Liquid-based cell automatic dyeing and tableting machine

Abstract

The utility model relates to the technical field of cell flaking and dyeing equipment, and discloses a liquid-based cell automatic dyeing flaking machine which comprises a machine body, a controller is fixedly connected to the surface of the front side of the machine body, a dyeing flaking mechanism is arranged on the upper surface of the machine body, and a protective cover is hinged to the upper portion of the machine body. Fixing cylinders are fixedly connected to the left side and the right side of the inner top surface of the protective cover, pressure springs are fixedly connected to the inner top surfaces of the fixing cylinders, extrusion columns are fixedly connected to the bottom ends of the pressure springs, cavities are formed in the inner walls of the left side and the right side of the machine body, moving plates are arranged in the cavities in a sleeved mode, and detection units are arranged at the bottoms of the moving plates. According to the utility model, through the cooperation of the fixed cylinder, the pressure spring, the extrusion column, the cavity, the through groove, the movable plate and the detection unit, the dyeing slide making mechanism can be started only after the protection cover is completely covered and the upper part of the machine body is sealed, so that the operation error of a worker is avoided.

Description

Technical Field

[0001] This utility model relates to the field of cell slide preparation and staining equipment, and in particular to an automatic liquid-based cell staining and slide preparation machine. Background Technology

[0002] The liquid-based automated cytology staining and slide preparation machine is an automated device used for cytological testing. It is widely used in cervical cancer screening, pathological diagnosis and other fields. It can realize the fully automated operation of specimen pretreatment, slide preparation and staining without human supervision. It adopts advanced slide preparation technology, such as the patented "membrane sedimentation" technology, which can remove mucus and white blood cell interference, improve the quality of slide preparation and the efficiency and accuracy of cytological testing, and reduce the errors caused by manual operation. It is particularly suitable for large-scale screening and diagnosis.

[0003] Existing automated staining and slide preparation machines include a slide preparation chamber and a specimen chamber for loading slide cups and specimen cups. The slide cups and specimen cups are loaded into the working chamber via a turntable. The rotation and positioning of the turntable realizes the automatic transfer and processing of samples. Gradient centrifugation technology, combined with the principle of cell sedimentation, is used to remove impurities and mucus from the specimens, and to preferentially collect diseased cells, thereby improving the positive detection rate. At the same time, a high-precision syringe pump is equipped to accurately control the amount of sample and reagents used, ensuring the consistency of slide preparation and staining effects. In addition, the patented liquid level detection and tracking technology ensures the uniform distribution of cells.

[0004] Existing automated staining and slide preparation machines require the protective shield to be closed before staining and slide preparation to ensure that samples remain sealed during centrifugation, slide preparation, and staining, preventing liquid splashing, cross-contamination, and the entry of external impurities. However, in actual use, operational errors can easily lead to situations where the protective shield is not closed before slide preparation, resulting in errors in the post-slide testing results. Therefore, an automated liquid-based cell staining and slide preparation machine is proposed to solve the above problems. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides an automated liquid-based cell staining and slide preparation machine, which aims to improve the problem of slide preparation operations being performed without closing the protective cover in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: an automatic liquid-based cell staining and slide preparation machine, comprising a body, a controller fixedly connected to the front surface of the body, a staining and slide preparation mechanism provided on the upper surface of the body, a protective cover hinged to the top of the body, a hydraulic strut provided at the connection between the body and the protective cover, fixed cylinders fixedly connected to the left and right sides of the inner top surface of the protective cover, a pressure spring fixedly connected to the inner top surface of the fixed cylinder, a compression column fixedly connected to the bottom end of the pressure spring, cavities provided in the inner walls of the left and right sides of the body, through grooves provided on the upper surface of the cavities, a movable plate sleeved inside the cavities, and a detection unit provided at the bottom of the movable plate for detecting the pressure borne by the movable plate.

[0007] As a further description of the above technical solution:

[0008] The extrusion column is inserted into the interior of the fixed cylinder, and the extrusion column is located directly above the through groove.

[0009] As a further description of the above technical solution:

[0010] The detection unit includes an elastic element, which is fixedly connected to the bottom surface of the moving plate. A fixed plate is fixedly connected to the center of the cavity, and a pressure sensor is fixedly connected to the upper surface of the fixed plate.

