Gas metabolism cage for mice

Abstract

The utility model discloses a gas metabolism cage for mice, which relates to the technical field of experimental animal rearing cages and comprises a cage frame, a cage enclosure is arranged in the cage frame, a cage cover is arranged at the top end of the cage enclosure, a cage bottom is arranged at the bottom end of the cage enclosure, a clamping groove is arranged in the middle of the cage enclosure and connected with a separation net, and the separation net is connected with the cage cover. The cage enclosure is divided into a movable cavity and a separation cavity through the separation net, a food box and a water box which penetrate through the cage cover are arranged at the top end of the movable cavity, an excrement and urine separation device is arranged in the separation cavity, an excrement and urine collection device penetrating through the cage bottom is arranged at the bottom of the separation cavity, and gas collection devices are arranged on the outer sides of the upper end and the lower end of the cage enclosure. A cooling device is arranged at the bottom of the cage frame, the cooling device is arranged at the bottom end of the excrement and urine collecting device, and the bottom end of the cooling device is fixedly connected with a platform. The metabolism cage solves the problems that in the prior art, a metabolism cage cannot collect excrement and urine and metabolism gas at the same time, and the sample stability cannot be guaranteed in the sample collection process.

Description

TECHNICAL FIELD

[0001] The utility model relates to experimental animal feeding cage technical field, concretely is a mouse gas metabolism cage. BACKGROUND

[0002] In biomedical and pharmaceutical research fields, rats are often used as test animals to study the metabolism of drugs in animals, and by sampling and analyzing animal metabolites and animal tissues, the absorption, distribution, metabolism and excretion of drugs in animals are obtained, so as to scientifically evaluate the effectiveness and safety of drugs and the transformation of drugs in the biological body. The existing mouse metabolism cage has the function of separating and collecting fecal and urine samples, but the existing metabolism cage is in a relatively exposed test environment, and cannot collect animal metabolism gas while collecting feces and urine. In recent years, with the rapid development of biological medicine, the stability of biological samples is particularly important in the test process, but the existing conventional metabolism cage cannot guarantee the stability of the samples during the sampling process. In radioactive metabolism test, good cage sealing is necessary for safe operation of test personnel. Therefore, a mouse gas metabolism cage is needed to maximize the stability of the sample from sampling to detection, completely isolate the animal feeding environment from the laboratory environment, ensure that the animal is not affected by the laboratory environment, and also isolate the test personnel from the test animal, providing a good safety guarantee for radioactive metabolism test. SUMMARY

[0003] Therefore, the utility model provides a mouse gas metabolism cage, solves the problem that the existing technology cannot collect gas while collecting fecal and urine samples, provides a good metabolism gas collection idea for radioactive metabolism test, and also solves the problem that the stability of the sample cannot be guaranteed during the sample collection process.

[0004] In order to achieve the above purpose, the utility model adopts the following technical scheme:

[0005] A mouse gas metabolism cage, comprising a cage frame, a cage enclosure is arranged in the cage frame, a cage cover is arranged at the top end of the cage enclosure, a cage bottom is arranged at the bottom end of the cage enclosure, a clamping groove is arranged at the middle part of the cage enclosure, a separation net is connected to the clamping groove, the separation net divides the cage enclosure into a movable cavity and a separation cavity, a food box and a water box are arranged at the top end of the movable cavity and penetrate through the cage cover, a fecal and urine separation device is arranged in the separation cavity, a fecal and urine collection device is arranged at the bottom of the separation cavity and penetrates through the cage bottom, a gas collection device is arranged on the outer side of the upper and lower ends of the cage enclosure, a cooling device is arranged at the bottom of the cage frame, the cooling device is arranged at the bottom end of the fecal and urine collection device, and a platform is fixedly connected to the bottom end of the cooling device.

[0006] Further, the cage is in a cylindrical structure, the upper edge and the lower edge of the cage are provided with buckles, the upper edge buckle of the cage is matched with the cage cover, the cage cover is provided with a gas port, a food box lock and a water box lock, the lower edge buckle of the cage is matched with the cage bottom, and the cage bottom is provided with a sealing thread for fixing a feces and urine collecting device.

