Chromatographic column support

Abstract

The utility model discloses a chromatographic column bracket, which belongs to the field of experimental equipment, and comprises a shell, the bottom of the shell is connected with a plurality of trundles, the shell is of a cylindrical structure with an open top surface and a closed bottom surface, a supporting hole is formed in the center of the bottom surface of the shell, and the supporting hole is used for supporting the bottom of a chromatographic column and allowing an underflow conduit to pass through; a clamping mechanism used for clamping the chromatographic column is further arranged in the shell and comprises a plurality of movable rods, the movable rods are arranged in the direction parallel to the axial direction of the shell, the movable rods are arranged around the axis of the shell in the circumferential direction at intervals, the distances between the movable rods and the axis of the shell are the same, and each movable rod is movably connected relative to the radial direction of the shell; a spring is connected between each movable rod and the shell and used for providing elastic force enabling the movable rod to move in the direction close to the axis of the shell, and each movable rod is provided with a contact piece used for making contact with and pressing the corresponding chromatographic column. According to the utility model, chromatographic columns with different diameters can be clamped, and meanwhile, manual intervention adjustment is not needed.

Description

TECHNICAL FIELD

[0001] The utility model relates to experimental equipment field, especially a kind of chromatography column support. BACKGROUND

[0002] Chromatography column is a kind of laboratory equipment, for separating different components in mixture. It is usually composed of a column tube and stationary phase filled in it. Chromatography column is widely used in biochemistry, chemistry, pharmaceutical and environmental science fields, for purifying protein, nucleic acid, small molecule compound etc.

[0003] The working principle of chromatography column is based on the difference of interaction between different components in mobile phase (liquid moving through column) and stationary phase (substance filled in column). When mixture is loaded onto column, mobile phase will push each component in mixture through column at different speeds. Because different components have different affinities with stationary phase, their moving speeds in column will also be different, so as to realize separation.

[0004] Chromatography column usually needs to be kept fixed posture by support when using, for example, the Chinese utility model patent with publication number CN215234333U discloses a protein chromatography column purification support, but the support in the patent can only adapt to the fixation of chromatography column of specific size, and cannot fix chromatography column of different diameter sizes.

[0005] Although some chromatography column supports can fix chromatography column of different diameter sizes, manual intervention is needed for adjustment operation when fixing chromatography column, which leads to inconvenience in use, for example, the Chinese utility model patent with publication number CN217410837U discloses an adjustable chromatography column support, which needs manual operation to adjust exposed screw in adjusting piece. SUMMARY

[0006] In view of the problem that chromatography column support in prior art needs manual intervention for adjustment to adapt to clamping fixation of chromatography column of different diameter specifications, the purpose of the utility model is to provide a chromatography column support, so as to at least partially solve the above problems.

[0007] To achieve the above purpose, the technical scheme of the utility model is as follows:

[0008] A chromatography column holder comprises a housing connected with several casters at the bottom, the housing is in a cylindrical structure with an open top and a closed bottom, a support hole is formed at the center of the bottom of the housing, the support hole is used to support the bottom of the chromatography column and the bottom flow conduit passes through the support hole, a clamping mechanism is arranged inside the housing to clamp the chromatography column, the clamping mechanism comprises several movable rods, the movable rods are arranged in the direction parallel to the axis of the housing, the movable rods are arranged at intervals around the axis of the housing and have the same distance from the axis of the housing, each movable rod is connected with the housing in a radial manner and a spring is arranged between each movable rod and the housing, the spring provides a spring force to move the movable rod towards the axis of the housing, and a contact piece is arranged on each movable rod to contact and compress the chromatography column.

[0009] In some preferred embodiments, a telescopic guide structure is fixedly connected between the movable rod and the inner wall of the housing, the telescopic guide structure comprises a matched outer sleeve and inner guide rod, the outer sleeve is fixed on one of the housing and the movable rod, and the inner guide rod is fixed on the other one of the housing and the movable rod.

[0010] In some preferred embodiments, the spring is sleeved outside the telescopic guide structure.

[0011] In some preferred embodiments, several telescopic guide structures are arranged between the movable rod and the inner wall of the housing, and the telescopic guide structures are arranged at intervals in the axial direction of the housing.

[0012] In some preferred embodiments, both ends of each telescopic guide structure are hingedly connected to the housing and the movable rod.

[0013] In some preferred embodiments, the upper end of each movable rod is provided with a guide angle.

[0014] In some preferred embodiments, the contact piece is a roller rotatably connected to the movable rod, and the rotation axis of the roller is perpendicular to the axis of the housing.

[0015] In some preferred embodiments, there are multiple rollers arranged at intervals along the length direction of the movable rod.

[0016] In some preferred embodiments, the circumferential side wall of the roller is arc-shaped.

[0017] In some preferred embodiments, a buffer layer made of elastic or flexible material is arranged on the circumferential side wall of the roller.

