Mouse embryo incubator with temperature control function

Abstract

The utility model relates to the technical field of mouse embryo culture, in particular to a mouse embryo incubator with a temperature control function, which comprises a rack and the like, the rack is a support carrier of the mouse embryo incubator and is a square cabinet, and a plurality of storage compartments are arranged in the rack at intervals in an array manner; the hatching box bodies are installed in the compartments of the rack, and openings for placing mouse culture dishes are formed in the front sides of the hatching box bodies; the fixing blocks are symmetrically and fixedly arranged on the two sides, close to the opening, of the front side of the incubation box body. The motor drives the lead screw to adjust the position of the heat insulation plate, the interior of the rack can be flexibly divided into two incubation compartments with different temperatures, independent temperature control over each compartment is achieved through the cooperation of the miniature air conditioners on the two sides, the most suitable temperature environment is provided according to different development stages of mouse embryos, and the incubation efficiency is improved. The success rate and the consistency of embryo culture are improved.

Description

Technical Field

[0001] This utility model relates to the field of mouse embryo culture technology, specifically to a mouse embryo incubator with temperature control function. Background Technology

[0002] In the field of life science research, especially in reproductive biology, developmental biology and gene editing research, mice play a crucial role as model organisms. To support these studies, scientists need to precisely control environmental conditions to ensure the healthy development of mouse embryos. The mouse embryo incubator is a key device that has emerged in this context. It provides stable temperature, humidity and other necessary environmental parameters to simulate the natural conditions inside the mother's uterus, thereby providing the best growth environment for the embryos.

[0003] Current mouse embryo culture equipment has largely supported these research activities, but it still faces several challenges in practical applications. The most significant of these is the issue of temperature control precision. Mouse embryos have specific temperature requirements at different stages of their development. For example, early embryos may prefer higher temperatures (around 37 degrees Celsius) to accelerate cell division, while as the embryo grows, the required suitable temperature will decrease slightly in order to better simulate the in vivo uterine environment. Therefore, we propose a temperature-controlled mouse embryo incubator to solve the above problems. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, this utility model provides a mouse embryo incubator with temperature control function, which can manage the temperature of mouse embryos at different stages of culture in batches.

[0005] A mouse embryo incubator with temperature control function includes a frame, which serves as the support carrier for the incubator. The frame is a square cabinet, and multiple storage compartments are arranged in an array at intervals inside the frame. It also includes: an incubation chamber, having multiple compartments installed within each compartment of the frame, with an opening on the front side for placing mouse culture dishes; fixing blocks symmetrically fixed on both sides of the front side of the incubation chamber near the opening; a door panel hinged to the front opening of the incubation chamber via the fixing blocks; a grid ventilation panel disposed on the rear wall of the incubation chamber, with multiple grid ventilation openings; a miniature air conditioner symmetrically installed on both side walls of the frame, used to regulate the incubation temperature within the frame; and a motor fixedly installed on... On one side of the inner wall of the rack, the motor is located behind the storage compartment of the rack; a lead screw is rotatably installed inside the rack, and the output shaft of the motor is connected to the lead screw; a guide rod is fixed inside the rack, and the guide rod and the lead screw are arranged parallel to each other; a heat insulation plate is slidably installed inside the rack through the guide rod, and the heat insulation plate and the lead screw are threadedly matched. The heat insulation plate seals and separates the incubation chambers on both sides inside the rack. The heat insulation plate is used to flexibly divide the rack into different incubation temperatures for mouse embryos. According to the culture stage of the mouse embryos, the motor drives the lead screw to adjust the heat insulation plate to divide the rack into two incubation compartments with different temperatures. With the help of two miniature air conditioners, the temperature of each incubation compartment is precisely adjusted, achieving the effect of precise and batch temperature adjustment for different incubation stages of mouse embryos.

[0006] To further explain, multiple ventilation openings of the grid ventilation plate are equipped with dust filters. These dust filters block dust and other impurities that may be present during incubation ventilation in the incubation chamber, thus preventing the mouse culture dishes from being contaminated by external dust and impurities during temperature-controlled incubation.

