Chemiluminescence immunoassay analyzer

Abstract

The utility model relates to the technical field of medical equipment, in particular to a chemiluminescence immunoassay analyzer which comprises a first shell, a tray assembly, a bottom plate assembly and a photomultiplier assembly, an x-axis movement assembly and a y-axis movement assembly are arranged on the bottom plate assembly, the photomultiplier assembly is transversely installed on the x-axis movement assembly, and the y-axis movement assembly is transversely installed on the y-axis movement assembly. The tray assembly is installed on the y-axis movement assembly, the transmitting end of the photomultiplier assembly is provided with the testing head sleeve assembly, the first shell is arranged outside the second shell in a sleeving mode, and the front panel assembly and the rear panel assembly are connected to the two sides of the first shell through screws respectively. The test head sleeve assembly comprises a z-axis motor, a lead screw nut mechanism and a test head, the z-axis motor is connected to the photomultiplier assembly through a mounting bracket, the z-axis motor is connected with the test head through the lead screw nut mechanism, and a spring is arranged in the test head. According to the utility model, the problems of large occupied space and high integration difficulty in vertical arrangement of the existing photomultiplier are solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical equipment technical field especially relates to a chemiluminescence immunoassay analyzer. BACKGROUND

[0002] Chemiluminescence immunoassay mainly contains two parts, namely immune response system and chemiluminescence analysis system. The immune response system is same as antigen antibody reaction system in radioimmunoassay determination, and the chemiluminescence system is that certain compounds such as luminol, isoluminol, adamantane (AMPPD) and acridine ester (AE) are oxidized by oxidizing agent or catalyzed by catalyst to become excited state product, when it returns to ground state, it will convert the remaining energy into photon, and then the light quantum yield is measured by using the light signal energy instrument. The light emitting substance is directly marked on the antigen (chemiluminescence immunoassay) or antibody (immunochemiluminescence analysis), or enzyme acts on the light emitting substrate, and the intensity of the light quantum produced can be proportional to the concentration of the measured substance.

[0003] The core detection device in chemiluminescence immunoassay instrument is photomultiplier tube (PMT) or other high sensitivity sensor, which detects single photon and transmits to amplifier, and amplifies by high voltage current, and the amplifier converts analog signal into digital signal, and the digital signal transmits the light signal to computer and calculates, and obtains clinical results.

[0004] The existing photomultiplier tube assembly adopts vertical arrangement mode, which may face some defects as follows: large space occupation: vertical arrangement usually increases the height of the instrument, so that the volume of the whole device is increased, which not only affects the space use efficiency of the laboratory, but also limits the application of the device in the space-limited environment; structural stability: the higher vertical structure may reduce the overall stability of the device, especially when it needs to be frequently moved or works in unstable environment, the risk of device toppling is increased. Integration difficulty: when designing compact instrument, the vertically arranged photomultiplier tube assembly may bring challenges to the coordination between other components, resulting in more complex integration of the whole system.

[0005] The utility model discloses a chemiluminescence immunoassay analyzer. Utility model content

[0006] The utility model provides a chemiluminescence immunoassay analyzer, aims at solving the problem of large space occupation and high integration difficulty of the existing photomultiplier tube vertical arrangement, and the technical scheme is as follows:

[0007] A kind of chemiluminescence immunoassay analyzer, including first shell, tray assembly, bottom plate assembly and photomultiplier tube assembly, x-axis movement component and y-axis movement component are provided on the bottom plate assembly, the photomultiplier tube assembly is transversely installed on x-axis movement component, the tray assembly is installed on y-axis movement component, the emitting end of the photomultiplier tube assembly is installed test head cover assembly, the first shell is sleeved outside second shell, front panel assembly and rear panel assembly are respectively screw-connected on the two sides of first shell.

[0008] On the basis of the above technical scheme, the x-axis movement component includes x-axis mounting plate, x-axis belt, the x-axis motor is installed on the x-axis mounting plate, the output end of the x-axis motor is connected with x-axis driving wheel, x-axis driven wheel is installed on the x-axis mounting plate, the x-axis belt is sleeved on x-axis driving wheel and x-axis driven wheel, x-axis sliding plate is provided on the x-axis belt, and the photomultiplier tube assembly is installed on the x-axis sliding plate.

