Automatic quantitative liquid adding device of liquid chromatograph

Abstract

The utility model aims to provide an automatic quantitative liquid adding device of a liquid chromatograph, and relates to the technical field of chromatographic instruments, a sealing cover is arranged in a liquid adding tank to seal the liquid adding tank, and liquid in a liquid storage cavity is conveyed to the liquid adding tank through liquid conveying degassing equipment; by moving the blocking plate of the batcher, the height of the overflow opening in the blocking plate can be adjusted, the sensor is arranged on the overflow pipe communicated with the overflow opening, when it is detected that liquid flows through, the infusion degassing equipment is controlled to stop conveying the liquid, then the electromagnetic valve at the bottom of the liquid adding tank is opened to enable the liquid to flow into the mobile phase bottle body, and quantitative liquid adding is achieved; shutdown liquid adding is avoided, and reagent waste and environmental pollution are reduced; the liquid adding head is arranged in the mobile phase bottle body and clings to the inner wall of the mobile phase bottle body, and the liquid outlet of the liquid adding head faces the inner wall of the mobile phase bottle body, so that added liquid can flow down along the inner wall of the mobile phase bottle body, liquid level shaking and gas introduction are avoided, and the stability of a liquid phase system and the utilization efficiency of an instrument are improved.

Description

Technical Field

[0001] This utility model relates to the field of chromatography technology, and in particular to an automatic quantitative liquid addition device for a liquid chromatograph. Background Technology

[0002] Liquid chromatography (LC) is a highly efficient, rapid, and sensitive analytical instrument widely used in biology, medicine, chemical engineering, environmental science, food science, and many other fields. Based on chromatographic principles, LC utilizes the differences in partition coefficients between the stationary and mobile phases of different substances to separate and detect components in a mixture. When a sample solution containing multiple components enters the chromatographic column, the differences in adsorption, dissolution, and partitioning between the stationary and mobile phases cause the components to migrate at different speeds within the column, thus achieving separation. The separated components then sequentially enter a detector, which converts the component concentration into an electrical signal, outputting it to a data processing system to produce a chromatogram.

[0003] Currently, high-performance liquid chromatography (HPLC) consumes a significant amount of mobile phase during continuous operation. Since HPLC vials are typically 1000 mL, replenishment of the mobile phase is usually necessary during continuous operation. Conventional methods often involve manually adding or replacing the mobile phase during downtime, which is time-consuming, disrupts normal detection, and makes it difficult to control the amount added, easily resulting in over- or under-addition. During the process of adding or replacing the mobile phase, liquid surface sloshing and splashing often occur, inevitably introducing gases that cause pressure instability, baseline drift, and variations in retention time and peak area, thus affecting the accuracy of the experimental results. Furthermore, manually opening the HPLC vials can lead to the volatilization of some highly toxic organic reagents, potentially causing environmental pollution and posing certain health risks. Utility Model Content

[0004] To address the shortcomings of existing technologies, this utility model provides the following technical solution:

[0005] An automatic quantitative liquid addition device for a liquid chromatograph includes a housing, a conduit, and a mobile phase bottle. The mobile phase bottle is detachably mounted on the housing, and several addition tanks are detachably mounted on the housing and communicate with the mobile phase bottle. A dispensing head is disposed close to the inner wall of each mobile phase bottle. A notch is formed on the side of each addition tank, and a metering device is movably mounted at the notch to block it. The metering device includes a sealing plate, an overflow pipe, a limiting plate, and a limiting bolt. The sealing plate is located on the inner wall of the addition tank to block the notch. The front end of the overflow pipe is fixedly mounted on the sealing plate, and an overflow port is formed on the sealing plate, allowing the overflow pipe to communicate with the addition tank. The limiting plate is located on the outer wall of the liquid filling tank. The limiting bolt is threaded onto the overflow pipe. One end of the limiting bolt is rotatably connected to the limiting plate. By rotating the limiting bolt, the limiting plate is driven to abut against the outer wall of the liquid filling tank. This, together with the sealing plate, fixes the metering device at the notch of the liquid filling tank. The box body is provided with several liquid storage chambers, and a liquid delivery and degassing device is installed on the box body and communicates with the liquid storage chambers. The rear end of the overflow pipe is connected to the liquid storage chamber through a conduit. The liquid delivery and degassing device is connected to the liquid filling tank through a conduit. The liquid in the liquid storage chamber is transported to the liquid filling tank through the liquid delivery and degassing device. During the transportation process, the liquid is defoamed and degassed by the liquid delivery and degassing device.

