Gravity flow layout and material transfer structure of oral solid preparation workshop

Abstract

The utility model relates to a gravity flow layout and material transfer structure of an oral solid preparation workshop. The gravity flow layout and material transfer structure comprises a first production assembly, a second production assembly, a third production assembly and a fourth production assembly, the first production assembly is arranged in a first-layer packaging equipment area; the second production assembly is arranged in the second-layer process material receiving area; the third production assembly is arranged in a three-layer process equipment area; the fourth production assembly is arranged in a four-layer process feeding and raw and auxiliary material weighing area; the first production assembly is communicated with the second production assembly, the second production assembly is communicated with the third production assembly, and the third production assembly is communicated with the fourth production assembly. The fourth production assembly comprises a tabletting feeding station, a weighing chamber, a coating feeding station, a wet granulation feeding station and a total mixing feeding station; the gravity flow layout and material transfer structure of the oral solid preparation workshop aims at overcoming the existing defects, improves the operation efficiency and reduces the risk of cross contamination.

Description

TECHNICAL FIELD

[0001] The utility model relates to a gravity flow layout and material transfer structure of oral solid preparation workshop. BACKGROUND

[0002] In the oral solid preparation production workshop of pharmaceutical chemical industry, the production process of solid preparation needs to transfer powder among different processes. Under the requirement of GMP standard (good manufacturing practice of drugs) to equipment, it is necessary to ensure the safety and reliability of material turnover, minimize human intervention and prevent cross contamination.

[0003] The existing technical equipment layout is usually flat design, or the main process equipment is concentrated in one layer. The material transfer from the previous process to the next process is mainly through the equipment discharge to the bucket, and then the manual transfer of the bucket to the next process room. The bucket is lifted by the elevator and fed to the equipment of the next process. These processes are completed by manually transferring the bucket. There is a cross flow of people and materials in the process room, and the material flow is in the clean area. It is difficult to use AGV (automatic guided vehicle, which automatically completes the material handling task without the need for driver operation) for automatic handling of the transfer of the bucket. Usually, the material transfer is carried out by manually pushing the bucket.

[0004] The above problems exist, the transportation efficiency is low, and there is a risk of cross contamination. Therefore, a gravity flow layout and material transfer structure of oral solid preparation workshop is proposed to solve the above problems. UTILITY MODEL CONTENT

[0005] The utility model aims at overcoming the defects of the prior art and providing a gravity flow layout and material transfer structure of oral solid preparation workshop, which improves the operation efficiency and reduces the risk of cross contamination.

[0006] The technical scheme for achieving the above-mentioned purpose is: a gravity flow layout and material transfer structure of oral solid preparation workshop, comprising a first production assembly, a second production assembly, a third production assembly and a fourth production assembly.

[0007] The first production assembly is arranged in a first layer packaging equipment area. The second production assembly is arranged in a second layer process material receiving area. The third production assembly is arranged in a third layer process equipment area. The fourth production assembly is arranged in a fourth layer process material feeding and raw and auxiliary material weighing area.

[0008] The first production assembly is connected to the second production assembly. The second production assembly is connected to the third production assembly. The third production assembly is connected to the fourth production assembly.

[0009] Preferably, the fourth production component includes a tableting feeding station, a weighing chamber, a coating feeding station, a wet granulation feeding station, and a general mixing feeding station; the four-layer process feeding and raw material weighing areas are arranged from left to right as follows: the tableting feeding station, the weighing chamber, the coating feeding station, the wet granulation feeding station, and the general mixing feeding station.

[0010] Preferably, the third production component includes a tablet press, a coating machine, a dry granulation buffer tank, a fluidized bed, a wet granulation machine, and a mixer; the two-layer process receiving area is arranged from left to right as follows: the tablet press, the coating machine, the dry granulation buffer tank, the fluidized bed, the wet granulation machine, and the mixer.

