Nucleoside monomer synthesis reaction kettle

Abstract

The utility model relates to the technical field of nucleoside reaction, in particular to a nucleoside monomer synthesis reaction kettle which comprises a reaction kettle tank and an outer side cooling tank detachably installed on the outer side surface of the reaction kettle tank, a circulating liquid guide pipe is fixedly connected to the back face of the outer side cooling tank, one end of the circulating liquid guide pipe is fixedly connected with a cooling pipe, and the other end of the circulating liquid guide pipe is fixedly connected with the cooling pipe. A sleeve shell is arranged on the inner side wall face of the cooling pipe, and a liquid accumulation cavity is formed in the cooling pipe. According to the nucleoside liquid stirring device, a motor is matched to rotate, then a transmission crawler belt is driven to rotate stirring rods on the two sides, the stirring rods drive stirring blades to repeatedly stir nucleoside liquid in a reaction kettle tank while rotating, and at the moment, a hydraulic rod is matched to repeatedly pull and push a pressing plate up and down; and when the pushing and pressing plate slides upwards on the inner side wall face of the inner container sleeve, the bottom layer space of the inner container sleeve is in a pressure loss state, and when the pushing and pressing plate slides upwards on the inner side wall face of the inner container sleeve, the bottom layer space of the inner container sleeve is in a pressure loss state.

Description

TECHNICAL FIELD

[0001] The utility model relates to nucleoside reaction technical field especially is nucleoside monomer synthesis reaction kettle. BACKGROUND

[0002] Nucleoside monomer is the important raw material for synthesizing genetic material (DNA and RNA) in organism, and belongs to the basic constituent unit of nucleic acid; nucleoside is a glycoside compound composed of ribose or deoxyribose and purine base or pyrimidine base; according to the difference of sugar, nucleoside can be divided into ribonucleoside (participate in RNA composition) and deoxyribonucleoside (participate in DNA composition).

[0003] Publication No. CN118925643A discloses a kind of cycloalkene polymer monomer synthesis reaction kettle with monitoring mechanism, including reaction kettle body, the inside of reaction kettle body is equipped with finished product temperature sensor, and finished product pressure transmitter is equipped at the top left side of reaction kettle body, driving bin is arranged on the upper portion of reaction kettle body, pressurizing pipe is inserted and equipped at the top right side of reaction kettle body, inside reaction kettle body is staggered and equipped with scrape stirring frame and stirring frame, and scrape stirring frame and stirring frame are driven to rotate by drive assembly;The assembly of scrape stirring frame and stirring frame is set in the present application, so that raw materials are not easy to stick to the inner wall of reaction kettle body for a long time to cause scorched, also make stirring more sufficient, also facilitate to keep its internal temperature relatively balanced, by setting finished product temperature sensor and finished product pressure transmitter, the temperature and pressure inside reaction kettle body are monitored in real time.

[0004] When nucleoside monomer is synthesized, the inside of reaction kettle is in high temperature and high pressure state, if temperature is too high, the synthesis reaction of internal nucleoside monomer will be affected, and the inside of reaction kettle is in sealed state, internal heat source cannot be discharged in time, under the condition of continuous high temperature, internal nucleoside monomer cannot effectively carry out synthesis reaction. UTILITY MODEL CONTENT

[0005] Therefore, the technical problem to be solved by the utility model lies in overcoming the problem that the inside of reaction kettle is in sealed state in the prior art, internal heat source cannot be discharged in time, under the condition of continuous high temperature, internal nucleoside monomer cannot effectively carry out synthesis reaction.

[0006] To solve the above technical problem, the utility model provides nucleoside monomer synthesis reaction kettle, including reaction kettle jar and the outside cooling tank of detachable installation on the outside surface of reaction kettle jar, the back of outside cooling tank is fixedly connected with circulating liquid guide pipe, one end of circulating liquid guide pipe is fixedly connected with cooling pipe, the inside wall surface of cooling pipe is provided with sleeve, the inside wall surface of sleeve is fixedly connected with hollow heat-conducting aluminum plate, the outside surface of one side of cooling pipe is provided with fan.

[0007] In one embodiment of the utility model, the outer surface of the cooling pipe is fixedly connected with a limiting sleeve, and the outer surface of the fan is fixedly installed on the inner wall surface of the limiting sleeve.