[0006] Furthermore, the liquid filling tank has an open top structure, and a sealing cap can be detachably installed at the opening to block the opening of the liquid filling tank. The sealing cap slides into the liquid filling tank and abuts against the sealing plate. A liquid filling pipe is fixedly installed on the sealing cap and communicates with the inside of the sealing cap. A conduit installed on the liquid delivery and degassing equipment is connected to the liquid filling pipe.

[0007] Furthermore, each liquid storage chamber is fixedly equipped with a drain port and a filling port on the housing, and the drain port and the filling port are connected to the liquid storage chamber.

[0008] Furthermore, the liquid dispensing head is an annular structure that fits tightly against the inner wall of the mobile phase bottle. The liquid dispensing head has a dispensing chamber inside and several liquid outlets below the dispensing chamber, with the liquid outlets facing the inner wall of the mobile phase bottle. The dispensing head is connected to the lower part of the dispensing tank and the dispensing chamber of the dispensing head through a conduit. A solenoid valve is installed below the dispensing tank to control the flow of the conduit below the dispensing tank.

[0009] Furthermore, the bottom of the liquid addition tank is higher than the top of the mobile phase bottle.

[0010] Furthermore, an installation groove is provided on the housing corresponding to the mobile phase bottle and the liquid addition tank; an ultrasonic generator is provided at the bottom of the installation groove on the housing corresponding to the liquid addition tank, and the bottom of the liquid addition tank is in contact with the ultrasonic generator, so that the liquid in the liquid addition tank is ultrasonically defoamed and degassed by the ultrasonic generator.

[0011] Furthermore, a sensor is installed on the overflow pipe to detect the flow of liquid within the overflow pipe.

[0012] Furthermore, the length and width of the sealing plate are both greater than the length and width of the notch.

[0013] Furthermore, the liquid addition tank is equipped with graduations.

[0014] Furthermore, a control panel is provided on the enclosure.

[0015] Furthermore, a sealing ring is provided on the sealing plate, which is located between the sealing plate and the inner wall of the liquid filling tank, which can effectively prevent liquid leakage.

[0016] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0017] This invention features a detachable liquid filling tank mounted on a housing, with a sealing cap inside to prevent contamination of the liquid. A liquid storage chamber is located within the housing and connected to a liquid delivery and degassing device, which transfers the liquid from the storage chamber to the filling tank. A metering device seals the opening of the filling tank; by moving the sealing plate, the height of the overflow port on the sealing plate can be adjusted. A sensor is installed on the overflow pipe connecting to the overflow port; when liquid flow is detected, the sensor sends a signal, which, via the control panel, stops the liquid delivery via an electromagnetic induction device at the bottom of the filling tank. The valve opens to allow liquid to flow into the mobile phase bottle, enabling quantitative liquid addition. This avoids the difficulty in controlling the amount added manually, preventing over- or under-addition and avoiding downtime for liquid addition. Furthermore, when adding liquid manually, the sealing cap can be removed, and the liquid can be poured directly into the addition tank. Excess liquid can flow through the overflow port of the sealing plate into the overflow pipe and into the storage chamber, preventing over-addition and collecting excess liquid to avoid waste. A dispensing head is installed close to the inner wall of the mobile phase bottle, with the outlet facing the inner wall, allowing the added liquid to flow down the inner wall of the mobile phase bottle, preventing splashing and reducing liquid surface sloshing. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the front structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the rear view structure of this utility model;

[0020] Figure 3 This is an enlarged schematic diagram of the rear view structure at point A of this utility model;

[0021] Figure 4 This is a side view sectional structural diagram of the present invention;

[0022] Figure 5 This is an enlarged schematic diagram of section B in the side view of the structure of this utility model;

[0023] Figure 6 This is an enlarged schematic diagram of section C in the side view of the present invention;

[0024] Figure 7 This is a schematic diagram of the metering device structure of this utility model.

[0025] In the diagram: Box-1, Drain-101, Injection-102, Control Panel-2, Mobile Phase Bottle-3, Injection Head-301, Injection Hole-3011, Injection Tank-4, Notch-401, Sealing Cap-5, Injection Pipe-501, Meter-6, Sealing Plate-601, Overflow Pipe-602, Limiting Plate-603, Limiting Bolt-604, Storage Chamber-7, Infusion Degassing Equipment-8, Ultrasonic Generator-9. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] Example 1:

