Triple negative breast cancer biological pathology analysis section sampling tool
By improving the structural design of the pathological slide sampling tool, and adopting a sliding mechanism between the nut block and the lead screw and a rotating mechanism between the shaft and the connecting rod, the problems of cumbersome cutting operations and low efficiency in the existing technology have been solved, achieving rapid cutting and controllable thickness.
Patent Information
- Application Number
- CN202520420528.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-11
- Publication Date
- 2026-02-10
- Estimated Expiration
- 2035-03-11
AI Technical Summary
Existing pathological embedded tissue sectioning machines are cumbersome to operate during the cutting process, inconvenient to rotate the screw sleeve, slow to cut, and difficult to control the section thickness, resulting in low efficiency.
The design employs a sliding fit between the nut block and the lead screw, and a rotating device between the shaft and the connecting rod. The nut block and the slider are driven by a crank to slide and rotate within the groove, thereby achieving horizontal and vertical movement of the pallet. The thickness of the slice is controlled by the scale lines.
It enables rapid cutting and convenient control of the slicing process, improving the accuracy of slice thickness and cutting efficiency.
Smart Images
Figure CN223897064U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of slide sampling technology, and more specifically, to a slide sampling tool for biopathological analysis of triple-negative breast cancer. Background Technology
[0002] Triple-negative breast cancer is a subtype of breast cancer characterized by negative estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). This type of breast cancer accounts for approximately 10-15% of all breast cancer cases and is characterized by its high invasiveness, high recurrence rate, and poor prognosis. Pathological section analysis of triple-negative breast cancer is a crucial step in diagnosis and treatment. A certain size of lesion tissue is taken and prepared into pathological sections using histological methods (usually, the lesion tissue is embedded in a paraffin block, cut into thin sections using a microtome, and then stained with hematoxylin and eosin). The lesion is further examined under a microscope to observe its occurrence and development process, and finally, a diagnosis is made.
[0003] The existing patent publication number CN 216559799 U discloses a pathological embedded tissue slicer. The pathological block is placed on the pressing block, and when the pressing block is released, it clamps the pathological block tightly. Due to the limiting effect of two telescopic rods, the screw begins to move and drives the pathological block on the U-shaped block to fit against the blade. This makes the pathological block stable when cutting, and the distance between the pathological block and the blade can be adjusted in time. However, the operation of rotating the screw sleeve is relatively cumbersome and it is not easy to control the cutting thickness. Moreover, the transmission method of reciprocating screw and nut block will make the cutting speed slow, requiring many rotations to cut one piece, resulting in low efficiency.
[0004] In view of this, we have studied and improved upon the existing problems to provide a biopathological analysis slide sampling tool for triple-negative breast cancer. The aim of this technology is to solve the problems and improve its practical value. Utility Model Content
[0005] The purpose of this invention is to provide a biopathological analysis slide sampling tool for triple-negative breast cancer, so as to solve the problems and deficiencies mentioned in the background art.
[0006] To achieve the above objectives, this utility model provides a sampling tool for biopathological analysis of triple-negative breast cancer slides, which is achieved through the following specific technical means:
[0007] A biopathological analysis slide sampling tool for triple-negative breast cancer includes: a base, a column, a groove, a lead screw, a first crank handle, a nut block, a support plate, a blade assembly, a storage box, a pointer, scale lines, a slider, a clamping device, a rotating sleeve, a rotating shaft, a turntable, a second crank handle, and a connecting rod; one end of the base has a column, and the top of the base has a groove; both ends of the lead screw are mounted on the inner wall of the groove via bearings, and the end of the lead screw extending to the outside of the base has a first crank handle; the nut block is inserted and slidably connected to the inner wall of the groove via a clearance fit, and the nut block is connected to the lead screw via a threaded rotation, and the top of the nut block has a support plate; A blade device is fixedly installed on the side of the tray near the column, and a storage box is placed on the top of the tray; a pointer is provided on the outer wall of the tray, and a scale line is provided on the outer wall of the base near the pointer; the slider is inserted and connected to the inner wall of the column by a clearance fit, and a clamping device is provided at one end of the slider, and the clamping device is located outside the column; a rotating sleeve is provided on the inner wall of the column, and a rotating shaft is installed on the inner wall of the rotating sleeve through a bearing; a turntable is inserted and connected to the end of the rotating shaft inside the column, and a second crank is fixedly connected to the end of the rotating shaft outside the column, and the two ends of the connecting rod are connected to the outer walls of the slider and the turntable through bearing sleeves.
[0008] As a further optimization of this technical solution, the nut block of the sampling tool for biopathological analysis of triple-negative breast cancer is inserted and connected to the inner wall of the slide groove as a sliding device, and the outer wall of the nut block is provided with a threaded hole for cooperating with the lead screw.
[0009] As a further optimization of this technical solution, the slide of the sampling tool for biopathological analysis of triple-negative breast cancer of this utility model has round holes at both ends for installing bearings, and the two ends of the lead screw are connected to the inner walls of the two ends of the slide through the bearings to form a rotating device.
