Reaction kettle for producing avibactam

Abstract

The utility model discloses a reaction kettle for producing avibactam, which comprises a reaction kettle body, supporting feet are arranged at the bottom of the reaction kettle body, a second motor is arranged at the bottom in the reaction kettle body, a rotary reaction cylinder is arranged on the second motor, the interior of the rotary reaction cylinder is divided into a liquid collecting cavity and a reaction cavity through a partition plate, and the liquid collecting cavity is communicated with the reaction cavity. An inner heating and stirring assembly and a temperature sensor are arranged in the reaction cavity, pressurizing boxes are arranged on the two sides of the inner wall of the reaction kettle, a cover plate is arranged on the reaction kettle, a heat conduction oil circulating box and a control box are arranged on the cover plate, and the second motor and the temperature sensor are electrically connected with the control box. According to the utility model, the heating speed and efficiency are improved through two heating modes of internal heating and external heating of the reaction cavity, so that the temperature in the reaction cavity can be quickly increased to a set value when being lower than the set value, the production stability is ensured, and the production quality and efficiency are improved.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology for producing avibactam, and more particularly to a reaction vessel for producing avibactam. Background Technology

[0002] Avibactam is a beta-lactamase inhibitor with antibacterial activity. However, existing reactors used for producing avibactam have the following drawbacks: When stirring the raw materials, the stirring device used in the reactor creates dead zones, resulting in uneven and insufficient mixing; the heating device is usually located on the outer wall, preventing the center of the reactor from being heated evenly; and the reaction temperature within the reactor becomes unstable over time due to heat loss, reducing production quality and efficiency. Utility Model Content

[0003] The purpose of this invention is to solve the technical problems existing in the prior art and to provide a reaction vessel for producing avibactam.

[0004] To achieve the above objectives, the technical solution provided by this utility model is: a reaction vessel for producing avibactam, comprising a reaction vessel, a supporting foot at the bottom of the reaction vessel, a second motor at the bottom of the reaction vessel, a rotating reaction cylinder mounted on the second motor, the rotating reaction cylinder being divided into a liquid collection chamber and a reaction chamber by a partition, an internal heating and stirring assembly and a temperature sensor being mounted in the reaction chamber, pressure boxes being mounted on both sides of the inner wall of the reaction vessel, a cover plate being mounted on the reaction vessel, a heat transfer oil circulation box and a control box being mounted on the cover plate, and the second motor and the temperature sensor being electrically connected to the control box.

[0005] Preferably, the internal heating stirring assembly includes a hollow rotating shaft, on which an arc-shaped perforated plate is provided, and the hollow rotating shaft is in communication with the interior of the arc-shaped perforated plate.

[0006] Preferably, the hollow rotating shaft is connected to the cover plate, a driven bevel gear is provided on the hollow rotating shaft, a first motor is fixedly provided at the bottom of the cover plate, a main bevel gear is provided at the output end of the first motor, and the main bevel gear meshes with the driven bevel gear.

[0007] Preferably, the heat transfer oil circulation tank is equipped with a heating device, and the heat transfer oil circulation tank is equipped with an input pipe and an output pipe assembly. The heat transfer oil circulation tank is connected to the bottom of the reactor through the input pipe. The output pipe assembly includes an output main pipe and an output side pipe. The output main pipe is connected to the hollow rotating shaft, and the output side pipe is connected to the pressure tank.

[0008] Preferably, the input pipe, the main output pipe, and the output side pipe are all equipped with solenoid valves. One end of the input pipe is connected to the heat transfer oil circulation tank, and the other end of the input pipe is connected to the reaction vessel. A pump body is installed on the input pipe.

[0009] Preferably, the rotating reaction cylinder is further provided with a placement frame, and a desiccant is placed in the placement frame.

[0010] Preferably, the pressure chamber has multiple nozzles arranged at equal intervals in both the longitudinal and transverse directions on its surface.