[0008] In one embodiment of the utility model, the outer surface of the cooling pipe is fixedly connected with a limiting sleeve, and the outer surface of the fan is fixedly installed on the inner wall surface of the limiting sleeve.

[0009] In one embodiment of the utility model, the inner wall surface of the top of the reaction kettle is fixedly connected with an inner container sleeve, the outer surface of the inner container sleeve is provided with a gas permeation hole at the bottom edge position, the bottom inner wall surface of the inner container sleeve is fixedly connected with a filter plate, and the inner wall surface of the inner container sleeve is fixedly connected with a limiting sealing plate at the middle position.

[0010] In one embodiment of the utility model, the top surface of the reaction kettle is fixedly installed with a hydraulic rod, the output end of the hydraulic rod extends to the inner wall surface of the inner container sleeve through the reaction kettle, and the outer surface of the hydraulic rod is movably sleeved on the inner wall surface of the limiting sealing plate.

[0011] In one embodiment of the utility model, the output end of the hydraulic rod is fixedly connected with a push plate movably sleeved on the inner wall surface of the inner container sleeve, and the top surface of the reaction kettle is fixedly installed with a motor at one side edge position.

[0012] In one embodiment of the utility model, the top surface of the reaction kettle is movably sleeved with a rotating drum at the other side edge position, and the output end of the motor and the outer surface of the rotating drum are fixedly installed with a stirring rod arranged on the inner wall surface of the reaction kettle.

[0013] In one embodiment of the utility model, the outer surface of the stirring rod is fixedly connected with a stirring blade, and the output end of the motor is movably sleeved with a transmission track arranged on the outer surface of the rotating drum.

[0014] The above technical scheme of the utility model has the following advantages compared with the prior art:

[0015] The nucleotide monomer synthesis reaction kettle is characterized by the following: the nucleotide monomer synthesis reaction kettle is provided with a reaction kettle, a cooling pipe, a circulating liquid guide pipe, an outside cooling tank, a hollow heat conduction aluminum plate, a limiting sleeve, a fan, a filter plate and a limiting sealing plate.

[0016] The nucleotide monomer synthesis reaction kettle has the advantages that when the nucleotide raw solution in the reaction kettle is processed, if the temperature inside is too high, the inside low-temperature cooling water is injected into the inside of the outside cooling tank through the circulating liquid guide pipe by the cooling pipe, heat absorption treatment is performed on the inside too high temperature when the cooling water is attached to the outside surface of the reaction kettle, and the temperature inside the reaction kettle is gradually reduced; after the temperature inside the reaction kettle is stable, the cooling pipe stops injecting cooling water into the inside of the outside cooling tank, the water source in the inside of the outside cooling tank is injected into the inside of the cooling pipe, and the flowing water source is drained through the hollow heat conduction aluminum plate on the inside of the sleeve, so that the water source passes through the hollow heat conduction aluminum plate and enters the inside of the liquid accumulation cavity; when the fan in the inside of the limiting sleeve injects air source into the inside of the cooling pipe on both sides, the fast-flowing air source can quickly cool the heat source left on the surface of the hollow heat conduction aluminum plate.

[0017] The nucleotide monomer synthesis reaction kettle has the advantages that when the nucleotide raw solution in the reaction kettle is processed, if the temperature inside is too high, the inside low-temperature cooling water is injected into the inside of the outside cooling tank through the circulating liquid guide pipe by the cooling pipe, heat absorption treatment is performed on the inside too high temperature when the cooling water is attached to the outside surface of the reaction kettle, and the temperature inside the reaction kettle is gradually reduced; after the temperature inside the reaction kettle is stable, the cooling pipe stops injecting cooling water into the inside of the outside cooling tank, the water source in the inside of the outside cooling tank is injected into the inside of the cooling pipe, and the flowing water source is drained through the hollow heat conduction aluminum plate on the inside of the sleeve, so that the water source passes through the hollow heat conduction aluminum plate and enters the inside of the liquid accumulation cavity; when the fan in the inside of the limiting sleeve injects air source into the inside of the cooling pipe on both sides, the fast-flowing air source can quickly cool the heat source left on the surface of the hollow heat conduction aluminum plate. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to make the content of the utility model more easily understood clearly, the following is according to the specific embodiment of the utility model and combines the drawings, and the utility model is further detailed.