[0009] On the basis of the above technical scheme, the y-axis movement component includes y-axis mounting plate, y-axis belt, the y-axis motor is installed on the y-axis mounting plate by support, the output end of the y-axis motor is connected with y-axis driving wheel, y-axis driven wheel is installed on the y-axis mounting plate, the y-axis belt is sleeved on y-axis driving wheel and y-axis driven wheel, y-axis sliding plate is provided on the y-axis belt, and the tray assembly is installed on the y-axis sliding plate.

[0010] Further, the test head cover assembly includes z-axis motor, screw nut mechanism and test head, the z-axis motor is connected on the photomultiplier tube assembly by mounting support, the z-axis motor is connected with test head by screw nut mechanism, and spring is provided in the test head.

[0011] Preferably, the tray assembly is provided with a placing hole, and the placing hole is used for placing a microplate.

[0012] Preferably, the first shell is made of reinforced plastic, and the second shell is made of metal.

[0013] Beneficial effects

[0014] Compared with the prior art, the beneficial effects of the present application are as follows: on the one hand, the photomultiplier tube is transversely installed, which can effectively reduce the height of the equipment and make the overall volume of the instrument more compact; on the other hand, the photomultiplier tube assembly and the tray assembly are accurately controlled by the x-axis and the y-axis respectively, so that the photomultiplier tube assembly can be accurately positioned to the position of the sample to be detected, thereby improving the accuracy and repeatability of the detection; on the other hand, the double-layer shell design, the first layer is made of reinforced plastic, and the second layer is made of metal material, which not only ensures the portability of the equipment but also provides sufficient structural strength, thereby improving the overall stability of the equipment. BRIEF DESCRIPTION OF DRAWINGS

[0015] In order to more clearly illustrate the technical solutions of the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiment or prior art description. Obviously, the drawings in the following description are only one embodiment of the present application, and for those skilled in the art, other drawings can be obtained from the provided drawings without creative labor.

[0016] Figure 1 The structural schematic diagram of the present application;

[0017] Figure 2 The explosion diagram of the present application;

[0018] Figure 3 The structural schematic diagram of the x-axis motion assembly and the y-axis motion assembly of the present application;

[0019] Figure 4 The schematic diagram of the present application. DETAILED DESCRIPTION

[0020] The present application will be further described below in conjunction with the drawings and examples:

[0021] The embodiments of the present application will be described in detail below, and the examples of the embodiments are shown in the drawings, wherein the same or similar reference signs represent the same or similar elements or elements with the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present application, and cannot be understood as a limitation of the present application.

[0022] In the description of the present application, it should be explained that, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be directly connected, or indirectly connected through intermediate medium. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0023] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation of the present application.

[0024] As Figure 1 and Figure 2As shown, a chemiluminescence immunoassay analyzer is characterized by comprising a first housing 11, a tray assembly 2, a base plate assembly 4, and a photomultiplier tube assembly 6. An x-axis motion assembly 7 and a y-axis motion assembly 8 are mounted on the base plate assembly 4. The photomultiplier tube assembly 6 is horizontally mounted on the x-axis motion assembly 7. The tray assembly 2 is mounted on the y-axis motion assembly 8. A test head assembly 9 is mounted on the emitting end of the photomultiplier tube assembly 6. The first housing 11 is fitted over a second housing 12. The front panel assembly 3 and the rear panel assembly 5 are screwed to both sides of the first housing 11. A power adapter is connected to the rear panel assembly 5.

[0025] It also includes an electronic control component that controls the x-axis motion component 7, the y-axis motion component 8, and the z-axis motor.

[0026] Setting the photomultiplier tube assembly 6 horizontally has several advantages over setting it vertically: horizontal installation can effectively reduce the height of the equipment, making the overall size of the instrument more compact and more suitable for laboratory environments with limited space.

[0027] Compared to vertical installation, horizontal installation can improve the stability of the equipment, reduce deviations caused by vibration or collision, and help improve the reliability of test results.

[0028] like Figure 3 As shown, the x-axis motion assembly 7 includes an x-axis mounting plate 71 and an x-axis belt 75. An x-axis motor 72 is mounted on the x-axis mounting plate 71, and the output end of the x-axis motor 72 is connected to an x-axis drive pulley 73. An x-axis driven pulley 74 is mounted on the x-axis mounting plate 71. The x-axis belt 75 is fitted onto the x-axis drive pulley 73 and the x-axis driven pulley 74. An x-axis sliding plate 76 is provided on the x-axis belt 75, and the electromultiplier tube assembly 6 is mounted on the x-axis sliding plate 76. An x-axis slide rail 711 is provided on the x-axis mounting plate 71, and the x-axis sliding plate 76 is slidably connected to the x-axis slide rail 711.

