Vacuum distillation device for 4-aminotetrahydro-2H-pyran-3-ol hydrochloride

Abstract

The utility model discloses a 4-aminotetrahydro-2H-pyran-3-ol hydrochloride vacuum distillation device, which relates to the technical field of vacuum distillation devices and comprises a fixed seat, and a support plate is fixedly arranged on the left side of the top of the fixed seat. According to the device, distilled 4-aminotetrahydro-2-H-pyran-3-ol hydrochloride is poured into the distillation bottle, the distillation bottle is placed on the supporting frame, the alcohol heating bottle is lighted for heating distillation, the T-shaped plate drives the L-shaped strip to move leftwards by observing the temperature of the thermometer, the pressure spring is extruded, and the contact between the transverse strip of the L-shaped strip and the rack is released, so that the alcohol is heated, and the alcohol is distilled. According to the temperature tested by a thermometer, a movable plate drives a supporting frame and a distillation bottle to move, the distillation bottle is made to be away from or close to flames of an alcohol heating bottle, a T-shaped plate is loosened, the T-shaped plate drives an L-shaped strip to reset through a compression spring, at the moment, a transverse strip of the L-shaped strip moves to be attached to the inner wall of a rack, and the movable plate is rapidly fixed; and further, the heating temperature of the 4-aminotetrahydro-2-H-pyran-3-alcohol hydrochloride is rapidly adjusted.

Description

TECHNICAL FIELD

[0001] The utility model relates to vacuum distillation device technical field especially is related to a kind of 4-amino tetrahydro-2H-pyran-3-ol hydrochloride vacuum distillation device. BACKGROUND

[0002] 4-amino tetrahydro-2H-pyran-3-ol hydrochloride is a kind of organic chemical substance, has been found to be applied in the synthesis of therapeutic compound or composition for treating or preventing disease and disorder related to cystic fibrosis transmembrane conductance regulator activity, when purifying 4-amino tetrahydro-2H-pyran-3-ol hydrochloride, need to use vacuum distillation device.

[0003] When purifying 4-amino tetrahydro-2H-pyran-3-ol hydrochloride, 4-amino tetrahydro-2H-pyran-3-ol hydrochloride is placed in distillation flask, alcohol lamp is placed at the bottom, 4-amino tetrahydro-2H-pyran-3-ol hydrochloride inside distillation flask is heated, and excess moisture inside it is evaporated, but it is difficult to control the temperature of heating distillation flask by alcohol lamp, and then 4-amino tetrahydro-2H-pyran-3-ol hydrochloride is not controlled in the distillation purification range that staff wants. UTILITY MODEL CONTENT

[0004] In order to improve the above-mentioned 4-amino tetrahydro-2H-pyran-3-ol hydrochloride is placed in distillation flask, alcohol lamp is placed at the bottom, 4-amino tetrahydro-2H-pyran-3-ol hydrochloride inside distillation flask is heated, and excess moisture inside it is evaporated, but it is difficult to control the temperature of heating distillation flask by alcohol lamp, and then 4-amino tetrahydro-2H-pyran-3-ol hydrochloride is not controlled in the distillation purification range that staff wants, the utility model provides a kind of 4-amino tetrahydro-2H-pyran-3-ol hydrochloride vacuum distillation device.

[0005] The utility model provides a kind of 4-amino tetrahydro-2H-pyran-3-ol hydrochloride vacuum distillation device, adopt following technical scheme:

[0006] A kind of 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride vacuum distillation device, including fixed seat, the left side of the top of the fixed seat is fixedly arranged with support plate, adjusting groove is opened in the inside of the support plate, the inside of the adjusting groove is slidably provided with fixed piece;

[0007] The left side of the fixed piece is fixedly arranged with support frame, distillation flask is placed in the inside of the support frame, alcohol heating bottle is placed in the right side of the top of the fixed seat, storage bottle is placed in the left side of the top of the fixed seat, support piece is fixedly arranged on the middle part of the top surface of the fixed seat, conveying pipe is fixedly arranged on the front side of the support piece.

[0008] By the above technical scheme, the mobile plate can be quickly fixed, the temperature for heating 4-amino tetrahydro 2-H-pyran-3-ol hydrochloride can be quickly adjusted, and water distilled from the 4-amino tetrahydro 2-H-pyran-3-ol hydrochloride can be quickly moved to the storage bottle.

[0009] Optionally, in the above-mentioned 4-amino tetrahydro 2-H-pyran-3-ol hydrochloride vacuum distillation device, two long grooves are formed on the left side of the support plate, and a rack is fixedly arranged in the long grooves.

[0010] By the above technical scheme, the horizontal bar of the L-shaped bar can be moved to the side of the rack to contact and fix the mobile plate.