[0011] As a further description of the above technical solution:

[0012] The bottom end of the elastic element is fixedly connected to the inner bottom surface of the cavity, and the pressure sensor is located directly below the moving plate.

[0013] As a further description of the above technical solution:

[0014] The elastic element includes a telescopic rod and a return spring, with the return spring sleeved on the outside of the telescopic rod.

[0015] As a further description of the above technical solution:

[0016] A sealing plate is fixedly connected to the upper surface of the movable plate, and a sealing ring is sleeved on the outer side of the sealing plate.

[0017] As a further description of the above technical solution:

[0018] The sealing plate is inserted into the inside of the through groove, and the bottom surface of the sealing ring is fixedly connected to the upper surface of the moving plate.

[0019] As a further description of the above technical solution:

[0020] A rubber pad is fixedly connected to the bottom surface of the extrusion column.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this utility model, the combination of the fixed cylinder, pressure spring, extrusion column, cavity, through groove, moving plate and detection unit ensures that the staining slide preparation mechanism can only be started after the protective cover is completely in place and the top of the machine body is sealed. This avoids operational errors by the staff, which could lead to liquid splashing, cross-contamination of samples and entry of external impurities. The detection unit is also hidden to reduce interference from external objects on the detection.

[0023] 2. In this utility model, the sealing plate and sealing ring work together to seal the inside of the through groove after the protective cover is opened, preventing external objects or liquids from entering the cavity through the through groove and affecting the use of the pressure sensor. The rubber pad reduces the contact wear between the extrusion column and the sealing plate, extending the service life of both. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the overall liquid-based automated cell staining and slide preparation machine proposed in this utility model;

[0025] Figure 2 This is a schematic diagram of a frontal cross-section of an automated liquid-based cell staining and slide preparation machine proposed in this utility model;

[0026] Figure 3 This is a schematic diagram of the fixed cylinder, pressure spring, extrusion column, and rubber pad of an automated liquid-based cell staining slide preparation machine proposed in this utility model;

[0027] Figure 4 This is a schematic cross-sectional view of the front part of the body of the liquid-based automatic cell staining and slide preparation machine proposed in this utility model;

[0028] Figure 5 This is a schematic diagram of the moving plate, detection unit, sealing plate, and sealing ring of an automated liquid-based cell staining slide preparation machine proposed in this utility model.

[0029] Legend:

[0030] 1. Machine body; 2. Controller; 3. Dyeing and slide-making mechanism; 4. Protective cover; 5. Hydraulic strut; 6. Fixed cylinder; 7. Pressure spring; 8. Extrusion column; 9. Cavity; 10. Through groove; 11. Moving plate; 111. Elastic element; 112. Fixed plate; 113. Pressure sensor; 12. Sealing plate; 13. Sealing ring; 14. Rubber pad. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Reference Figure 1 - Figure 3 This utility model provides an embodiment of an automated liquid-based cell staining and slide preparation machine, comprising a body 1, a controller 2 fixedly connected to the front surface of the body 1, which can control the electrical components inside the staining and slide preparation machine. The upper surface of the body 1 is provided with a staining and slide preparation mechanism 3, which consists of multiple modules such as a vortex oscillator, a centrifuge, and a slide preparation and staining chamber module. The sample bottle is placed on the vortex oscillator, and the cells are evenly distributed by oscillation. The sample is then transferred to a centrifuge tube, and after centrifugation, the supernatant is removed, and the cell precipitate is retained. The centrifuged cell precipitate is transferred to a glass slide, and the cells are evenly distributed by natural sedimentation or filtration membrane technology. Staining solution is added to the glass slide through a sample needle to complete the staining process. The above structure is a prior art in this field and will not be described in detail here.