[0011] The upper end of the tablet press is connected to the tablet feeding station; the upper end of the coating machine is connected to the coating feeding station; the dry granulation buffer tank is connected to the fluidized bed, the fluidized bed is connected to the wet granulation machine, the upper end of the wet granulation machine is connected to the wet granulation feeding station; the upper end of the mixer is connected to the main mixing feeding station.

[0012] Preferably, the second production component includes a tableting receiving station, a coating receiving station, a dry granulation receiving station, a packaging line feeding station, and a total mixing receiving station; the two-layer process receiving area is arranged from left to right as follows: the tableting receiving station, the coating receiving station, the dry granulation receiving station, the packaging line feeding station, and the total mixing receiving station;

[0013] The tableting receiving station is connected to the tableting machine at its upper end; the coating receiving station is connected to the coating machine at its upper end; the dry granulation receiving station is connected to the dry granulation buffer tank at its upper end; and the total mixing receiving station is connected to the mixer at its upper end.

[0014] Preferably, the first production component includes a packaging line, which is disposed within the first-layer packaging equipment area; the upper end of the packaging line is connected to the packaging line feeding station.

[0015] Preferably, AGV trolleys and material buckets are provided in the second-layer process receiving area and the fourth-layer process feeding and raw material weighing area.

[0016] Preferably, each of the tableting feeding station, the coating feeding station, the wet granulation feeding station, and the total mixing feeding station is equipped with a feeding station cleaning device.

[0017] Preferably, each of the tableting receiving station, the coating receiving station, the dry granulation receiving station, the packaging line feeding station, and the total mixing receiving station is equipped with a receiving station cleaning device.

[0018] Preferably, an interlayer elevator is provided on the left side of the second-layer process receiving area, the third-layer process equipment area, and the fourth-layer process feeding and raw material weighing area.

[0019] Preferably, the upper and lower ends of the material hopper are connected to a sealed passive valve.

[0020] The beneficial effects of this utility model are as follows: The gravity flow layout and material transfer structure of this oral solid dosage form workshop optimize the gravity flow layout and rationally utilize floor height differences: vertical material drop feeding is achieved through floor height differences, reducing mechanical handling of materials between different processes, thereby reducing energy consumption and equipment failure rate. The optimized floor function distribution rationally distributes different processes across floors, ensuring smooth material transfer and avoiding excessive manual intervention and cross-flow of materials. Effective isolation between clean and non-clean areas is ensured through a rational layout design, using closed passive valves and closed active valves for effective isolation, reducing the clean area area while achieving automated transfer and docking, reducing the risk of cross-contamination and improving product quality. Production energy consumption is reduced by decreasing the clean area area and optimizing the production process, thus reducing the overall energy consumption of the workshop. Automated material transfer is achieved; all material barrel docking, feeding, and receiving are carried out automatically via AGVs and rollers, requiring no manual intervention.

[0021] The gravity flow layout and material transfer structure of this oral solid dosage form workshop have a high degree of automation and are suitable for large-scale automated production workshops in the field of oral solid dosage forms. Through reasonable floor function distribution and optimized single-machine equipment design, it can realize the automation of material transfer and effective isolation between clean and non-clean areas, improve production efficiency, reduce manual operation, improve product quality consistency, and reduce energy consumption. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the entire utility model;

[0023] Figure 2 This is a schematic diagram showing the partitioning of the clean area and the non-clean area in this utility model;

[0024] Figure 3 This is a schematic diagram of the material bucket of this utility model;

[0025] Figure 4 This is a schematic diagram of the automatic sealed feeding system of this utility model;

[0026] Figure 5 This is a schematic diagram of the automatic sealed material receiving system of this utility model.

