Oseltamivir preparation reaction kettle with quantitative feeding structure

Abstract

The utility model discloses an oseltamivir preparation reaction kettle with a quantitative feeding structure, which belongs to the technical field of medicine preparation devices and comprises a storage box, a storage box is arranged in the storage box, and a discharging box is arranged at the bottom of one end of the storage box; according to the reaction kettle, impurity particles in raw materials can be filtered through the filter screen at the bottom of the inner side of the discharging box, impurities are prevented from entering the reaction kettle to influence the reaction quality, the crushing blades connected with the bottom of the barrier can crush larger crystal blocks, and the crystal blocks and crystal powder are prevented from entering the reaction kettle through the filter screen to influence the metering of the raw materials. Raw materials are stirred through a stirring rod, so that the raw materials are kept in a uniform state in a storage box and a discharging box, crystallization caused by too high local concentration is prevented, a resistance wire in a cavity in a stirring roller can heat the raw materials under the action of a transformer, crystals can be dissolved through the synergistic effect of stirring and heating, and the crystallization effect is improved. And raw materials can smoothly enter the reaction kettle through the discharge pipe.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical preparation equipment technology, specifically relating to a reaction vessel for preparing oseltamivir with a quantitative feeding structure. Background Technology

[0002] Oseltamivir, a highly effective antiviral drug for influenza, plays a vital role in global public health. It exhibits significant inhibitory activity against both influenza A and B viruses, effectively blocking the replication and spread of the influenza virus within the body. Especially during seasonal influenza outbreaks and global influenza pandemics, oseltamivir has become one of the first-line drugs for the prevention and treatment of influenza. With increasing global population mobility and the influence of factors such as climate change, the frequency and spread of influenza outbreaks are on the rise, leading to a continued increase in market demand for oseltamivir.

[0003] Existing methods for oseltamivir preparation often involve metering the raw materials using only metering pumps and flow control valves. However, during the oseltamivir preparation process, some raw materials are significantly affected by temperature, which can easily lead to crystallization and blockage of the discharge pipe, thus affecting the addition of raw materials. Therefore, a reaction vessel for oseltamivir preparation with a quantitative feeding structure is needed to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to provide a reaction vessel for oseltamivir preparation with a quantitative feeding structure, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a reaction vessel for preparing oseltamivir with a quantitative feeding structure, comprising a storage tank, a storage box inside the storage tank, a discharge box at one end of the storage box, a stirring assembly inside the discharge box, a discharge pipe at one end of the discharge box, a reaction vessel at one end of the discharge pipe, a flow regulating valve on the outside of the discharge pipe, a metering pump between the discharge pipe and the discharge box, a motor, a connecting rod at the output end of the motor, a bevel gear at one end of the connecting rod, two bevel gears meshing together, a stirring roller at one end of one bevel gear, a stirring rod on the outside of the stirring roller, a crushing blade at one end of the stirring roller, a resistance wire inside the stirring roller through an opening cavity, and a transformer at one end of the resistance wire.

[0006] In a preferred embodiment, the number of storage boxes is several, and each storage box has a ramp on its inner bottom, with a temperature sensor at the bottom of the ramp.

[0007] In a preferred embodiment, a filter screen is provided at the bottom inner side of the discharge box, and a partition is provided at the top inner side of the discharge box. The bottom of the partition is connected to the crushing blades, and the number of crushing blades is three.

[0008] In a preferred embodiment, a motor housing is provided on the outside of the motor, the bottom of the transformer is connected to the bottom of the inner side of the motor housing, and a limiting plate is provided between the transformer and the motor.

[0009] In a preferred embodiment, a protective box is provided on the outside of the resistance wire and the two bevel gears, and the protective box is connected through one side of the discharge box.

[0010] In a preferred embodiment, the bottom of the storage box is provided with a support frame, the number of stirring components is the same as the number of storage boxes, and each stirring component works independently.

[0011] Compared with the prior art, the beneficial effects of this utility model are:

[0012] This invention utilizes a filter screen at the bottom of the discharge box to remove impurities from the raw materials, preventing them from entering the reactor and affecting the reaction quality. A crushing blade connected to the bottom of the partition can crush larger crystals, allowing them to dissolve better in the solution. The filter screen prevents crystals and undissolved powder from entering the reactor, thus affecting the metering of the raw materials. A motor drives a connecting rod, bevel gear, stirring roller, and stirring rod to stir the raw materials, maintaining a uniform state in the storage and discharge boxes and preventing excessively high local concentrations that could lead to crystallization. Simultaneously, a resistance wire inside the stirring roller, powered by a transformer, heats the raw materials. When a small amount of crystals appear, the combined effect of stirring and heating dissolves them, ensuring the raw materials smoothly pass through the discharge pipe into the reactor.