[0007] Further, the food box is divided into a feeding cavity, a flowing cavity and an eating cavity by two gates penetrating the cage cover, the feeding cavity is located outside the cage cover, the two gates penetrate the cage cover and are integrally formed with the cage cover, the eating cavity is located inside the movable cavity, one side of the eating cavity is provided with an eating port, the eating cavity is circumferentially provided with a stainless steel barrier net, and a mouse food collecting box is arranged below the eating cavity.

[0008] Further, the water box comprises a water bottle, a pressing water structure, a U-shaped tube, a micro check valve, a water storage box and a drinking water port, the water bottle and the water storage box are located outside the cage cover, the water bottle is provided below the pressing water structure, the water storage box is provided with the micro check valve, one end of the U-shaped tube is connected with the pressing water structure, the other end penetrates the cage cover and is connected with the micro check valve, and the bottom of the water storage box is provided with the drinking water port penetrating the cage cover.

[0009] Further, the feces and urine separating device comprises a feces and urine separator, a conical cover, a urine sample flow guide groove and a feces sample flow guide groove, the isolation net is connected with the conical cover and the feces and urine separator below, the feces and urine separator is connected with the urine sample flow guide groove below, and the urine sample flow guide groove is provided with the feces sample flow guide groove below.

[0010] Further, the feces and urine separator is in a reverse conical structure and is matched with the isolation net through a clamping groove.

[0011] Further, the feces and urine collecting device comprises a feces sample collecting cup and a urine sample collecting cup, the bottom of the feces sample collecting cup and the urine sample collecting cup is in a conical structure and extends into the cooling device, and the cup wall is provided with a scale and the upper edge is provided with a thread.

[0012] Further, the gas collecting device comprises a gas pump, a gas flow meter, a gas pipeline and a gas collecting device, one end of the gas pipeline penetrates the cage cover, the other end is connected with the gas pump, the outlet end of the gas pump is provided with the flow meter, one end of the other gas pipeline penetrates the cage bottom, and the other end is connected with the gas collecting device.

[0013] Further, the cooling device comprises a condenser and a lifting platform, and the condenser is installed above the lifting platform.

[0014] Further, the condenser is a semiconductor condenser, the condensing module in the condenser is composed of a metal aluminum block, and the condenser is provided with a feces sample collecting groove and a urine sample collecting groove at the upper end, matched with the feces sample collecting cup and the urine sample collecting cup.

[0015] The utility model discloses the beneficial effect lies in:

[0016] The utility model discloses simple structure, easy operation, practicality is strong, realized the collection of animal metabolism excrement urine's simultaneously, the gas that collection animal metabolism comes out, will test animal be isolated in a relatively closed environment, maximum limit reduced the influence of outside environment to the animal, through the food box and water box of bolt type, guarantee personnel when feeding, the cage is all in sealed state, through the mode that the urine sample diversion groove and urine sample collection cup of excrement sample are combined, realized good excrement urine collection effect, also guarantee the sealing property of cage simultaneously, through the connection mode of sealing screw and buckle, let whole device every component can dismantle, convenient for the user to dismantle and clean the cage, and the condensing device creates low temperature environment for excrement urine collection cup, prevents urine sample volatilization, guarantees sample to be in low temperature state all the time, ensures the stability of sample. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical scheme in the embodiment of the utility model or prior art, below will to the drawing needed using in the embodiment or prior art description briefly introduce, obviously, the drawing in the following description only is the embodiment of the utility model, for the ordinary skilled person in the art comes, under the premise of not paying the creative labor, can also obtain other drawings according to the drawing provided.

[0018] Fig. 1 It is the whole structure schematic diagram of the utility model;

[0019] Fig. 2 It is the whole structure schematic diagram of the utility model food box;

[0020] Fig. 3 It is the whole structure schematic diagram of the utility model water box;

[0021] Among them, in the drawing:

[0022] 1-gas pump;2-gas flowmeter;3-cage frame;4-cage;5-clamping groove;6-isolation net;7-excrement urine separator;8-urine sample diversion groove;9-gas collection device;10-urine sample collection cup;11-urine sample collection groove;12-condenser;13-lifting platform;14-platform;15-excrement sample collection groove;16-excrement sample collection cup;17-excrement sample diversion groove;18-cage bottom;19-conical cover;20-excrement urine separation device;21-food box;22-water box;23-cage cover;24-gas pipeline;25-feeding cavity;26-feeding port;27-stainless steel blocking net;28-rat food collection box;29-flow-through cavity;30-feeding cavity;31-gate;32-water bottle;33-pressing water structure;34-U-shaped pipe;35-drinking water port;36-micro check valve;37-water storage box. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the utility model.

