Liquid nitrogen pot convenient for storing and taking cryopreservation tube

Abstract

The liquid nitrogen pot comprises a pot body, a containing cavity is formed in the pot body, an opening communicated with the interior and the exterior of the containing cavity is formed in the upper end of the pot body, a first connecting part is arranged on the opening, and a limiting part is arranged at the bottom of the containing cavity; and the storing and taking frame comprises a pipe disc matched with the limiting part, a plurality of inserting holes are formed in the pipe disc, and a fixing rod is installed at the upper end of the pipe disc in an upward extending mode. According to the liquid nitrogen pot facilitating storing and taking of the cryopreservation tubes, a limiting part restrains a tube disc on the lower portion of the storing and taking frame in the horizontal direction, a second connecting part on a movable rod is connected with a second connecting part of an opening, so that the upper portion of the storing and taking frame is restrained in the horizontal direction, and it is ensured that the relative positions of the storing and taking frame and the pot body are fixed in the transferring process; and the situation that liquid nitrogen shakes to collide the cryopreservation pipe on the storing and taking frame with the inner wall of the pot body, and consequently a pipe opening of the cryopreservation pipe is polluted is avoided.

Description

Technical Field

[0001] This utility model relates to the field of liquid nitrogen container technology, and in particular to a liquid nitrogen container that facilitates the storage and retrieval of cryopreservation tubes. Background Technology

[0002] Cells, as a novel type of drug, such as immune cells, mesenchymal stem cells, and neural stem cells, have made great progress in the treatment of diseases, especially in the treatment of a variety of intractable diseases, achieving unprecedented success. The cell therapy industry is booming and showing great development prospects, becoming a new track in the biopharmaceutical industry. The initial stage of cell preparation production involves cell resuscitation. The operator pours an appropriate amount of liquid nitrogen into the liquid nitrogen container, and then uses tweezers to immerse the cryopreservation tube containing cells in the liquid nitrogen. The liquid nitrogen container is then transferred to the production workshop, where tweezers are used to pick up the cryopreservation tube and insert it into the float. The water bath is then manually shaken to thaw the cells. The liquid nitrogen container is divided into a liquid nitrogen insulated container and a dry liquid nitrogen container.

[0003] However, existing liquid nitrogen containers have the following problems during use:

[0004] The stability of liquid nitrogen insulated containers is insufficient. Cryopreservation tubes float in liquid nitrogen, and during the transfer of liquid nitrogen containers, the shaking of the liquid nitrogen can easily cause the cryopreservation tubes to collide with the inner wall of the container. The tube openings may become loose and contaminated. Furthermore, because the cryopreservation tubes are cylindrical, they are inconvenient to handle with tweezers and are prone to slipping, posing a significant operational risk. In addition, current technology uses tweezers to transfer cryopreservation tubes one by one, which is slow in verifying the label information on the cryopreservation tubes. The time from taking them out of the liquid nitrogen container to thawing is long, which affects the cell state.

[0005] Therefore, in order to solve the above problems, this utility model proposes a liquid nitrogen container that can avoid collision between the cryopreservation tube and the inner wall of the liquid nitrogen container during transportation, and has high operating efficiency and facilitates the storage and retrieval of the cryopreservation tube. Utility Model Content

[0006] To address the problems existing in the use of the above-mentioned liquid nitrogen containers, this utility model provides a liquid nitrogen container that facilitates the storage and retrieval of cryopreservation tubes.

[0007] According to one objective of this utility model, this utility model provides a liquid nitrogen container for easy storage and retrieval of cryovials, including a container body, a receiving cavity provided inside the container body, an opening communicating with the inside and outside of the receiving cavity at the upper end of the container body, a first connecting part provided on the opening, and a limiting part provided at the bottom of the receiving cavity.

[0008] The storage rack includes a tube plate that matches the limiting part. The tube plate has several insertion holes. A fixing rod is installed on the upper end of the tube plate in an upward extending manner. A movable rod is movably connected to the fixing rod. A second connecting part that is detachably engaged with the first connecting part is provided on the movable rod.

