Washing plate sealing machine

Abstract

The utility model discloses a plate washing sealing machine which comprises a main machine, a conveying belt used for conveying microwell plates is arranged in the main machine, a plate placing mechanism is arranged at one end of the main machine, and a plate collecting mechanism is arranged at the other end of the main machine. A plurality of liquid adding mechanisms and drying mechanisms are alternately arranged on the main machine; the liquid adding mechanism is connected with the liquid adding pipe; the liquid adding pipe is connected with the liquid adding pump; the suction-drying mechanism is connected with the suction-drying barrel through a liquid discharge pipe; the drying barrel is connected with an air pump and a liquid discharge pump; the host is also provided with a detection mechanism. The detection mechanism is arranged, a liquid level detection head in the detection mechanism can be driven by a translation block to detect the liquid level height of each hole site in the microwell plate, whether the measured value in each hole exceeds an allowable deviation range or not is judged, and if the detection result is qualified, the microwell plate continuously moves forwards and is collected by the plate collecting mechanism; and if the detection is not qualified, the microwell plate moves forwards by one station and then stops waiting for an instruction: the microwell plate continues to move forwards and is collected by the plate collecting mechanism, or returns back by one station to enter the detection mechanism for re-detection.

Description

TECHNICAL FIELD

[0001] The utility model relates to a kind of plate washing sealing machines, belong to in-vitro diagnostic reagent production equipment technical field. BACKGROUND

[0002] In-vitro diagnostic reagent product is mainly composed by in-vitro detection diagnostic kit. The production of the kit is completed by relevant manufacturers. The production process of the kit mainly includes coating, incubation, sealing after plate washing and other steps. After the incubation process of the coated microwell plate, specific antigens, antibodies or other specific substances are firmly attached to the microwell plate bottom, and some coating residual liquid is in the microwell plate, so it is necessary to empty these residual liquid. Coating is to re-coat the microwell plate with high-concentration irrelevant protein solution to prevent the re-adsorption of interfering substances in actual testing. In the prior art, there is a device that integrates plate washing and sealing processes into an automatic assembly line, such as the flow-type plate washing and sealing integrated machine disclosed in Chinese Patent No. 2009201062885. However, this device still has the following defects: after completing the plate washing and sealing processes, there is no liquid level detection function for the microwell plate, so it is not possible to determine whether the liquid level in the microwell plate is within the allowable deviation range in a timely manner, and it is not possible to adjust the liquid level in the microwell plate as appropriate through the liquid adding head according to the actual situation. Therefore, further improvement is needed. SUMMARY

[0003] The utility model aims to overcome the above technical deficiencies and proposes a plate washing and sealing machine with high automation, precise liquid level control, convenient liquid level adjustment and reasonable lifting method.

[0004] A plate washing and sealing machine includes a main machine, a conveyor belt for conveying microwell plates is arranged in the main machine, a plate placing mechanism is arranged at one end of the main machine, and a plate collecting mechanism is arranged at the other end of the main machine. A plurality of liquid adding mechanisms and suction drying mechanisms are arranged on the main machine in an alternating manner. The liquid adding mechanism is connected with a liquid adding pipe. The liquid adding pipe is connected with a liquid adding pump. The suction drying mechanism is connected with a suction drying barrel through a liquid discharge pipe. The suction drying barrel is connected with an air pump and a liquid discharge pump. A detection mechanism is further arranged on the main machine.

[0005] Further, the detection mechanism is located between the plate collecting mechanism and the last liquid adding mechanism. The detection mechanism includes a plurality of liquid level detection heads. The liquid level detection heads are arranged at the bottom of a translation block. The utility model further includes a control system. The control system is connected with the detection mechanism, the liquid adding mechanism, the suction drying mechanism, the first lifting mechanism and the second lifting mechanism, respectively.

[0006] Further, the first lifting mechanism is arranged at the bottom of the plate placing mechanism and the plate collecting mechanism. The first lifting mechanism includes four first support columns. The first support columns are arranged at the top of a first support. The four first support columns are evenly arranged on both sides of the conveyor belt. The first support is provided with a first gap relative to the conveyor belt. A first motor is arranged at the bottom of the first support.

[0007] Furthermore, a bracket is provided on the surface of the main unit; the bracket is located on both sides of the conveyor belt; the liquid adding mechanism and the drying mechanism are mounted on the surface of the bracket; each drying mechanism includes a drying head; the drying head is connected to the drying bucket through a drain pipe; the middle part of the drain pipe is clamped in the drain pump, which is a peristaltic pump; several suction needles are also provided at the bottom of the drying head; the drying bucket is located at the bottom of the main unit.