[0027] In the diagram: 1. Weighing chamber; 2. Material hopper; 3. AGV trolley; 4. Wet granulation feeding station; 5. Feeding station cleaning device; 6. Wet granulator; 7. Fluidized bed; 8. Dry granulation buffer tank; 9. Dry granulation receiving station; 10. Receiving station cleaning device; 11. Interlayer elevator; 12. Main mixing feeding station; 13. Mixer; 14. Main mixing receiving station; 15. Tableting feeding station; 16. Tableting machine; 17. Tableting receiving station; 18. Coating feeding station; 19. Coating machine; 20. Coating receiving station; 21. Packaging line feeding station; 22. Packaging line; 23. Sealed passive valve; 24. Sealed active valve; 25. Roller conveyor; 26. Feeding station discharge pipe; 27. Receiving station receiving pipe. Detailed Implementation

[0028] The technical solution of this utility model will now be clearly and completely described in conjunction with the accompanying drawings. In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0029] The present invention will be further described below with reference to the accompanying drawings.

[0030] like Figures 1-5 As shown, a gravity flow layout and material transfer structure for an oral solid dosage form workshop includes a first production component, a second production component, a third production component, and a fourth production component; the first production component is located in the packaging equipment area on the first floor; the second production component is located in the process receiving area on the second floor; the third production component is located in the process equipment area on the third floor; and the fourth production component is located in the process feeding and raw material weighing area on the fourth floor; the first production component is connected to the second production component, the second production component is connected to the third production component, and the third production component is connected to the fourth production component.

[0031] The first-floor packaging equipment area is mainly used for inner and outer packaging of capsules or tablets, after which the contents are temporarily stored in the warehouse. Located on the ground floor, this area facilitates the transfer and shipment of finished products.

[0032] Second-floor receiving area: Used to collect and temporarily store intermediate products after production by various process equipment. The design of the second floor facilitates the collection of materials by gravity after production by the process equipment, where AGV carts automatically transport the material bins to the receiving position for collection.

[0033] The third-floor process equipment area mainly houses various process equipment, such as wet granulation machines, fluidized beds, mixers, tablet presses, and coating machines. After undergoing various processing steps on the third floor, materials fall to the receiving layer on the second floor by gravity.

[0034] The fourth-floor process feeding and raw material weighing area is used for weighing and feeding materials. Raw materials are transported to the fourth floor via freight elevator, pre-processed, weighed, and then placed into material bins. AGV carts automatically transport the materials to the feeding positions for feeding.

[0035] Specifically, the fourth production component includes a tableting feeding station 15, a weighing chamber 1, a coating feeding station 18, a wet granulation feeding station 4, and a general mixing feeding station 12. The four-layer process feeding and raw material weighing areas are arranged from left to right as follows: tableting feeding station 15, weighing chamber 1, coating feeding station 18, wet granulation feeding station 4, and general mixing feeding station 12. Each of the tableting feeding station 15, coating feeding station 18, wet granulation feeding station 4, and general mixing feeding station 12 is equipped with a feeding station cleaning device 5.

[0036] Specifically, the third production component includes a tablet press 16, a coating machine 19, a dry granulation buffer tank 8, a fluidized bed 7, a wet granulator 6, and a mixer 13. The second-level process receiving area, from left to right, is equipped with the tablet press 16, coating machine 19, dry granulation buffer tank 8, fluidized bed 7, wet granulator 6, and mixer 13. The upper end of the tablet press 16 is connected to the tablet feeding station 15; the upper end of the coating machine 19 is connected to the coating feeding station 18; the dry granulation buffer tank 8 is connected to the fluidized bed 7, the fluidized bed 7 is connected to the wet granulator 6, and the upper end of the wet granulator 6 is connected to the wet granulation feeding station 4; the upper end of the mixer 13 is connected to the main mixing feeding station 12. AGV trolleys 3 and material bins 2 are installed in both the second-level process receiving area and the fourth-level process feeding and raw material weighing area. Sealed passive valves 23 are connected to the upper and lower ends of the material bins 2.