[0018] The utility model discloses the beneficial effect lies in: the utility model discloses the setting of clamping mechanism makes the chromatographic column of different diameter use can through the mode of opening the movable rod and make spring store certain elastic force to the utility model discloses, and then through the elastic force of spring to clamp chromatographic column to the utility model discloses, thereby when clamping the chromatographic column of different diameter, also need not manual intervention adjustment. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is the front view of chromatographic column support in the utility model.

[0020] Figure 2 It is the plan view of chromatographic column support in the utility model.

[0021] Figure 3 It is the section view along Figure 2 A-A line (not including trundle).

[0022] Figure 4 It is Figure 3 The local enlarged view of B.

[0023] Figure 5 It is the plan view of shell in the utility model.

[0024] Figure 6 It is the section view of contact in the utility model.

[0025] In the drawing: 1-shell, 2-trundle, 3-support hole, 4-chromatographic column, 5-movable rod, 6-telescopic guide structure, 61-outer sleeve, 62-inner guide rod, 7-spring, 8-contact. DETAILED DESCRIPTION

[0026] The specific implementation of the utility model will be further explained in combination with the drawings. It needs to be explained here that the explanation of these implementation is used to help understanding the utility model, but does not constitute the limitation of the utility model. In addition, the technical features involved in each embodiment of the utility model described below can be combined with each other as long as they do not conflict with each other.

[0027] It needs to be explained that in the description of the utility model, the orientation or position relationship indicated by the terms "upper", "lower", "left", "right", "front", "back" and the like is the explanation of the structure of the utility model shown in the drawings, and is only for the convenience of describing the utility model. It is not intended to indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the utility model.

[0028] For the "first" and "second" in the technical solution, it is only a distinction for the same or similar structure, or the corresponding structure with similar functions, and it is not the arrangement of the importance of these structures, nor the order, or the comparison of size, or other meanings.

[0029] In addition, unless otherwise expressly specified and limited, the terms "mounting", "connection" should be understood broadly, for example, the connection can be fixed connection, or detachable connection, or integrally connected; can be mechanical connection, or electrical connection; can be directly connected, or indirectly connected through an intermediate medium, can be the communication inside two structures. For those skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the overall idea of the utility model and the specific circumstances of the present scheme. Embodiment

[0030] A chromatography column support, as shown in Figures 1-6 It comprises a shell 1, a caster 2 and a clamping mechanism.

[0031] The shell 1 is in a cylindrical structure, the top surface of the shell 1 is open and the bottom surface is closed. The caster 2 is fixedly connected to the bottom outer wall of the shell 1, and the caster 2 is a self-locking caster and usually a universal caster with self-locking function.

[0032] A support hole 3 is formed at the central position of the bottom surface of the shell 1, which is used to support the bottom of the chromatography column 4, and also for the bottom flow conduit of the chromatography column 4 to pass through. The support hole 3 is usually U-shaped, and the center of curvature of the support hole 3 coincides with the center of the shell 1.

[0033] The clamping mechanism is arranged inside the shell 1, and is used to clamp the chromatography column 4. The clamping mechanism in the embodiment comprises a movable rod 5, a telescopic guide structure 6, a spring 7 and a contact piece 8.

[0034] The movable rod 5 has three straight rod structures, and the three movable rods 5 are arranged in parallel to the axial direction of the shell 1, and the arrangement height of the three (or other number greater than 3) movable rods 5 is the same. The three movable rods 5 are arranged circumferentially around the axis of the shell 1, and the distance of the three movable rods 5 from the axis of the shell 1 is the same.

[0035] Each movable rod 5 is radially movably connected relative to the shell 1, and the telescopic guide structure 6 is specifically connected between the movable rod 5 and the inner wall of the shell 1. The telescopic guide structure 6 comprises an outer sleeve 61 and an inner guide rod 62, the inner guide rod 62 is inserted in the outer sleeve 61 in a clearance fit manner, the outer sleeve 61 is fixed on the inner wall of the shell 1, and the inner guide rod 62 is fixed on the movable rod 5, or vice versa, the outer sleeve 61 is fixed on the movable rod 5, and the inner guide rod 62 is fixed on the inner wall of the shell 1.

[0036] Generally, each movable rod 5 is provided with multiple telescopic guiding structures 6, for example, three (or other number greater than or equal to 2), which are arranged along the axial direction of the shell 1. Generally, the upper end of the movable rod 5 is shaped with a guide angle to facilitate guiding the chromatography column 4 to enter.

[0037] In addition, it is easy to understand that the two ends of each telescopic guiding structure 6 can also be hingedly connected to the shell 1 and the movable rod 5, respectively, so that the telescopic guiding structure 6 can rotate relative to the shell 1 and the movable rod 5, and the rotation axis is perpendicular to the axis of the shell 1, so that each movable rod 5 can be inclined relative to the axis of the shell 1. Thus, when the bottom end of the chromatography column 4 is just inserted into the upper end of the clamping mechanism, the spring 7 at the upper end of each movable rod 5 will be forced to move away from the axis of the shell 1, and the spring 7 at the lower end will be slightly forced and the elastic force will remain basically unchanged, that is, each movable rod 5 forms a large upper and small lower conical profile, which can effectively reduce the resistance when the chromatography column 4 enters.

