Purification device for production of medical intermediates

Abstract

The utility model discloses a purification device for medical intermediate production, which relates to the field of medical intermediate processing equipment and comprises a reaction kettle, a kettle cover, a base, a discharge valve, a permeation mechanism and an adsorption mechanism, the top end of the reaction kettle is connected with the kettle cover, the bottom end of the reaction kettle is connected with the base, a discharge port is formed in the bottom of the reaction kettle, and a discharge valve is mounted at the discharge port; the permeation mechanism comprises a motor, a rotating shaft, a stirring frame and a permeation membrane; a rotating shaft is arranged in the center of the interior of the reaction kettle, and the top end of the rotating shaft is connected with the output end of the motor; the left and right side surfaces of the rotating shaft are connected with symmetrically distributed stirring frames, and permeable membranes are arranged in the stirring frames; according to the device, the adsorption mechanism for adsorbing impurities can be replaced during purification, a kettle cover of the reaction kettle does not need to be opened and closed, normal purification procedures are not affected, and operation is convenient.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of pharmaceutical intermediates processing equipment, especially to a purification device for pharmaceutical intermediates production. BACKGROUND

[0002] Pharmaceutical intermediates are some chemical raw materials or chemical products used in the synthesis process of drugs. This chemical product does not require a drug production license and can be produced in an ordinary chemical plant. As long as it reaches a certain level, it can be used for drug synthesis. Pharmaceutical intermediates are rough processed and contain a large amount of impurities, which cannot be directly used for drug production and need to be purified.

[0003] The existing purification device for pharmaceutical intermediates pours the raw material solution containing intermediates into the reaction kettle, and the permeation membrane and the adsorbent adsorb the impurities in the raw material solution to obtain the target intermediate. However, since the adsorbent is usually placed inside the reaction kettle, when the adsorbent needs to be replaced, the purification needs to be paused first, then the top cover of the reaction kettle is opened, and the adsorbent is taken out for replacement. This operation is troublesome, time-consuming and labor-intensive, and affects the normal purification process. SUMMARY

[0004] To solve the above-mentioned prior art problems, the utility model provides a purification device for pharmaceutical intermediates production, which can replace the adsorption mechanism for impurity adsorption during purification without opening the kettle cover of the reaction kettle, without affecting the normal purification process, and is easy to operate.

[0005] The utility model solves the technical problems by adopting the following technical scheme: a purification device for pharmaceutical intermediates production, comprising a reaction kettle, a kettle cover, a base, a discharge valve, a permeation mechanism, and an adsorption mechanism.

[0006] The permeation mechanism comprises a motor, a rotating shaft, a stirring frame, and a permeation membrane. The motor is installed at the top center of the kettle cover. A rotating shaft is arranged at the center of the inside of the reaction kettle, and the top end of the rotating shaft is connected to the output end of the motor. The left and right sides of the rotating shaft are connected to symmetrically distributed stirring frames, and the inside of the stirring frame is provided with a permeation membrane.

[0007] The adsorption mechanism comprises an adsorption rod clamping pipe, a top cover, an adsorption rod, and a fastening bolt. The top of the kettle cover is provided with a plurality of through holes that are equally distributed around the motor. The adsorption rod clamping pipe is arranged in the through hole, the top end of the adsorption rod clamping pipe is connected to the top cover, and the diameter of the top cover is greater than that of the through hole. The bottom of the adsorption rod clamping pipe is connected to the adsorption rod, which is located inside the reaction kettle. The side wall of the adsorption rod clamping pipe is provided with a fastening bolt for fixing the adsorption rod.

[0008] Furthermore, the top surface of the through hole is provided with a groove, and the bottom end of the top cover is connected to a sealing gasket that conforms to the shape of the groove. The sealing gasket is located inside the groove. The sealing gasket and the groove can cooperate to increase the sealing performance of the through hole.

[0009] Furthermore, the top of the top cover is connected to a clamping block, which can be clamped by mechanical components to lift the entire adsorption mechanism upwards and remove it from the reactor for easy replacement.