[0007] To further explain, handles are installed on the outer walls of the door panels, and sealing gaskets with adapted openings are provided on the side of the door panel near the incubation box. The door panels can seal and cover the incubation box, reducing the impact of the external environment on the incubation box inside the rack.

[0008] To further explain, all the incubation boxes are detachably installed in the storage compartment of the rack. Each incubation box can be removed from the storage compartment of the rack, which facilitates cleaning and other maintenance operations and reduces the maintenance cost of the incubation box.

[0009] To further explain, temperature detectors are symmetrically installed on both sides of the inner wall of the rack, and the insulation plate is located between the two temperature detectors. The top surface of the rack is equipped with temperature displays of the same number as the temperature detectors. The temperature displays are electrically connected to the temperature detectors on the same side. The temperature detectors are used to monitor the temperature changes in the corresponding compartments and display them intuitively through the corresponding temperature displays, so that the hatching personnel can monitor the cultivation temperature in different compartments of the rack in real time.

[0010] Further explanation: It also includes a transparent observation plate. An observation opening is provided on the rear side wall of the frame corresponding to the lead screw and guide rod. A transparent observation plate is provided at the observation opening of the frame. The transparent observation plate is used to observe the position of the heat insulation plate within the frame, so as to avoid the heat insulation plate being adjusted to the grid ventilation plate, which would cause the temperature of the two places to mix and affect the normal heat insulation culture of mouse embryos at different stages.

[0011] The beneficial effects of this utility model are as follows:

[0012] 1. This utility model uses a motor-driven lead screw to adjust the position of the insulation plate, which can flexibly divide the inside of the frame into two incubation compartments with different temperatures. With the help of miniature air conditioners on both sides, independent temperature control can be achieved for each compartment, providing the most suitable temperature environment according to the different developmental stages of mouse embryos, thereby improving the success rate and consistency of embryo culture.

[0013] 2. This utility model can ensure good air circulation through the grid ventilation plate on the rear side wall of the incubation box, and also set up a dust filter to block the entry of external dust and impurities, effectively avoiding the risk of contamination of the petri dish during temperature-controlled culture and ensuring the reliability of experimental results.

[0014] 3. The combination of the built-in temperature detector and the external temperature display in this invention allows incubators to monitor the actual temperature changes in each compartment at any time, ensuring the accuracy and stability of temperature control and providing researchers with intuitive data support. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0016] Figure 2 This diagram shows the connection relationship between the incubation box, door panel, fixing block, and handle of this utility model.

[0017] Figure 3 This is a schematic diagram of the frame, temperature display, miniature air conditioner, and transparent observation plate of this utility model.

[0018] Figure 4 This diagram shows the connection relationships of the components of this utility model, including the motor, lead screw, guide rod, and insulation plate.

[0019] The markings in the attached diagram are as follows: 1: rack, 2: incubator, 3: door panel, 4: fixing block, 5: handle, 6: grid ventilation panel, 61: dust filter, 7: mini air conditioner, 8: motor, 9: lead screw, 10: guide rod, 11: insulation board, 12: temperature detector, 13: temperature display, 14: transparent observation panel. Detailed Implementation

[0020] The present invention will be further described below with reference to specific embodiments. The illustrative embodiments and descriptions of the present invention are used to explain the present invention, but are not intended to limit the present invention.

