Adding device for medical intermediate production

Abstract

The utility model provides an adding device for medical intermediate production, which comprises a shell, a filter screen is arranged in the shell, the filter screen is a conical filter screen, and a blocking component is arranged in the shell and on one side of a discharge end of the filter screen. Particles or crystals are prevented from entering the metering pump to block small channels; meanwhile, the dismounting and cleaning times of the metering pump are reduced, internal precise parts are prevented from being damaged due to misoperation, and long-term stable operation and metering accuracy of the metering pump are ensured.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production technology, specifically to an additive device for the production of pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are key compounds in the synthesis of active pharmaceutical ingredients (APIs) and belong to the field of fine chemicals.

[0003] In existing technologies, pharmaceutical intermediates are typically added by metering pumps (such as gear pumps or plunger pumps) to deliver additives in a quantitative manner, which can be combined with flow meters or controllers to achieve precise addition.

[0004] However, when metering pumps deliver liquid additives, they may become clogged by particles in the additive (metering pumps have many tiny channels that are easily blocked) or by additive crystallization (crystallization occurs when solubility decreases due to temperature and pressure). This necessitates frequent disassembly and cleaning of the metering pump. Improper operation during cleaning may damage the components inside the metering pump, and frequent cleaning may affect its metering accuracy. In severe cases, it may affect the accuracy of adding additives during the production of pharmaceutical intermediates. Utility Model Content

[0005] In view of this, the present invention provides an additive device for the production of pharmaceutical intermediates, which can intercept impurities through an external filter screen to prevent particles or crystals from entering the metering pump and clogging the narrow channels; at the same time, it reduces the number of times the metering pump needs to be disassembled and cleaned, prevents damage to internal precision components due to improper operation, and ensures its long-term stable operation and metering accuracy.

[0006] To solve the above-mentioned technical problems, this utility model provides an additive device for the production of pharmaceutical intermediates, including a shell. The shell is configured as a cylindrical structure and can be manufactured by rolling and welding steel plates. A filter screen is provided inside the shell. The filter screen is configured as a conical filter screen to reduce clogging.

[0007] A blocking component is provided inside the housing and on the discharge end side of the filter screen to keep one side of the housing sealed when cleaning the filter screen.

[0008] The filter screen is connected to the inner wall of the housing via a connecting assembly for quick disassembly and assembly when the filter screen needs to be replaced. The connecting assembly includes a support frame set on the outer wall of the filter screen. The support frame is a hollow disc structure to fit the shape of the housing. A mounting frame is connected to one side of the support frame. The mounting frame is also a hollow disc structure. The mounting frame is connected to the housing via multiple positioning bolts. The multiple positioning bolts pass through the mounting frame and are connected to the housing via threaded engagement.

[0009] An air blowing pipe is connected to the outer wall of the housing. The air blowing pipe is welded to the outer wall of the housing and is connected to the housing. That is, a circular hole with the same diameter as the air blowing pipe is opened on the housing. The outer wall of one end of the air blowing pipe is welded to the inner wall of the circular hole. It is used to blow air into the housing through the air blowing pipe to clean the filter screen.

[0010] The blocking assembly includes a blocking disc disposed on the inner side wall of the housing, the blocking disc being rotatably connected to the inner side wall of the housing, a rotating rod connected to the blocking disc, the rotating rod being fixedly connected to the upper part of the blocking disc, the rotating rod passing through the housing and being rotatably connected to the housing.

[0011] A hanging ring is connected to the upper part of the rotating rod. The hanging ring is fixedly connected to the upper part of the rotating rod and is used to distinguish the position of the blocking disc inside the housing.

[0012] The curved outer wall of the blocking disc is covered with a rubber pad, which is fixedly connected to the curved outer wall of the blocking disc by a solvent bonding method.

[0013] The beneficial effects of the above-mentioned technical solution of this utility model are as follows:

[0014] 1. Protect metering pump components and maintain metering accuracy: Impurities are intercepted through an external filter screen to prevent particles or crystals from entering the metering pump and clogging the fine channels; at the same time, the number of times the metering pump is disassembled and cleaned is reduced to prevent damage to internal precision components due to improper operation, thus ensuring its long-term stable operation and metering accuracy.

[0015] 2. Dual anti-clogging structure enhances operational stability: The conical filter design combined with the air-blowing pipe backflushing structure allows liquid additives to be diverted from both sides of the filter, effectively reducing impurity accumulation; during cleaning, high-pressure gas is used for reverse flushing, which can quickly remove crystals and particulate matter, significantly reducing the risk of filter clogging and ensuring continuous and stable delivery of additives.

[0016] 3. Improved cleaning speed: The rotating baffle plate, combined with the rubber sealing layer, can quickly seal the shell outlet during cleaning operations, forming a directional high-pressure airflow channel to ensure that impurities are completely discharged from the outside of the shell.