[0009] The storage rack has at least two working states: a transfer state and a positioning state. When the storage rack is in the positioning state, the tube tray is located at the bottom of the receiving cavity. The limiting part constrains and connects the tube tray in the horizontal direction. The movable rod is located on one side of the fixed rod in the horizontal direction. The first connecting part and the second connecting part on the movable rod are connected to constrain the tube tray in the horizontal direction.

[0010] When the storage rack is in the transfer state, the movable rod is located above the fixed rod, wherein the movable rod is arranged along the length direction of the fixed rod, and the top of the movable rod is higher than the opening of the receiving cavity.

[0011] Preferably, the first connecting part is located inside the opening, the first connecting part is a downwardly extending notch, and the second connecting part is a plate-shaped piece formed by bending the end of the movable rod away from the fixed rod downward. When the storage rack is in a positioning state, the second connecting part is engaged with the inside of the first connecting part.

[0012] Preferably, the limiting part is a downwardly extending groove, the limiting part and the opening are arranged opposite to each other, and when the storage rack is in the positioning state, the side wall of the limiting part and the side wall of the tube tray are in contact.

[0013] Preferably, the tube coil is disc-shaped, the insertion holes are arranged at intervals along the circumference of the tube coil, and the axis of the fixing rod coincides with the axis of the tube coil.

[0014] Preferably, when the access rack is in a positioned state, a gap is reserved between the inner edge of the opening and the outer edge of the fixing rod.

[0015] Preferably, the movable rod is positioned near the top of the fixed rod, and when the storage rack is in a transfer state, the top of the fixed rod is not lower than the opening.

[0016] Preferably, the movable rod and the fixed rod are connected by a revolute joint. When the storage rack is in a positioning state, the movable rod is arranged in a horizontal direction, and when the storage rack is in a transfer state, the movable rod is arranged in a vertical direction, wherein the movable rod and the fixed rod abut against each other in the horizontal direction.

[0017] Preferably, the fixed rod has a movable rod on each of its opposite sides in the horizontal direction.

[0018] Preferably, the movable rod is provided with an anti-slip pad arranged along its length, and when the storage rack is in a transfer state, the anti-slip pad is located on the outer side of the movable rod in the horizontal direction.

[0019] Compared with the prior art, the beneficial effects of this utility model are:

[0020] This liquid nitrogen container, which facilitates the storage and retrieval of cryovials, allows the cryovials to be inserted into the sockets on the tube tray, and the retrieval rack in a positioned state to be placed at the bottom of the receiving cavity. The limiting part constrains the tube tray at the lower part of the retrieval rack in the horizontal direction, and connects the second connecting part on the movable rod with the second connecting part of the opening to constrain the upper part of the retrieval rack in the horizontal direction. This ensures that the relative position between the retrieval rack and the container body is fixed during the transfer process, and prevents the cryovials on the retrieval rack from colliding with the inner wall of the container body due to the shaking of liquid nitrogen, which could lead to contamination of the cryovial openings.

[0021] When it is necessary to transfer or remove cryovials from the storage rack, adjust the storage rack to the transfer position, move the movable lever above the fixed lever, and the operator can grab the movable lever to transfer all cryovials on the storage rack to the outside of the container body at once. The label information of the cryovials on the storage rack can be checked in batches. The cryovials transferred to the outside of the container body can be thawed or frozen at the same time, which improves the efficiency of operation to a certain extent.

[0022] The present invention will be further described below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the main body of the liquid nitrogen container within the container of the present invention, which facilitates the storage and retrieval of cryopreservation tubes;

[0024] Figure 2 This is a schematic diagram of a liquid nitrogen container storage rack for easy access to cryopreservation tubes, as described in this utility model. Detailed Implementation

[0025] The following description is intended to provide a detailed account of the present invention so that those skilled in the art can implement it. The preferred embodiments described below are merely examples, and other obvious variations will occur to those skilled in the art. The basic principles of the present invention defined in the following description can be applied to other embodiments, modifications, improvements, equivalents, and other technical solutions that do not depart from the spirit and scope of the present invention.