[0019] Figure 1 is a perspective view of the utility model;

[0020] Figure 2 is a cutaway perspective view of the outer cooling tank in the utility model;

[0021] Figure 3 is a cutaway perspective view of the cooling pipe in the utility model;

[0022] Figure 4 is a cutaway perspective view of the reaction kettle tank in the utility model;

[0023] Figure 5 is a folding cutaway perspective view of the push plate in the utility model;

[0024] The description of the drawing signs of the utility model is as follows: 11, reaction kettle tank; 111, inner liner sleeve; 112, air hole; 113, filter plate; 114, limit sealing plate; 115, hydraulic rod; 116, push plate; 117, motor; 118, stirring rod; 119, stirring piece; 1110, transmission track; 12, outer cooling tank; 121, circulating liquid guide pipe; 122, cooling pipe; 123, limit sleeve; 124, fan; 125, circulating drainage pipe; 126, sleeve; 127, liquid accumulation cavity; 128, hollow heat-conducting aluminum plate. DETAILED DESCRIPTION

[0025] The utility model will be further explained in combination with the drawings and specific embodiments, so that the person skilled in the art can better understand the utility model and can be implemented, but the embodiment is not as the limitation of the utility model.

[0026] Refer to Figure 1 - Figure 5 As shown in the utility model nucleoside monomer synthesis reaction kettle, including reaction kettle tank 11 and detachable installation on the outer side surface of reaction kettle tank 11 outer cooling tank 12, the back of outer cooling tank 12 is fixedly connected with circulating liquid guide pipe 121, one end of circulating liquid guide pipe 121 is fixedly connected with cooling pipe 122, the inner side wall surface of cooling pipe 122 is provided with sleeve 126, the inside of cooling pipe 122 is provided with liquid accumulation cavity 127, the inner side wall surface of sleeve 126 is fixedly connected with hollow heat-conducting aluminum plate 128, the outer side surface of one side of cooling pipe 122 is provided with fan 124, the outer side surface of cooling pipe 122 is fixedly connected with limit sleeve 123, the outer side surface of fan 124 is fixedly installed on the inner side wall surface of limit sleeve 123, the outer side surface of cooling pipe 122 and located on the upper and lower two side edge positions are fixedly connected with circulating drainage pipe 125, the outer side surface of circulating drainage pipe 125 is arranged on the outer side surface of limit sleeve 123, and the two ends of circulating drainage pipe 125 extend to the inside of liquid accumulation cavity 127 respectively.

[0027] When the nucleotide stock solution inside the reaction kettle 11 is processed, if the internal temperature is too high, the cooling pipe 122 is matched to fill the internal low-temperature cooling water into the inside of the external cooling tank 12 through the circulating liquid guide pipe 121, and when the cooling water is attached to the outer surface of the reaction kettle 11, the internal temperature is too high. Heat absorption treatment is carried out, and the temperature inside the reaction kettle 11 is gradually reduced. After the temperature inside the reaction kettle 11 is stable, the cooling pipe 122 stops filling the cooling water inside the external cooling tank 12, and the water source inside the external cooling tank 12 is filled into the inside of the cooling pipe 122, and the flowing water source is guided through the hollow heat-conducting aluminum plate 128 on the inner wall surface of the sleeve 126. The water source passes through the hollow heat-conducting aluminum plate 128 into the inside of the liquid chamber 127. At this time, the fan 124 inside the limiting sleeve 123 fills the air source into the inside of the cooling pipe 122 on both sides. When the air source quickly passes through the outer surface of the hollow heat-conducting aluminum plate 128, the rapidly flowing air source can quickly cool the heat source left on the surface of the hollow heat-conducting aluminum plate 128.

[0028] Referring to Figure 1 - Figure 5 As shown in the figure, in an embodiment of the utility model, the top inner wall surface of the reaction kettle 11 is fixedly connected with the liner sleeve 111, the outer surface of the liner sleeve 111 and the bottom edge position are provided with the air hole 112, the bottom inner wall surface of the liner sleeve 111 is fixedly connected with the filter plate 113, the inner wall surface of the liner sleeve 111 and the middle position are fixedly connected with the limiting sealing plate 114, the top surface of the reaction kettle 11 is fixedly installed with the hydraulic rod 115, the output end of the hydraulic rod 115 extends to the inner wall surface of the liner sleeve 111 through the reaction kettle 11, the outer surface of the hydraulic rod 115 is movably sleeved on the inner wall surface of the limiting sealing plate 114, the output end of the hydraulic rod 115 is fixedly connected with the push plate 116 movably sleeved on the inner wall surface of the liner sleeve 111, the top surface of the reaction kettle 11 and the one side edge position are fixedly installed with the motor 117, the top surface of the reaction kettle 11 and the other side edge position are movably sleeved with the rotating drum, the output end of the motor 117 and the outer surface of the rotating drum are fixedly installed with the stirring rod 118 arranged on the inner wall surface of the reaction kettle 11, the outer surface of the stirring rod 118 is fixedly connected with the stirring blade 119, the output end of the motor 117 is movably sleeved with the transmission track 1110 arranged on the outer surface of the rotating drum;