[0008] Furthermore, the liquid addition mechanism includes a liquid addition head; the liquid addition pump is a peristaltic pump; the liquid addition pump corresponds one-to-one with the liquid addition mechanism; a square groove is provided on the side of the bracket; a filling box is inserted into the square groove; one end of the liquid addition tube is connected to the liquid addition head, and the other end is located in the liquid; the middle tube part of the liquid addition tube is clamped in the liquid addition pump; and several liquid addition needles are provided at the bottom of the liquid addition head.

[0009] Furthermore, the second lifting mechanism comprises several units and is arranged along the direction of the conveyor belt; the second lifting mechanism includes a second support; a second motor is provided at the bottom of the second support; and a second notch is provided on the second support relative to the conveyor belt.

[0010] Furthermore, a crossbeam is provided on the top of the second support; the second lifting mechanism also includes a second support column; the second support column is provided on the surface of the crossbeam; the crossbeam and the second support column are located on both sides of the conveyor belt.

[0011] This utility model has the following beneficial effects: By setting a detection mechanism between the liquid addition mechanism and the plate collection mechanism at the end, the liquid level detection head in the detection mechanism can detect the liquid level height of each hole in the microplate under the drive of the translation block, and determine whether the measured value in each hole exceeds the allowable deviation range. If the detection result is qualified, the microplate continues to move forward and is collected by the plate collection mechanism; if the detection is unqualified, the microplate moves forward one station and then pauses to wait for instructions: it can continue to move forward and be collected by the plate collection mechanism, or it can retreat one station to enter the detection mechanism for re-detection.

[0012] Meanwhile, two adjacent microplates share a second lifting mechanism to control their lifting, which corresponds to the liquid addition mechanism and the drying mechanism respectively, and the washing and sealing process is carried out in an orderly manner; the plate placement mechanism and the plate collection mechanism are controlled by the first lifting mechanism; both the first lifting mechanism and the second lifting mechanism are driven by motors, which simplifies the transmission method, ensures smooth operation, and facilitates automated control. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0014] Figure 2 This is a schematic diagram of the internal structure of the liquid addition mechanism and the drying mechanism.

[0015] Figure 3It is the schematic view of the installation structure of the liquid adding pump.

[0016] Figure 4 It is the schematic view of the structure of the first lifting mechanism.

[0017] Figure 5 It is the schematic view of the structure of the second lifting mechanism.

[0018] Figure 6 It is the schematic view of the internal structure of the detection mechanism.

[0019] In the figure, 1 is a main machine, 2 is a microplate, 3 is a conveying belt, 4 is a plate placing mechanism, 4-1 is a plate claw, 5 is a plate collecting mechanism, 6 is a liquid adding mechanism, 6-1 is a liquid adding head, 6-2 is a liquid adding needle, 7 is a dry sucking mechanism, 7-1 is a dry sucking head, 7-2 is a sucking needle, 8 is a liquid adding pump, 9 is a dry sucking barrel, 10 is a detection mechanism, 10-1 is a liquid level detection head, 10-2 is a translation block, 11 is a control system, 12 is a first lifting mechanism, 12-1 is a first support column, 13 is a second lifting mechanism, 13-1 is a second support, 13-2 is a second motor, 13-3 is a second support column, 13-4 is a cross frame, 13-5 is a second gap, 14 is a first support, 14-1 is a first gap, 15 is a first motor, 16 is a bracket, and 17 is a liquid discharging pump. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical scheme and advantages of the utility model more clearly, the utility model is further described in detail below by combining with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the utility model and not used to limit the utility model.

[0021] A plate washing and sealing machine comprises a main machine 1, a conveying belt 3 arranged in the main machine 1 for conveying a microplate 2, a plate placing mechanism 4 arranged at one end of the main machine 1, and a plate collecting mechanism 5 arranged at the other end of the main machine 1; a plurality of liquid adding mechanisms 6 and dry sucking mechanisms 7 are arranged on the main machine 1 at intervals; the liquid adding mechanism 6 is connected with a liquid adding pipe; the liquid adding pipe is connected with a liquid adding pump 8; the dry sucking mechanism 7 is connected with a dry sucking barrel 9 through a liquid discharging pipe; the dry sucking barrel 9 is connected with an air pump and a liquid discharging pump; and a detection mechanism 10 is further arranged on the main machine 1.