[0011] The beneficial effects of this utility model are:

[0012] In this invention, when the temperature sensor detects that the temperature inside the rotating reaction cylinder is lower than the set value, the control box controls the heat transfer oil circulation tank and the solenoid valve to start. The internal heating and stirring assembly drives the arc-shaped perforated plate to agitate and stir the raw materials. While the hollow rotating shaft and the arc-shaped perforated plate agitate and stir the raw materials, they are heated by heat transfer oil. The raw materials are heated from inside the reaction chamber, and then the heat transfer oil is evenly sprayed out through the nozzle on the pressurization box to heat the outer wall of the rotating reaction cylinder. This invention improves the heating speed and efficiency by using two heating methods, internal heating and external heating, so that when the temperature inside the reaction chamber is lower than the set value, it can quickly rise to the set value, ensuring production stability and improving production quality and efficiency. Attached Figure Description

[0013] The accompanying drawings, which are provided to further illustrate the present invention and constitute a part of the present invention, illustrate exemplary embodiments of the present invention and are used to explain the present invention, but do not constitute an undue limitation of the present invention.

[0014] Figure 1 This is a schematic diagram of the overall structure of a preferred embodiment of the present invention;

[0015] Figure 2 This is a schematic diagram of the structure of the heat transfer oil circulation box of this utility model;

[0016] Figure 3 This is a schematic diagram of the nozzle structure of this utility model.

[0017] Attached image captions:

[0018] 1-Reaction vessel 2-Cover plate 3-Output side pipe 4-Heat transfer oil circulation box 5-Main bevel gear 6-First motor 7-Output main pipe 8-Passive bevel gear 9-Hollow rotating shaft 10-Arc-shaped orifice plate 11-Rotating reaction cylinder 12-Pressure chamber 13-Input pipe 14-Solenoid valve 15-Baffle plate 16-Drain pipe 17-Second motor 18-Collection chamber 19-Control box 20-Temperature sensor 21-Placement frame 22-Supporting foot 23-Pump body 24-Nozzle 25-Heating device. Detailed Implementation

[0019] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but they should not be construed as limiting the scope of protection of the present utility model.

[0020] In the description of this utility model, it should be understood that the directional descriptions, such as up, down, front, back, left, right, etc., indicate the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0021] In the description of this utility model, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. If "first" or "second" is used in the description, it is only for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the order of the indicated technical features.

[0022] In the description of this utility model, unless otherwise explicitly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in conjunction with the specific content of the technical solution.

[0023] Reference Figures 1-3 In a preferred embodiment of this utility model, a reactor for producing avibactam includes a reactor 1. The reactor 1 has a supporting foot 22 at its bottom. A second motor 17 is installed at the bottom of the reactor 1, and a rotating reaction cylinder 11 is mounted on the second motor 17. (Preferably, the top plate of the rotating reaction cylinder 11 is detachable.) The rotating reaction cylinder 11 is divided into a liquid collection chamber 18 and a reaction chamber by a partition 15. An internal heating and stirring assembly and a temperature sensor 20 are installed in the reaction chamber. Pressure tanks 12 are installed on both sides of the inner wall of the reactor 1. A cover plate 2 (detachable) is installed on the reactor 1. A heat transfer oil circulation tank 4 and a control box 19 are installed on the cover plate 2. The second motor 17 and the temperature sensor 20 are both electrically connected to the control box 19.

[0024] A heating device 25 is installed inside the heat transfer oil circulation tank 4. The heat transfer oil circulation tank 4 is equipped with an input pipe 13 and an output pipe assembly. The heat transfer oil circulation tank 4 is connected to the bottom of the reactor 1 through the input pipe 13. The output pipe assembly includes an output main pipe 7 and an output side pipe 3. The output main pipe 7 is connected to the hollow rotating shaft 9, and the output side pipe 3 is connected to the pressure tank 12. Switch valves 14 are installed on the input pipe 13, the output main pipe 7, and the output side pipe 3. One end of the input pipe 13 is connected to the heat transfer oil circulation tank 4, and the other end of the input pipe 13 is connected to the reactor 1. A pump body 23 is installed on the input pipe 13.

