Disposable freeze-drying tray

Abstract

The utility model discloses a disposable freeze-drying disc which comprises a tray, the top of the tray is provided with an upper opening and a top sealing film connected with the upper opening in a sealing mode, and the bottom of the tray is provided with a lower opening and a bottom sealing film connected with the lower opening in a sealing mode. The top sealing film comprises a waterproof breathable film close to the inner side of the tray and a protective layer located on the outer side of the waterproof breathable film, and the bottom sealing film comprises a smooth area and an anti-skid area located on the edge of the smooth area. The utility model aims to effectively improve the overall strength of the top sealing film, thereby ensuring the integrity of the top sealing film.

Description

Technical Field

[0001] This utility model belongs to the field of freeze-drying technology, and in particular relates to a disposable freeze-drying tray. Background Technology

[0002] Freeze-drying technology, also known as vacuum freeze-drying technology, is a novel drying method that freezes water-containing materials into solids and utilizes the sublimation properties of water under low temperature and low pressure conditions to dehydrate the materials and achieve dryness. A freeze dryer is an essential piece of equipment in the freeze-drying process. Commonly used freeze-drying trays in freeze dryers are open-top stainless steel trays and disposable plastic trays. Stainless steel freeze-drying trays are often reused, which can easily lead to cross-contamination risks. Currently, commonly used disposable freeze-drying trays can solve these problems. For example, CN112810954A discloses a disposable sterile container used in freeze-drying processes, including a bottom sealing film, side walls, and an upper film. The upper film is usually made of waterproof and breathable material; however, due to insufficient overall strength of the upper film, the fibers of the waterproof and breathable material are prone to shedding, affecting the cleanliness of the sample to be processed. Utility Model Content

[0003] This invention provides a disposable freeze-drying tray that effectively improves the overall strength of the top sealing film, thereby ensuring the integrity of the top sealing film.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] A disposable freeze-drying tray includes a tray with an upper opening and a top sealing film sealingly connected to the upper opening at the top, and a lower opening and a bottom sealing film sealingly connected to the lower opening at the bottom. The top sealing film includes a waterproof and breathable membrane near the inner side of the tray and a protective layer on the outer side of the waterproof and breathable membrane. The bottom sealing film includes a smooth area and an anti-slip area at the edge of the smooth area. The protective layer, located on the outer side of the waterproof and breathable membrane, provides support and protection for the membrane, improving the overall strength of the top sealing film, reducing the risk of delamination of the waterproof and breathable membrane, and helping to ensure the cleanliness of the sample to be processed. The anti-slip area improves the stability of the disposable freeze-drying tray during liquid addition and freeze-drying processes.

[0006] Preferably, the protective layer is made of at least one layer of nonwoven fabric, and the waterproof and breathable membrane and the protective layer are formed by hot-pressing to create the top sealing film. Nonwoven fabric is lightweight, easy to shape, and has a significantly smaller pore size than common support materials such as sieves and mesh fabrics. When combined with the waterproof and breathable membrane, it has higher strength, further reducing the risk of delamination. At the same time, nonwoven fabric can provide a more uniform covering layer, which helps to ensure a more consistent distribution of irradiation energy across the entire surface of the waterproof and breathable membrane during irradiation sterilization.

[0007] Preferably, the thickness of the top sealing film is 0.18-0.28 mm. A suitable top sealing film thickness effectively ensures the performance and biosafety of the freeze-drying tray after sterilization, while also helping to control costs and reduce the impact on the air permeability of the top sealing film.

[0008] Preferably, the thickness ratio of the waterproof and breathable membrane to the protective layer is 1:8 to 1:4, and the density of the nonwoven fabric is 0.25-0.5 g / cm³. 3 A nonwoven fabric of suitable thickness and with a tight seal can ensure effective penetration of electron beams or rays, which is beneficial for ensuring sterilization effect.

[0009] Preferably, the waterproof and breathable membrane material is one of PTFE, PU and TPU.

[0010] Preferably, the upper opening has an inner edge that is sealed to the top sealing film, and the lower opening has an outer edge that is sealed to the bottom sealing film. The inner edge is sealed to the top film, and the outer edge is sealed to the bottom sealing film, which improves the connection between the tray and the top / bottom sealing film.

[0011] Preferably, the sealing connection width between the inner edge and the top sealing film is 0.3-1 cm; and / or, the sealing connection width between the outer edge and the bottom sealing film is 0.3-1 cm. A suitable sealing connection width ensures the overall sealing effect of the freeze-drying tray, while also helping to ensure the flatness of the connection, improve heat exchange efficiency, and enhance the uniformity of product temperature.

[0012] Preferably, the anti-slip area is sealed to the bottom surface of the outer edge, and the roughness of the anti-slip area is greater than that of the smooth area. The greater roughness of the anti-slip area helps to ensure a stable and reliable sealing connection between the anti-slip area and the outer edge, guaranteeing a sealing effect.