[0013] This invention, by incorporating several storage boxes, allows for the categorized storage and management of different types of raw materials. Each storage box independently corresponds to a set of stirring components and a discharge system, avoiding mutual interference between different raw materials. This facilitates the precise addition of specific raw materials to the reactor according to the reaction process and formula requirements, improving the convenience and flexibility of production operations. It also helps to improve the accuracy and reliability of metering. The slope at the bottom of the inner side of the storage box helps the raw materials flow towards the discharge box. The temperature sensor at the bottom can monitor the raw material temperature in real time. When the raw material temperature is detected to be close to the crystallization temperature, the storage box can be heated or cooled to ensure that the raw materials maintain a suitable temperature, preventing crystallization and avoiding blockage of the discharge pipe and poor raw material addition caused by crystallization, thus ensuring the continuity of production. Attached Figure Description

[0014] Figure 1This is a schematic diagram of the three-dimensional structure of the main body of this utility model;

[0015] Figure 2 This is a schematic diagram of the three-dimensional structure of the main body of this utility model from a side view sectional section.

[0016] Figure 3 This utility model Figure 2 A schematic diagram of the enlarged three-dimensional structure of A in the middle;

[0017] Figure 4 This is a schematic diagram of the three-dimensional structure of the stirring component of this utility model.

[0018] In the diagram: 1. Storage bin; 2. Storage box; 3. Discharge box; 4. Stirring assembly; 5. Discharge pipe; 6. Reactor; 7. Flow regulating valve; 8. Metering pump; 9. Support frame; 10. Inclined ramp; 11. Temperature sensor; 12. Filter screen; 13. Motor box; 14. Limiting plate; 15. Partition; 16. Protective box; 401. Motor; 402. Connecting rod; 403. Bevel gear; 404. Stirring roller; 405. Stirring rod; 406. Crushing blade; 407. Transformer; 408. Resistance wire. Detailed Implementation

[0019] The present invention will be further described below with reference to the embodiments.

[0020] The following embodiments are used to illustrate the present invention, but should not be used to limit the scope of protection of the present invention. The conditions in the embodiments can be further adjusted according to specific conditions, and simple improvements to the method of the present invention under the premise of the concept of the present invention are all within the scope of protection claimed by the present invention.

[0021] Please see Figure 1-4This utility model provides a reaction vessel for oseltamivir preparation with a quantitative feeding structure, including a storage tank 1, a storage box 2 inside the storage tank 1, a discharge box 3 at one end of the storage box 2, a stirring assembly 4 inside the discharge box 3, a discharge pipe 5 at one end of the discharge box 3, a reaction vessel 6 at one end of the discharge pipe 5, a flow regulating valve 7 on the outside of the discharge pipe 5, and a metering pump 8 between the discharge pipe 5 and the discharge box 3. The stirring assembly 4 includes a motor 401, a connecting rod 402 at the output end of the motor 401, and a bevel gear 403 at one end of the connecting rod 402. There are two bevel gears 403, which are meshed together. One end of one bevel gear 403 is equipped with a stirring roller 404. A stirring rod 405 is provided on the outer side of the stirring roller 404, and a crushing blade 406 is provided at one end of the stirring roller 404. A resistance wire 408 is provided inside the stirring roller 404 through an opening cavity. A transformer 407 is provided at one end of the resistance wire 408. The motor 401 drives the connecting rod 402, bevel gear 403, stirring roller 404 and stirring rod 405 to stir the raw material, so that the raw material is kept in a uniform state in the storage box 2 and the discharge box 3. The resistance wire 408 in the cavity inside the stirring roller 404 can heat the raw material under the action of the transformer 407. When a small amount of crystals appear in the raw material, the synergistic effect of stirring and heating can dissolve the crystals. The crushing blade 406 connected to the bottom of the partition 15 can crush larger crystal blocks.

[0022] There are several storage boxes 2, and each storage box 2 has a ramp 10 on the bottom inner side, and a temperature sensor 11 is installed at the bottom of the ramp 10.

[0023] The bottom inner side of the discharge box 3 is provided with a filter screen 12, and the top inner side of the discharge box 3 is provided with a partition 15. The bottom of the partition 15 is connected to the crushing blade 406, and there are three crushing blades 406.

[0024] A motor housing 13 is provided on the outside of the motor 401. The bottom of the transformer 407 is connected to the bottom of the inner side of the motor housing 13. A limiting plate 14 is provided between the transformer 407 and the motor 401.

