High and low temperature controlled hot melting granulation equipment

Abstract

The utility model discloses high and low temperature control hot melting granulation equipment which comprises a main machine space and an auxiliary machine space, a vacuum feeding machine and a high-position wet process mixing granulator are respectively arranged in the main machine space, a plurality of water storage tanks are arranged in the auxiliary machine space, one side of the high-position wet process mixing granulator is connected with a plurality of swinging granulation machines, and the swinging granulation machines are connected with the vacuum feeding machine and the high-position wet process mixing granulator. Compared with the prior art, the dry humidity of the medicine granules can be controlled, so that the medicine granules meet the required moisture and particle size requirements, the medicine yield is improved, meanwhile, different medicines can be processed, the heating and cooling functions are achieved in the granulation process, and the heating and cooling temperatures in the granulation process are accurately controlled.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical granulation technology, and in particular to a hot melt granulation device with high and low temperature control. Background Technology

[0002] Wet granulation is a method of preparing granules by adding a binder to drug powder, which then aggregates the powder through bridging or binding. It includes extrusion granulation, rotary granulation, fluidized bed granulation, and stirred granulation. Particles produced by wet granulation have advantages such as high particle quality, attractive appearance, strong wear resistance, and good compressibility, making it the most widely used process in the pharmaceutical industry.

[0003] Currently, in the wet granulation process, raw materials are fed into a hopper. However, the moisture content of the raw materials cannot be well controlled during this process, leading to an increased defect rate of the drugs. In addition, the existing wet granulation system only uses one wet granulator and is a low-position wet granulator, which makes it impossible to process different drugs during the production process. Utility Model Content

[0004] The purpose of this invention is to provide a hot melt granulation device with high and low temperature control, which can solve at least one of the above-mentioned technical problems. The technical solution of this invention is as follows:

[0005] A hot melt granulation device with high and low temperature control includes: a main machine space and an auxiliary machine space. A vacuum feeder and a high-level wet mixing granulator are respectively installed in the main machine space. Multiple water storage tanks are installed in the auxiliary machine space. Multiple swing granulators are connected to one side of the high-level wet mixing granulator.

[0006] Furthermore, multiple high-level wet mixing granulators can be arrayed and arranged. Each high-level wet mixing granulator includes a climbing frame, a mixing granulation tank is provided on the climbing frame, a mixing paddle lifting device is provided on the climbing frame in front of the mixing granulation tank, a discharge port is provided on the rear side of the mixing granulation tank, a feeding port is provided above the mixing granulation tank, and a granulation cutting section is connected to the front side of the mixing granulation tank.

[0007] Furthermore, the oscillating pellet mill includes a support frame disposed within the main machine space, a processing box fixedly installed on the rear side of the support frame, multiple roller pelletizing devices spaced from top to bottom on the processing box, an inlet and an outlet valve respectively connected to the upper and lower sides of the processing box, and multiple observation ports provided on the rear side of the processing box.

[0008] Furthermore, the plurality of water storage tanks are respectively a hot water tank, a cold water tank, and a warm water tank.

[0009] Preferably, a wet-process electrical control cabinet is installed in the auxiliary machine space.

[0010] In summary, the advantages of this utility model over the prior art are:

[0011] This utility model provides a hot-melt granulation equipment with high and low temperature control. During production, powder is fed to a gyratory granulator via a vacuum feeder. The gyratory granulator then grinds the powder into fine granules. The granulated medicine is then fed to a high-level wet mixing granulator, which performs dry mixing, wet mixing, and fluidized granulation on the granules. Multiple water tanks, including hot water, cold water, and warm water tanks, are connected to the wet mixing granulator. These tanks work together to ensure the granules achieve the required moisture content and particle size. Users can install the required number of high-level wet mixing granulators, enabling simultaneous production of different medicines and improving production efficiency. This equipment is also adaptable to the review requirements of different medicines. Compared to existing technologies, this equipment can control the moisture content of the granules, ensuring they meet the required moisture and particle size, thus improving the yield of the medicine. It can also process different medicines and features heating and cooling functions during the granulation process, allowing for precise control of the heating and cooling temperatures. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the overall design of this utility model.