[0029] The motor 117 rotates the transmission track 1110, which in turn rotates the stirring rods 118 on both sides. The stirring rods 118 rotate and drive the stirring blades 119 to repeatedly stir the nucleoside liquid inside the reaction kettle 11. At the same time, the hydraulic rod 115 repeatedly pulls and pushes the pressing plate 116 up and down, causing the pressing plate 116 to slide up and down on the inner wall of the inner sleeve 111. When the pressing plate 116 slides up on the inner wall of the inner sleeve 111, the bottom space of the inner sleeve 111 loses pressure, causing the nucleoside inside the reaction kettle 11 to enter the inner sleeve 111 through the bottom layer of the inner sleeve 111. At this time, the filter plate 113 differentiates the penetrated nucleoside liquid, thereby differentiating some undissolved or clumped nucleoside raw materials, achieving the effect of fully mixing the nucleoside into the liquid.

[0030] When the hydraulic rod 115 pushes down the pressing plate 116, the nucleoside raw liquid inside the inner sleeve 111 cannot be discharged at once due to the blockage of the filter plate 113 at the bottom outlet of the inner sleeve 111. However, under the push of the pressing plate 116, the nucleoside raw liquid is discharged from the air holes 112 on the outer surface of the inner sleeve 111, and the nucleoside raw liquid discharged to the surrounding area will impact and mix with the nucleoside raw liquid around the stirring rods 118 and stirring blades 119. The repeated pulling and pushing of the pressing plate 116 by the hydraulic rod 115 causes the nucleoside raw liquid at the bottom of the reaction kettle 11 to fully mix with the raw liquid stirred by the stirring blades 119, allowing the nucleoside raw liquid at different positions in the reaction kettle 11 to circulate and fully mix. The limitation of the limiting and sealing plate 114 prevents the nucleoside raw liquid from accumulating on the top layer of the pressing plate 116.

[0031] Working principle: The motor 117 rotates the transmission track 1110, which in turn rotates the stirring rods 118 on both sides. The stirring rods 118 rotate and drive the stirring blades 119 to repeatedly stir the nucleoside liquid inside the reaction kettle 11. At the same time, the hydraulic rod 115 repeatedly pulls and pushes the pressing plate 116 up and down, causing the pressing plate 116 to slide up and down on the inner wall of the inner sleeve 111. When the pressing plate 116 slides up on the inner wall of the inner sleeve 111, the bottom space of the inner sleeve 111 loses pressure, causing the nucleoside inside the reaction kettle 11 to enter the inner sleeve 111 through the bottom layer of the inner sleeve 111. At this time, the filter plate 113 differentiates the penetrated nucleoside liquid, thereby differentiating some undissolved or clumped nucleoside raw materials, achieving the effect of fully mixing the nucleoside into the liquid.

[0032] When the hydraulic rod 115 presses the push plate 116, the nucleotide stock solution in the inner sleeve 111 cannot be discharged in time due to the bottom outlet of the inner sleeve 111 being blocked by the filter plate 113, and is discharged from the air holes 112 on the outer surface of the inner sleeve 111 under the pushing of the push plate 116. The nucleotide stock solution discharged to the surroundings will impact and mix with the nucleotide stock solution around the stirring rod 118 and the stirring blade 119. Repeated pulling of the push plate 116 by the hydraulic rod 115 enables the nucleotide stock solution at the bottom of the reaction kettle 11 to be fully mixed with the nucleotide stock solution stirred by the stirring blade 119, so that the nucleotide stock solution at different positions in the reaction kettle 11 can flow in a cycle, be fully mixed, and be prevented from accumulating at the top of the push plate 116 by the limiting and sealing plate 114.