[0010] As a further optimization of this technical solution, the slider of the sampling tool for biopathological analysis of triple-negative breast cancer is inserted and connected to the inner wall of the column as a sliding device.
[0011] As a further optimization of this technical solution, the rotating shaft of the sampling tool for biopathological analysis of triple-negative breast cancer is connected to the inner wall of the rotating sleeve through a bearing and serves as a rotating device.
[0012] As a further optimization of this technical solution, the outer walls of the turntable and the slider of the sampling tool for biopathological analysis of triple-negative breast cancer of this utility model are provided with cylindrical protrusions, and the two ends of the connecting rod are provided with round holes for installing bearings. The two ends of the connecting rod are connected to the outer walls of the slider and the turntable through the bearings to form a rotating device.
[0013] Due to the application of the above technical solution, this utility model has the following advantages compared with the prior art:
[0014] 1. The nut block of this utility model is inserted and connected to the inner wall of the slide groove as a sliding device, and the outer wall of the nut block is provided with a threaded hole for cooperating with the lead screw; the two ends of the slide groove are provided with round holes for installing bearings, and the two ends of the lead screw are inserted and connected to the inner walls of the two ends of the slide groove through the bearings as a rotating device. Shaking the first crank handle can rotate the lead screw, which can make the nut block slide on the inner wall of the slide groove, and can make the pallet move horizontally for feeding and cutting.
[0015] 2. In this utility model, the slider is inserted and connected to the inner wall of the column as a sliding device; the rotating shaft is inserted and connected to the inner wall of the rotating sleeve through the bearing as a rotating device; both the outer walls of the turntable and the slider are provided with cylindrical protrusions, and the two ends of the connecting rod are provided with round holes for installing bearings, and the two ends of the connecting rod are connected to the outer walls of the slider and the turntable through the bearings as a rotating device. Shaking the second crank handle once can make the turntable rotate, which can make the connecting rod pull the slider up and down, so that the clamping device clamps the cutting tissue and moves it relative to the blade device for cutting.
[0016] 3. This utility model improves a biopathological analysis slide sampling tool for triple-negative breast cancer, which has the advantages of reasonable structural design, rapid cutting, and easy control of slide thickness, thus effectively solving the problems and shortcomings of existing technologies and equipment. Attached Figure Description
[0017] The accompanying drawings, which form part of this application, are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an undue limitation of the present invention. In the drawings:
[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;
[0019] Figure 2 This is a schematic diagram of the exploded structure of this utility model;
[0020] Figure 3 This is a schematic diagram of the cross-sectional structure of this utility model;
[0021] Figure 4 This is a schematic diagram of the cross-sectional structure of this utility model;
[0022] Figure 5 This is a partial structural schematic diagram of the present invention.
[0023] In the diagram: 1. Base; 2. Column; 3. Slide; 4. Lead screw; 5. First crank handle; 6. Nut block; 7. Support plate; 8. Blade device; 9. Storage box; 10. Pointer; 11. Scale line; 12. Slider; 13. Clamping device; 14. Rotating sleeve; 15. Rotating shaft; 16. Turntable; 17. Second crank handle; 18. Connecting rod. Detailed Implementation
[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0025] Please see Figures 1 to 5 This utility model provides a specific technical implementation scheme for a biopathological analysis slide sampling tool for triple-negative breast cancer:
[0026] A biopathological analysis slide sampling tool for triple-negative breast cancer includes: a base 1, a column 2, a groove 3, a lead screw 4, a first crank handle 5, a nut block 6, a support plate 7, a blade assembly 8, a storage box 9, a pointer 10, a scale line 11, a slider 12, a clamping device 13, a rotating sleeve 14, a rotating shaft 15, a turntable 16, a second crank handle 17, and a connecting rod 18; the base 1 has a column 2 at one end, and a groove 3 at the top; the two ends of the lead screw 4 are mounted on the inner wall of the groove 3 via bearings, and the first crank handle 5 is located at the end of the lead screw 4 extending to the outside of the base 1; the nut block 6 slides with a clearance fit. The nut block 6 is inserted into the inner wall of the slide groove 3, and is connected to the lead screw 4 by a threaded rotation. The top of the nut block 6 is provided with a support plate 7. The nut block 6 is inserted into the inner wall of the slide groove 3 as a sliding device, and the outer wall of the nut block 6 is provided with a threaded hole for cooperating with the lead screw 4. The two ends of the slide groove 3 are provided with round holes for installing bearings, and the two ends of the lead screw 4 are inserted into the inner walls of the two ends of the slide groove 3 by bearings as a rotating device. Shaking the first crank handle 5 can rotate the lead screw 4, which can make the nut block 6 slide on the inner wall of the slide groove 3, and can make the support plate 7 move horizontally for feeding and cutting.