[0025] A protective box 16 is provided on the outside of the resistance wire 408 and the two bevel gears 403, and the protective box 16 is connected through to one side of the discharge box 3.

[0026] The bottom of the storage box 1 is equipped with a support frame 9. The number of stirring components 4 is the same as the number of storage boxes 2. Each stirring component 4 works independently. Impurities in the raw materials can be filtered out by the filter screen 12 at the bottom of the inner side of the discharge box 3. By having several storage boxes 2, different types of raw materials can be stored and managed in categories. Each storage box 2 corresponds to an independent set of stirring components 4 and discharge system, avoiding mutual interference between different raw materials. The slope 10 at the bottom of the inner side of the storage box 2 helps the raw materials flow towards the discharge box 3. The temperature sensor 11 at the bottom can monitor the temperature of the raw materials in real time.

[0027] The working principle and usage process of this utility model are as follows: First, the raw materials required for the preparation of oseltamivir are added to each storage box 2 as needed. The metering pump 8 and the flow regulating valve 7 are turned on to meter the raw materials added to the reaction vessel 6. Then, by having several storage boxes 2, different types of raw materials can be classified, stored, and managed. Each storage box 2 corresponds to an independent set of stirring components 4 and a discharge system, avoiding mutual interference between different raw materials. The slope 10 at the bottom of the inner side of the storage box 2 helps the raw materials flow towards the discharge box 3. The temperature sensor 11 at the bottom can monitor the temperature of the raw materials in real time. Impurities in the raw material can be filtered out by the filter screen 12 at the bottom of the inner side of the discharge box 3. Finally, the raw material is stirred by the motor 401 driving the connecting rod 402, bevel gear 403, stirring roller 404 and stirring rod 405, so that the raw material is kept in a uniform state in the storage box 2 and the discharge box 3. The resistance wire 408 in the cavity of the stirring roller 404 can heat the raw material under the action of the transformer 407. When a small amount of crystals appear in the raw material, the synergistic effect of stirring and heating can dissolve the crystals. The crushing blade 406 connected to the bottom of the partition 15 can crush larger crystal blocks.

[0028] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A reaction vessel for preparing oseltamivir with a quantitative feeding structure, comprising a storage tank (1), characterized in that: The storage tank (1) is equipped with a storage box (2) inside. A discharge box (3) is provided at the bottom of one end of the storage box (2). A stirring assembly (4) is provided inside the discharge box (3). A discharge pipe (5) is provided at one end of the discharge box (3). A reaction vessel (6) is provided at one end of the discharge pipe (5). A flow regulating valve (7) is provided on the outside of the discharge pipe (5). A metering pump (8) is provided between the discharge pipe (5) and the discharge box (3). The stirring assembly (4) includes a motor (401). A connecting rod (402) is provided at the output end of the motor (401). The connecting rod (402) has a bevel gear (403) at one end, and there are two bevel gears (403) that are meshed together. One end of one bevel gear (403) is provided with a stirring roller (404). A stirring rod (405) is provided on the outside of the stirring roller (404). A crushing blade (406) is provided at one end of the stirring roller (404). A resistance wire (408) is provided inside the stirring roller (404) through an opening cavity. A transformer (407) is provided at one end of the resistance wire (408).

2. The oseltamivir preparation reactor with a quantitative feeding structure according to claim 1, characterized in that: The number of storage boxes (2) is several, and each storage box (2) has a ramp (10) on the bottom inner side, and a temperature sensor (11) is provided at the bottom of the ramp (10).

3. The oseltamivir preparation reactor with a quantitative feeding structure according to claim 1, characterized in that: The bottom inner side of the discharge box (3) is provided with a filter screen (12), and the top inner side of the discharge box (3) is provided with a partition (15). The bottom of the partition (15) is connected to the crushing blade (406), and the number of the crushing blade (406) is three.

4. The reaction vessel for preparing oseltamivir with a quantitative feeding structure according to claim 1, characterized in that: The motor (401) has a motor housing (13) on its outer side, the bottom of the transformer (407) is connected to the bottom of the inner side of the motor housing (13), and a limiting plate (14) is provided between the transformer (407) and the motor (401).

5. The reaction vessel for preparing oseltamivir with a quantitative feeding structure according to claim 1, characterized in that: The resistance wire (408) and the two bevel gears (403) are provided with a protective box (16) on the outside, and the protective box (16) is connected through to one side of the discharge box (3).

6. The reaction vessel for preparing oseltamivir with a quantitative feeding structure according to claim 1, characterized in that: The bottom of the storage box (1) is provided with a support frame (9), and the number of the stirring components (4) is the same as the number of the storage boxes (2), and each stirring component (4) works independently.

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