[0033] When the nucleotide stock solution in the reaction kettle 11 is processed, if the temperature inside is too high, the low-temperature cooling water in the inside is injected into the inside of the outside cooling tank 12 through the circulating liquid guide pipe 121 in cooperation with the cooling pipe 122. When the cooling water adheres to the outer surface of the reaction kettle 11, the heat absorption treatment is performed on the excessively high temperature in the inside, and the temperature in the inside of the reaction kettle 11 is gradually reduced. After the temperature in the inside of the reaction kettle 11 is stable, the cooling water in the inside of the outside cooling tank 12 is injected into the inside of the cooling pipe 122 in cooperation with the cooling pipe 122, and the flowing water source is guided through the hollow heat-conducting aluminum plate 128 on the inner wall surface of the sleeve 126, so that the water source passes through the hollow heat-conducting aluminum plate 128 and enters the inside of the liquid accumulation cavity 127. At this time, the fan 124 in the limiting sleeve 123 blows air into the inside of the cooling pipe 122 on both sides. When the air source quickly passes through the outer surface of the hollow heat-conducting aluminum plate 128, the quickly flowing air source quickly cools the heat source left on the surface of the hollow heat-conducting aluminum plate 128.

[0034] Obviously, the above embodiments are only examples for clear illustration, and are not a limitation on the embodiments. Based on the above description, those skilled in the art can make other different forms of changes or variations. Here, all the embodiments need not and cannot be exhausted. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. A nucleoside monomer synthesis reactor, comprising a reactor vessel (11) and an external cooling tank (12) detachably mounted on the outer surface of the reactor vessel (11), characterized in that: A circulating liquid guide pipe (121) is fixedly connected to the back of the outer cooling tank (12). A cooling pipe (122) is fixedly connected to one end of the circulating liquid guide pipe (121). A sleeve (126) is provided on the inner wall of the cooling pipe (122). A liquid accumulation chamber (127) is provided inside the cooling pipe (122). A hollow heat-conducting aluminum plate (128) is fixedly connected to the inner wall of the sleeve (126). A fan (124) is provided on one outer surface of the cooling pipe (122).

2. The nucleoside monomer synthesis reactor according to claim 1, characterized in that: A limiting sleeve (123) is fixedly connected to the outer surface of the cooling pipe (122), and the outer surface of the fan (124) is fixedly installed on the inner wall of the limiting sleeve (123).

3. The nucleoside monomer synthesis reactor according to claim 2, characterized in that: A circulation drain pipe (125) is fixedly connected to the outer surface of the cooling pipe (122) and at the upper and lower edges. The outer surface of the circulation drain pipe (125) is set on the outer surface of the limiting sleeve (123). The two ends of the circulation drain pipe (125) extend into the interior of the liquid accumulation chamber (127).

4. The nucleoside monomer synthesis reactor according to claim 3, characterized in that: An inner sleeve (111) is fixedly connected to the inner wall of the top of the reactor vessel (11). A vent hole (112) is provided on the outer surface of the inner sleeve (111) at the bottom edge. A filter plate (113) is fixedly connected to the inner wall of the bottom of the inner sleeve (111). A limit sealing plate (114) is fixedly connected to the inner wall of the inner sleeve (111) at the middle position.

5. The nucleoside monomer synthesis reactor according to claim 4, characterized in that: A hydraulic rod (115) is fixedly installed on the top surface of the reactor (11). The output end of the hydraulic rod (115) extends through the reactor (11) to the inner wall of the inner sleeve (111). The outer surface of the hydraulic rod (115) is movably sleeved on the inner wall of the limiting sealing plate (114).

6. The nucleoside monomer synthesis reactor according to claim 5, characterized in that: A push plate (116) is fixedly connected to the output end of the hydraulic rod (115) and is movably sleeved on the inner wall of the inner sleeve (111). A motor (117) is fixedly installed on the top surface of the reactor (11) and at one edge position.

7. The nucleoside monomer synthesis reactor according to claim 6, characterized in that: A rotating drum is movably fitted onto the top surface of the reactor (11) and at the other edge. A stirring rod (118) is fixedly installed on the inner wall of the reactor (11) at the output end of the motor (117) and on the outer surface of the rotating drum.

8. The nucleoside monomer synthesis reactor according to claim 7, characterized in that: A stirring blade (119) is fixedly connected to the outer surface of the stirring rod (118), and a transmission track (1110) is movably sleeved on the outer surface of the output end of the motor (117) and disposed on the outer surface of the rotating drum.

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