[0013] Preferably, the sidewalls of the tray are inclined inwards. The inclined sidewalls of the tray ensure the overall stability of the disposable freeze-drying tray and the flatness of the bottom sealing film.

[0014] Preferably, the bottom sealing film material is one of PE, PP, or PET, and the thickness of the bottom sealing film is 0.2-0.7 mm.

[0015] The beneficial effects of this utility model are: (1) A protective layer is set on the outside of the waterproof and breathable membrane, which improves the water pressure resistance and tensile strength of the top sealing film and ensures the integrity of the waterproof and breathable membrane; (2) The non-woven protective layer can play a role in resisting radiation, so that the radiation sterilization is more evenly distributed on the top sealing film and reduces the adverse effects on the waterproof and breathable membrane; (3) The bottom sealing film and the top sealing film are reliably sealed to the tray, which ensures the stability of the tray in supporting the internal samples; (4) The bottom sealing film is provided with an anti-slip area and a smooth area, which improves the stability of the disposable freeze-drying tray during the liquid addition and freeze-drying process. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of this utility model;

[0017] Figure 2 This is a schematic diagram of the top structure of the tray of this utility model;

[0018] Figure 3 This is a schematic diagram of the bottom structure of the tray of this utility model.

[0019] In the diagram: tray 1, inlet 1a, top opening 1b, bottom opening 1c, inner edge 11, outer edge 12, side wall 13, top sealing film 2, protective layer 21, waterproof and breathable membrane 22, bottom sealing film 3, anti-slip area 3a, smooth area 3b. Detailed Implementation

[0020] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0021] like Figure 1 In the illustrated embodiment, a disposable freeze-drying tray includes a tray 1. The top of the tray 1 has an upper opening 1b and a top sealing film 2 that is sealed to the upper opening 1b. The bottom of the tray 1 has a lower opening 1c and a bottom sealing film 3 that is sealed to the lower opening 1c. The top of the tray 1 also has an inlet 1a with threads that can be used to seal with an inlet cover (not shown in the figure). The material to be freeze-dried enters through this inlet 1a. The tray 1, the top sealing film 2, and the bottom sealing film 3 together form a closed and sealed structure, preventing splashing and spillage of the material.

[0022] The top sealing film 2 includes a waterproof and breathable membrane 22 near the inner side of the tray 1 and a protective layer 21 located on the outer side of the waterproof and breathable membrane 22. The waterproof and breathable membrane 22 is made of one of PTFE, PU, ​​and TPU, and the protective layer 21 is made of a non-woven fabric. The waterproof and breathable membrane 22 and the protective layer 21 are formed by hot-pressing to form the top sealing film 2. Because non-woven fabric is lightweight, easy to shape, and has a pore size significantly smaller than common support materials such as sieves and mesh fabrics, it has higher strength after being combined with the waterproof and breathable membrane 22, effectively reducing the risk of delamination. The non-woven fabric material has excellent breathability and will not significantly affect the waterproof and breathable membrane 22 after being combined, while ensuring an airflow velocity of 0.2-0.4 L / min / cm for the top sealing film 2. 2 @7KPa, with a water pressure resistance of 400-800KPa. The top sealing membrane 2 adopts this design, which further enhances its pressure resistance, achieving an overall tensile strength greater than 18MPa. Under this pressure, the top sealing membrane 2 can maintain its integrity. Simultaneously, the non-woven fabric provides a more uniform covering layer, helping to ensure a more consistent distribution of irradiation energy across the entire surface of the waterproof and breathable membrane 22 during irradiation sterilization.

[0023] The thickness of the top sealing film 2 is 0.18-0.28 mm. Since electron beam sterilization is used, no chemical residues are left after electron beam sterilization. The appropriate thickness of the top sealing film 2 can effectively ensure the performance and biosafety of the freeze-drying tray after sterilization, while avoiding increased production costs and reduced air permeability of the top sealing film 2 due to excessive thickness.

[0024] The thickness ratio of the waterproof and breathable membrane 22 to the protective layer 21 is 1:8 to 1:4, and the density of the nonwoven fabric is 0.25-0.5 g / cm³. 3 If the nonwoven fabric is too thick or has a high density, it may hinder the effective penetration of electron beams or rays, reducing the sterilization effect. The appropriate thickness and density of the nonwoven fabric can ensure the overall strength of the radiation-resistant sealing film on top, and also effectively control the sterilization effect.

[0025] Combination Figure 2 , Figure 3 As shown, the side walls 13 of the tray 1 are inclined inward. All four side walls 13 of the tray 1 are set to be inclined, so that the longitudinal section of the freeze-drying tray is trapezoidal, thereby ensuring the overall stability of the disposable freeze-drying tray and the flatness of the bottom sealing film 3.