[0025] Specifically, the heat transfer oil in the hollow rotating shaft 9 flows into the liquid collection chamber 18 below the partition 15, and then is discharged into the reactor 1 through the discharge pipe 16. The heat transfer oil sprayed out from the pressurization box 12 also falls into the reactor 1 after heating the rotating reaction cylinder 11. Both are pumped into the heat transfer oil circulation box 4 through the input pipe 13, thereby realizing the recycling of heat transfer oil.

[0026] Multiple nozzles 24 are equidistantly arranged on the surface of the pressure chamber 12 in both the longitudinal and transverse directions. Specifically, a booster pump is installed inside the pressure chamber 12. The heat transfer oil is introduced into the pressure chambers 12 on both sides through the output side pipe 3. After being pressurized by the pressure chamber 12, the heat transfer oil is evenly sprayed out through the nozzles 24 to heat the raw materials from the outer wall of the reaction chamber.

[0027] The internal heating and stirring assembly includes a hollow rotating shaft 9, on which an arc-shaped perforated plate 10 is provided, and the hollow rotating shaft 9 communicates internally with the arc-shaped perforated plate 10. The hollow rotating shaft 9 is connected to the cover plate 2. Specifically, both the cover plate 2 and the partition plate 15 are provided with grooves, and the partition plate 15 is also provided with through holes communicating with the grooves. A driven bevel gear 8 is provided on the hollow rotating shaft 9. A first motor 6 is fixedly provided at the bottom of the cover plate 2, and a main bevel gear 5 is provided at the output end of the first motor 6. The main bevel gear 5 meshes with the driven bevel gear 8.

[0028] Specifically, the first motor 6 drives the hollow rotating shaft 9 to rotate, which in turn drives the arc-shaped orifice plate 10 to stir and agitate the raw materials for producing avibactam, making the reaction more complete and uniform. While the hollow rotating shaft 9 and the arc-shaped orifice plate 10 stir and agitate the raw materials, they are heated by heat transfer oil from inside the reaction chamber.

[0029] Furthermore, the temperature sensor 20 is used to monitor the temperature of the rotating reaction cylinder 11. When the temperature sensor 20 detects that the temperature inside the rotating reaction cylinder 11 is lower than the set value, the control box 19 controls the heating device 25 (preferably an electric heating wire) and the solenoid valve 14 in the heat transfer oil circulation box 4 to start heating the rotating reaction cylinder 11. When the temperature reaches the set value, the control box 19 controls the heating device 25 and the solenoid valve 14 in the heat transfer oil circulation box 4 to close.

[0030] The rotating reaction cylinder 11 is also equipped with a placement frame 21, in which a desiccant is placed. This ensures the dryness of the reaction chamber during the reaction process.

[0031] The working principle of this utility model is as follows: First, the control box 19 presets a temperature value suitable for the production of avibactam. When the temperature sensor 20 detects that the temperature inside the rotating reaction cylinder 11 is lower than the set value, the control box 19 controls the heat transfer oil circulation tank 4 and the solenoid valve 14 to start, starting the first motor 6 and the second motor 17 (the first motor 6 and the second motor 17 are equipped with high-temperature resistant protective sleeves). The first motor 6 drives the main bevel gear 5 to rotate, thereby driving the driven bevel gear 8 to rotate, which in turn drives the hollow rotating shaft 9 and the arc-shaped perforated plate 10 in the reaction chamber to rotate, thereby agitating and stirring the raw materials. While stirring, the second motor 17 drives the rotating reaction cylinder 11 to rotate. The heat transfer oil is introduced into the pressure tanks 12 on both sides through the output side pipe 3. After being pressurized by the pressure tank 12, the heat transfer oil is sprayed out through the nozzle 24 to uniformly heat the outer wall of the rotating reaction cylinder 11. Next, the heat transfer oil in the hollow rotating shaft 9 flows into the liquid collection chamber 18, and then is discharged into the storage reactor 1 through the discharge pipe 16. The heat transfer oil sprayed out by the pressure tank 12 also falls into the reactor 1. Finally, the heat transfer oil is pumped into the heat transfer oil circulation tank 4 through the input pipe 13, thereby realizing the recycling of the heat transfer oil.

