Platelet aggregation instrument

Abstract

The utility model relates to a platelet aggregation instrument, and relates to the technical field of platelet aggregation instruments. The platelet aggregation instrument comprises a rack assembly, a sample cup assembly, a reaction cup assembly, an incubation detection assembly, a reagent washing needle storage assembly and a mechanical arm assembly, the mechanical arm assembly comprises a mounting support capable of moving relative to the rack assembly, and a sampling needle, a reagent needle and a gripper are mounted on the mounting support. The positions of the sampling needle, the reagent needle and the gripper can be adjusted at the same time by moving the first support, the number of the mechanical arm assemblies is reduced, and the cost of the platelet aggregation instrument is reduced.

Description

Technical Field

[0001] This utility model relates to the field of platelet aggregator technology, and particularly to a platelet aggregator. Background Technology

[0002] When detecting platelet aggregation, plasma and reagents need to be added to a reaction vessel and thoroughly mixed. The degree of platelet aggregation is then determined by measuring the properties of the resulting liquid. To achieve automated and efficient stirring, magnetic stirring is often used. Specifically, a reaction vessel equipped with a magnetic stir bar is prepared, placed on a magnetic stirring device, and then activated to rotate the stir bar, thus agitating the liquid within the vessel.

[0003] In related technologies, multiple reaction cups equipped with magnetic stirrers are prepared first, and the reaction cups are picked up and placed at the magnetic stirring device to avoid cleaning the magnetic stirring rotor or reaction cups after each reaction, thereby improving detection efficiency.

[0004] In other words, a platelet aggregator not only needs to be equipped with a robotic arm that moves the sampling needle and reagent needle, but also needs to be equipped with an additional robotic arm moving and grasping device, which increases the cost of the aggregator. Summary of the Invention

[0005] This invention provides a platelet aggregation analyzer to reduce the cost of the analyzer.

[0006] This utility model provides a platelet aggregation analyzer, including: a frame assembly; a housing; and a touch screen operating device.

[0007] A sample cup assembly, which is mounted on the rack assembly, is used to hold sample tubes;

[0008] The reaction cup assembly, which is mounted on the rack assembly, is used to hold the reaction cups;

[0009] An incubation detection assembly, mounted on the rack assembly, is used to receive reaction cups and incubate and detect the degree of aggregation of samples in the reaction cups;

[0010] A reagent needle washing and storage assembly is installed on the rack assembly. The reagent needle washing and storage assembly includes a reagent module and a needle washing module. The reagent module is used to store reagents, and the needle washing module is used to clean steel needles.

[0011] A robotic arm assembly is mounted on a frame assembly and includes a mounting bracket movable relative to the frame assembly. The mounting bracket is equipped with a sampling needle, a reagent needle, and a gripper. The gripper is used to move a reaction cup to an incubation detection assembly, from detection to discarding the cup. The sampling needle is used to extract a sample from the sample cup and dispense it into the reaction cup. The reagent needle is used to extract a reagent from a reagent washing needle storage assembly and dispense it into the reaction cup.

[0012] In one embodiment, a sampling needle is mounted on a mounting bracket via a first driving member, which can drive the sampling needle to move relative to the mounting bracket; a reagent needle is mounted on the mounting bracket via a second driving member, which can drive the reagent needle to move relative to the mounting bracket; and a gripper is mounted on the mounting bracket via a third driving member, which can drive the gripper to move relative to the mounting bracket.

[0013] In one embodiment, sampling needles, reagent needles, and grippers are mounted on a mounting bracket arranged at intervals in a horizontal direction; the driving directions of the first driving member, the second driving member, and the third driving member are all in a vertical direction.

[0014] In one embodiment, the robotic arm assembly includes a first guide and a second guide. The first guide is mounted on the frame assembly, and the second guide is mounted on the first guide and is movable relative to the first guide along a first direction. A mounting bracket is mounted on the second guide and is movable relative to the second guide along a second direction, wherein the first direction is perpendicular to the second direction.

[0015] In one embodiment, the reagent washing needle storage assembly further includes a cooling module for cooling the reagents stored in the reagent washing needle storage assembly.

[0016] In one embodiment, the cooling module is used to cool the reagent to 14±4°C.

[0017] In one embodiment, the incubation detection module includes a heating module.

[0018] In one embodiment, the heating module is used to heat the liquid in the reaction vessel to 37±1°C.