[0033] A protective cover 4 is hinged to the top of the machine body 1. The protective cover 4 can seal the operating space above the machine body 1 to prevent liquid splashing, sample cross-contamination, and the entry of external impurities. A hydraulic strut 5 is provided at the connection between the machine body 1 and the protective cover 4. The hydraulic strut 5 can support and limit the protective cover 4 when it is flipped up and opened, so that the protective cover 4 remains stable after opening and does not affect the operation of the staff. Fixed cylinders 6 are fixedly connected to the left and right sides of the inner top surface of the protective cover 4. A pressure spring 7 is fixedly connected to the inner top surface of the fixed cylinder 6. A squeezing column 8 is fixedly connected to the bottom end of the pressure spring 7. The squeezing column 8 is inserted into the inside of the fixed cylinder 6. When the protective cover 4 moves, it can drive the fixed cylinder 6, the pressure spring 7 and the squeezing column 8 to move synchronously. When the squeezing column 8 is pressed and moves into the fixed cylinder 6, it will squeeze the pressure spring 7, causing the pressure spring 7 to compress and generate elastic potential energy.

[0034] Reference Figure 3 - Figure 5Cavities 9 are provided in the inner walls of both sides of the machine body 1. A through groove 10 is provided on the upper surface of the cavity 9. The extrusion column 8 is located directly above the through groove 10. A movable plate 11 is fitted inside the cavity 9. The movable plate 11 can move linearly up and down inside the cavity 9. When the protective cover 4 is flipped down to close, it will drive the fixed cylinder 6 and the extrusion column 8 to move synchronously. When the protective cover 4 is completely closed, the extrusion column 8 will be inserted into the cavity 9 through the through groove 10. At this time, the extrusion column 8 will squeeze the movable plate 11, causing the movable plate 11 to move downward.

[0035] A detection unit is provided at the bottom of the movable plate 11. The detection unit includes an elastic element 111, which is fixedly connected to the bottom surface of the movable plate 11. The bottom end of the elastic element 111 is fixedly connected to the inner bottom surface of the cavity 9. The elastic element 111 includes a telescopic rod and a return spring. The return spring is sleeved on the outside of the telescopic rod. The pressure of the return spring is less than that of the pressure spring 7. When the movable plate 11 is pressed down, it will squeeze the elastic element 111, causing the return spring to compress and generate elastic potential energy. At this time, the pressure spring 7 does not compress. A fixed element is fixedly connected at the center of the cavity 9. A pressure sensor 113 is fixedly connected to the upper surface of the plate 112. The pressure sensor 113 is located directly below the moving plate 11. During the downward movement of the moving plate 11, it will come into contact with the pressure sensor 113. At this time, the pressure sensor 113 will detect the squeezing force from the squeezing column 8 and the pressure spring 7 on the moving plate 11, and at the same time, it will prevent the squeezing column 8 from moving further downward. At this time, the squeezing column 8 will be pressed into the fixed cylinder 6 to squeeze the pressure spring 7, so that the pressure spring 7 is compressed and generates elastic potential energy, and the elastic potential energy is applied to the moving plate 11.

[0036] After the protective cover 4 completely seals the top of the machine body 1, the weight of the protective cover 4 is much greater than that of the pressure spring 7, which will squeeze and limit the pressure spring 7 and the squeezing column 8, so that the pressure sensor 113 detects a stable pressure value. When the pressure values ​​detected by the pressure sensors 113 on both sides are constant and the same, the staff can control the staining and slide preparation mechanism 3 to operate through the controller 2 to prevent liquid splashing, sample cross-contamination and the entry of external impurities. At the same time, the detection unit is hidden inside the cavity 9, and the moving plate 11 can shield the top of the detection unit to reduce the interference of external objects on the detection.

[0037] Reference Figure 3 - Figure 5A sealing plate 12 is fixedly connected to the upper surface of the movable plate 11. When the movable plate 11 moves, it will drive the sealing plate 12 to move synchronously. The sealing plate 12 is inserted into the inside of the through groove 10. When the sealing plate 12 is inside the through groove 10, it will seal the through groove 10. A sealing ring 13 is sleeved on the outside of the sealing plate 12. The bottom surface of the sealing ring 13 is fixedly connected to the upper surface of the movable plate 11. The sealing ring 13 will further seal the gap between the movable plate 11 and the through groove 10 to prevent liquid from entering the cavity 9. When the protective cover 4 is opened, the sealing plate 12 and the movable plate 11 will move upward and reset under the action of the elastic element 111 to seal the through groove 10 and prevent objects or liquids from entering the through groove 10 and the cavity 9. A rubber pad 14 is fixedly connected to the bottom surface of the extrusion column 8. The rubber pad 14 can prevent the extrusion column 8 from making hard contact with the sealing plate 12, which would cause wear and affect the service life of both.

