 12, and one end of the base hole 12 is a first opening 13 located on the base mounting surface 11, which is used to face the target position.

[0043] Transducer 2 has a transducer channel 21 through which an experimental device (not shown) can pass so that the experimental device can contact the target location. Transducer 2 is mounted in a base hole 12, and one end face of transducer 2 is a working surface 22 facing the target location along the extension direction of transducer channel 21. Transducer 2 emits ultrasonic waves that are transmitted from the working surface 22 to the target location.

[0044] Since the transducer 2 of the head-mounted ultrasound probe 100 forms a transducer channel 21, after the base 1 is installed on the living head, the experimental devices connected to other devices can be brought out through the transducer 2 via the transducer channel 21 and the first orifice 13 to contact the target position on the living body, thereby realizing the linkage between the ultrasound probe and other devices, and providing convenience for observing the activity of neurons during the control process.

[0045] It should be noted that the experimental device described in this application can be of any required type. For example, in one embodiment, please refer to... Figure 3 The experimental device is the fiber optic ferrule 6 of the fiber optic recording system, which passes through the transducer channel 21; for example, in one embodiment, please refer to... Figure 4 The experimental device is a mini two-photon microscope 7, a portion of which passes through the transducer channel 21; for example, in one embodiment, the experimental device can also be an electrophysiological electrode used for acquiring electroencephalogram (EEG) / electromyogram (EMG) signals; for example, in another embodiment, the experimental device can also be a drug delivery tube used for administering drugs to the head of a living organism.

[0046] In one embodiment, please refer to Figure 1 and Figure 2 The transducer 2 includes a piezoelectric ceramic, which converts electrical energy into acoustic energy to achieve the processing of the target position.

[0047] In one embodiment, please refer to Figures 1 to 4 The transducer 2 is annular and forms a transducer channel 21. The annular transducer 2 can better adapt to the shape of the skull of a living head and reduce energy loss during sound propagation.

[0048] In addition to employing a ring-shaped transducer 2, in one embodiment, please refer to... Figure 6 and Figure 7 The transducer 2 is plate-shaped, and the transducer channel 21 is a through hole on the transducer 2. Specifically, in one embodiment, please refer to... Figure 6 The transducer 2 is a spherical cap transducer plate, which allows for better contact with the head of the mouse 8. In one embodiment, please refer to... Figure 7 Transducer 2 is a flat transducer plate.

[0049] In one embodiment, please refer to Figure 1 and Figure 2 The head-mounted ultrasound probe 100 includes a transducer housing 3, in which a transducer 2 is fixed. The transducer 2 is fixed to a base hole 12 via the transducer housing 3. The transducer housing 3 provides better protection for the transducer 2 and facilitates its installation in the base hole 12. In some other embodiments, the transducer 2 can also be directly installed in the base hole 12. For one embodiment, please refer to... Figure 1 and Figure 2 The transducer housing 3 is a resin housing, which is manufactured using 3D printing. Alternatively, the transducer housing 3 can be injection molded as a single piece. The transducer housing 3 can also be made of any feasible material other than resin, such as rubber or ceramics.

[0050] In one embodiment, the transducer housing 3 and the base 1 are fixed in a detachable manner. Specifically, the transducer housing 3 and the base 1 can be fixed by at least one of magnetic attraction, fasteners (such as screws), snap-fit, interference fit, and adsorption. In another embodiment, the transducer housing 3 and the base 1 are held in position by friction, and a coupling agent is used between them to facilitate disassembly.

[0051] By detachably fixing the transducer housing 3 to the base 1, the transducer housing 3 can be removed during or before the experiment to replace the transducer 2. In one embodiment, when conducting experiments on mice 8, the base 1 can be fixed to the head of the mouse 8. When it is necessary to remove the transducer 2, it is not necessary to remove the base 1; only the transducer housing 3 needs to be removed from the base 1, which facilitates experimental operation.

[0052] In one embodiment, please refer to Figure 1 and Figure 2The transducer 2 is bonded and fixed in the transducer housing 3. Specifically, in one embodiment, the transducer 2 and the transducer housing 3 are sealed with PDMS material and epoxy resin. In some other embodiments, the transducer 2 can also be fixed in the transducer housing 3 by any feasible method such as interference fit, snap-fit, fastener fixation, magnetic fixation, etc.