[0024] Please refer to the drawings of the embodiments of the utility model Figs. 1-3 The utility model provides a kind of gas metabolism cage for mouse, including cage 3, cage 3 is provided with cage 4 in, the top of cage 4 is equipped with cage cover 23, the bottom of cage 4 is equipped with cage bottom 18, the middle part of cage 4 is equipped with slot 5, slot 5 is connected with isolation net 6, isolation net 6 divides cage 4 into movable cavity and separation cavity, the top of movable cavity is equipped with food box 21 and water box 22 penetrating cage cover 23, separation cavity is provided with feces and urine separation device 20, the bottom of separation cavity is equipped with feces and urine collection device penetrating cage bottom 18, the upper and lower ends of cage 4 are equipped with gas collection device outside, the bottom of cooling device is arranged in feces and urine collection device, the bottom of cooling device is fixedly connected with platform 14, cage 3 adopts transparent acrylic material, overall seal, to raise rat.

[0025] Preferably, the cage 4 is in a cylindrical structure, the upper edge and the lower edge of the cage 4 are provided with buckles for fixing the cage cover 23 and the cage bottom 18 and pressing tightly to ensure the sealing of the metabolism cage, the upper edge buckle of the cage 4 cooperates with the cage cover 23 for fixing the cage cover 23 and the cage bottom 18 and pressing tightly to ensure the sealing of the metabolism cage, the cage cover 23 is provided with a gas port, a latch of the food box 21 and a latch of the water box 22, the lower edge buckle of the cage 4 cooperates with the cage bottom 18, the cage bottom 18 is provided with a sealing thread for fixing the feces and urine collection device, and a sealing ring is arranged in the thread to achieve good sealing effect for fixing the feces and urine collection cup.

[0026] Preferably, the food box 21 is divided into a feeding cavity 30, a flow-through cavity 29 and a feeding cavity 25 by two gates 31 penetrating the cage cover 23, the feeding cavity 30 is located outside the cage cover 23, the two gates 31 penetrate the cage cover 23 and are integrally formed with the cage cover 23, the feeding cavity 25 is located inside the movable cavity, one side of the feeding cavity 25 is provided with a feeding port 26, the feeding cavity 25 is circumferentially provided with a stainless steel barrier net 27, and a mouse food collection box 28 is arranged below the feeding cavity 25 to prevent mouse food from falling and causing rats to be unable to eat, and the stainless steel barrier net can prevent mouse food from sliding into the cage.

[0027] Preferably, the water box 22 comprises a water bottle 32, a press water structure 33, a U-shaped tube 34, a micro check valve 36, a water storage box 37 and a drinking water outlet 35. The water bottle 32 and the water storage box 37 are located outside the cage cover 23. The press water structure 33 is arranged below the water bottle 32. The micro check valve 36 is arranged in the water storage box 37. One end of the U-shaped tube 34 is connected to the press water structure 33, and the other end penetrates the cage cover 23 and is connected to the micro check valve 36. The drinking water outlet 35 is arranged at the bottom of the water storage box 37 and penetrates the cage cover 23. The water bottle 32 can contain about 2 / 3 of the volume of drinking water. The press water structure 33 is arranged in the water bottle 32. When the water bottle 32 is inserted into the water box 22, the water in the water bottle 32 flows out through the U-shaped tube 34, passes through the micro check valve 36 and enters the water storage box 37. The water storage box 37 is connected to the drinking water outlet 35. The top of the water bottle 32 is provided with an air hole to prevent the water from flowing into the water storage box 37 due to the pressure difference.