[0029] The y-axis motion assembly 8 includes a y-axis mounting plate 81 and a y-axis belt 85. A y-axis motor 82 is mounted on the y-axis mounting plate 81 via a bracket. The output end of the y-axis motor 82 is connected to a y-axis drive wheel 83. A y-axis driven wheel 84 is mounted on the y-axis mounting plate 81. The y-axis belt 85 is fitted onto the y-axis drive wheel 83 and the y-axis driven wheel 84. A y-axis sliding plate is provided on the y-axis belt 85, and the tray assembly 2 is mounted on the y-axis sliding plate. A y-axis slide rail 811 is provided on the y-axis mounting plate 81, and the y-axis sliding plate is slidably connected to the y-axis slide rail 811.

[0030] The test head assembly 9 includes a Z-axis motor, a lead screw and nut mechanism, and a test head. The Z-axis motor is connected to the photomultiplier tube assembly 6 via a mounting bracket. The Z-axis motor is connected to the test head via the lead screw and nut mechanism. A spring is installed in the test head. The spring provides a certain elastic force to the test head, allowing it to automatically adjust the pressure according to changes in the sample surface when in contact with the sample, ensuring good contact between the test head and the sample surface, while preventing excessive pressure from damaging the sample or the test head itself. When the test head contacts the sample or microplate, the spring pressure allows for a tight fit, forming a good physical seal and reducing the possibility of external light entering.

[0031] The x-axis motion assembly 7 and the y-axis motion assembly 8 respectively control the design of the photomultiplier tube assembly 6 and the tray assembly 2. Compared with the x and y axes jointly controlling the same component, this has the following advantages:

[0032] Because each axis independently controls its corresponding components, more precise positioning can be achieved, thereby improving the accuracy and repeatability of the inspection process. Separate control reduces mutual interference between moving parts, making the control logic clearer and reducing the design complexity of the control system. Independent motion control allows for rapid position adjustments during inspection, reducing waiting time caused by a single axis controlling multiple components and improving work efficiency. If one axis fails, only that axis needs to be repaired or replaced without affecting the function of other parts, reducing maintenance costs and downtime. This design allows for future upgrades or expansions of one component without affecting the function of another, enhancing the system's scalability and adaptability.

[0033] The front panel 31 has a placement opening 311.

[0034] like Figure 4 As shown, an indicator light 111 and a button 112 are provided on the first housing 11.

[0035] The tray assembly 2 has a placement hole, which is used to place a microplate 22.

[0036] The first outer shell 11 is made of reinforced plastic, while the second outer shell 12 is made of metal. This dual-layer design balances performance with cost through the appropriate selection of materials; for example, plastic has lower processing costs, while metal provides necessary protection in critical areas. The metal shell provides a robust protective layer, effectively resisting external impacts and other physical damage, while the plastic shell absorbs vibrations, acting as a cushion. The metal shell also offers excellent electromagnetic shielding, preventing external electromagnetic interference from affecting the normal operation of the instrument and improving the accuracy and stability of the test results.

[0037] In use, first, the sample to be tested is placed in a specially designed microplate, such as a 96-well plate. The microplate 22 is placed on the tray assembly 2. The power is turned on, and the system performs an initialization check to ensure that all components are in working order. At this time, the status of the device can be monitored or simple operations can be performed through the indicator light 111 and the button 112 on the first housing 11. According to the needs of the detection project, the corresponding reagent is added to the sample. This step can be completed manually, or in an instrument with high automation, it can be automatically executed by the built-in sample adding system. Under certain conditions, the target molecules in the sample and the antibodies / antigens in the reagent undergo specific binding reactions to form complexes. Add a luminescent substrate, such as luminol, isoluminol, adamantane, or acridine ester, to initiate a chemiluminescence reaction. The activated luminescent substance produces photons. Through the coordinated work of the x-axis movement assembly 7 and the y-axis movement assembly 8, the photomultiplier tube assembly 6 and the tray assembly 2 are precisely positioned above each reaction well. The test head sleeve assembly 9 on the photomultiplier tube assembly 6 is lowered to the appropriate position by the drive of the z-axis motor, and the detection of the intensity of light quanta begins. The spring in the test head can ensure good contact between the test head and the microplate. The detected light quantum intensity information is converted into an electrical signal by the photomultiplier tube, and after amplification and analog-to-digital conversion, it is transmitted to the computer for data analysis. By comparing the intensity of the light quanta with the standard curve, the concentration of the substance to be tested is obtained.