[0053] To further facilitate the installation of transducer 2, in one embodiment, please refer to... Figure 1 and Figure 2 The transducer housing 3 has a positioning structure 31 inside, which contacts the transducer 2 to position it. The positioning structure 31 facilitates determining the position of the transducer 2, thereby improving the assembly efficiency of the transducer 2 and the transducer housing 3. In one embodiment, the positioning structure 31 contacts the end face of the transducer 2 to position it. In some other embodiments, the transducer 2 can also be directly fixed in the base hole 12, in which case the positioning structure 31 is disposed on the base 1.

[0054] In some other embodiments, in addition to positioning the transducer 2 by the positioning structure 31 in the transducer housing 3, the transducer 2 can also be positioned by any other feasible method. For example, when assembling the transducer 2 and the transducer housing 3, a positioning auxiliary tool can be used to position the transducer 2. After the transducer 2 and the transducer housing 3 are assembled, the positioning auxiliary tool can be removed.

[0055] Furthermore, in one embodiment, please refer to Figure 1 and Figure 2 The positioning structure 31 includes a positioning protrusion 310, which has a positioning surface 311 that positions with the end face of the transducer 2. The positioning protrusion 310 protrudes inward from the inner surface of the transducer housing 3, enabling better positioning of the transducer 2.

[0056] In one embodiment, please refer to Figure 1 , Figure 2 and Figure 5 The positioning protrusion 310 is an annular protrusion with a notch 312 for the power supply line 23 of the transducer 2 to pass through. The annular protrusion provides better positioning for the transducer 2. In some other embodiments, in addition to the annular protrusion, multiple positioning protrusions 310 arranged at intervals can also be used to position the transducer 2. In some other embodiments, the positioning structure 31 can adopt any feasible positioning structure 31 besides the protrusion, such as an annular positioning step in the transducer housing 3.

[0057] In one embodiment, please refer to Figure 1The power supply line 23 of the transducer 2 is welded to the end face of the transducer 2 facing the positioning protrusion 310. The power supply line 23 passes through the notch 312 and is led out of the transducer housing 3.

[0058] In one embodiment, please refer to Figure 1 and Figure 2 The working surface 22 of the transducer 2 is flush with one end face of the transducer housing 3. The positioning structure 31 makes it easier to align the working surface 22 of the transducer 2 with one end face of the transducer housing 3, improving assembly efficiency. In one embodiment, the transducer housing 3 is a cylindrical structure with openings at both ends, and the openings at both ends of the transducer housing 3 are aligned with the openings at both ends of the base hole 12. In some other embodiments, the length of the transducer housing 3 may be less than the length of the base, in which case one end opening of the transducer housing may also be located within the base hole.

[0059] To improve the performance of the head-mounted ultrasound probe 100, in one embodiment, please refer to... Figures 1 to 4 The head-mounted ultrasonic probe 100 includes a protective cover 4, which is located on the side of the transducer 2 facing away from the first opening 13. A backing layer 5 is formed on the side of the protective cover 4 facing away from the transducer 2.

[0060] Specifically, in one embodiment, please refer to Figure 1 and Figure 2 The protective cover 4 is bonded and fixed to the side of the transducer facing away from the first opening 13. In some other embodiments, the protective cover 4 can also be fixed to the transducer housing 3, for example, fixed to the side of the positioning protrusion 310 facing away from the first opening.

[0061] Regarding the form of the protective cover 4, in one embodiment, please refer to... Figure 1 , Figure 3 and Figure 4 The protective cover 4 has a protective cover notch 41, which allows the power supply line of the transducer 2 to pass through, as well as the leads of the experimental devices to pass through. In one embodiment, please refer to... Figure 3 and Figure 4 The protective cover 4 has a protective cover through hole 42 in the center, which allows experimental devices to pass through. At this time, the experimental devices can be fiber optic ferrules 6 or mini two-photon microscopes 7.

[0062] Besides using a protective cover, in one embodiment, a waterproof membrane can be used instead of a protective cover. The waterproof membrane is located on the side of the transducer 2 facing away from the first opening 13, and a backing layer 5 is formed on the side of the waterproof membrane facing away from the transducer 2. The waterproof membrane is used to prevent liquid from flowing between the transducer 2 and the backing layer 5. The waterproof membrane can improve the stability of the acoustic performance of the ultrasonic probe. In one embodiment, the waterproof membrane is made of PDMS material and is bonded to the transducer housing 3 with epoxy resin. In one embodiment, the waterproof membrane is bonded to the transducer 2. In another embodiment, the waterproof membrane is bonded to the positioning protrusion 310. In yet another embodiment, the waterproof membrane is bonded to the inner wall of the transducer housing 3.