[0011] Optionally, in the above-mentioned 4-amino tetrahydro 2-H-pyran-3-ol hydrochloride vacuum distillation device, the fixing member comprises a mobile plate, the mobile plate is slidingly arranged in the adjusting groove, the right side of the mobile plate is fixedly matched with the side of the support frame, a T-shaped groove is formed on the left side of the mobile plate, a T-shaped plate is slidingly arranged in the T-shaped groove, a compression spring is fixedly arranged on the side of each horizontal plate of the T-shaped plate, the side of the compression spring is fixedly matched with the inside of the T-shaped groove, and an L-shaped bar is fixedly arranged on the front and back sides of the vertical plate of the T-shaped plate.

[0012] By the above technical scheme, the T-shaped plate can drive the L-shaped bar to move, thereby conveniently adjusting and fixing the mobile plate.

[0013] Optionally, in the above-mentioned 4-amino tetrahydro 2-H-pyran-3-ol hydrochloride vacuum distillation device, the upper and lower sides of the horizontal bar of the L-shaped bar are bevelled, and the side of the horizontal bar of the L-shaped bar is slidingly matched with the side of the rack.

[0014] By the above technical scheme, the side of the L-shaped bar with bevelled processing has a larger disengagement area with the rack.

[0015] Optionally, in the above-mentioned 4-amino tetrahydro 2-H-pyran-3-ol hydrochloride vacuum distillation device, limit blocks are fixedly arranged on the front and back sides of the mobile plate, the adjusting groove is in the shape of a Chinese character "zhong", and the inner sides of the two vertical grooves of the Chinese character "zhong" adjusting groove are slidingly matched with the sides of the two limit blocks, respectively.

[0016] By the above technical scheme, the limit blocks can drive the mobile plate to move vertically and stably in the adjusting groove.

[0017] Optionally, in the above-mentioned vacuum distillation device for 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride, a sealing plug is fixedly inserted into the top of the inner wall of the distillation flask, and a thermometer is fixedly inserted into the sealing plug.

[0018] Through the above technical solution, the material of the sealing plug can be a synthetic cork, the distillation flask can be sealed by the sealing plug, and the temperature of the material inside the distillation flask can be measured by the thermometer.

[0019] Optionally, in the above-mentioned vacuum distillation device for 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride, the support comprises a long frame fixedly arranged at the top of the fixed seat, a screw rod slidingly arranged in the inside of the long frame, an outer hexagonal nut rotatably arranged at the rear side of the screw rod, and a C-shaped clamp sleeve fixedly arranged at the front side of the screw rod.

[0020] Through the above technical solution, the C-shaped clamp sleeve can be made of hard rubber material, and the conveying pipe can be fixed by the C-shaped clamp sleeve.

[0021] Optionally, in the above-mentioned vacuum distillation device for 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride, the conveying pipe is connected to the inside of the C-shaped clamp sleeve, the left end of the conveying pipe extends into the inside of the distillation flask, the right end of the conveying pipe is fixedly sleeved with a flow guide pipe, and one end of the flow guide pipe extends into the inside of the storage bottle.

[0022] Through the above technical solution, the water generated after the distillation of 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride can be moved from the conveying pipe and the flow guide pipe to the inside of the storage bottle for storage.

[0023] In summary, the present application has at least one of the following beneficial effects:

[0024] The distilled 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride is poured into the distillation flask, the distillation flask is placed on the support frame, the alcohol heating flask is lit for heating distillation, the temperature of the thermometer is observed, the L-shaped strip is moved to the left under the action of the T-shaped plate, the compression spring is pressed, and the contact between the horizontal bar of the L-shaped strip and the rack is released, the temperature measured by the thermometer is used to move the support frame and the distillation flask under the action of the moving plate, the distillation flask is moved away from or close to the flame of the alcohol heating flask, the T-shaped plate is relaxed, the L-shaped strip is reset under the action of the compression spring, the horizontal bar of the L-shaped strip is moved to fit the inner wall of the rack, the moving plate can be quickly fixed, and the temperature of the 4-amino tetrahydro-2-H-pyran-3-ol hydrochloride can be quickly adjusted.

[0025] By rotating the outer hexagonal nut counterclockwise, the fixing of the screw rod is released, according to the height of the distillation bottle and the storage bottle, the screw rod and the C-shaped clamp sleeve are deflected, the conveying pipe is deflected to the appropriate angle, the outlet of the flow guide pipe is aligned with the inlet of the storage bottle, the outer hexagonal nut is rotated clockwise to tighten the screw rod, and then the water distilled out of the 4-amino tetrahydro-2-H-pyrane-3-ol hydrochloride can be quickly moved to the storage bottle. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 is a three-dimensional structure schematic diagram of the utility model;

[0027] Figure 2 is a three-dimensional structure schematic diagram of the support plate of the utility model;

[0028] Figure 3 is a three-dimensional structure development diagram of the fixing piece of the utility model;

[0029] Figure 4 is a three-dimensional structure development diagram of the support piece of the utility model.