[0028] Preferably, the feces and urine separation device 20 comprises a feces and urine separator 7, a conical cover 19, a urine sample flow guide groove 8 and a feces sample flow guide groove 17. The conical cover 19 and the feces and urine separator 7 are connected below the isolation net 6. The urine sample flow guide groove 8 is connected below the feces and urine separator 7. The feces sample flow guide groove 17 is arranged below the urine sample flow guide groove 8. The bottom of the urine sample flow guide groove 8 is in trapezoidal structure, which can guide the flow of liquid and prevent the feces sample from falling into the urine sample collection cup 10. The bottom of the feces sample flow guide groove 17 is in columnar structure, which can catch the falling feces sample and prevent the feces sample from splashing, and facilitate the collection of the feces sample into the feces sample collection cup 16.

[0029] When the animal urine sample is discharged, it drops on the conical cover 19, slides onto the feces and urine separator 7, and then flows along the slope to the urine sample flow guide groove 8. The surface tension of the liquid causes the urine sample to flow along the surface of the urine sample flow guide groove 8 to the drip nozzle below, and then to fall into the urine sample collection cup 10 below. When the animal feces sample is discharged, it rolls down on the surface of the conical cover 19 and the feces and urine separator 7, and then falls vertically into the feces sample flow guide groove 17 due to its own gravity. Under the guidance of the feces sample flow guide groove 17, the feces sample falls into the feces sample collection cup 16 below, thereby completing the collection of the feces sample and the urine sample.

[0030] Preferably, the feces and urine separator 7 is in inverted conical structure and is matched with the isolation net 6 through the clamping groove 5. The feces and urine separator 7 is made of transparent acrylic material and is combined with the isolation net 6 through the clamping groove 5. The feces and urine separator 7 mainly separates the feces sample and the urine sample by the different flow patterns of solid and liquid on the slope.

[0031] Preferably, the feces and urine collection device comprises a feces sample collection cup 16 and a urine sample collection cup 10. The bottom of the feces sample collection cup 16 and the urine sample collection cup 10 is in conical structure and extends into the inside of the cooling device. The cup wall is provided with a scale and the upper edge is provided with a screw thread, which ensures the sealing of the whole device and allows the collected amount to be clearly viewed, thereby facilitating the subsequent use.

[0032] Preferably, the gas collecting device comprises a gas pump 1, a gas flow meter 2, a gas pipeline 24, and a gas collecting device, one end of the gas pipeline 24 penetrates through the cage cover 23, and the other end is connected with the gas pump 1, the outlet end of the gas pump 1 is provided with the gas flow meter 2, one end of the other gas pipeline 24 penetrates through the cage bottom 18, and the other end is connected with the gas collecting device 9, the gas collecting device 9 can be a gas collecting bag for collecting all gases metabolized by the animal, or a gas collecting bottle for collecting a single component gas by chemical method or filtering method.

[0033] Preferably, the cooling device comprises a condenser 12 and a lifting platform 13, the condenser 12 is installed above the lifting platform 13, the lifting platform 13 is a whole I-shaped mechanical mechanism, the height of the platform can be adjusted by adjusting the metal screw rod in the middle, and then the height of the condenser 12 is adjusted to fit the fecal sample collecting cup 16 and the urine sample collecting cup 10, so as to ensure the low-temperature preservation of the sample.

[0034] Preferably, the condenser 12 adopts a semiconductor condenser, the condensing module in the condenser 12 is composed of a metal aluminum block, the condenser 12 is provided with a fecal sample collecting groove 15 and a urine sample collecting groove 11 at the upper end, and is matched with the fecal sample collecting cup 16 and the urine sample collecting cup 10, when the condenser 12 operates, the sample can be cooled, and the temperature of the sample is ensured to be about minus 5℃.

[0035] The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the difference from other embodiments, and the same and similar parts between the various embodiments can be referred to each other. For the device disclosed in the embodiments, since it corresponds to the method disclosed in the embodiments, the description is relatively simple, and the related parts can be referred to the method part.

[0036] The above description of the disclosed embodiments enables a person skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A gas metabolism cage for mice, characterized in that, The cage (3) is provided with a cage (4) inside, the top end of the cage (4) is provided with a cage cover (23), the bottom end of the cage (4) is provided with a cage bottom (18), the middle part of the cage (4) is provided with a clamping groove (5), the clamping groove (5) is connected with a separation net (6), the separation net (6) divides the cage (4) into a movable cavity and a separation cavity, the top end of the movable cavity is provided with a food box (21) and a water box (22) penetrating through the cage cover (23), the separation cavity is provided with a feces and urine separation device (20), the bottom of the separation cavity is provided with a feces and urine collection device penetrating through the cage bottom (18), the upper and lower ends of the cage (4) are provided with gas collection devices outside, the bottom of the cage (3) is provided with a cooling device, the cooling device is arranged at the bottom end of the feces and urine collection device, and the bottom end of the cooling device is fixedly connected with a platform (14).