[0019] In one embodiment, the incubation detection assembly includes a magnetic stirring base, and a magnetic stirring rod is placed in the reaction cup of the reaction cup assembly. The magnetic stirring base is used to drive the magnetic stirring rod to rotate, thereby stirring the liquid in the reaction cup.

[0020] Compared with the prior art, the advantages of this utility model are that the sampling needle, reagent needle and gripper are all installed on the mounting bracket of the robotic arm assembly. The sampling needle, reagent needle and gripper can be moved when the robotic arm assembly moves the mounting bracket. Compared with setting three independent robotic arm assemblies to move the sampling needle, reagent needle and gripper separately, the number of robotic arm assemblies is reduced, thereby reducing the cost of the platelet aggregation instrument. Attached Figure Description

[0021] The present invention will be described in more detail below based on embodiments and with reference to the accompanying drawings.

[0022] Figure 1 This is a three-dimensional structural diagram of the platelet aggregator after the cover of the frame assembly is removed in an embodiment of this utility model;

[0023] Figure 2 This is a three-dimensional structural schematic diagram of the platelet aggregator in an embodiment of this utility model;

[0024] Figure 3 This is a three-dimensional structural diagram of the robotic arm assembly in an embodiment of this utility model.

[0025] Figure label:

[0026] 1. Rack assembly; 11. Cover;

[0027] 2. Sample cup assembly;

[0028] 3. Reaction cup assembly;

[0029] 4. Incubation detection components;

[0030] 5. Reagent washing needle storage assembly;

[0031] 6. Robotic arm assembly; 61. Mounting bracket; 62. Sampling needle; 63. Reagent needle; 64. Gripper; 65. First guide; 66. Second guide. Detailed Implementation

[0032] The present invention will be further described below with reference to the accompanying drawings.

[0033] See Figures 1 to 3 As shown, this utility model provides a platelet aggregation instrument, which includes: a frame assembly 1, a sample cup assembly 2, a reaction cup assembly 3, an incubation and detection assembly 4, a reagent washing and storage assembly 5, and a robotic arm assembly 6.

[0034] Sample cup assembly 2, reaction cup assembly 3, incubation and detection assembly 4, reagent needle washing and storage assembly 5, and robotic arm assembly 6 are all mounted on frame assembly 1. Robotic arm assembly 6 includes a mounting bracket 61 that can move relative to frame assembly 1. A needle, a reagent needle 63, and a gripper 64 are mounted on the mounting bracket 61.

[0035] The device comprises: a frame assembly 1 including a housing and a touchscreen operating device; a reaction vessel assembly 3 containing a reaction vessel equipped with a magnetic stir bar; and a sample vessel assembly 2 containing a sample tube containing a sample. The incubation and detection assembly 4 rotates the magnetic stir bar in the reaction vessel, ensuring a thorough reaction of the liquid within. The incubation and detection assembly 4 also detects the degree of liquid aggregation in the reaction vessel. The reagent and needle washing storage assembly 5 includes a reagent module for storing reagents and a needle washing module for cleaning the steel needle.

[0036] When using the platelet aggregator provided in this application, the robotic arm assembly 6 is controlled via a touchscreen operating device. First, the reaction cup containing the magnetic stirrer in the reaction cup assembly 3 is grasped by the gripper 64 mounted on the mounting bracket 61. The robotic arm assembly 6 then moves the mounting bracket 61 to place the reaction cup at the incubation detection assembly 4. Next, by controlling the movement of the mounting bracket 61 of the robotic arm assembly 6, the sampling needle 62 collects samples from the sample tube in the sample cup assembly 2, and the reagent needle 63 collects reagents from the reagent washing needle storage assembly 5. The collected samples and reagents are then added to the reaction cup placed at the incubation detection assembly 4. The magnetic stirring device at the incubation detection assembly 4 rotates the magnetic stirrer in the reaction cup, ensuring a thorough reaction between the sample and reagents. The detection module of the incubation detection assembly 4 then detects the degree of platelet aggregation.

[0037] Compared to using a separate robotic arm assembly 6 to move the gripper 64, and then using another robotic arm assembly 6 to move the sampling needle 62 and the reagent needle 63, the number of robotic arm assemblies 6 is reduced, thus lowering the cost of the platelet aggregator.

[0038] See Figure 1 and Figure 2 As shown, the rack assembly 1 includes a cover 11. When the cover 11 is closed, a closed cavity is formed inside the rack. The sample cup assembly 2, reaction cup assembly 3, incubation and detection assembly 4, reagent needle washing and storage assembly 5, and robotic arm assembly 6 are all located in the closed cavity. During the detection process, the cover 11 can be closed to reduce the contact of external contaminants with the sample.