[0030] In the drawing: 1, fixed seat; 2, support plate; 201, long groove; 202, rack; 3, adjusting groove; 4, fixing piece; 401, moving plate; 402, T-shaped groove; 403, T-shaped plate; 404, compression spring; 405, L-shaped strip; 406, limit block; 5, support frame; 6, distillation bottle; 601, sealing plug; 602, thermometer; 7, alcohol heating bottle; 8, storage bottle; 9, support piece; 901, long frame; 902, screw rod; 903, outer hexagonal nut; 904, C-shaped clamp sleeve; 10, conveying pipe; 1001, flow guide pipe. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings Figures 1-4 The utility model is further explained in detail.

[0032] Please refer to the drawings in the specification Figure 1 , Figure 2 , Figure 3 and Figure 4 , the utility model provides an embodiment: a kind of 4-amino tetrahydro-2H-pyrane-3-ol hydrochloride vacuum distillation device, including fixed seat 1, support plate 2 is fixedly arranged on the left side of the top of fixed seat 1, adjusting groove 3 is set in the inside of support plate 2, adjusting groove 3 is slidably arranged with fixed piece 4 in the inside;

[0033] The left side of fixed piece 4 is fixedly provided with support frame 5, distillation bottle 6 is placed in the inside of support frame 5, alcohol heating bottle 7 is placed on the right side of the top of fixed seat 1, storage bottle 8 is placed on the left side of the top of fixed seat 1, support piece 9 is fixedly arranged on the top surface of fixed seat 1, conveying pipe 10 is fixedly arranged on the front side of support piece 9.

[0034] Working principle: when using the 4-amino tetrahydro-2H-pyran-3-ol hydrochloride vacuum distillation device, first fill the 4-amino tetrahydro-2H-pyran-3-ol hydrochloride to be distilled into the inside of the distillation flask 6, and place the distillation flask on the upper side of the support frame 5, then light the alcohol heating flask 7, heat and distill the 4-amino tetrahydro-2H-pyran-3-ol hydrochloride in the inside of the distillation flask 6, then observe the temperature of the thermometer 602, move the two L-shaped strips 405 to the left through the T-shaped plate 4403, press the compression springs 404, and release the contact between the horizontal strips of the L-shaped strips 405 and the rack 202, according to the temperature tested by the thermometer 602, move the support frame 5 and the distillation flask 6 through the moving plate 401, so that the distillation flask 6 moves away from or approaches the flame of the alcohol heating flask 7, then relax the T-shaped plate 403, and reset the L-shaped strips 405 through the rebounding force of the compression springs 404, at this time the horizontal strips of the L-shaped strips 405 are moved to fit the inner wall of the rack 202, so that the moving plate 401 can be quickly fixed, and the temperature of the 4-amino tetrahydro-2H-pyran-3-ol hydrochloride heating can be quickly adjusted.

[0035] By rotating the outer hexagonal nut 903 counterclockwise, the fixation of the screw rod 902 is released, according to the height of the distillation flask 6 and the height of the storage bottle 8, the C-shaped clamp sleeve 904 is deflected through the screw rod 902, so that the conveying pipe 10 is deflected to the appropriate angle, and the outlet of the flow guide pipe 1001 is aligned with the inlet of the storage bottle 8, then the outer hexagonal nut 903 is rotated clockwise to fix and tighten the screw rod 902, so that the water distilled from the inside of the 4-amino tetrahydro-2H-pyran-3-ol hydrochloride can be quickly moved to the inside of the storage bottle 8.

[0036] It should be noted that the left side of the support plate 2 is provided with two long grooves 201, and the inside of the long groove 201 is fixedly provided with a rack 202.

[0037] By moving the horizontal strips of the L-shaped strips 405 to contact the side surface of the rack 202, the fixed state of the moving plate 401 can be contacted.

[0038] It should be noted that the fixing member 4 includes a moving plate 401, the moving plate 401 is slidingly arranged in the adjusting groove 3, the right side of the moving plate 401 is fixedly matched with the side surface of the support frame 5, the left side of the moving plate 401 is provided with a T-shaped groove 402, the T-shaped plate 403 is slidingly arranged in the inside of the T-shaped groove 402, the side surfaces of the two horizontal plates of the T-shaped plate 403 are fixedly provided with compression springs 404, the side surfaces of the compression springs 404 are fixedly matched with the inside of the T-shaped groove 402, and the vertical plates of the T-shaped plate 403 are fixedly provided with L-shaped strips 405 on the front and back sides.

[0039] By the above technical scheme, the T-shaped plate 403 can drive the L-shaped strip 405 to move, thereby facilitating the adjustment and fixation of the moving plate 401.