[0037] Specifically, the second production component includes a tableting receiving station 17, a coating receiving station 20, a dry granulation receiving station 9, a packaging line feeding station 21, and a total mixing receiving station 14. The second-layer process receiving area is arranged from left to right as follows: tableting receiving station 17, coating receiving station 20, dry granulation receiving station 9, packaging line feeding station 21, and total mixing receiving station 14. The upper end of tableting receiving station 17 is connected to the tableting machine 16; the upper end of coating receiving station 20 is connected to the coating machine 19; the upper end of dry granulation receiving station 9 is connected to the dry granulation buffer tank 8; and the upper end of total mixing receiving station 14 is connected to the mixer 13. Each of the tableting receiving station 17, coating receiving station 20, dry granulation receiving station 9, packaging line feeding station 21, and total mixing receiving station 14 is equipped with a receiving station cleaning device 10. A through-level elevator 11 is installed on the left side of the second-level process receiving area, the third-level process equipment area, and the fourth-level process feeding and raw material weighing area.

[0038] Specifically, the first production component includes a packaging line 22, which is set up in the first-floor packaging equipment area; the upper end of the packaging line 22 is connected to the packaging line feeding station 21.

[0039] Specifically, the material is weighed and prepared in the weighing chamber 1 on the fourth floor. After weighing, it is fed into the feeding bucket 2. The AGV trolley 3 transports the feeding bucket 2 to the wet granulation feeding station 4 for feeding. After the material is fed into the wet granulator 6 on the third floor, the wet granulator 6 completes the wet granulation process and is vacuum conveyed to the fluidized bed 7. After the fluidized bed 7 completes the drying process, it is vacuum conveyed to the dry granulation buffer tank 8. After dry granulation, it is discharged to the second floor by gravity. The second floor is equipped with a dry granulation receiving station 9. The AGV trolley 3 transports the feeding bucket 2 and docks with the dry granulation receiving station 9 to complete the receiving.

[0040] Specifically, the AGV trolley 3 transports the dry pellet collection bin 2 to the interlayer elevator 11. The interlayer elevator 11 is internally designed with a roller conveyor, and externally has connecting buffer rollers on the second and fourth floors. The AGV trolley 3 first places the collection bin 2 on the buffer rollers, and then the buffer rollers send it into the interlayer elevator 11. The interlayer elevator 11 then transports the collection bin from the second floor to the fourth floor. The AGV trolley 3 on the fourth floor then transports the collection bin 2 to the main mixing and feeding station 12 for feeding. The material is then gravity-fed into the mixer 13. After the mixing process is completed, the material is gravity-fed back to the second floor. The second floor is equipped with a main mixing and receiving station 14. The AGV trolley 3 transports the collection bin 2 and connects with the main mixing and receiving station 14 to complete the receiving process.

[0041] Specifically, the AGV cart 3 transports the material bucket 2, which has completed the total mixed material collection, to the inter-layer elevator 11. The material bucket 2 is then transported from the second floor to the fourth floor by the inter-layer elevator 11. The AGV cart 3 on the fourth floor then transports the material bucket 2 to the tableting feeding station 15 for feeding. The material is then fed to the tableting machine 16 by gravity. After the tableting process is completed, the material is discharged to the second floor by gravity. The second floor is equipped with a tableting receiving station 17. The AGV cart 3 transports the material bucket 2 and docks with the tableting receiving station 17 to complete the receiving.

[0042] Specifically, the AGV cart 3 transports the material bucket 2, which has completed the tableting and receiving process, to the inter-layer elevator 11. The material bucket 2 is then transported from the second floor to the fourth floor via the inter-layer elevator 11. The AGV cart 3 on the fourth floor then transports the material bucket 2 to the coating feeding station 18 for feeding. The material is then fed by gravity to the coating machine 19. After the coating process is completed, the material is discharged by gravity to the second floor. The second floor is equipped with a coating receiving station 20. The AGV cart 3 transports the material bucket 2 and docks with the coating receiving station 20 to complete the receiving process.

[0043] Specifically, after the coating and receiving process is completed, the AGV trolley 3 transports the material bucket 2 to the second floor and feeds it through the packaging line feeding station 21. The material is then gravity-fed onto the packaging line 22 to complete the inner and outer packaging of capsules or tablets. After outer packaging, the capsules or tablets are sent to the warehouse for temporary storage.