[0063] It should be noted that, when the experimental device needs to pass through transducer 2, in one embodiment, the experimental device or its connecting wire can be passed through the waterproof membrane, and sealant can be applied to the position where it passes through the waterproof membrane. Alternatively, in another embodiment, the experimental device or its connecting wire can be routed around one side of the waterproof membrane. In one embodiment, when the waterproof membrane is adhered to the positioning protrusion 310, the experimental device or its connecting wire can pass through the notch 312.

[0064] In one embodiment, please refer to Figure 2 The backing layer 5 is an air backing layer. In some other embodiments, the backing layer 5 may also be any feasible type other than an air backing layer, such as an epoxy resin backing, a rubber material backing, etc.

[0065] In one embodiment, please refer to Figure 1 and Figure 2 The transducer housing 3 is a cylindrical shape with openings at both ends. The transducer housing 3 has a first housing opening 33 and a second housing opening 34. The transducer is inserted into the transducer housing 3 through the first housing opening 33. The transducer housing 3 also has a spare positioning structure 32, which is arranged along the extension direction of the transducer channel 21 with the positioning structure 31. The spare positioning structure 32 has a spare positioning surface 321, which is used to contact the end face of the transducer 2 after the transducer 2 is inserted through the second housing opening 34 to position the transducer 2. The spare positioning surface 321 faces away from the positioning structure 31. If one end of the transducer housing 3 is damaged, the spare positioning structure 32 at the other end can be used.

[0066] In one embodiment, please refer to Figure 1 and Figure 2The inner hole of the transducer housing 3 is a straight hole with a constant diameter. In some other embodiments, the diameters of the first housing opening 33 and the second housing opening 34 may be different as needed. The inner hole of the transducer housing 3 includes a large-diameter section and a small-diameter section, which are suitable for transducers of different sizes, so that the same transducer housing can be used for two different sizes of transducers.

[0067] In one embodiment, the spare positioning structure 32 is an annular protrusion.

[0068] In one embodiment, please refer to Figure 1 and Figure 2 The base 1 includes an outwardly protruding edge 14, which is located at the end where the first opening 13 is located. This increases the contact area between the base 1 and the living head, improving the reliability of the connection between the base 1 and the living head. In one embodiment, the base 1 is fixed to the skull of the living head using dental cement and light-cured material.

[0069] In one embodiment, please refer to Figure 2 The base mounting surface 11 is a curved surface designed to fit the head of a living organism, thus allowing for a better fit between the base 1 and the head. Of course, in some other embodiments, the base mounting surface 11 can also be a flat surface.

[0070] In one embodiment, the head-mounted ultrasound probe 100 is used for ultrasound neuromodulation. The transducer 2 focuses on selecting a piezoelectric material with high emitted acoustic energy, such as PZT-4 from lead zirconate titanate (PZT) as the piezoelectric material of the transducer 2.

[0071] In one embodiment, please refer to Figure 5 The experiment was conducted using mice as live subjects, with the head-mounted ultrasound probe 100 attached to the head of mouse 8. The procedure is as follows:

[0072] To record electroencephalograms (EEG) and electromyograms (EMG), self-made electrodes were first soldered using a circuit board and silver wire. Mice were anesthetized using isoflurane and fixed to a stereotaxic apparatus. The hair on the head and neck of mice was shaved to expose the skull. Holes were drilled using a skull drill, and screws were used as EEG electrodes, implanted into the skull surface. The screws were screwed into the skull holes. Two silver wire electrodes were implanted into the trapezius muscles on both sides of the neck. The screws were fixed to the skull surface with dental cement. After the dental cement had hardened, the corresponding silver wire electrodes were soldered to the circuit board, and the circuit board was again fixed to the head with dental cement. The base 1 was adhered to the skull surface at the target site using dental cement, and the exposed skull and screws were covered with dental cement. After complete curing, anesthesia was stopped, and mice were awakened and housed individually in cages. They were used for experiments one week after surgery.

[0073] During the experiment, degassed ultrasonic coupling agent was first filled into the first orifice 13 of the base 1. Then, the transducer 2 was fixed in the base hole 12 through the transducer housing 3, and the leads of the transducer 2 were connected to the power amplifier. Ultrasonic neuromodulation was then performed according to the preset ultrasonic parameters.