[0040] It should be noted that the upper and lower sides of the horizontal strip of the L-shaped strip 405 are beveled, and the side surface of the horizontal strip of the L-shaped strip 405 is in sliding fit with the side surface of the rack 202.

[0041] By the above technical scheme, the L-shaped strip 405 with beveling has a larger disengagement area with the rack 202.

[0042] It should be noted that the front and rear sides of the moving plate 401 are fixedly provided with limiting blocks 406, and the shape of the adjusting groove 3 inside is a Chinese character shape, and the inner sides of the two vertical grooves of the Chinese character-shaped adjusting groove 3 are in sliding fit with the side surfaces of the two limiting blocks 406.

[0043] By the above technical scheme, the limiting block 406 can drive the moving plate 401 to move vertically and stably inside the adjusting groove 3.

[0044] It should be noted that the top of the inner wall of the distillation flask 6 is fixedly inserted with a sealing plug 601, and the inside of the sealing plug 601 is fixedly inserted with a thermometer 602.

[0045] By the above technical scheme, the material of the sealing plug 601 can be a synthetic cork, the distillation flask 6 can be sealed by the sealing plug 601, and the temperature of the material inside the distillation flask 6 can be measured by the thermometer 602.

[0046] It should be noted that the support 9 includes a long frame 901 fixedly arranged at the top of the fixed seat 1, a screw rod 902 slidingly arranged inside the long frame 901, an outer hexagonal nut 903 rotatably arranged at the rear side of the screw rod 902, and a C-shaped clamp sleeve 904 fixedly arranged at the front side of the screw rod 902.

[0047] By the above technical scheme, the C-shaped clamp sleeve 904 can be made of hard rubber material, and the conveying pipe 10 can be fixed by the C-shaped clamp sleeve 904.

[0048] It should be noted that the side surface of the conveying pipe 10 is in clamping fit with the inside of the C-shaped clamp sleeve 904, the left end of the conveying pipe 10 extends into the inside of the distillation flask 6, the right end of the conveying pipe 10 is fixedly sleeved with a flow guide pipe 1001, and one end of the flow guide pipe 1001 extends into the inside of the storage bottle 8.

[0049] By the above technical scheme, the water generated after distillation of 4-amino tetrahydro-2H-pyran-3-ol hydrochloride can be moved from the conveying pipe 10 and the flow guide pipe 1001 to the inside of the storage bottle 8 for storage.

[0050] The above are preferred embodiments of the present application, and are not intended to limit the protection scope of the present application, so that: any equivalent changes made according to the structure, shape, principle of the present application should be covered within the protection scope of the present application.

Claims

1. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride, comprising a fixed base (1), characterised in that: The left side of the top of the fixing seat (1) is fixedly provided with a supporting plate (2), and the inside of the supporting plate (2) is provided with an adjusting groove (3). The left side of the fixing piece (4) is fixedly provided with a supporting frame (5), and the inside of the supporting frame (5) is placed with a distillation flask (6).

2. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 1, characterized in that: The left side of the supporting plate (2) is provided with two long grooves (201), and the inside of the long groove (201) is fixedly provided with a rack (202).

3. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 1, characterized by: The fixing piece (4) comprises a moving plate (401), which is slidably arranged in the adjusting groove (3), and the right side of the moving plate (401) is fixedly connected with the side of the supporting frame (5).

4. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 3, characterized in that: The left side of the moving plate (401) is provided with a T-shaped groove (402), and the inside of the T-shaped groove (402) is slidably provided with a T-shaped plate (403).

5. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 3, characterized by: The left and right sides of the vertical plate of the T-shaped plate (403) are fixedly provided with L-shaped strips (405).

6. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 1, characterized by: The upper and lower sides of the horizontal bar of the L-shaped strip (405) are beveled, and the side surface of the horizontal bar of the L-shaped strip (405) is slidably connected with the side surface of the rack (202).

7. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 1, characterized by: The front and rear sides of the moving plate (401) are fixedly provided with limiting blocks (406), and the inside of the adjusting groove (3) is in the shape of a Chinese character "zhong".

8. A vacuum distillation apparatus for 4-amino tetrahydro-2H-pyran-3-ol hydrochloride according to claim 7, characterized by: The inside of the sealing plug (601) is fixedly connected with a thermometer (602). The supporting piece (9) comprises a long frame (901), which is fixedly arranged on the top of the fixing seat (1). The inside of the supporting piece (9) is slidably provided with a screw rod (902), and the rear side of the screw rod (902) is rotatably provided with an outer hexagonal nut (903). The side surface of the conveying pipe (10) is clamped with the inside of the C-shaped clamp sleeve (904), the left end of the conveying pipe (10) extends into the inside of the distillation flask (6), the right end of the conveying pipe (10) is fixedly sleeved with a flow guide pipe (1001), and one end of the flow guide pipe (1001) extends into the inside of the storage bottle (8).

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