[0038] It should be noted that the lead screw nut mechanism, test head, and spring in this embodiment are general standard parts or components known to those skilled in the art, and their structure and principles can be known to those skilled in the art through technical manuals or through conventional experimental methods.

[0039] The utility model has been described above by way of example, but the utility model is not limited to the above specific embodiments, and any modification or variation made based on the utility model falls within the scope of protection required by the utility model.

Claims

1. A chemiluminescent immunoassay analyzer characterized by comprising: It includes first shell (11), tray assembly (2), bottom plate assembly (4) and photomultiplier tube assembly (6), the bottom plate assembly (4) is provided with x-axis movement assembly (7) and y-axis movement assembly (8), the photomultiplier tube assembly (6) is transversely installed on x-axis movement assembly (7), the tray assembly (2) is installed on y-axis movement assembly (8), the emission end of the photomultiplier tube assembly (6) is installed test head cover assembly (9), the first shell (11) is sleeved outside the second shell (12), the front panel assembly (3) and rear panel assembly (5) are respectively screw-connected on the two sides of the first shell (11).

2. The chemiluminescent immunoassay analyzer according to claim 1, characterized by: The x-axis movement assembly (7) includes x-axis mounting plate (71), x-axis belt (75), the x-axis motor (72) is installed on the x-axis mounting plate (71), the output end of the x-axis motor (72) is connected with x-axis driving wheel (73), the x-axis driving wheel (74) is installed on the x-axis mounting plate (71), the x-axis belt (75) is sleeved on the x-axis driving wheel (73) and the x-axis driving wheel (74), the x-axis belt (75) is provided with x-axis sliding plate (76), and the photomultiplier tube assembly (6) is installed on the x-axis sliding plate (76).

3. The chemiluminescent immunoassay analyzer according to claim 2, characterized by: The x-axis mounting plate (71) is provided with x-axis sliding rail (711), and the x-axis sliding plate (76) is slidably connected on the x-axis sliding rail (711).

4. The chemiluminescent immunoassay analyzer according to claim 1, characterized by: The y-axis movement assembly (8) includes y-axis mounting plate (81), y-axis belt (85), the y-axis motor (82) is installed on the y-axis mounting plate (81) through a support, the output end of the y-axis motor (82) is connected with y-axis driving wheel (83), the y-axis driving wheel (84) is installed on the y-axis mounting plate (81), the y-axis belt (85) is sleeved on the y-axis driving wheel (83) and the y-axis driving wheel (84), the y-axis belt (85) is provided with y-axis sliding plate, and the tray assembly (2) is installed on the y-axis sliding plate.

5. The chemiluminescent immunoassay analyzer according to claim 4, characterized by: The y-axis mounting plate (81) is provided with y-axis sliding rail (811), and the y-axis sliding plate is slidably connected on the y-axis sliding rail (811).

6. The chemiluminescent immunoassay analyzer according to claim 1, wherein: The front panel (31) is provided with placing opening (311).

7. The chemiluminescent immunoassay analyzer according to claim 1, wherein: The first shell (11) is provided with indicator light (111) and button (112).

8. The chemiluminescent immunoassay analyzer according to claim 1, wherein: The test head cover assembly (9) includes z-axis motor, screw nut mechanism and test head, the z-axis motor is connected on the photomultiplier tube assembly (6) through a mounting bracket, the z-axis motor is connected with the test head through the screw nut mechanism, and the test head is provided with a spring.

9. The chemiluminescent immunoassay analyzer according to claim 1, characterized by: The tray assembly (2) is provided with a placing hole, and the placing hole is used for placing microplate (22).

10. The chemiluminescent immunoassay analyzer according to claim 1, characterized by: The first shell (11) is made of reinforced plastic, and the second shell (12) is made of metal.

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