Batch filling device of solid-phase extraction column

Abstract

The utility model relates to a solid-phase extraction column batch filling device, and belongs to the field of solid-phase extraction column filling equipment.The solid-phase extraction column batch filling device comprises a capacity plate, a column placing plate and a column pressing plate, a plurality of quantitative-volume discharging grooves are formed in the capacity plate in an array mode, and a plurality of column placing holes allowing extraction columns to be placed in a penetrating mode are formed in the column placing plate in an array mode; a plurality of avoiding holes corresponding to the column placing holes are formed in the column pressing plate, the column pressing plate is placed on the surface of the column placing plate and can abut against and fix the extraction columns, and the column placing plate and the column pressing plate are placed on a capacity plate filled with quantitative filler together; notches of a plurality of discharging grooves in the capacity plate correspond to pipe orifices of the extraction columns placed on the column placing plate through the receding holes, and the capacity plate, the column pressing plate and the column placing plate carry the extraction columns to be integrally inverted, so that fillers in the discharging grooves fall into the extraction columns placed on the column placing plate. The device has the advantage of high extraction column filling efficiency.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of solid phase extraction column filler equipment, in particular to a batch filler device of a solid phase extraction column. BACKGROUND

[0002] A solid phase extraction column (SPE column for short) is a sample pretreatment device for extraction, separation and concentration developed from a chromatographic column. It is mainly applied to sample pretreatment of target compounds in various food, agricultural and livestock products, environmental samples and biological samples.

[0003] The principle of the solid phase extraction column is to use a specific adsorbent filled in the column to selectively enrich and separate target compounds in the sample through physical or chemical action. When a complex sample solution passes through the adsorbent, the adsorbent will selectively retain the target and a small amount of components similar in nature to the target through polar interaction, hydrophobic interaction or ion exchange force, and other components will flow out of the column. Then, the target is selectively eluted with another solvent system. This method has been widely used in many national standards (GB / T) and industry analysis standards.

[0004] The solid phase extraction column is usually a syringe type device made of polypropylene (PP), which contains two polyethylene (PE) or glass fiber plugs, and a certain amount of chromatographic adsorbent (filler) is filled between the two plugs.

[0005] The existing solid phase extraction column filler needs to be quantitatively filled one by one, which results in low filling efficiency of the solid phase extraction column, and therefore needs to be improved. CONTENT OF THE INVENTION

[0006] In order to improve the filling efficiency of the solid phase extraction column, the present application provides a batch filler device of a solid phase extraction column.

[0007] The batch filler device of the solid phase extraction column provided by the present application adopts the following technical scheme:

[0008] The batch filling device of solid phase extraction column comprises a capacity plate, a column placing plate and a column pressing plate, a plurality of dosing grooves with a certain volume are arranged on the capacity plate, a plurality of column placing holes for placing the extraction column are arranged on the column placing plate, and a plurality of accommodation holes corresponding to the column placing holes are arranged on the column pressing plate. The column pressing plate is placed on the surface of the column placing plate and can press and fix the extraction column. The column placing plate and the column pressing plate are placed on the capacity plate filled with the dosing material. The openings of the dosing grooves on the capacity plate correspond to the openings of the extraction column placed on the column placing plate through the accommodation holes. The capacity plate, the column pressing plate and the column placing plate carry the extraction column as a whole and are inverted so that the dosing material in the dosing grooves falls into the extraction column placed on the column placing plate.

[0009] By adopting the above technical scheme, the dosing material is poured into the capacity plate so that the dosing material falls into the dosing grooves, the dosing material on the surface of the capacity plate is scraped flat so that the volume of the dosing material in each dosing groove is consistent. In addition, a plurality of extraction columns are inserted and placed on the column placing plate through the column placing holes, and then the column pressing plate is placed on the column placing plate so that the ears on the upper end of the extraction column are clamped between the column pressing plate and the column placing plate, thereby stably placing the extraction column on the column placing plate. Then, the column pressing plate and the column placing plate carry the extraction column and are placed on the capacity plate so that the openings of the dosing grooves correspond to the openings of the extraction column through the accommodation holes. Then, the whole is inverted so that the dosing material in the dosing grooves falls into the extraction column, thereby filling the dosing material into the extraction column in batches, and the filling efficiency of the extraction column is improved.

[0010] Preferably, the surface of the column placing plate at the edge of the column placing holes is provided with an embedding groove for embedding the ears on the upper end of the extraction column so that the upper end of the extraction column is flush with the surface of the column placing plate.

[0011] By adopting the above technical scheme, the extraction column is inserted on the column placing plate through the column placing holes, and then the ears on the upper end of the extraction column are embedded in the embedding groove so that the extraction column is flush with the surface of the column placing plate, thereby enabling the column pressing plate to fully contact the surface of the column placing plate, thereby improving the stability of the extraction column placed on the column placing plate and facilitating subsequent filling.