[0074] Because transducer 2 has a transducer channel 21, its hollow design allows experimental devices such as fiber optic recorders, drug delivery tubes, electrophysiological electrodes, and miniature microscopes to pass through. This design is suitable for experiments such as ultrasound stimulation combined with intracranial drug delivery, EEG / EMG signal acquisition, optogenetics, and fiber optic photometric recording. For reusable equipment, installation and disassembly are very convenient. The head-mounted ultrasound probe 100 is small in weight and size, making it suitable for animal behavioral experiments. This head-mounted ultrasound probe 100 can observe behavioral changes in freely moving mice 8 before, during, and after ultrasound stimulation.

[0075] In one embodiment of the experimental setup, the setup includes an ultrasound host and a head-mounted ultrasound probe 100 as described in any of the above embodiments. In another embodiment, the setup may further include a fiber optic recorder and a two-photon imaging device. During neural modulation, the head-mounted transducer can be linked with the fiber optic recorder, two-photon imaging device, etc., to observe neuronal activity during the modulation process. In one embodiment, the two-photon imaging device is a miniature two-photon microscope.

[0076] The above examples illustrate this application only to aid understanding and are not intended to limit its scope. Those skilled in the art to which this application pertains can make various simple deductions, modifications, or substitutions based on the ideas presented.

Claims

1. A head-mounted ultrasound probe, characterized by, The head-mounted ultrasonic probe comprises: a base having a base mounting surface for mounting the base at a target position on a living body head; the base has a base hole, one end of the base hole having a first hole opening on the base mounting surface for facing the target position; and a transducer having a transducer channel, the transducer channel being capable of passing an experimental device to enable the experimental device to contact the target position; the transducer being mounted in the base hole; in the extension direction of the transducer channel, one end of the transducer having an operating surface for facing the target position.

2. The head-mounted ultrasonic probe of claim 1, wherein, The transducer is annular and surrounds the transducer channel.

3. The head-mountable ultrasonic probe of claim 1, wherein, The transducer is sheet-shaped, and the transducer channel is a through hole on the transducer.

4. The head-mountable ultrasonic probe of claim 1 or 2 or 3, wherein, The head-mounted ultrasonic probe comprises a transducer housing, the transducer being fixed in the transducer housing, the transducer being fixed in the base hole through the transducer housing, the transducer housing having a positioning structure inside, the positioning structure being in contact with the transducer to position the transducer.

5. The head-mountable ultrasonic probe of claim 4, wherein, The positioning structure comprises a positioning protrusion having a positioning surface positioned with the end surface of the transducer, the positioning protrusion being an annular protrusion, the positioning protrusion having a gap for passing a power supply wire of the transducer.

6. The head-mountable ultrasonic probe of claim 4, wherein, The transducer housing is open at both ends and is cylindrical, the transducer housing having a first housing opening and a second housing opening, the transducer being loaded into the transducer housing from the first housing opening; The transducer housing further has a backup positioning structure inside, the backup positioning structure being arranged in the extension direction of the transducer channel with the positioning structure, the backup positioning structure having a backup structure positioning surface for being in contact with the end surface of the transducer to position the transducer after the transducer is loaded from the second housing opening, the backup structure positioning surface being opposite to the positioning structure.

7. The head-mounted ultrasonic probe of claim 4, wherein, The transducer housing is detachably fixed with the base.

8. The head-mountable ultrasonic probe of claim 1 or 2 or 3, wherein, The transducer is directly fixed in the base hole, the base having a positioning structure; the positioning structure being in contact with the transducer to position the transducer.

9. The head-mountable ultrasonic probe of claim 1 or 2 or 3, wherein, The head-mounted ultrasonic probe comprises a waterproof film on the side of the transducer opposite to the first hole opening, the waterproof film having a backing layer on the side opposite to the transducer, the waterproof film being used to block the flow of liquid between the transducer and the backing layer, or the head-mounted ultrasonic probe comprises a protective cover on the side of the transducer opposite to the first hole opening, the protective cover having a backing layer on the side opposite to the transducer.

10. An experimental apparatus characterized by, The head-mounted ultrasonic probe comprises an ultrasonic main machine and the head-mounted ultrasonic probe according to any one of claims 1-9.