[0021] A mouse embryo incubator with temperature control function, such as Figures 1-4 As shown, the device includes a frame 1, which serves as the support for the mouse embryo incubator 2. The frame 1 is a square cabinet with multiple storage compartments arranged in an array inside. It also includes: an incubator 2 body, which has multiple compartments installed within each compartment of the frame 1, with an opening on the front side for placing mouse culture dishes; fixing blocks 4, symmetrically fixed on both sides of the front side of the incubator 2 body near the opening; a door panel 3, hinged to the front opening of the incubator 2 body via the fixing blocks 4; a grid ventilation panel 6, located on the rear wall of the incubator 2 body, with multiple grid ventilation openings, each equipped with a dust filter 61 to block dust and other impurities that may be present during incubation ventilation, preventing contamination of the mouse culture dishes during temperature-controlled culture; and a miniature air conditioner 7, symmetrically installed on both sides of the frame 1. The incubation chamber 1 is used to regulate the incubation temperature within the rack 1. A motor 8 is fixedly installed on one side of the inner wall of the rack 1, located behind the storage compartment of the rack 1. A lead screw 9 is rotatably installed inside the rack 1, with the output shaft of the motor 8 connected to the lead screw 9. A guide rod 10 is fixed inside the rack 1, and the guide rod 10 and the lead screw 9 are arranged parallel to each other. A heat insulation plate 11 is slidably installed inside the rack 1 via the guide rod 10. The heat insulation plate 11 and the lead screw 9 are threadedly matched. The heat insulation plate 11 seals and separates the incubation chambers 2 on both sides of the rack 1. The heat insulation plate 11 is used to flexibly divide the incubation temperature of mouse embryos within the rack 1. According to the culture stage of the mouse embryos, the motor 8 drives the lead screw 9 to adjust the heat insulation plate 11 to divide the rack 1 into two incubation compartments with different temperatures. Combined with two miniature air conditioners 7, the temperature of each incubation compartment is precisely adjusted, achieving precise and batch temperature regulation for different incubation stages of mouse embryos.

[0022] like Figure 1 and Figure 2As shown, handles 5 are installed on the outer wall of the door panel 3. The side of the door panel 3 near the incubator 2 is provided with a sealing gasket adapted to the opening. The door panel 3 can seal and cover the incubator 2, reducing the impact of the external environment on the incubator 2 inside the rack 1. The incubator 2 is detachably installed in the storage compartment of the rack 1. Each incubator 2 can be removed from the storage compartment of the rack 1, which facilitates cleaning and other maintenance operations of the incubator 2 and reduces the maintenance cost of the incubator 2.

[0023] like Figure 1 and Figure 4 As shown, temperature detectors 12 are symmetrically installed on both sides of the inner side wall of the rack 1. The insulation plate 11 is located between the two temperature detectors 12. The top surface of the rack 1 is equipped with temperature displays 13 in the same number as the temperature detectors 12. The temperature displays 13 are electrically connected to the temperature detectors 12 on the same side. The temperature detectors 12 are used to monitor the temperature changes in the corresponding compartments and display them intuitively through the corresponding temperature displays 13, so that the hatching personnel can control the cultivation temperature in different compartments in the rack 1 in real time.

[0024] like Figure 3 As shown, it also includes a transparent observation plate 14. An observation opening is provided on the rear side wall of the frame 1 at the corresponding positions of the lead screw 9 and the guide rod 10. The transparent observation plate 14 is provided at the observation opening of the frame 1. The transparent observation plate 14 is used to observe the position of the heat insulation plate 11 within the frame 1, so as to avoid the heat insulation plate 11 being adjusted to the grid ventilation plate 6, which would cause the temperature of the two places to mix and affect the normal heat insulation culture of mouse embryos at different stages.

[0025] Firstly, the incubator 2 controls the temperature of each storage compartment within the rack 1 through its internal miniature air conditioning system 7. The miniature air conditioners 7 are installed on both side walls of the rack 1 and can adjust the temperature environment throughout the rack 1 as needed to adapt to the specific temperature conditions required for different developmental stages of mouse embryos. When different temperatures are required for different embryo incubation stages, the motor 8 starts working, driving the lead screw 9 to rotate. The lead screw 9 is threadedly connected to the insulation plate 11, allowing the insulation plate 11 to slide along the inside of the rack 1 under the guidance of the guide rod 10. The insulation plate 11 divides the inside of the rack 1 into two independent temperature zones, each of which can be regulated by the corresponding miniature air conditioner 7, thereby achieving temperature control for mouse embryos at different incubation stages. For precise temperature control, in order to ensure air circulation within each incubator 2 and prevent dust from entering, dust filters 61 are installed on the grid ventilation panel 6. These filters allow air circulation but prevent dust and other impurities from entering, ensuring the cleanliness of the mouse culture dishes. The sealing gasket on the door panel 3 further enhances the airtightness of the incubator 2, reducing the impact of external environmental changes on the internal temperature. The rack 1 is also equipped with a temperature detector 12 to monitor the temperature in each compartment in real time and feed the data back to the temperature display 13, so that the operator can understand and adjust the temperature settings at any time. The transparent observation panel 14 allows the operator to see the position of the insulation plate 11 intuitively, avoiding temperature mixing problems caused by improper placement of the insulation plate 11.