[0010] The bottom surface of the vessel lid is provided with an extension tube below the corresponding through hole. The extension tube is located outside the adsorption rod clamping tube. The extension tube can increase the contact area between the vessel lid and the adsorption rod clamping tube, thereby improving the stability of the adsorption mechanism.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows: the purification device for pharmaceutical intermediate production is equipped with a permeation mechanism and an adsorption mechanism for removing impurities in the solution. When the motor drives the stirring, it can cause the impurities in the solution to remain in the permeation membrane, thereby separating them from the solution; the adsorption rod in the adsorption mechanism simultaneously adsorbs the impurities in the solution, thereby improving the purity of the solution; and the adsorption mechanism can be replaced during purification without opening or closing the lid of the reaction vessel, without affecting the normal purification process, making it easy to operate. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a schematic diagram of the structure of this utility model;

[0014] Figure 2 yes Figure 1 Enlarged diagram of point A in the middle.

[0015] The diagram shows: 1. Reactor, 2. Reactor lid, 3. Base, 4. Discharge valve, 5. Motor, 6. Shaft, 7. Stirring frame, 8. Permeable membrane, 9. Adsorption rod clamping tube, 10. Top cover, 11. Adsorption rod, 12. Fastening bolt, 13. Sealing gasket, 14. Clamping block, 15. Extension tube. Detailed Implementation

[0016] To make the objectives, technical solutions, and advantages of this utility model clearer, the following detailed description is provided in conjunction with embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this utility model.

[0017] Reference Figures 1-2 This embodiment provides a purification device for the production of pharmaceutical intermediates, including a reaction vessel 1, a vessel cover 2, a base 3, a discharge valve 4, a permeation mechanism, and an adsorption mechanism; the top of the reaction vessel 1 is connected to the vessel cover 2, the bottom of the reaction vessel 1 is connected to the base 3, the bottom of the reaction vessel 1 is provided with a discharge port, and a discharge valve 4 is installed at the discharge port.

[0018] In this embodiment, the permeation mechanism includes a motor 5, a rotating shaft 6, a stirring frame 7, and a permeation membrane 8. The motor 5 is installed at the center of the top of the vessel cover 2, and the rotating shaft 6 is located in the center of the interior of the reaction vessel 1. The top of the rotating shaft 6 is connected to the output end of the bottom of the motor 5. The left and right sides of the rotating shaft 6 are connected to symmetrically distributed stirring frames 7, and the interior of the stirring frames 7 is equipped with a removable permeation membrane 8. When the motor 5 is started, it can drive the rotating shaft 6 to rotate, thereby driving the stirring frames 7 to rotate and stir the pharmaceutical intermediate solution in the reaction vessel 1. When rotating, the permeation membrane 8 can adsorb impurities in the solution.

[0019] In this embodiment, the adsorption mechanism includes an adsorption rod clamping tube 9, a top cover 10, an adsorption rod 11, and fastening bolts 12. The top of the reactor cover 2 is provided with multiple through holes evenly distributed around the motor 5. The adsorption rod clamping tube 9 is installed in the through holes. The top end of the adsorption rod clamping tube 9 is fixedly connected to the top cover 10. The diameter of the top cover 10 is larger than the diameter of the through holes so that the top cover 10 can be fastened above the through holes. The bottom of the adsorption rod clamping tube 9 is detachably connected to the adsorption rod 11. The adsorption rod 11 is located inside the reactor 1. The side wall of the adsorption rod clamping tube 9 is provided with fastening bolts 12 to fix the adsorption rod 11. When the fastening bolts 12 are loosened, the adsorption rod 11 can be removed and replaced. When the fastening bolts 12 are tightened, the adsorption rod 11 is clamped and fixed. The adsorption mechanism is fixed to the reactor 1 by its own weight and the cooperation with the through holes. When the pharmaceutical intermediate solution is stirred, it will frequently come into contact with the adsorption rod 11, and the adsorption rod 11 adsorbs impurities in the solution.

[0020] In this embodiment, the adsorption rod 11 can be made of activated carbon composite material.