[0026] Please see Figure 1-2 This utility model provides a technical solution: a liquid nitrogen container for easy storage and retrieval of cryopreservation tubes, the container body 100, the container body 100 having a receiving cavity 100a inside, the upper end of the container body 100 having an opening 100b communicating with the inside and outside of the receiving cavity 100a, the opening 100b having a first connecting part 101, and the bottom of the receiving cavity 100a having a limiting part 102;

[0027] The storage rack 200 includes a tube tray 201 that matches the limiting part 102. The tube tray 201 has a plurality of insertion holes 2011. A fixing rod 202 is installed at the upper end of the tube tray 201 in an upward extending manner. A movable rod 203 is movably connected to the fixing rod 202. The movable rod 203 is provided with a second connecting part 2031 that is detachably engaged with the first connecting part 101.

[0028] The access rack 200 has at least two working states: a transfer state and a positioning state. When the access rack 200 is in the positioning state, the tube tray 201 is located at the bottom of the receiving cavity 100a. The limiting part 102 constrains and connects the tube tray 201 in the horizontal direction. The movable rod 203 is located on one side of the fixed rod 202 in the horizontal direction. The first connecting part 101 and the second connecting part 2031 on the movable rod 203 are connected to constrain the tube tray 201 in the horizontal direction.

[0029] When the access rack 200 is in the transfer state, the movable rod 203 moves to above the fixed rod 202 by separating the first connecting part 101 and the second connecting part 2031, wherein the movable rod 203 is arranged along the length direction of the fixed rod 202, and in the vertical direction, the top of the movable rod 203 is higher than the opening 100b of the receiving cavity 100a.

[0030] The cryopreservation tube can be inserted into the insertion hole 2011 on the tube tray 201, and the positioning storage rack 200 is placed at the bottom of the receiving cavity 100a. The limiting part 102 constrains the tube tray 201 at the lower part of the storage rack 200 in the horizontal direction, and connects the second connecting part 2031 on the movable rod 203 and the second connecting part 2031 of the opening 100b to constrain the upper part of the storage rack 200 in the horizontal direction. This ensures that the relative position between the storage rack 200 and the container body 100 is fixed during the transfer process, and prevents the cryopreservation tube on the storage rack 200 from colliding with the inner wall of the container body 100 due to the shaking of liquid nitrogen, which would cause contamination of the tube opening.

[0031] When it is necessary to transfer or remove the cryopreservation tubes on the storage rack 200, the storage rack 200 is adjusted to the transfer state, and the movable rod 203 moves above the fixed rod 202. The operator can grab the movable rod 203 to transfer all the cryopreservation tubes on the storage rack 200 to the outside of the container body 100 at one time. The label information of the cryopreservation tubes on the storage rack 200 can be checked in batches. The cryopreservation tubes transferred to the outside of the container body 100 can be thawed or frozen at the same time, which improves the operation efficiency to a certain extent.

[0032] Dry liquid nitrogen containers use a large amount of liquid nitrogen, which is expensive and has high operating costs. In addition, dry liquid nitrogen containers are heavy and inconvenient for operators to carry. The liquid nitrogen container proposed in this application uses the same amount of liquid nitrogen as ordinary liquid nitrogen thermos containers, and can achieve a freezing effect similar to that of dry liquid nitrogen containers. Compared with dry liquid nitrogen containers, the liquid nitrogen container proposed in this application also has the advantages of using less liquid nitrogen, lower operating costs, lighter weight, and easier portability.

[0033] In this embodiment, the first connecting part 101 is located inside the opening 100b. The first connecting part 101 is a downwardly extending notch. The second connecting part 2031 is a plate-shaped piece formed by bending the end of the movable rod 203 away from the fixed rod 202 downward. When the storage rack 200 is in a positioning state, the second connecting part 2031 is engaged with the inside of the first connecting part 101.

[0034] The limiting part 102 is a downwardly extending groove. The limiting part 102 and the opening 100b are arranged opposite to each other. When the storage rack 200 is in the positioning state, the side wall of the groove and the side wall of the tube tray 201 are in contact. In another embodiment, both the limiting part 102 and the tube tray 201 are magnetic, and the magnetic properties of the opposite sides of the limiting part 102 and the tube tray 201 are opposite.