[0038] Each movable rod 5 is connected with a spring 7 between the movable rod 5 and the shell 1, and the spring 7 is used to provide an elastic force for moving the movable rod 5 towards the axis of the shell 1. In the embodiment, the spring 7 is sleeved outside the telescopic guiding structure 6, and generally, each telescopic guiding structure 6 is sleeved with a spring 7 outside.

[0039] Each movable rod 5 is provided with a contact piece 8 for contacting and pressing the chromatography column 4. In the embodiment, the contact piece 8 is configured as a roller rotatably connected to the movable rod 5, and the rotation axis of the roller is perpendicular to the axis of the shell 1. Generally, each movable rod 5 is also provided with multiple contact pieces 8, which are arranged along the length direction of the movable rod 5.

[0040] In addition, the circumferential side wall of the roller is generally configured in an arc shape to better contact the outer circumferential wall of the chromatography column 4. The circumferential side wall of the roller is generally also coated with a buffer layer made of elastic or flexible material to prevent extrusion damage to the outer circumferential wall of the chromatography column 4.

[0041] The use process of the chromatography column support provided in the embodiment of the present application is as follows:

[0042] When using, firstly lock the casters 2, then move the chromatography column 4 to the upper of the shell 1 with the bottom end downward and coaxial, meanwhile, make the transverse joint at the bottom end of the chromatography column 4 circumferentially staggered with the movable rods 5 of the clamping mechanism, then the chromatography column 4 is extended into the shell 1, when the bottom end contacts the movable rods 5, then force each movable rod 5 radially away from the axis of the shell 1, meanwhile, the spring 7 stores the elastic force, under the action of the elastic force, each movable rod 5 contacts the outer wall of the chromatography column 4 and provides a certain clamping force to the chromatography column 4, until the bottom end of the chromatography column 4 falls on the supporting hole 3, the bottom flow conduit of the chromatography column 4 extends from the supporting hole 3, the chromatography column 4 can be used. Compared with the prior art, the chromatography column support provided by the utility model does not need additional fastening operation when using, and can adapt to chromatography columns of various diameter specifications.

[0043] The embodiments of the utility model are described in detail above in combination with the drawings, but the utility model is not limited to the described embodiments. For those skilled in the art, various changes, modifications, replacements and modifications can be made to these embodiments without departing from the principles and spirits of the utility model, and still fall within the protection scope of the utility model.

Claims

1. A chromatography column holder, characterized by: The application relates to a chromatographic column supporting device, which comprises a shell connected with several casters at the bottom, wherein the shell is in a cylindrical structure with an open top surface and a closed bottom surface, a supporting hole is arranged at the central position of the bottom surface of the shell, the supporting hole is used for supporting the bottom of a chromatographic column and allowing a bottom flow conduit to pass through, and a clamping mechanism for clamping the chromatographic column is arranged in the shell, the clamping mechanism comprises several movable rods arranged in the direction parallel to the axial direction of the shell, the movable rods are arranged at the same distance from the axial line of the shell in a circumferential direction, each movable rod is connected with the shell in a radial direction, a spring is arranged between each movable rod and the shell, the spring is used for providing elastic force for moving the movable rod towards the axial line of the shell, and a contact piece for contacting and compressing the chromatographic column is arranged on each movable rod.

2. The chromatography column holder of claim 1, wherein: The movable rod and the inner wall of the shell are fixedly connected with a telescopic guide structure, the telescopic guide structure comprises a matched outer sleeve and an inner guide rod, the outer sleeve is fixed on one of the shell and the movable rod, and the inner guide rod is fixed on the other one of the shell and the movable rod.

3. The chromatography column holder of claim 2, wherein: The spring is sleeved outside the telescopic guide structure.

4. The chromatography column holder of claim 2, wherein: The movable rod and the inner wall of the shell are provided with several telescopic guide structures, and the telescopic guide structures are arranged in the axial direction of the shell.

5. The chromatography column holder of claim 4, wherein: The two ends of each telescopic guide structure are hingedly connected with the shell and the movable rod.

6. The chromatography column holder of claim 1, wherein: The upper end of the movable rod is provided with a guide angle.

7. The chromatography column holder of claim 1, wherein: The contact piece is a roller rotatably connected with the movable rod, and the rotation axis of the roller is perpendicular to the axial line of the shell.

8. The chromatography column holder of claim 7, wherein: The roller has a plurality of rollers arranged in the length direction of the movable rod.

9. The chromatography column holder of claim 7, wherein: The circumferential side wall of the roller is arc-shaped.

10. The chromatography column holder of claim 7, wherein: An elastic or flexible material is coated on the circumferential side wall of the roller.

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