[0022] Further, the detection mechanism 10 is located between the plate collecting mechanism 5 and the last liquid adding mechanism 6; the detection mechanism 10 comprises a plurality of liquid level detection heads 10-1; the liquid level detection heads 10-1 are arranged at the bottom of a translation block 10-2; and a control system 11 is further included; the control system 11 is connected with the detection mechanism 10, the liquid adding mechanism 6, the dry sucking mechanism 7, a first lifting mechanism 12 and a second lifting mechanism 13 respectively.

[0023] Regarding the detection mechanism 10, reference is made to the accompanying drawings Figure 6; several liquid level detection heads 10-1 are uniformly arranged at the bottom of the translation block 10-2; the liquid level detection head 10-1 can detect a column or a row of hole positions of the micro-hole plate 2 each time, and then under the driving of the translation block 10-2, the next column or row of hole positions of the micro-hole plate 2 is detected; until all the hole positions are detected; and feedback the detection data to the control system 11, to judge whether the liquid level in the micro-hole plate is within the allowable deviation range, so as to carry out liquid level calibration or return to the plate washing closed process to adjust the liquid level position.

[0024] Further, the first lifting mechanism 12 is arranged at the bottom of the plate placing mechanism 4 and the plate collecting mechanism 5; the first lifting mechanism 12 comprises four first support columns 12-1; the first support column 12-1 is arranged at the top of the first support 14; the four first support columns 12-1 are uniformly arranged on both sides of the conveying belt 3; the first support 14 is provided with a first notch 14-1 opposite to the conveying belt 3; the first support 14 is provided with a first motor 15 at the bottom.

[0025] Regarding the first lifting mechanism 12, it is used to control the work of the plate placing mechanism 4 and the plate collecting mechanism 5, taking the plate placing mechanism 4 as an example, the micro-hole plate is placed in the plate placing mechanism 4 by artificial, the plate claw 4-1 in the plate placing mechanism 4 supports the micro-hole plate; with the work of the first motor 15, the first support 14 and the first support column 12-1 will be lifted; because the first support 14 is provided with the first notch 14-1 opposite to the conveying belt, and the first support column 12-1 is arranged on both sides of the conveying belt, so there is no interference between the first support column and the conveying belt 3, the first support column pushes away the plate claw 4-1 to let the micro-hole plate descend and contact with the conveying belt 3, and then moves forward with the conveying belt to pass through the drying mechanism 7 and the liquid adding mechanism 6 in turn, and then the second lifting mechanism 13 controls the lifting.

[0026] Further, the main machine 1 is provided with a bracket 16 on the surface; the bracket 16 is located on both sides of the conveying belt 3; the liquid adding mechanism 6 and the drying mechanism 7 are arranged on the surface of the bracket 16; each drying mechanism 7 comprises a drying head 7-1; the drying head 7-1 is connected with the drying barrel 9 through the drainage pipe; the middle pipe body of the drainage pipe is clamped in the drainage pump 17, and the drainage pump 17 is a peristaltic pump; the bottom of the drying head 7-1 is further provided with a plurality of suction needles 7-2; the drying barrel 9 is arranged at the bottom of the main machine 1. The liquid adding mechanism 6 comprises a liquid adding head 6-1; the liquid adding pump 8 is a peristaltic pump; the liquid adding pump 8 corresponds to the liquid adding mechanism 6 one by one; the side of the bracket 16 is provided with a square groove; the square groove is inserted with a perfusion box; one end of the liquid adding pipe is connected with the liquid adding head 6-1, and the other end is located in the liquid; the middle pipe body of the liquid adding pipe is clamped in the liquid adding pump 8; the bottom of the liquid adding head 6-1 is provided with a plurality of liquid adding needles 6-2.

[0027] As to the liquid adding mechanism 6 and the liquid absorbing mechanism 7, when the micro-hole plate is driven by the transmission belt to be below the liquid adding mechanism 6 or the liquid absorbing mechanism 7, the micro-hole plate is lifted up by the second lifting mechanism 13 to make the hole position close to the liquid adding needle 6-2 or the liquid absorbing needle 7-2. The liquid adding head 6-1 or the liquid absorbing head 7-1 is arranged above the bracket 16.

[0028] Further, the second lifting mechanism 13 comprises a plurality of second lifting mechanisms 13 arranged along the direction of the transmission belt 3; the second lifting mechanism 13 comprises a second bracket 13-1; the bottom of the second bracket 13-1 is provided with a second motor 13-2; the second bracket 13-1 is provided with a second notch 13-5 relative to the transmission belt 3.

[0029] Further, the top of the second bracket 13-1 is provided with a cross bracket 13-4; the second lifting mechanism 13 further comprises a second supporting column 13-3; the second supporting column 13-3 is arranged on the surface of the cross bracket 13-4; the cross bracket 13-4 and the second supporting column 13-3 are located on both sides of the transmission belt.