[0035] To facilitate observation and placement of the cryopreservation tubes on the tube tray 201, the tube tray 201 is further shaped like a disc, with the insertion holes 2011 spaced apart around the circumference of the tube tray 201. The axis of the fixing rod 202 coincides with the axis of the tube tray 201. In the horizontal direction, when the storage rack 200 is in the positioning state, a gap is reserved between the inner edge of the opening 100b and the outer edge of the fixing rod 202 to prevent the operator's hand from touching the opening 100b and causing contamination or injury when the storage rack 200 is moved to the outside of the container body 100 by operating the fixing rod 202. Furthermore, the fixing rod 202 corresponds to the center position of the opening 100b.

[0036] To facilitate easier movement of the storage rack 200 by the operator using the movable lever 203, the movable lever 203 is positioned close to the top of the fixed lever 202. When the storage rack 200 is in the transfer state, the top of the fixed lever 202 is not lower than the opening 100b. This ensures that when the storage rack 200 is switched to the transfer state, the movable lever 203 is fully exposed above the opening 100b, making it easier for the operator to grip the movable lever 203.

[0037] See Figure 2The movable rod 203 and the fixed rod 202 are connected by a rotating joint. When the storage rack 200 is in the positioning state, the movable rod 203 is arranged in the horizontal direction. When the storage rack 200 is in the transfer state, the movable rod 203 is arranged in the vertical direction. One side of the movable rod 203 in the horizontal direction abuts against the outer side of the fixed rod 202 in the horizontal direction.

[0038] There are two movable rods 203. One movable rod 203 is provided on each of the two opposite sides of the fixed rod 202 in the horizontal direction. Each movable rod 203 is provided with an anti-slip pad 204 extending along its length. When the storage rack 200 is in a transfer state, the anti-slip pad 204 is located on the outer side of the movable rod 203 in the horizontal direction. Preferably, the anti-slip pad 204 is made of rubber.

[0039] Furthermore, the main body of the container is equipped with a cover that opens and closes the opening. The inner side of the cover is configured to abut against the top of the fixing rod 201 of the storage rack 200 in the positioning state, so as to further constrain the position of the storage rack 200 in the vertical direction when the liquid nitrogen container is transferred, while preventing liquid nitrogen from spilling.

[0040] How to use:

[0041] First, insert the cryopreservation tube into the insertion hole 2011 on the tube tray 201, fold the movable rod 203 to make it vertical, and the operator holds the anti-slip pad 204 on the outside of the movable rod 203 to lift the storage rack 200 as a whole and transfer it into the container body 100, where the tube tray 201 is placed into the limiting part 102. Fold the movable rod 203 to a horizontal state so that the second connecting part 2031 on the outside of the movable rod 203 and the third connecting part on the opening 100b are engaged. Pour in an appropriate amount of liquid nitrogen for subsequent sample transfer.

[0042] This liquid nitrogen container, which facilitates the storage and retrieval of cryovials, allows the cryovials to be inserted into the insertion holes 2011 on the tube tray 201, and the retrieval rack 200 in a positioned state is placed at the bottom of the receiving cavity 100a. The limiting part 102 constrains the tube tray 201 at the lower part of the retrieval rack 200 in the horizontal direction, and connects the second connecting part 2031 on the movable rod 203 with the second connecting part 2031 of the opening 100b to constrain the upper part of the retrieval rack 200 in the horizontal direction. This ensures that the relative position between the retrieval rack 200 and the container body 100 is fixed during the transfer process, and prevents the cryovials on the retrieval rack 200 from colliding with the inner wall of the container body 100 due to the shaking of the liquid nitrogen, which could lead to contamination of the cryovial opening.

[0043] When it is necessary to transfer or remove the cryopreservation tubes on the storage rack 200, the storage rack 200 is adjusted to the transfer state, and the movable rod 203 moves above the fixed rod 202. The operator can then grab the movable rod 203 to transfer all the cryopreservation tubes on the storage rack 200 to the outside of the container body 100 at once, replacing the traditional method of transferring cryopreservation tubes one by one with tweezers. The label information of the cryopreservation tubes on the storage rack 200 can be checked in batches. The cryopreservation tubes transferred to the outside of the container body 100 can be thawed or frozen at the same time, which improves the efficiency of operation to a certain extent.