[0044] Specifically, all the above-mentioned feeding stations are equipped with feeding station cleaning devices 5, and all receiving stations are equipped with receiving station cleaning devices 10. After production is completed, online cleaning can be carried out through the control program without the need for manual intervention.

[0045] Specifically, all the aforementioned process equipment needs to be optimized and improved compared to traditional feeding and discharging methods. The feed inlet should be connected to the discharge pipe of the feeding station, and the discharge outlet should be connected to the receiving pipe of the receiving station. The non-control system of the single equipment should be able to communicate and interact with the upper-level control system.

[0046] like Figure 2 The diagram shows the partitioning of clean and non-clean areas. The grid lines represent clean areas, and the remaining areas represent non-clean areas. The clean area includes the raw material weighing and preparation area, the process equipment layer, and the inner packaging area of ​​the packaging line. The non-clean area includes the process feeding layer, the process receiving layer, and the outer packaging area of ​​the packaging line. The clean area occupies less space than the non-clean area. Compared to traditional oral solid dosage form production workshops, this patented solution significantly reduces the clean area, effectively reducing energy consumption and saving costs.

[0047] like Figure 3 As shown, the upper and lower openings of the material bin 2 are equipped with sealed passive valves 23, which can automatically dock with the sealed active valve 24 during material feeding and receiving. All material bins are suitable for docking and handling by AGV trolleys 3 and for transportation by roller conveyors 25.

[0048] like Figure 4 As shown, the material bucket 2 is transported onto the roller conveyor 25. The roller conveyor 25 transports the material bucket 2 to a position directly above the lower opening. The closed active valve 24 is installed on the roller conveyor 25. The closed active valve 24 can automatically lift and automatically connect with the closed passive valve 23 at the lower opening of the material bucket 2. After opening the closed valve, the material is automatically fed into the process equipment through the feeding station discharge pipe 26.

[0049] like Figure 5 As shown, the material bucket 2 is transported onto the roller conveyor 25. The roller conveyor 25 transports the material bucket 2 to a position directly below the closed active valve 24. The closed active valve 24 is installed at the lower end of the receiving pipe 27 of the receiving station. The closed active valve 24 can automatically descend and automatically connect with the closed passive valve 23 at the upper end of the material bucket 2. After the closed valve is opened, the material is automatically collected into the material bucket 2 through the receiving pipe 27 of the receiving station.

[0050] Specifically, closed passive valves and closed active valves are used for the closed and aseptic transport of materials, avoiding cross-contamination and effectively protecting operators and the operating environment. They are suitable for loading / unloading, batching, crushing, and sampling under closed conditions. Clean Area: In pharmaceutical manufacturing, a clean area refers to a specific area within the factory building where airborne dust particles and microorganisms are controlled within specified limits through a series of air purification technologies and strict environmental control measures. Its purpose is to provide a relatively sterile, particulate-free environment for drug production, ensuring drug quality, safety, and efficacy, and preventing contamination and cross-contamination during the production process. Non-Clean Area: In pharmaceutical manufacturing, a non-clean area is a production area relative to the clean area, with relatively lower requirements for air cleanliness and microbial limits. It is mainly used for pharmaceutical processes or activities where product quality and production environment requirements are not particularly high, and is part of the overall production environment of the pharmaceutical factory.

[0051] The gravity flow layout and material transfer structure of this oral solid dosage form workshop are optimized by making reasonable use of floor height differences: vertical material drop is achieved through these differences, reducing mechanical handling between different processes, thereby reducing energy consumption and equipment failure rates. The functional distribution of floors is optimized, with different processes rationally distributed across floors to ensure smooth material transfer and avoid excessive manual intervention and cross-flow. Effective isolation between clean and non-clean areas is ensured through a rational layout design using closed passive and closed active valves, reducing the clean area while achieving automated transfer and docking, reducing the risk of cross-contamination and improving product quality. Production energy consumption is reduced by minimizing the clean area and optimizing the production process. Automated material transfer is achieved; all material container docking, feeding, and receiving are automated via AGVs and rollers, requiring no manual intervention.