[0030] As to the second lifting mechanism 13, the second bracket 13-1 is also controlled to lift by the second motor 13-2; the two sides of the second bracket are provided with the cross bracket 13-4; the two cross brackets 13-4 are respectively provided with a plurality of second supporting columns 13-3; because of the two cross brackets 13-4, two micro-hole plates can be lifted at the same time to be below the adjacent liquid adding mechanism 6 and the liquid absorbing mechanism 7.

[0031] The above-mentioned specific embodiments of the utility model do not constitute the limitation to the protection scope of the utility model. Any various other corresponding changes and deformation according to the technical concept of the utility model should be contained in the protection scope of the utility model claim.

Claims

1. A plate washing and sealing machine comprising a main machine (1) in which a conveyor belt (3) for conveying microplate (2) is arranged, characterized in that: One end of the host (1) is provided with a plate mechanism (4), the other end is provided with a plate mechanism (5); a plurality of liquid adding mechanism (6) and suction mechanism (7) are arranged on the host (1) alternately; liquid adding mechanism (6) and liquid adding pipe are connected; liquid adding pipe and liquid adding pump (8) are connected; suction mechanism (7) is connected with suction barrel (9) through liquid discharge pipe; suction barrel (9) is connected with air pump and liquid discharge pump; the host (1) is further provided with detection mechanism (10).

2. A plate washing enclosure according to claim 1, wherein: The detection mechanism (10) is located between the plate mechanism (5) and the last liquid adding mechanism (6); the detection mechanism (10) comprises a plurality of liquid level detection heads (10-1); the liquid level detection head (10-1) is arranged at the bottom of the translation block (10-2); further comprising control system (11); the control system (11) is connected with the detection mechanism (10), liquid adding mechanism (6), suction mechanism (7), first lifting mechanism (12) and second lifting mechanism (13) respectively.

3. A plate washing enclosure according to claim 2, wherein: The first lifting mechanism is arranged at the bottom of the plate mechanism (4) and the plate mechanism (5); the first lifting mechanism (12) comprises four first support columns (12-1); the first support column (12-1) is arranged at the top of the first support (14); four first support columns (12-1) are evenly arranged on both sides of the conveyor belt (3); the first support (14) is provided with a first gap (14-1) relative to the conveyor belt (3); the first support (14) is provided with a first motor (15) at the bottom; the plate mechanism (4) is hinged with a jaw (4-1); the first support column (12-1) is in contact or separated from the jaw (4-1).

4. A plate washing enclosure according to claim 2, wherein: The surface of the host (1) is provided with a bracket (16); the bracket (16) is located on both sides of the conveyor belt (3); the liquid adding mechanism (6) and the suction mechanism (7) are arranged on the surface of the bracket (16); each suction mechanism (7) comprises a suction head (7-1); the suction head (7-1) is connected with the suction barrel (9) through the liquid discharge pipe; the middle pipe body part of the liquid discharge pipe is clamped in the liquid discharge pump (17), and the liquid discharge pump (17) is a peristaltic pump; a plurality of suction needles (7-2) are further arranged at the bottom of the suction head (7-1); the suction barrel (9) is arranged at the bottom of the host (1).

5. A plate washing enclosure according to claim 4, wherein: The liquid adding mechanism (6) comprises a liquid adding head (6-1); the liquid adding pump (8) is a peristaltic pump; the liquid adding pump (8) corresponds to the liquid adding mechanism (6) one by one; the side of the bracket (16) is provided with a square groove; the square groove is inserted with a perfusion box; one end of the liquid adding pipe is connected with the liquid adding head (6-1), and the other end is located in the liquid; the middle pipe body part of the liquid adding pipe is clamped in the liquid adding pump (8); a plurality of liquid adding needles (6-2) are arranged at the bottom of the liquid adding head (6-1).

6. A plate washing enclosure according to claim 5, wherein: The second lifting mechanism (13) comprises a plurality of and is arranged along the direction of the conveyor belt (3); the second lifting mechanism (13) comprises a second support (13-1); the second support (13-1) is provided with a second motor (13-2) at the bottom; the second support (13-1) is provided with a second gap (13-5) relative to the conveyor belt (3).

7. A plate washing enclosure according to claim 6, wherein: The top of the second support is provided with a crossbeam (13-4); the second lifting mechanism (13) also includes a second support column (13-3); the second support column is provided on the surface of the crossbeam (13-4); the crossbeam (13-4) and the second support column (13-3) are located on both sides of the conveyor belt.

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