2. The gas metabolism chamber for mice according to claim 1, wherein The cage (4) is in a columnar structure, the upper edge and the lower edge of the cage (4) are provided with buckles, the upper edge buckle of the cage (4) is matched with the cage cover (23), the cage cover (23) is provided with a gas path interface, a food box (21) and a water box (22), the lower edge buckle of the cage (4) is matched with the cage bottom (18), and the cage bottom (18) is provided with a sealing screw thread for fixing the feces and urine collection device.

3. The gas metabolism chamber for mice according to claim 1, wherein The food box (21) is divided into a feeding cavity (30), a flow cavity (29) and an eating cavity (25) by penetrating through the cage cover (23) through two gates (31), the feeding cavity (30) is located outside the cage cover (23), the two gates (31) penetrate through the cage cover (23) and are integrally formed with the cage cover (23), the eating cavity (25) is located inside the movable cavity, one side of the eating cavity (25) is provided with an eating port (26), the eating cavity (25) is circumferentially provided with a stainless steel blocking net (27), and the eating cavity (25) is provided with a mouse food collection box (28) below.

4. The gas metabolism chamber for mice according to claim 1, wherein The water box (22) comprises a water bottle (32), a pressing water structure (33), a U-shaped tube (34), a micro check valve (36), a water storage box (37) and a drinking water port (35), the water bottle (32) and the water storage box (37) are located outside the cage cover (23), the water bottle (32) is provided with the pressing water structure (33) below, the water storage box (37) is provided with the micro check valve (36) inside, one end of the U-shaped tube (34) is connected with the pressing water structure (33), the other end penetrates through the cage cover (23) and is connected with the micro check valve (36), and the bottom of the water storage box (37) is provided with the drinking water port (35) penetrating through the cage cover (23).

5. The gas metabolism chamber for mice according to claim 1, wherein The feces and urine separation device (20) comprises a feces and urine separator (7), a conical cover (19), a urine sample flow guide groove (8) and a feces sample flow guide groove (17), the conical cover (19) and the feces and urine separator (7) are connected below the separation net (6), the feces and urine separator (7) is connected with the urine sample flow guide groove (8) below, and the urine sample flow guide groove (8) is provided with the feces sample flow guide groove (17) below.

6. A gas metabolism cage for mice according to claim 5, characterized in that The feces and urine separator (7) is a reverse conical structure and is matched with the separation net (6) through the clamping groove (5).

7. The gas metabolism chamber for mice according to claim 1, wherein The excrement and urine collecting device comprises an excrement sample collecting cup (16) and a urine sample collecting cup (10), the bottom of the excrement sample collecting cup (16) and the urine sample collecting cup (10) is of a conical structure and extends into the inside of the cooling device, and the cup wall is provided with a scale and an upper thread.

8. The gas metabolism chamber for mice according to claim 1, wherein The gas collecting device comprises a gas pump (1), a gas flow meter (2), gas pipelines (24) and a gas collecting device, one end of one of the gas pipelines (24) penetrates through the cage cover (23), the other end is connected with the gas pump (1), the outlet end of the gas pump (1) is provided with the gas flow meter (2), one end of the other of the gas pipelines (24) penetrates through the cage bottom (18), the other end is connected with the gas collecting device (9).

9. The gas metabolism chamber for mice according to claim 1, wherein The cooling device comprises a condenser (12) and a lifting platform (13), the condenser (12) is installed above the lifting platform (13).

10. A gas metabolism cage for mice according to claim 9, characterized in that The condenser (12) adopts a semiconductor condenser, the condensing module in the condenser (12) is composed of a metal aluminum block, the upper end of the condenser (12) is provided with an excrement sample collecting groove (15) and a urine sample collecting groove (11) which are matched with the excrement sample collecting cup (16) and the urine sample collecting cup (10).

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