[0052] The gravity flow layout and material transfer structure of this oral solid dosage form workshop have a high degree of automation and are suitable for large-scale automated production workshops in the field of oral solid dosage forms. Through reasonable floor function distribution and optimized single-machine equipment design, it can realize the automation of material transfer and effective isolation between clean and non-clean areas, improve production efficiency, reduce manual operation, improve product quality consistency, and reduce energy consumption.

[0053] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model.

Claims

1. A gravity flow layout and material transfer structure for an oral solid dosage form workshop, characterized in that, It includes a first production component, a second production component, a third production component, and a fourth production component; The first production component is located in the first-floor packaging equipment area; the second production component is located in the second-floor process receiving area; the third production component is located in the third-floor process equipment area; and the fourth production component is located in the fourth-floor process feeding and raw material weighing area. The first production component is connected to the second production component, the second production component is connected to the third production component, and the third production component is connected to the fourth production component.

2. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 1, characterized in that, The fourth production component includes a tableting feeding station (15), a weighing chamber (1), a coating feeding station (18), a wet granulation feeding station (4), and a total mixing feeding station (12); the four-layer process feeding and raw material weighing areas are arranged from left to right as follows: the tableting feeding station (15), the weighing chamber (1), the coating feeding station (18), the wet granulation feeding station (4), and the total mixing feeding station (12).

3. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 2, characterized in that, The third production component includes a tablet press (16), a coating machine (19), a dry granulation buffer tank (8), a fluidized bed (7), a wet granulation machine (6), and a mixer (13); the second-layer process receiving area is arranged from left to right as follows: the tablet press (16), the coating machine (19), the dry granulation buffer tank (8), the fluidized bed (7), the wet granulation machine (6), and the mixer (13); The upper end of the tablet press (16) is connected to the tablet feeding station (15); the upper end of the coating machine (19) is connected to the coating feeding station (18); the dry granulation buffer tank (8) is connected to the fluidized bed (7), the fluidized bed (7) is connected to the wet granulation machine (6), the upper end of the wet granulation machine (6) is connected to the wet granulation feeding station (4); the upper end of the mixer (13) is connected to the total mixing feeding station (12).

4. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 3, characterized in that, The second production component includes a tableting receiving station (17), a coating receiving station (20), a dry granulation receiving station (9), a packaging line feeding station (21), and a total mixing receiving station (14); the two-layer process receiving area is arranged from left to right as follows: the tableting receiving station (17), the coating receiving station (20), the dry granulation receiving station (9), the packaging line feeding station (21), and the total mixing receiving station (14); The tableting receiving station (17) is connected to the tableting machine (16) at its upper end; the coating receiving station (20) is connected to the coating machine (19) at its upper end; the dry granulation receiving station (9) is connected to the dry granulation buffer tank (8) at its upper end; and the total mixing receiving station (14) is connected to the mixer (13) at its upper end.

5. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 4, characterized in that, The first production component includes a packaging line (22), which is located in the first layer of packaging equipment area; the upper end of the packaging line (22) is connected to the packaging line feeding station (21).

6. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 4, characterized in that, AGV carts (3) and material buckets (2) are each set up in the second-level process receiving area and the fourth-level process feeding and raw material weighing area.

7. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 2, characterized in that, Each of the tableting feeding station (15), the coating feeding station (18), the wet granulation feeding station (4), and the total mixing feeding station (12) is equipped with a feeding station cleaning device (5).

8. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 4, characterized in that, Each of the tablet receiving station (17), the coating receiving station (20), the dry granulation receiving station (9), the packaging line feeding station (21), and the total mixing receiving station (14) is equipped with a receiving station cleaning device (10).

9. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 1, characterized in that, An interlayer elevator (11) is provided on the left side of the second-layer process receiving area, the third-layer process equipment area, and the fourth-layer process feeding and raw material weighing area.

10. The gravity flow layout and material transfer structure of the oral solid dosage form workshop according to claim 6, characterized in that, The upper and lower ends of the material bucket (2) are connected to a closed passive valve (23).

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