[0038] Working principle: After the sample is placed inside the staining and slide preparation mechanism 3, if the pressure sensors 113 on both sides do not detect a constant pressure value, the operator cannot start the staining and slide preparation mechanism 3 through the controller 2. After the protective cover 4 is flipped to seal the top of the machine body 1, the extrusion column 8 will squeeze the sealing plate 12 and the moving plate 11 into the cavity 9. When the moving plate 11 is pressed down and stops moving after it is in contact with the pressure sensor 113, the moving plate 11 will squeeze the extrusion column 8 in the opposite direction, so that the extrusion column 8 enters the fixed cylinder 6 and squeezes the pressure spring 7, so that the pressure spring 7 is compressed and generates elastic potential energy. The pressure sensor 113 will detect the extrusion force from the extrusion column 8 and the pressure spring 7 on the moving plate 11. When the protective cover 4 completely seals the machine body 1, the pressure sensor 113 detects a stable pressure value. When the pressure values ​​detected by the pressure sensors 113 on both sides are constant and the same, the operator can control the staining and slide preparation mechanism 3 to run through the controller 2, so as to avoid the device starting to run when the protective cover 4 is not sealed and closed.

[0039] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An automated liquid-based cell staining and slide preparation machine, comprising a body (1), characterized in that: A controller (2) is fixedly connected to the front surface of the machine body (1). A dyeing and film-making mechanism (3) is provided on the upper surface of the machine body (1). A protective cover (4) is hinged to the top of the machine body (1). A hydraulic strut (5) is provided at the connection between the machine body (1) and the protective cover (4). Fixed cylinders (6) are fixedly connected to the left and right sides of the inner top surface of the protective cover (4). A pressure spring (7) is fixedly connected to the inner top surface of the fixed cylinder (6). A squeezing column (8) is fixedly connected to the bottom end of the pressure spring (7). A cavity (9) is opened in the inner wall of the left and right sides of the machine body (1). A through groove (10) is opened on the upper surface of the cavity (9). A moving plate (11) is sleeved inside the cavity (9). A detection unit is provided at the bottom of the moving plate (11). The detection unit is used to detect the pressure borne by the moving plate (11).

2. The liquid-based automated cell staining and slide preparation machine according to claim 1, characterized in that: The extrusion column (8) is inserted into the interior of the fixed cylinder (6), and the extrusion column (8) is located directly above the through groove (10).

3. The liquid-based automated cell staining and slide preparation machine according to claim 1, characterized in that: The detection unit includes an elastic element (111), which is fixedly connected to the bottom surface of the moving plate (11). A fixed plate (112) is fixedly connected to the center of the cavity (9), and a pressure sensor (113) is fixedly connected to the upper surface of the fixed plate (112).

4. The liquid-based automated cell staining and slide preparation machine according to claim 3, characterized in that: The bottom end of the elastic element (111) is fixedly connected to the inner bottom surface of the cavity (9), and the pressure sensor (113) is located directly below the moving plate (11).

5. The liquid-based automated cell staining and slide preparation machine according to claim 3, characterized in that: The elastic element (111) includes a telescopic rod and a return spring, with the return spring sleeved on the outside of the telescopic rod.

6. The liquid-based automated cell staining and slide preparation machine according to claim 1, characterized in that: A sealing plate (12) is fixedly connected to the upper surface of the movable plate (11), and a sealing ring (13) is sleeved on the outer side of the sealing plate (12).

7. The liquid-based automated cell staining and slide preparation machine according to claim 6, characterized in that: The sealing plate (12) is inserted into the inside of the through groove (10), and the bottom surface of the sealing ring (13) is fixedly connected to the upper surface of the moving plate (11).

8. The liquid-based automated cell staining and slide preparation machine according to claim 1, characterized in that: A rubber pad (14) is fixedly connected to the bottom surface of the extrusion column (8).

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