[0021] In this embodiment, in order to increase the sealing performance of the through hole, a groove is provided on the top surface of the through hole, and a sealing gasket 13 that is adapted to the shape of the groove is connected to the bottom end of the top cover 2. The sealing gasket 13 is located in the groove and achieves a good sealing effect.

[0022] In this embodiment, in order to facilitate lifting the adsorption mechanism upwards, a clamping block 14 is fixedly connected to the top of the top cover 10. The entire adsorption mechanism can be lifted upwards and taken out from the reactor 1 by clamping the clamping block 14 with mechanical components. When it is necessary to put the adsorption mechanism in, it can be lowered by clamping the clamping block.

[0023] In this embodiment, in order to increase the stability of the adsorption mechanism, an extension tube 15 is provided on the bottom surface of the vessel cover 2 below the corresponding through hole. The extension tube 15 is located outside the adsorption rod clamping tube 9. The extension tube 15 can increase the contact surface between the vessel cover 2 and the adsorption rod clamping tube 9, and prevent the adsorption rod 11 from being displaced by the flow of the solution in the reaction vessel 1.

[0024] The working principle of this device is as follows: a pharmaceutical intermediate solution is poured into reaction vessel 1, and impurities in the solution are adsorbed through a osmosis mechanism and an adsorption mechanism. After purification, the discharge valve 4 can be opened to pour out the solution. The osmosis membrane 8 can be replaced after purification, while the adsorption mechanism can be replaced separately during the purification process.

[0025] Of course, the above description is not limited to the examples above. Technical features not described in this utility model can be implemented by or using existing technology, and will not be repeated here. The above embodiments and drawings are only used to illustrate the technical solution of this utility model and are not intended to limit this utility model. This utility model has been described in detail with reference to preferred embodiments. Those skilled in the art should understand that any changes, modifications, additions or substitutions made by those skilled in the art within the scope of this utility model do not depart from the spirit of this utility model and should also fall within the protection scope of the claims of this utility model.

Claims

1. A purification apparatus for the production of pharmaceutical intermediates, comprising a reaction vessel (1), a vessel cover (2), a base (3), a discharge valve (4), a permeation mechanism, and an adsorption mechanism; the top of the reaction vessel (1) is connected to the vessel cover (2), the bottom of the reaction vessel (1) is connected to the base (3), and a discharge port is provided at the bottom of the reaction vessel (1), with the discharge valve (4) installed at the discharge port; characterized in that, The permeation mechanism includes a motor (5), a rotating shaft (6), a stirring frame (7), and a permeation membrane (8); the motor (5) is installed in the center of the top of the vessel cover (2), and the rotating shaft (6) is located in the center of the interior of the reactor (1), with the top of the rotating shaft (6) connected to the output end of the motor (5); the left and right sides of the rotating shaft (6) are connected to symmetrically distributed stirring frames (7), and the permeation membrane (8) is installed inside the stirring frames (7); the adsorption mechanism includes an adsorption rod clamping tube (9), a top cover (10), and adsorption rods (11). The top of the lid (2) is provided with multiple through holes evenly distributed around the motor (5), and an adsorption rod clamping tube (9) is provided in the through hole. The top of the adsorption rod clamping tube (9) is connected to the top cover (10), and the diameter of the top cover (10) is larger than the diameter of the through hole. The bottom of the adsorption rod clamping tube (9) is connected to the adsorption rod (11), and the adsorption rod (11) is located inside the reactor (1). The side wall of the adsorption rod clamping tube (9) is provided with a fastening bolt (12) for fixing the adsorption rod (11).

2. The purification apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that, The top surface of the through hole is provided with a slot, and the bottom end of the top cover (10) is connected to a sealing gasket (13) that is adapted to the shape of the slot. The sealing gasket (13) is located inside the slot.

3. The purification apparatus for pharmaceutical intermediate production according to claim 1, characterized in that, The top of the top cover (10) is connected to the clamping block (14).

4. The purification apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that, The bottom surface of the lid (2) is provided with an extension tube (15) below the corresponding through hole, and the extension tube (15) is located outside the adsorption rod clamping tube (9).

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