[0026] The above embodiments are provided for those skilled in the art to implement or use the present invention. Those skilled in the art can make various modifications or changes to the above embodiments without departing from the inventive concept of the present invention. Therefore, the protection scope of the present invention is not limited to the above embodiments, but should be the maximum scope that conforms to the innovative features mentioned in the claims.

Claims

1. A mouse embryo incubator with temperature control function, comprising a frame (1), wherein the frame (1) is a square cabinet, and the frame (1) is provided with multiple storage compartments arranged in an array at intervals inside; Its characteristic is that it also include: The incubator (2) body is provided with multiple incubators and installed in each compartment of the frame (1). The front side of the incubator (2) body has an opening for placing mouse culture dishes. Fixed blocks (4) are symmetrically fixed on both sides of the front side of the incubator (2) near the opening; The door panel (3) is hinged to the front opening of the incubator (2) body by a fixing block (4); A grid ventilation panel (6) is provided on the rear side wall of the incubator (2), and the grid ventilation panel (6) has multiple grid ventilation openings; Miniature air conditioners (7) are symmetrically installed on both sides of the frame (1); The motor (8) is fixedly installed on one side of the inner wall of the frame (1), and the motor (8) is located on the rear side of the storage compartment of the frame (1); The lead screw (9) is rotatably installed inside the frame (1), and the output shaft of the motor (8) is connected to the lead screw (9); The guide rod (10) is fixed inside the frame (1), and the guide rod (10) and the lead screw (9) are arranged in parallel. The heat insulation plate (11) is slidably installed inside the frame (1) via the guide rod (10). The heat insulation plate (11) and the lead screw (9) are threadedly matched. The heat insulation plate (11) seals and separates the incubator (2) body on both sides inside the frame (1). The heat insulation plate (11) is used to flexibly divide the incubation temperature of mouse embryos at different stages inside the frame (1).

2. The mouse embryo incubator with temperature control function according to claim 1, characterized in that, Dust filters (61) are provided on multiple ventilation openings of the grid ventilation panel (6).

3. A mouse embryo incubator with temperature control function according to claim 2, characterized in that, Each door panel (3) is equipped with a handle (5) on its outer wall, and a sealing gasket with an appropriate opening is provided on the side of the door panel (3) near the incubator (2).

4. A mouse embryo incubator with temperature control function according to claim 3, characterized in that, The incubators (2) are all detachable and installed in the storage compartment of the rack (1).

5. A mouse embryo incubator with temperature control function according to claim 4, characterized in that, Temperature detectors (12) are symmetrically installed on the two inner side walls of the frame (1). The insulation plate (11) is located between the two temperature detectors (12). Temperature displays (13) with the same number of temperature detectors (12) are installed on the top surface of the frame (1). The temperature displays (13) are electrically connected to the temperature detectors (12) on the same side. The temperature detectors (12) are used to monitor the temperature changes in the corresponding compartment.

6. A mouse embryo incubator with temperature control function according to claim 5, characterized in that, It also includes a transparent observation plate (14). An observation opening is provided on the rear side wall of the frame (1) corresponding to the lead screw (9) and the guide rod (10). A transparent observation plate (14) is provided at the observation opening of the frame (1). The transparent observation plate (14) is used to observe the position of the insulation plate (11) within the frame (1).

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