[0012] Preferably, the openings of the accommodation holes on the surface of the column pressing plate in contact with the capacity plate are outwardly open.

[0013] By adopting the above technical scheme, the openings of the accommodation holes on the surface of the column pressing plate in contact with the capacity plate are outwardly open, thereby playing a guiding role in the process of filling the dosing material into the extraction column when the capacity plate is inverted, thereby enabling the dosing material in the dosing grooves to fully enter the extraction column.

[0014] Preferably, at least two positioning columns are arranged on the column placing plate, and positioning holes for inserting the positioning columns are arranged on the column pressing plate and the capacity plate.

[0015] By adopting the technical scheme, the positioning column is inserted into the positioning holes on the pressure column plate and the capacity plate to accurately correspond the position holes on the pressure column plate and the discharge grooves to the pipe openings of the extraction column, so that the fillers in the discharge grooves fully enter the extraction column, thereby reducing the filling error of the extraction column.

[0016] Preferably, the capacity plate, the pressure column plate and the column placing plate are all made of transparent acrylic plate.

[0017] By adopting the technical scheme, the transparent acrylic plate can be clearly seen by the operator whether the fillers are fully filled in the extraction column.

[0018] Preferably, the inner wall of the discharge groove is smooth.

[0019] By adopting the technical scheme, the inner wall of the discharge groove is smooth, thereby avoiding the fillers remaining in the discharge groove and reducing the filling error.

[0020] Preferably, the frame is further provided, the capacity plate or the column placing plate is placed on the frame, and the frame has a hollow part for the extraction column.

[0021] By adopting the technical scheme, the capacity plate and the column placing plate are placed on the frame, thereby facilitating the batch filling operation of the extraction column.

[0022] Preferably, the pressure plate for pressing the fillers of the extraction column after batch filling is further provided, a plurality of pressure rods are arranged on the surface of the pressure plate at intervals, and the distribution interval of the plurality of pressure rods is matched with the extraction column placed on the column placing plate.

[0023] By adopting the technical scheme, when the fillers in the capacity plate enter the extraction column, the fillers are compacted by inserting the pressure rods on the pressure plate into the extraction column, thereby improving the operation efficiency.

[0024] In summary, the present application has at least one of the following beneficial technical effects:

[0025] The fillers are poured into the capacity plate, so that the fillers fall into the discharge grooves, the fillers on the surface of the capacity plate are scraped, so that the volume of the fillers in each discharge groove is consistent, a plurality of extraction columns are inserted and placed on the column placing plate through the column placing holes, then the pressure column plate is placed on the column placing plate, so that the ear plates on the upper end of the extraction column are clamped between the pressure column plate and the discharge plate, thereby stably placing the extraction column on the column placing plate, then the pressure column plate and the column placing plate carrying the extraction column are placed on the capacity plate, so that the grooves of the discharge grooves correspond to the pipe openings of the extraction column through the position holes, then the whole is inverted, so that the fillers in the discharge grooves fall into the extraction column, thereby filling the fillers into the extraction column in batches, and the filling efficiency of the extraction column is improved. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 is a structure diagram of the column placing plate and the column pressing plate to be assembled in the embodiment of the application.

[0027] Figure 2 is an explosion structure diagram of the main plate and the column pressing plate after being assembled and the capacity plate in the embodiment of the application.

[0028] Figure 3 is a structure diagram of the batch filling device placed on the frame in the embodiment of the application.

[0029] Figure 4 is a structure diagram of the frame in the embodiment of the application.

[0030] Figure 5 is a structure diagram of the batch filling device placed upside down on the frame in the embodiment of the application.

[0031] Figure 6 is a structure diagram of the pressure plate in the embodiment of the application.

[0032] Legend: 1, column placing plate; 11, column placing hole; 12, embedding groove; 13, positioning column; 2, column pressing plate; 21, let-position hole; 3, capacity plate; 31, material placing groove; 4, extraction column; 5, positioning hole; 6, frame; 7, pressure plate; 71, pressure rod. DETAILED DESCRIPTION

[0033] The following will be described in detail in combination with the accompanying Figures 1-6 The application is further described in detail.