[0026] The upper opening 1b has an inner edge 11 that is sealed to the top sealing film 2, and the lower opening 1c has an outer edge 12 that is sealed to the bottom sealing film 3. The sealing connection width between the inner edge 11 and the top sealing film 2, and the sealing connection width between the outer edge 12 and the bottom sealing film 3, are both 0.3-1cm. When the sealing connection width is less than 0.3cm, it will affect the overall sealing effect of the freeze-drying tray. When the sealing connection width is greater than 1cm, the bonding area between the bottom sealing film 3 and the tray 1 during melting and heat sealing is large, which will cause the bottom sealing film 3 to soften excessively and become uneven after cooling.

[0027] The bottom sealing film 3 is made of one of PE, PP, or PET, and its thickness is 0.2-0.7 mm. For example... Figure 1 As shown, the bottom sealing film 3 includes a smooth area 3b and an anti-slip area 3a located at the edge of the smooth area 3b. The anti-slip area 3a is in contact with the bottom surface of the outer edge 12, and the roughness of the anti-slip area 3a is greater than that of the smooth area 3b. When liquid products are added through the inlet 1a, the disturbance caused by the fluid flow may cause the disposable freeze-drying tray to slide and spill liquid. The relatively large roughness of the anti-slip area 3a ensures the reliability of the connection between the bottom sealing film 3 and the tray 1, and improves the stability of the disposable freeze-drying tray during liquid addition and freeze-drying processes. The area that is not in contact with the outer edge is set as the smooth area 3b, which is used to improve the flatness of the bottom sealing film 3 and ensure heat exchange efficiency.

[0028] In the actual use of disposable freeze-drying trays, liquid products are quantitatively added into the tray through the inlet 1a and then resealed. Due to liquid surface tension, the solution will not flow out through the top sealing membrane 2. Simultaneously, the microporous structure of the waterproof and breathable membrane 22 effectively prevents bacteria and other contaminants from entering the freeze-drying tray. This avoids solution leakage and effectively controls the risk of microbial contamination during freeze-drying and handling. The freeze-drying tray containing the solution is placed in a vacuum freeze dryer for freeze-drying. During this process, the water in the solution first condenses into ice and then sublimates directly into water vapor under vacuum conditions. Due to the pressure difference, the water vapor can penetrate the waterproof and breathable membrane 22 and escape into the external environment until the entire drying process is completed. During freeze-drying, some freeze-dried powder may be carried along with the flow of water vapor, but this powder is blocked by the waterproof and breathable membrane 22, thereby reducing powder escape and waste, preventing powder contamination of the surrounding environment and equipment, and ensuring the safety of operators.

[0029] The embodiments of this utility model have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this utility model. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of this utility model. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this utility model. Therefore, the content of this specification should not be construed as a limitation of this utility model.

Claims

1. A disposable freeze-drying tray, comprising a tray (1), characterized in that, The tray (1) has an upper opening (1b) at the top and a top sealing film (2) sealed to the upper opening (1b). The tray (1) has a lower opening (1c) at the bottom and a bottom sealing film (3) sealed to the lower opening (1c). The top sealing film (2) includes a waterproof and breathable membrane (22) near the inside of the tray (1) and a protective layer (21) on the outside of the waterproof and breathable membrane (22). The bottom sealing film (3) includes a smooth area (3b) and an anti-slip area (3a) at the edge of the smooth area (3b).

2. The disposable freeze-drying tray according to claim 1, characterized in that, The protective layer (21) is made of at least one layer of non-woven fabric, and the waterproof and breathable membrane (22) and the protective layer (21) are formed by hot pressing to form the top sealing film (2).

3. The disposable freeze-drying tray according to claim 1, characterized in that, The thickness of the top sealing film (2) is 0.18-0.28 mm.

4. A disposable freeze-drying tray according to claim 2, characterized in that, The thickness ratio of the waterproof and breathable membrane (22) to the protective layer (21) is 1:8 to 1:4, and the density of the nonwoven fabric is 0.25-0.5 g / cm³. 3 .

5. A disposable freeze-drying tray according to claim 1, characterized in that, The waterproof and breathable membrane (22) is made of one of PTFE, PU and TPU.

6. A disposable freeze-drying tray according to claim 1, characterized in that, The upper opening (1b) has an inner edge (11) that is sealed to the top sealing film (2), and the lower opening (1c) has an outer edge (12) that is sealed to the bottom sealing film (3).

7. A disposable freeze-drying tray according to claim 6, characterized in that, The sealing connection width between the inner edge (11) and the top sealing film (2) is 0.3-1cm; and / or, the sealing connection width between the outer edge (12) and the bottom sealing film (3) is 0.3-1cm.

8. A disposable freeze-drying tray according to claim 6 or 7, characterized in that, The anti-slip area (3a) is in contact with the bottom surface of the outer edge (12), and the roughness of the anti-slip area (3a) is greater than that of the smooth area (3b).

9. A disposable freeze-drying tray according to claim 1, characterized in that, The sidewall (13) of the tray (1) is inclined inward.

10. A disposable freeze-drying tray according to claim 1, characterized in that, The bottom sealing film (3) is made of one of PE, PP, or PET, and the thickness of the bottom sealing film (3) is 0.2-0.7 mm.

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