[0032] In this invention, when the temperature sensor 20 detects that the temperature inside the rotating reaction cylinder 11 is lower than the set value, the control box 19 controls the heat transfer oil circulation box 4 and the solenoid valve 14 to start. The internal heating and stirring assembly drives the arc-shaped perforated plate 10 to stir and agitate the raw materials. While the hollow rotating shaft 9 and the arc-shaped perforated plate 10 stir and agitate the raw materials, the heat transfer oil heats the raw materials from inside the reaction chamber. Then, the heat transfer oil is evenly sprayed out through the nozzle 24 on the pressure box 12 to heat the outer wall of the rotating reaction cylinder 11. This invention improves the heating speed and efficiency by using two heating methods, internal heating and external heating, so that when the temperature inside the reaction chamber is lower than the set value, it can quickly rise to the set value, ensuring the stability of production and improving production quality and efficiency.

[0033] Without causing conflict, those skilled in the art can freely combine and use the above-mentioned additional technical features.

[0034] The above description is only a preferred embodiment of the present utility model. Any technical solution that achieves the purpose of the present utility model by essentially the same means shall fall within the protection scope of the present utility model.

Claims

1. A reactor for producing avibactam, characterized in that: The reactor includes a reaction vessel (1), with a support foot (22) at the bottom. A second motor (17) is installed at the bottom of the reactor (1), and a rotating reaction cylinder (11) is installed on the second motor (17). The rotating reaction cylinder (11) is divided into a liquid collection chamber (18) and a reaction chamber by a partition (15). An internal heating and stirring assembly and a temperature sensor (20) are installed in the reaction chamber. A pressure box (12) is installed on both sides of the inner wall of the reactor (1). A cover plate (2) is installed on the reactor (1), and a heat transfer oil circulation box (4) and a control box (19) are installed on the cover plate (2). The second motor (17) and the temperature sensor (20) are electrically connected to the control box (19).

2. The reactor for producing avibactam according to claim 1, characterized in that: The internal heating stirring assembly includes a hollow rotating shaft (9), on which an arc-shaped perforated plate (10) is provided, and the hollow rotating shaft (9) is internally connected to the arc-shaped perforated plate (10).

3. The reactor for producing avibactam according to claim 2, characterized in that: The hollow shaft (9) is connected to the cover plate (2). A driven bevel gear (8) is provided on the hollow shaft (9). A first motor (6) is fixedly provided at the bottom of the cover plate (2). A main bevel gear (5) is provided at the output end of the first motor (6). The main bevel gear (5) meshes with the driven bevel gear (8).

4. The reactor for producing avibactam according to claim 2, characterized in that: The heat transfer oil circulation tank I (4) is equipped with a heating device (25). The heat transfer oil circulation tank (4) is equipped with an input pipe (13) and an output pipe group. The heat transfer oil circulation tank (4) is connected to the bottom of the reactor (1) through the input pipe (13). The output pipe group includes an output main pipe (7) and an output side pipe (3). The output main pipe (7) is connected to the hollow rotating shaft (9). The output side pipe (3) is connected to the pressure tank (12).

5. The reactor for producing avibactam according to claim 4, characterized in that: Solenoid valves (14) are provided on the input pipe (13), the main output pipe (7), and the output side pipe (3). One end of the input pipe (13) is connected to the heat transfer oil circulation tank (4), and the other end of the input pipe (13) is connected to the reactor (1). A pump body (23) is provided on the input pipe (13).

6. The reactor for producing avibactam according to claim 1, characterized in that: The rotating reaction cylinder (11) is also provided with a placement frame (21), and a desiccant is placed in the placement frame (21).

7. The reactor for producing avibactam according to claim 1, characterized in that: The pressure chamber (12) has multiple nozzles (24) arranged at equal intervals in both the longitudinal and transverse directions on its surface.

Images