[0034] The embodiment of the application discloses a batch filling device for a solid-phase extraction column. Referring to Figure 1 and Figure 2 , the batch filling device for the solid-phase extraction column comprises a column placing plate 1, a column pressing plate 2 and a capacity plate 3, and the column placing plate 1, the column pressing plate 2 and the capacity plate 3 are all arranged in the shape of a cuboid. A plurality of column placing holes 11 for placing the extraction column 4 are arranged in the middle position of the column placing plate 1, a plurality of let-position holes 21 corresponding to the column placing holes 11 are arranged in the middle position of the column pressing plate 2, and a plurality of material placing grooves 31 with a fixed volume are arranged in the middle position of the capacity plate 3. The column pressing plate 2 is placed on the surface of the column placing plate 1 and can press and fix the extraction column 4, the column placing plate 1 and the column pressing plate 2 are placed on the capacity plate 3 filled with a fixed amount of material, the openings of the plurality of material placing grooves 31 on the capacity plate 3 correspond to the pipe openings of the extraction column 4 placed on the column placing plate 1 through the let-position holes 21, and the capacity plate 3, the column pressing plate 2 and the column placing plate 1 carrying the extraction column 4 are inverted as a whole, so that the material in the material placing grooves 31 falls into the extraction column 4 placed on the column placing plate 1. Meanwhile, the column placing holes 11 with different sizes and the material placing grooves 31 with different capacities can be set according to the specifications of the extraction column 4.

[0035] Referring to Figure 1 , the upper end of the extraction column 4 has an ear plate perpendicular to the column body, and the surface of the column placing plate 1 located at the edge of the column placing hole 11 is provided with an embedding groove 12 for embedding the upper end ear plate of the extraction column 4, so that the upper end of the extraction column 4 is flush with the surface of the column placing plate 1. Thus, the column pressing plate 2 can be in full contact with the surface of the column placing plate 1, thereby improving the stability of the extraction column 4 placed on the column placing plate 1 and facilitating subsequent filling.

[0036] Referring to Figure 1 , the let-out hole 21 on the side of the column pressing plate 2 in contact with the capacity plate 3 is outwardly open. The let-out hole 21 on the side of the column pressing plate 2 in contact with the capacity plate 3 is outwardly open, thereby playing a role of guiding material during the filling process of the capacity plate 3 to the extraction column 4, so that the filler in the discharging groove 31 fully enters the extraction column 4.

[0037] Referring to Figure 1 and Figure 2 , at least two positioning columns 13 are distributed on the column placing plate 1, and the column pressing plate 2 and the capacity plate 3 are provided with positioning holes 5 for inserting the positioning columns 13. During the placement of the column pressing plate 2 on the column placing plate 1, the positioning columns 13 are inserted into the positioning holes 5 on the column pressing plate 2 and the capacity plate 3 for positioning, so that the let-out hole 21 and the discharging groove 31 on the column pressing plate 2 can be accurately corresponded to the pipe opening of the extraction column 4, the filler in the discharging groove 31 fully enters the extraction column 4, thereby reducing the filling error of the extraction column 4. In the embodiment, four positioning columns 13 are provided on the placing plate, the four positioning columns 13 are distributed at the corners of the column placing plate 1, four positioning holes 5 are provided on the column pressing plate 2, and the four positioning columns 13 can be inserted into the positioning holes 5 on the column pressing plate 2, wherein the lengths of two opposite positioning columns 13 are greater than those of the other two opposite positioning columns 13, and the positioning holes 5 of the capacity plate 3 are provided with two, and the two longer positioning columns 13 can be inserted into the positioning holes 5 on the capacity plate 3 through the positioning holes 5 on the column pressing plate 2.

[0038] The capacity plate 3, the column pressing plate 2 and the column placing plate 1 are all made of transparent acrylic plate. The transparent acrylic plate can enable the operator to clearly see whether the filler is fully filled in the extraction column 4. Moreover, the inner wall of the discharging groove 31 is smooth. The smooth treatment of the inner wall of the discharging groove 31 can avoid the filler remaining in the discharging groove 31 and reduce the filling error.

[0039] Referring to Figures 3 to 5 , it also includes a cuboid frame 6, the middle of the frame 6 is hollow, and the frame 6 is used for placing the capacity plate 3 or the column placing plate 1. During the batch filling of the extraction column 4, the capacity plate 3 and the column placing plate 1 are placed on the frame 6, which facilitates the batch filling operation of the extraction column 4.

[0040] Referring to Figure 6The pressure plate 7 is arranged for compacting the extraction column 4 after the column is filled with the batch of filler, and a plurality of pressure rods 71 are arranged on the surface of the pressure plate 7 at intervals, and the interval of the plurality of pressure rods 71 is matched with the extraction column 4 placed on the column placing plate 1. When the filler in the volume plate 3 is filled into the extraction column 4, the filler is compacted by the pressure rods 71 on the pressure plate 7 inserted into the extraction column 4, so as to improve the operation efficiency.