[0013] Figure 2 This is a separate schematic diagram of the high-position wet mixing granulator of this utility model.

[0014] Figure 3 This is a separate schematic diagram of the oscillating pellet mill of this utility model.

[0015] Explanation of reference numerals in the attached diagram: 4. Main machine space; 5. Auxiliary machine space; 6. High-level wet mixing granulator; 8. Water storage tank; 9. Swinging granulator; 61. Climbing frame; 62. Mixing granulation material tank; 63. Mixing paddle lifting device; 64. Discharge port; 65. Feed port; 91. Support frame; 92. Processing box; 93. Drum granulation equipment; 94. Feed inlet; 95. Discharge valve; 96. Observation port; 11. Steel frame platform; 71. Connecting pipe; 51. Wet process electrical control cabinet. Detailed Implementation

[0016] The present invention will be further described below with reference to the accompanying drawings and specific embodiments:

[0017] like Figures 1 to 3The hot melt granulation equipment with high and low temperature control shown is characterized by comprising: a main machine space 4 and an auxiliary machine space 5. A vacuum feeder 10 and a high-level wet mixing granulator 6 are respectively provided in the main machine space 4. A plurality of water storage tanks 8 are provided in the auxiliary machine space 5. A swing granulator 9 is connected to one side of the high-level wet mixing granulator 6. The plurality of water storage tanks 8 are respectively hot water tank, cold water tank and warm water tank. A steel frame platform is installed on the auxiliary machine space 5 located above. A wet process electrical control cabinet 51 is installed in the auxiliary machine space 5.

[0018] The above-described high and low temperature controlled hot melt granulation equipment, during production, feeds powder into a gyratory granulator 9 via a vacuum feeder 10. The gyratory granulator 9 then grinds the powder into fine granules. The granulated powder is then fed into a high-level wet mixing granulator 6, where it performs dry mixing, wet mixing, and fluidized bed granulation. The wet mixing granulator 6 is connected to multiple water tanks 8, which are designated as hot water tanks, cold water tanks, and warm water tanks, allowing the wet mixing granulator 6 to work in conjunction with the hot water tanks. The cold water tank and warm water tank bring the drug granules to the required moisture and particle size. At the same time, the user can install the required number of high-position wet mixing granulators 6 according to the needs. It can simultaneously manufacture different drugs, improve production efficiency, and adapt to the review requirements of different drugs. Compared with the existing technology, it can control the dryness and humidity of the drug granules, so that the drug granules meet the required moisture and particle size requirements, improve the yield of drugs, and can be adapted to the processing of different drugs. It has heating and cooling functions in the granulation process, and can accurately control the heating and cooling temperature in the granulation process.

[0019] like Figure 2 As shown, in some embodiments of this utility model, multiple high-level wet mixing granulators 6 can be arrayed. Each high-level wet mixing granulator 6 includes a climbing frame 61, a mixing granulation tank 62 mounted on the climbing frame 61, a stirring paddle lifting device 63 mounted on the climbing frame 61 at the front of the mixing granulation tank 62, a discharge port 64 at the rear of the mixing granulation tank 62, and a feeding port 65 above the mixing granulation tank 62. The front side is connected to a granulation and cutting section 66. After the medicine is granulated by the oscillating granulator 9, it is conveyed from the feeding port 65 into the mixing and granulation tank 62. At this time, the granulation and cutting section 66 shapes the medicine granules. At the same time, the stirring paddle in the mixing and granulation tank 62 stirs and mixes the binder and medicine granules. The stirring paddle lifting device 63 can drive the stirring paddle to pull upward. In daily operation, the user can climb the frame 61 to climb and maintain the high-level wet mixing granulator 6. The granulated tablets are discharged through the discharge port 64.