[0017] 4. Simplified maintenance process: The connecting components consisting of a support frame and positioning bolts enable one-click disassembly and assembly of the filter screen. Replacement or deep cleaning can be completed without professional tools, which greatly reduces equipment downtime and avoids the component wear problems caused by frequent disassembly of traditional metering pumps. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the filter screen and connecting components of this utility model;

[0020] Figure 3 This is a schematic diagram of the overall structure of the other side of this utility model;

[0021] Figure 4 This is a schematic diagram of the blocking component structure of this utility model.

[0022] In the diagram: 101, housing; 102, filter screen;

[0023] 201. Support frame; 202. Mounting frame; 203. Positioning bolts;

[0024] 301. Air blowing tube;

[0025] 401. Blocking disc; 402. Rotating rod; 403. Hanging ring. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the following will be described in conjunction with the accompanying drawings of the embodiments of this utility model. Figure 1-4 The technical solutions of the embodiments of this utility model are clearly and completely described herein. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the described embodiments of this utility model are within the protection scope of this utility model.

[0027] An additive device for the production of pharmaceutical intermediates, such as Figure 1 As shown: It includes a housing 101, both ends of which are connected to the hopper and the metering pump respectively via flanges. The housing 101 is a cylindrical structure, which is made by rolling and welding steel plates during manufacturing. This increases its structural strength and can evenly distribute pressure (whether it is the pressure of the filter medium inside or the pressure of the surrounding environment outside). The cylindrical structure can withstand the pressure well and is not prone to deformation or cracking, thus ensuring the service life of the housing 101. A filter screen 102 is installed inside the housing 101. The filter screen 102 is a conical filter screen, which can reduce clogging (because the liquid additive can flow out from both sides of the conical filter screen, and the blocked impurities will stay at the smaller diameter end of the filter screen 102 due to continuous flushing, which can avoid clogging and will not affect the normal addition rate).

[0028] like Figure 1 , 2As shown: The filter screen 102 is connected to the inner wall of the housing 101 via a connecting assembly. This assembly allows for quick disassembly and assembly when the filter screen 102 is damaged or has not been disassembled for cleaning for a long time. The connecting assembly includes a support frame 201 disposed on the outer wall of the filter screen 102. The support frame 201 is a hollow disc structure, which facilitates fitting the shape of the housing 101 and is easy to connect to the outer wall of the filter screen 102. A mounting frame 202 is fixedly connected to one side of the support frame 201. The mounting frame 202 is also a hollow disc structure, which further facilitates fitting the shape of the housing 101.

[0029] The mounting frame 202 is connected to the housing 101 by multiple positioning bolts 203. The multiple positioning bolts 203 pass through the mounting frame 202 and are connected to the housing 101 by threaded engagement. When it is necessary to disassemble or assemble the filter screen 102, simply remove the multiple positioning bolts 203 and then pull out the filter screen 102 to complete the disassembly process.

[0030] like Figure 1 , 3 As shown: An air blowing pipe 301 is connected to the outer wall of the housing 101. The air blowing pipe 301 can be connected to an air pump or other equipment that can blow out gas. After each addition, only the pipe of the hopper needs to be disconnected. After disconnecting the pipe connected to the hopper, air can be blown into the air blowing pipe 301 to remove impurities on the filter screen 102 by high-pressure gas. This avoids damage to the metering pump due to impurities by eliminating the need for frequent disassembly and assembly of the metering pump, and further avoids the need for frequent disassembly and assembly of the metering pump for cleaning.

[0031] When the air tube 301 is not needed, it can be blocked with a plug or other obstruction to prevent the additive from flowing out of the air tube 301 when it is added.

[0032] The air blowing pipe 301 is welded to the outer wall of the housing 101, which improves the connection structure between the air blowing pipe 301 and the housing 101 and increases the stability of the air blowing pipe 301 on the housing 101. The air blowing pipe 301 is connected to the housing 101, that is, the housing 101 has a circular hole with the same diameter as the air blowing pipe 301. The outer wall of one end of the air blowing pipe 301 is welded to the inner wall of the circular hole, so that the air blown by the air pump or other equipment that can blow out air can enter the housing 101 through the air blowing pipe 301 to clean the filter screen 102.

[0033] like Figure 3 , 4As shown: A blocking assembly is provided inside the housing 101 and on the discharge end side of the filter screen 102. This assembly is used to keep one side of the housing 101 sealed when cleaning the filter screen. The blocking assembly includes a blocking disc 401 provided on the inner side wall of the housing 101. The blocking disc 401 can be opened when additives need to be added, that is, the arc-shaped outer wall of the blocking disc 401 faces both ends of the housing 101. Conversely, when cleaning the filter screen 102, the position of the blocking disc 401 is adjusted so that the plane of the blocking disc 401 is parallel to both ends of the housing 101.