[0039] When it is necessary to replace the reaction cup at reaction cup assembly 3 or the sample at sample cup assembly 2, the cover 11 can be opened.

[0040] See Figure 1 as well as Figure 3 As shown, in some implementations, the sampling needle 62 is mounted on the mounting bracket 61 via a first driving member, which can drive the sampling needle 62 to move relative to the mounting bracket 61.

[0041] The reagent needle 63 is mounted on the mounting bracket 61 via a second driving component, which can drive the reagent needle 63 to move relative to the mounting bracket 61.

[0042] The gripper 64 is mounted on the mounting bracket 61 via a third drive component, which can drive the gripper 64 to move relative to the mounting bracket 61.

[0043] In other words, the first driving component, the second driving component, and the third driving component can be used to control the movement of the sampling needle 62, the reagent needle 63, and the gripper 64 relative to the mounting bracket 61, thereby avoiding sampling difficulties or gripping difficulties caused by the fixed relative positions of the three components during operation.

[0044] In some implementations, the sampling needle 62, reagent needle 63, and gripper 64 are arranged at intervals along the horizontal direction of the mounting bracket 61, and the driving directions of the first driving member, the second driving member, and the third driving member are all along the vertical direction.

[0045] Since the sampling needle 62, reagent needle 63, and gripper 64 are spaced horizontally along the mounting bracket 61, when the first driving element drives the sampling needle 62 to move vertically, the sampling needle 62 does not move horizontally relative to the mounting bracket 61, and the horizontal distance between the sampling needle 62 and reagent needle 63 does not decrease, thus avoiding interference between the sampling needle 62 and reagent needle 63. Similarly, interference between the sampling needle 62, reagent needle 63, and gripper 64 is avoided.

[0046] In this implementation, the first, second, and third driving components can be the same, such as all using a lead screw motor or all using a cylinder. In other implementations, the first, second, and third driving components can also be implemented using different driving components.

[0047] See Figure 1 as well as Figure 3 As shown, in some implementations, the robotic arm assembly 6 includes a first guide 65 and a second guide 66. The first guide 65 is mounted on the frame assembly 1, the second guide 66 is mounted on the first guide 65, and the second guide 66 is movable relative to the first guide 65 in a first direction. The mounting bracket 61 is mounted on the second guide 66, and the mounting bracket 61 is movable relative to the second guide 66 in a second direction, where the first direction is perpendicular to the second direction.

[0048] In other words, the mounting bracket 61 of the robotic arm assembly 6 can move relative to the frame assembly 1 and the sample cup assembly 2, reaction cup assembly 3, incubation detection assembly 4, and reagent needle storage assembly 5 mounted on the frame assembly 1 along a first or second direction. Combined with the vertical movement of the first, second, and third driving components, the sample needle, reagent needle 63, and gripper 64 can all move along three directions. The second guide 66 is equipped with a driving mechanism that cooperates with the first guide 65, used to drive the second guide 66 and the mounting bracket 61 mounted on the second guide 66 to move along the first guide 65. The mounting bracket 61 is equipped with a driving mechanism that matches the second guide 66, used to drive the mounting bracket 61 and the sampling needle 62, reagent needle 63, and gripper 64 mounted on the mounting bracket 61 to move linearly along the second guide 66.

[0049] In some implementations, both the first and second directions are horizontal. This effectively achieves three degrees of freedom in three directions for the three actuators using five drive components. Compared to each actuator having three drive components, this reduces the number of drive components by four, significantly lowering the cost of the device.

[0050] In some implementations, the reagent washing needle storage assembly 5 also includes a cooling module, which is used to cool the reagents stored in the reagent washing needle storage assembly 5. Using a cooling module to cool the reagents prevents their performance from being affected by temperature increases, thus ensuring the stability of the reagents.

[0051] In some implementations, a cooling module is used to cool the reagent to 14℃±4℃.

[0052] The specific cooling module can be a semiconductor freezing device or a related freezing structure. It simply needs to be able to cool the reagent to 14±1℃.

[0053] In some implementations, the reagent needle washing storage component 5 also includes a needle washing module for cleaning the sampling needle 62 and the reagent needle 63.

[0054] The needle washing module can clean the sampling needle 62 and reagent needle 63, reducing reagent and sample contamination and improving detection accuracy.

[0055] In some implementations, the incubation detection module includes a heating module, which can promote the reaction of the liquid in the reaction vessel by heating, thereby accelerating the detection speed.