[0041] The implementation principle of the batch filler device of the solid phase extraction column according to the embodiment of the application is as follows: the volume plate 3 is placed on the frame 6, the filler is poured into the volume plate 3, so that the filler falls into the filler placing groove 31, and the filler on the surface of the volume plate 3 is scraped flat, so that the volume of the filler in each filler placing groove 31 is consistent; in addition, a plug plate is placed into the extraction column 4, then a plurality of extraction columns 4 are placed on the column placing plate 1, the lug plate on the extraction column 4 is embedded into the embedding groove 12, then the pressure column plate 2 is placed on the column placing plate 1, so that the lug plate on the upper end of the extraction column 4 is clamped between the pressure column plate 2 and the filler placing plate, so that the extraction column 4 is stably placed on the column placing plate 1; then the pressure column plate 2 and the column placing plate 1 carrying the extraction column 4 are placed on the volume plate 3, the notch of the filler placing groove 31 corresponds to the pipe opening of the extraction column 4 through the gap hole 21, then the whole is inverted and placed on the frame 6, so that the filler in the filler placing groove 31 falls into the extraction column 4, so that the filler is filled into the extraction column 4 in batches, the filling efficiency of the extraction column 4 is improved, after completion, the volume plate 3 and the pressure column plate 2 are removed, the plug plate is plugged into each extraction column 4, then the plurality of pressure rods 71 on the pressure plate 7 are used to compact the filler synchronously.

[0042] Unless otherwise defined, technical terms or scientific terms used in the present application shall have the common meaning understood by one of ordinary skill in the art to which the present application pertains. The terms "first", "second", "third" and the like as used in the specification and claims of the present application do not denote any order, quantity, or importance, but are used to distinguish different components. The terms "one" or "a" or the like as used in the specification and claims of the present application do not denote a quantity restriction, but mean that there is at least one. The terms "including", "containing", and the like as used in the specification and claims of the present application mean that the elements or objects before the "including" or "containing" cover the elements or objects listed after the "including" or "containing" and their equivalents, and do not exclude other elements or objects. The terms "upper", "lower", "left", "right", and the like are used only to represent relative positional relationships, and when the absolute positions of the described objects are changed, the relative positional relationships may also be changed accordingly.

[0043] The above are preferred embodiments of the present application, which do not limit the protection scope of the present application, therefore: any equivalent changes made on the structure, shape, principle of the present application shall be covered within the protection scope of the present application.

Claims

1. A batch packing apparatus for solid phase extraction columns, characterized by: The device comprises a capacity plate (3), a column placing plate (1) and a column pressing plate (2), a plurality of dosing grooves (31) are arranged on the capacity plate (3), a plurality of column placing holes (11) for placing the extraction column (4) are arranged on the column placing plate (1), a plurality of accommodation holes (21) corresponding to the column placing holes (11) are arranged on the column pressing plate (2), the column pressing plate (2) is placed on the surface of the column placing plate (1) and can press and fix the extraction column (4), the column placing plate (1) and the column pressing plate (2) are placed on the capacity plate (3) filled with the dosing filler, the grooves of the dosing grooves (31) on the capacity plate (3) correspond to the pipe openings of the extraction column (4) placed on the column placing plate (1) through the accommodation holes (21), and the capacity plate (3), the column pressing plate (2) and the column placing plate (1) carry the extraction column (4) and are inverted as a whole, so that the filler in the dosing grooves (31) falls into the extraction column (4) placed on the column placing plate (1).

2. The bulk packing device for solid phase extraction columns according to claim 1, characterized in that: The surface of the column placing plate (1) at the edge of the column placing holes (11) is provided with an embedding groove (12) for embedding the upper end ear plate of the extraction column (4), so that the upper end of the extraction column (4) is flush with the surface of the column placing plate (1).

3. The bulk packing device for solid phase extraction columns of claim 1, wherein: The accommodation hole (21) on the contact surface of the column pressing plate (2) and the capacity plate (3) is outwardly open.

4. The bulk packing device for solid phase extraction columns of claim 1, wherein: At least two positioning columns (13) are arranged on the column placing plate (1), and the column pressing plate (2) and the capacity plate (3) are provided with positioning holes (5) matched with the positioning columns (13).

5. The bulk packing device for solid phase extraction columns of claim 1, wherein: The capacity plate (3), the column pressing plate (2) and the column placing plate (1) are all made of transparent acrylic plate.

6. The bulk packing device for solid phase extraction columns of claim 1, wherein: The inner wall of the dosing groove (31) is smooth.

7. The bulk packing device for solid phase extraction columns of claim 1, wherein: The device further comprises a frame body (6) for placing the capacity plate (3) or the column placing plate (1), and the frame body (6) is provided with a hollow part for accommodating the extraction column (4) in the middle.

8. The bulk packing device for solid phase extraction columns of claim 1, wherein: The device further comprises a pressing plate (7) for pressing the extraction column (4) filled with the batch filler, a plurality of pressing rods (71) are arranged on the surface of the pressing plate (7) at intervals, and the distribution interval of the plurality of pressing rods (71) is matched with the extraction column (4) placed on the column placing plate (1).

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