[0034] A rotating rod 402 is fixedly connected to the upper part of the blocking disc 401. The rotating rod 402 passes through the housing 101 and is rotatably connected to the housing 101 through a bearing. The rotating rod 402 facilitates the adjustment of the position of the blocking disc 401, and can be quickly adjusted according to the usage scenario of the blocking disc 401. The rotating rod 402 passes through the housing 101 and is rotatably connected to the housing 101. The rotating rod 402 is directly rotatably connected to the hole opened in the housing 101. The rotating rod 402 can be limited by friction to prevent the blocking disc 401 from rotating due to the continuous flow of additives. Furthermore, it can prevent the blocking disc 401 from rotating and blocking the flow of additives, thus preventing the additives from flowing.

[0035] like Figure 3 , 4 As shown: A hanging ring 403 is connected to the upper part of the rotating rod 402. The hanging ring 403 facilitates the adjustment of the rotating rod 402, thereby facilitating the adjustment of the position of the blocking disc 401. Furthermore, the position of the blocking disc 401 can be determined by observing the orientation of the hanging ring 403. When the parallel plane of the hanging ring 403 is parallel to one end of the housing 101, the blocking disc 401 is in a closed state, and the additive cannot flow inside the housing 101. When the parallel plane of the hanging ring 403 is perpendicular to one end, the blocking disc 401 is in an open state, and the additive can flow inside the housing 101.

[0036] The arc-shaped outer wall of the baffle plate 401 is wrapped with a rubber pad, which can improve the sealing effect and further improve the cleaning speed and cleaning effect when cleaning the filter screen 102. The rubber pad is fixedly connected to the outer wall of the baffle plate 401 by a solvent bonding method, which can improve the stability of the rubber pad and prevent the rubber pad from falling off.

[0037] When in use, the end of housing 101 near the filter screen is installed at the outlet of the additive hopper through a pipe, while the other end of housing 101 is connected to the inlet of the metering pump through a flange, and the air pipe 301 is plugged with a plug to keep it sealed.

[0038] When additives need to be added, simply turn on the metering pump to allow the liquid additives to enter the metering pump through the housing 101 and its internal filter 102, and then add them during the production of pharmaceutical intermediates.

[0039] After adding the additive, when cleaning the filter 102 (to prevent clogging during the next use), open the plug and disconnect the pipe connecting to the additive hopper (this operation is required after each addition). Connect one end of the air blowing pipe 301 to the air pump through the pipe and adjust the position of the baffle plate 401 to close it. At this time, turn on the air pump to allow air to enter the housing 101 and continuously blow away the impurities on the filter 102. This allows the impurities on the filter 102 to be discharged from one side of the housing 101, thus preventing the filter 102 from clogging during the next use and further avoiding affecting the addition rate and effect during the next use.

[0040] Furthermore, it should be noted that, in the description of this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0041] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and these improvements and modifications should also be considered within the protection scope of this utility model.

Claims

1. An additive device for the production of pharmaceutical intermediates, characterized in that: Includes a housing (101), and a filter screen (102) is provided inside the housing (101); The filter screen (102) is configured as a conical filter screen; A blocking component is provided inside the housing (101) and on the discharge end side of the filter screen (102) to keep one side of the housing (101) sealed when cleaning the filter screen (102).

2. The additive device for pharmaceutical intermediate production as described in claim 1, characterized in that: The filter screen (102) is connected to the inner wall of the housing (101) via a connecting assembly, which allows for quick disassembly and assembly when the filter screen (102) needs to be replaced. The connecting assembly includes a support frame (201) disposed on the outer wall of the filter screen (102), and a mounting frame (202) is connected to one side of the support frame (201). The mounting frame (202) is connected to the housing (101) by a plurality of positioning bolts (203).

3. The additive device for pharmaceutical intermediate production as described in claim 2, characterized in that: An air blowing pipe (301) is connected to the outer wall of the housing (101). The air blowing pipe (301) is connected to the housing (101) and is used to blow air into the housing (101) to clean the filter screen (102).

4. The additive device for pharmaceutical intermediate production as described in claim 1, characterized in that: The blocking assembly includes a blocking disc (401) disposed on the inner sidewall of the housing (101), and a rotating rod (402) is connected to the blocking disc (401). The rotating rod (402) passes through the housing (101) and is rotatably connected to the housing (101).

5. The additive device for pharmaceutical intermediate production as described in claim 4, characterized in that: The upper part of the rotating rod (402) is connected to a hanging ring (403) for distinguishing the position of the blocking disc (401) inside the housing (101).

6. The additive apparatus for producing pharmaceutical intermediates as described in claim 4, characterized in that: The arc-shaped outer wall of the blocking disc (401) is covered with a rubber pad.

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