[0020] like Figure 3As shown, in some embodiments of this utility model, the oscillating pellet mill 9 includes a support 91 set on the ground 2, a processing box 92 is installed and fixed on the rear side of the support 91, a plurality of roller pelletizing devices 93 are arranged at intervals from top to bottom on the processing box 92, a feed port 94 and a discharge valve 95 are respectively connected to the upper and lower sides of the processing box 92, and a plurality of observation ports 96 are provided on the rear side of the processing box 92.

[0021] like Figure 3 As shown, in some embodiments of this utility model, the fixing part 8 includes an insertion edge 81 disposed on the rear side of the rear housing 2. The opening of the front housing 1 is inserted into the insertion edge 81. Multiple slots 82 are spaced apart on the insertion edge 81, and multiple buckles 83 are spaced apart at the opening of the front housing 1. Each buckle 83 engages with an adjacent slot 82. Insertion holes 713 are provided on the left and right sides of the front housing 1, and second threaded holes 714 are provided on the left and right sides of the rear housing 2. The user moves the opening of the front housing 1 towards the rear housing 2, guiding the opening of the front housing 1 into the insertion edge 81. Multiple buckles 83, spaced apart at the opening of the front housing 1, engage with adjacent slots 82, thus fixing the front housing 1 and the rear housing 2 together. Finally, the user inserts screws into the insertion holes 713 and screws them into the adjacent second threaded holes 714 to strengthen the connection between the front housing 1 and the rear housing 2. The vacuum feeder 10 conveys the powder to the feed inlet 94, allowing the powder to be conveyed into the processing chamber 92. At this time, the powder is initially granulated by the roller granulation equipment 93. In daily use, the user can observe the internal working status through the observation port 96. Finally, the granules are conveyed into the processing chamber 92 through the discharge valve 95.

[0022] The foregoing has shown and described the basic principles and main features of this utility model, as well as its advantages. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A high and low temperature controlled hot melt granulation device, characterized in that, include: The main machine space (4) and the auxiliary machine space (5) are respectively equipped with a vacuum feeder (10) and a high-level wet mixing granulator (6) in the main machine space (4), and multiple water storage tanks (8) are provided in the auxiliary machine space (5). Multiple swing pellet mills (9) are connected to one side of the high-level wet mixing granulator (6).

2. The high and low temperature controlled hot melt granulation equipment according to claim 1, characterized in that... Multiple high-level wet mixing granulators (6) can be arranged in an array. Each high-level wet mixing granulator (6) includes a climbing frame (61), a mixing granulation tank (62) is provided on the climbing frame (61), a stirring paddle lifting device (63) is provided on the front side of the mixing granulation tank (62) on the climbing frame (61), a discharge port (64) is provided on the rear side of the mixing granulation tank (62), a feeding port (65) is provided above the mixing granulation tank (62), and a granulation cutting section (66) is connected to the front side of the mixing granulation tank (62).

3. The high and low temperature controlled hot melt granulation equipment according to claim 1, characterized in that... Each of the aforementioned oscillating pellet mills (9) includes a support (91) disposed in the main machine space (4), a processing box (92) is fixedly installed on the rear side of the support (91), a plurality of roller pelletizing devices (93) are arranged at intervals from top to bottom on the processing box (92), a feed port (94) and a discharge valve (95) are respectively connected to the upper and lower sides of the processing box (92), and a plurality of observation ports (96) are provided on the rear side of the processing box (92).

4. The high and low temperature controlled hot melt granulation equipment according to claim 1, characterized in that... The multiple water storage tanks (8) are respectively hot water tank, cold water tank and warm water tank.

5. The high and low temperature controlled hot melt granulation equipment according to claim 1, characterized in that... A wet-process electrical control cabinet (51) is installed in the auxiliary machine space (5).

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