[0056] In some implementations, a heating module is used to heat the liquid in the reaction vessel to 37±1℃. This temperature is approximately equal to human body temperature, and heating the liquid in the reaction vessel to this temperature results in measurements that are closer to the actual value.

[0057] In some implementations, the incubation detection component 4 includes a magnetic stirring base, and a magnetic stirring rod is placed in the reaction cup of the reaction cup component 3. The magnetic stirring base is used to drive the magnetic stirring rod to rotate, thereby stirring the liquid in the reaction cup.

[0058] By placing a magnetic stir bar in the reaction cup of reaction cup assembly 3, the magnetic stir base can be used to stir different reaction cups by changing the reaction cups on the magnetic stir base. Compared to cleaning the reaction cup after each test, changing the reaction cup is faster and shortens the test time.

[0059] In this embodiment, the incubation detection component 4 detects the degree of sample aggregation by measuring the transmittance of the liquid in the reaction vessel. In other implementations, the degree of platelet aggregation can also be measured by measuring the resistance of the liquid.

[0060] Although the present invention has been described with reference to preferred embodiments, various modifications can be made thereto and components can be replaced with equivalents without departing from the scope of the invention. In particular, the technical features mentioned in the various embodiments can be combined in any manner, provided there is no structural conflict. The present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A platelet aggregation instrument, characterized in that, It includes: Rack components; Includes a casing and a touchscreen operating device; A sample cup assembly, which is mounted on the rack assembly, is used to hold sample tubes; The reaction cup assembly, which is mounted on the rack assembly, is used to hold the reaction cups; An incubation detection assembly, mounted on the rack assembly, is used to receive reaction cups and incubate and detect the degree of aggregation of samples in the reaction cups; A reagent needle washing and storage assembly is installed on the rack assembly. The reagent needle washing and storage assembly includes a reagent module and a needle washing module. The reagent module is used to store reagents, and the needle washing module is used to clean steel needles. A robotic arm assembly is mounted on a frame assembly and includes a mounting bracket movable relative to the frame assembly. The mounting bracket is equipped with a sampling needle, a reagent needle, and a gripper. The gripper is used to move a reaction cup to an incubation detection assembly, from detection to discarding the cup. The sampling needle is used to extract a sample from the sample cup and dispense it into the reaction cup. The reagent needle is used to extract a reagent from a reagent washing needle storage assembly and dispense it into the reaction cup.

2. The platelet aggregation apparatus according to claim 1, characterized in that, The sampling needle is mounted on the mounting bracket via a first driving component, and the first driving component can drive the sampling needle to move relative to the mounting bracket. The reagent needle is mounted on the mounting bracket via a second driving component, and the second driving component can drive the reagent needle to move relative to the mounting bracket. The gripper is mounted on the mounting bracket via a third driving component, which can drive the gripper to move relative to the mounting bracket.

3. The platelet aggregation apparatus according to claim 2, characterized in that, The sampling needle, the reagent needle, and the gripper are arranged at intervals along the horizontal direction and mounted on the mounting bracket. The driving directions of the first driving member, the second driving member, and the third driving member are all vertical.

4. The platelet aggregation analyzer according to any one of claims 1-3, characterized in that, The robotic arm assembly includes a first guide and a second guide. The first guide is mounted on the frame assembly, and the second guide is mounted on the first guide. The second guide is movable relative to the first guide in a first direction. The mounting bracket is mounted on the second guide and is movable relative to the second guide in a second direction. The first direction is perpendicular to the second direction.

5. The platelet aggregation apparatus according to any one of claims 1-3, characterized in that, The reagent washing needle storage assembly also includes a cooling module, which is used to cool down the reagents stored in the reagent washing needle storage assembly.

6. The platelet aggregation apparatus according to claim 5, characterized in that, The cooling module is used to cool the reagent to 14±4℃.

7. The platelet aggregation apparatus according to any one of claims 1-3, characterized in that, The incubation detection component includes a heating module.

8. The platelet aggregation apparatus according to claim 7, characterized in that, The heating module is used to heat the liquid in the reaction vessel to 37±1℃.

9. The platelet aggregation apparatus according to claim 1, characterized in that, The incubation detection assembly includes a magnetic stirring base, and a magnetic stirring rod is placed in the reaction cup of the reaction cup assembly. The magnetic stirring base is used to drive the magnetic stirring rod to rotate, thereby stirring the liquid in the reaction cup.

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