[0044] In addition, the amount of liquid nitrogen used in the liquid nitrogen container proposed in this application is the same as that used in ordinary liquid nitrogen thermos containers, and the freezing effect that can be achieved is similar to that of dry liquid nitrogen containers. Compared with dry liquid nitrogen containers, the liquid nitrogen container proposed in this application also has the advantages of using less liquid nitrogen, lower cost, lighter weight and easier portability.

[0045] The embodiments described above are only used to illustrate the technical ideas and features of this utility model. Their purpose is to enable those skilled in the art to understand the content of this utility model and implement it accordingly. The scope of patent application of this utility model should not be limited by these embodiments. That is, any equivalent changes or modifications made in accordance with the spirit disclosed in this utility model still fall within the patent scope of this utility model.

Claims

1. A liquid nitrogen container for easy storage and retrieval of cryovials, characterized in that, include: The kettle body (100) has an internal cavity (100a) and an opening (100b) at the upper end of the kettle body (100) that connects the inside and outside of the cavity (100a). A first connecting part (101) is provided on the opening (100b) and a limiting part (102) is provided at the bottom of the cavity (100a). Access rack (200), the access rack (200) includes a tube plate (201) that matches the limiting part (102), the tube plate (201) is provided with a plurality of insertion holes (2011), the upper end of the tube plate (201) is provided with a fixing rod (202) extending upward, the fixing rod (202) is movably connected to a movable rod (203), the movable rod (203) is provided with a second connecting part (2031) that is detachably engaged with the first connecting part (101); The access rack (200) has at least two working states, namely a transfer state and a positioning state. When the access rack (200) is in the positioning state, the tube tray (201) is located at the bottom of the receiving cavity (100a), the limiting part (102) constrains and connects the tube tray (201) in the horizontal direction, the movable rod (203) is located on one side of the fixed rod (202) in the horizontal direction, and the first connecting part (101) and the second connecting part (2031) on the movable rod (203) are connected to constrain the tube tray (201) in the horizontal direction. When the access rack (200) is in the transfer state, the movable rod (203) is located above the fixed rod (202), wherein the movable rod (203) is arranged along the length direction of the fixed rod (202), and the top of the movable rod (203) is higher than the opening (100b) of the receiving cavity (100a).

2. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The first connecting part (101) is located inside the opening (100b). The first connecting part (101) is a downwardly extending notch. The second connecting part (2031) is a plate-shaped piece formed by bending the end of the movable rod (203) away from the fixed rod (202) downward. When the access rack (200) is in the positioning state, the second connecting part (2031) is engaged inside the first connecting part (101).

3. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The limiting part (102) is a downwardly extending groove. The limiting part (102) and the opening (100b) are arranged opposite to each other. When the storage rack (200) is in the positioning state, the side wall of the limiting part (102) and the side wall of the tube tray (201) are in contact.

4. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The tube disc (201) is disc-shaped, the insertion holes (2011) are arranged at intervals along the circumference of the tube disc (201), and the axis of the fixing rod (202) coincides with the axis of the tube disc (201).

5. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, When the access rack (200) is in the positioning state, a gap is reserved between the inner edge of the opening (100b) and the outer edge of the fixing rod (202).

6. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The movable rod (203) is positioned near the top of the fixed rod (202), and when the access rack (200) is in a transfer state, the top of the fixed rod (202) is not lower than the opening (100b).

7. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The movable rod (203) and the fixed rod (202) are connected by a rotating joint. When the storage rack (200) is in the positioning state, the movable rod (203) is arranged in the horizontal direction. When the storage rack (200) is in the transfer state, the movable rod (203) is arranged in the vertical direction. The movable rod (203) and the fixed rod (202) abut against each other in the horizontal direction.

8. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The fixed rod (202) has a movable rod (203) on each of its opposite sides in the horizontal direction.

9. A liquid nitrogen container for easy storage and retrieval of cryovials according to claim 1, characterized in that, The movable rod (203) is provided with an anti-slip pad (204) arranged along its length. When the storage rack (200) is in the transfer state, the anti-slip pad (204) is located on the outer side of the movable rod (203) in the horizontal direction.

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