[0028] Please see Figure 1-7An automatic quantitative liquid addition device for a liquid chromatograph includes a housing 1, a conduit, and a mobile phase bottle 3. The mobile phase bottle 3 is detachably mounted on the housing 1, and several addition tanks 4 are detachably mounted on the housing 1 and communicate with the mobile phase bottle 3. A notch 401 is formed on the side of each addition tank 4, and a metering device 6 is movably mounted at the notch 401 to block the notch 401. The metering device 6 includes a sealing plate 601, an overflow pipe 602, a limiting plate 603, and a limiting bolt 604. The sealing plate 601 is located on the inner wall of the addition tank 4, blocking the notch 401. A sealing ring is provided on the sealing plate 601, located between the sealing plate 601 and the inner wall of the addition tank 4, which can effectively prevent liquid leakage. The front end of the overflow pipe 602 is fixed. An overflow port is provided on the sealing plate 601, allowing the overflow pipe 602 to connect with the liquid filling tank 4. The limiting plate 603 is located on the outer wall of the liquid filling tank 4. The limiting bolt 604 is threaded onto the overflow pipe 602, with one end of the limiting bolt 604 rotatably connected to the limiting plate 603. By rotating the limiting bolt 604, the limiting plate 603 is driven to abut against the outer wall of the liquid filling tank 4, thus fixing the metering device 6 at the notch 401 of the liquid filling tank 4 in conjunction with the sealing plate 601. Several liquid storage chambers 7 are provided inside the housing 1, and a liquid delivery and degassing device 8 is provided on the housing 1 and connected to the liquid storage chambers 7. The rear end of the overflow pipe 602 is connected to the liquid storage chamber 7 through a conduit, and the liquid delivery and degassing device 8 is connected to the liquid filling tank 4 through a conduit.

[0029] In this embodiment, the liquid addition tank 4 has an open top structure, and a sealing cap 5 is detachably installed at the opening to block the opening of the liquid addition tank 4. The sealing cap 5 is slidably inserted into the liquid addition tank 4 and abuts against the sealing plate 601. A liquid addition pipe 501 is fixedly installed on the sealing cap 5 and communicates with the inside of the sealing cap 5. A conduit installed on the liquid infusion degassing device 8 communicates with the liquid addition pipe 501. The liquid infusion degassing device 8 is existing technology. Currently, liquid chromatographs use this type of device for degassing and liquid transportation. The liquid infusion degassing device 8 includes a vacuum degasser and a liquid pump. After the liquid passes through the vacuum degasser, the air bubbles carried by the liquid will be separated from the liquid, realizing degassing and defoaming.

[0030] In this embodiment, a drain port 101 and a filling port 102 are fixedly installed on the housing 1 for each liquid storage chamber 7. The drain port 101 and the filling port 102 are connected to the liquid storage chamber 7. Liquid is added to the liquid storage chamber 7 through the filling port 102, and liquid can be discharged through the drain port 101.

[0031] In this embodiment, the bottom of the liquid addition tank 4 is higher than the top of the mobile phase bottle 3, allowing liquid to flow into the mobile phase bottle 3. The housing 1 has mounting slots corresponding to the mobile phase bottle 3 and the liquid addition tank 4 for placement. A sensor is installed on the overflow pipe 602 to detect the flow of liquid within it. The length and width of the sealing plate 601 are both greater than the length and width of the notch 401, effectively sealing the notch 401 to prevent leakage. The liquid addition tank 4 has graduations to easily determine the height of the overflow port, thereby determining the liquid volume. A control panel 2 is installed on the housing 1 to control the operation of the infusion degassing device 8 and receive sensor signals. The sensor is existing technology and emits a signal when liquid passes through it.

[0032] In this embodiment, a liquid filling tank 4 is detachably installed on the housing 1, and a sealing cap 5 is installed inside the liquid filling tank 4 to seal it and prevent the liquid inside the liquid filling tank 4 from being contaminated. A liquid storage chamber 7 is provided inside the housing 1, and a liquid delivery and degassing device 8 is provided to communicate with the inside of the liquid storage chamber 7. The liquid in the liquid storage chamber 7 is delivered to the liquid filling tank 4 through the liquid delivery and degassing device 8. A metering device 6 is provided at the notch 401 of the liquid filling tank 4 to block the notch 401. By moving the sealing plate 601 of the metering device 6, the height of the overflow port on the sealing plate 601 can be adjusted. A sensor is provided on the overflow pipe 602 that connects to the overflow port. When a sensor detects that there is excess liquid, the sensor will detect the overflow. When the liquid flows through, the sensor sends a signal, which controls the liquid delivery and degassing device 8 to stop delivering the liquid via the control panel 2. Then, the solenoid valve at the bottom of the liquid addition tank 4 opens to allow the liquid to flow into the mobile phase bottle 3, achieving quantitative liquid addition. This avoids the problem of uncontrollable addition of liquid when manually adding liquid directly to the mobile phase bottle 3, resulting in over- or under-addition, and avoids the need to stop the machine for liquid addition. In addition, when adding liquid manually, the sealing cap 5 can be removed and the liquid can be poured directly into the liquid addition tank 4. Excess liquid can flow through the overflow port of the sealing plate 601 to the overflow pipe 602 and into the liquid storage chamber 7, which not only avoids over-addition but also collects excess liquid to avoid waste.

[0033] Example 2:

[0034] Please see Figure 1-7 According to Embodiment 1, a liquid filling head 301 is disposed close to the inner wall of the mobile phase bottle 3. The liquid filling head 301 is an annular structure that is close to the inner wall of the mobile phase bottle 3. A liquid filling chamber is disposed inside the liquid filling head 301, and several liquid outlets are disposed below the liquid filling chamber. The liquid outlets face the inner wall of the mobile phase bottle 3 and are connected to the liquid filling chamber of the liquid filling head 301 through a conduit. A solenoid valve is disposed below the liquid filling tank 4 to control the conduction of the conduit below the liquid filling tank 4. The solenoid valve is prior art.

[0035] In this embodiment, by providing a liquid inlet 301 close to the inner wall of the mobile phase bottle 3, with the outlet of the liquid inlet 301 facing the inner wall of the mobile phase bottle 3, the added liquid can flow down along the inner wall of the mobile phase bottle 3, avoiding liquid splashing and reducing liquid surface sloshing.

[0036] Example 3:

[0037] Please see Figure 1-7 According to embodiments 1-2, an ultrasonic generator 9 is provided at the bottom of the mounting groove corresponding to the liquid filling tank 4 on the box body 1. The bottom of the liquid filling tank 4 is in contact with the ultrasonic generator 9. The ultrasonic generator 9 performs ultrasonic defoaming and degassing on the liquid in the liquid filling tank 4, thereby further preventing the gas carried by the liquid when it flows into the mobile phase bottle 3. The ultrasonic generator 9 is the prior art.

[0038] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. An automatic quantitative liquid addition device for a liquid chromatograph, comprising a housing, a conduit, and a mobile phase bottle, characterized in that, The mobile phase bottle is detachably mounted on the housing, and several liquid addition tanks are detachably installed on the housing and communicate with the mobile phase bottle. A liquid addition head is installed close to the inner wall of each mobile phase bottle. A notch is opened on the side of each liquid addition tank, and a metering device is movably installed at the notch to block it. The metering device includes a sealing plate, an overflow pipe, a limiting plate, and a limiting bolt. The sealing plate is located on the inner wall of the liquid addition tank to block the notch. The front end of the overflow pipe is fixedly installed on the sealing plate, and an overflow port is opened on the plate, allowing the overflow pipe to... The liquid filling tank is connected, and the limiting plate is located on the outer wall of the liquid filling tank. The limiting bolt is threaded on the overflow pipe, and one end of the limiting bolt is rotatably connected to the limiting plate. By rotating the limiting bolt, the limiting plate is driven to abut against the outer wall of the liquid filling tank, which, together with the sealing plate, fixes the metering device at the notch of the liquid filling tank. The box body is provided with several liquid storage chambers, and a liquid delivery and degassing device is provided on the box body and connected to the liquid storage chambers. The rear end of the overflow pipe is connected to the liquid storage chamber through a conduit, and the liquid delivery and degassing device is connected to the liquid filling tank through a conduit.

2. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, The liquid filling tank has an open top structure, and a sealing cap can be detachably installed at the opening to block the opening of the liquid filling tank. The sealing cap is slidably inserted into the liquid filling tank and abuts against the sealing plate. A liquid filling pipe is fixedly installed on the sealing cap and communicates with the inside of the sealing cap. A conduit installed on the liquid delivery and degassing equipment is connected to the liquid filling pipe.

3. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, The housing is equipped with a drain port and an injection port for each liquid storage chamber, and the drain port and injection port are connected to the liquid storage chamber.

4. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, The dispensing head is an annular structure that fits tightly against the inner wall of the mobile phase bottle. The dispensing head has a dispensing chamber inside and several dispensing outlets below the dispensing chamber, with the outlets facing the inner wall of the mobile phase bottle. The dispensing head is connected to the dispensing chamber below the dispensing tank via a conduit. A solenoid valve is installed below the dispensing tank to control the flow of the conduit below the dispensing tank.

5. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, The bottom of the liquid addition tank is higher than the top of the mobile phase bottle.

6. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, The housing has mounting slots corresponding to the mobile phase bottle and the liquid addition tank.

7. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, The liquid filling tank is equipped with graduations; the length and width of the sealing plate are both greater than the length and width of the notch.

8. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 1, characterized in that, A sensor is installed on the overflow pipe, and a control panel is installed on the housing.

9. The automatic quantitative liquid addition device for a liquid chromatograph according to claim 6, characterized in that, An ultrasonic generator is installed at the bottom of the mounting slot corresponding to the liquid filling tank on the box body, and the bottom of the liquid filling tank is in contact with the ultrasonic generator.

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