[0027] A blade device 8 is fixedly installed on the side of the tray 7 near the column 2, and a storage box 9 is placed on the top of the tray 7; a pointer 10 is provided on the outer wall of the tray 7, and a scale line 11 is provided on the outer wall of the base 1 near the pointer 10; a slider 12 is inserted and connected to the inner wall of the column 2 by a clearance fit sliding method, and a clamping device 13 is provided at one end of the slider 12, and the clamping device 13 is located outside the column 2; the slider 12 is inserted and connected to the inner wall of the column 2 as a sliding device; the rotating shaft 15 is connected by a bearing The rotating device is connected to the inner wall of the rotating sleeve 14; the outer walls of the turntable 16 and the slider 12 are provided with cylindrical protrusions, and the two ends of the connecting rod 18 are provided with round holes for installing bearings. The two ends of the connecting rod 18 are connected to the outer walls of the slider 12 and the turntable 16 through bearing sleeves to form the rotating device. Shaking the second crank 17 once will make the turntable 16 rotate, which will make the connecting rod 18 pull the slider 12 up and down, so that the clamping device 13 clamps the cutting tissue and moves it relative to the blade device 8 for cutting.
[0028] The inner wall of the column 2 is provided with a rotating sleeve 14, and the rotating shaft 15 is mounted on the inner wall of the rotating sleeve 14 through a bearing; one end of the rotating shaft 15 located inside the column 2 is connected to a turntable 16, and the other end of the rotating shaft 15 located outside the column 2 is fixedly connected to a second rocker handle 17, and both ends of the connecting rod 18 are connected to the outer walls of the slider 12 and the turntable 16 through bearing sleeves.
[0029] Specific implementation steps:
[0030] The tissue to be cut is clamped in the clamping device 13. Shaking the first crank handle 5 can rotate the lead screw 4, which can make the nut block 6 slide on the inner wall of the slide groove 3, and can make the support plate 7 move horizontally to move the blade device 8 to the tissue to be cut. Shaking the second crank handle 17 one revolution can make the turntable 16 rotate, which can make the connecting rod 18 pull the slider 12 up and down, so that the clamping device 13 clamps the tissue to be cut and moves relative to the blade device 8 for cutting. Shaking the first crank handle 5 according to the relative position of the pointer 10 and the scale line 11 feeds the cutting, which makes it easy to control the thickness of the slice.
[0031] In summary: This sampling tool for biopathological analysis of triple-negative breast cancer comprises a sliding device consisting of a nut block inserted into the inner wall of a chute, and a threaded hole on the outer wall of the nut block for engaging a lead screw. The chute has round holes at both ends for mounting bearings, and the lead screw is connected to the inner walls of both ends of the chute via these bearings, forming a rotating mechanism. Rotating the first crank handle rotates the lead screw, allowing the nut block to slide along the inner wall of the chute, thus moving the pallet horizontally for feeding and cutting. A slider is inserted into the inner wall of the column, also forming a sliding mechanism. A rotating shaft is connected to the inner wall of the rotating sleeve via bearings, forming a rotating mechanism. The device features cylindrical protrusions on the outer walls of both the turntable and the slider, and circular holes for mounting bearings are provided at both ends of the connecting rod. The two ends of the connecting rod are connected to the outer walls of the slider and the turntable via the bearings, forming a rotating mechanism. Shaking the second crank handle once rotates the turntable, causing the connecting rod to pull the slider up and down, which in turn moves the clamping device relative to the blade device to perform cutting. Through the improvement of a biopathological analysis slide sampling tool for triple-negative breast cancer, the device has the advantages of reasonable structural design, rapid cutting, and easy control of slide thickness, thus effectively solving the problems and shortcomings of existing technologies and equipment.
[0032] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A sampling tool for biopathological analysis of triple-negative breast cancer slides, comprising: The base (1), column (2), slide groove (3), lead screw (4), first crank handle (5), nut block (6), support plate (7), blade device (8), storage box (9), pointer (10), scale line (11), slider (12), clamping device (13), rotating sleeve (14), rotating shaft (15), turntable (16), second crank handle (17), connecting rod (18) are characterized in that: one end of the base (1) is provided with a column (2), and the top end of the base (1) is provided with a slide groove (3); both ends of the lead screw (4) are mounted on the inner wall of the slide groove (3) by bearings, and the end of the lead screw (4) extending to the outside of the base (1) is provided with a first crank handle (5); the nut block (6) is inserted and connected to the inner wall of the slide groove (3) by clearance fit sliding, and the nut block (6) is connected to the lead screw (4) by thread rotation, and the top end of the nut block (6) is provided with a support plate (7); the support plate (7) is close to A blade device (8) is fixedly installed on one side of the column (2), and a storage box (9) is placed on the top of the tray (7); a pointer (10) is provided on the outer wall of the tray (7), and a scale line (11) is provided on the outer wall of the base (1) near the pointer (10); the slider (12) is inserted and connected to the inner wall of the column (2) by a clearance fit sliding method, and a clamping device (13) is provided at one end of the slider (12), and the clamping device (13) is located at The outside of the column (2); the inner wall of the column (2) is provided with a rotating sleeve (14), and the rotating shaft (15) is installed on the inner wall of the rotating sleeve (14) through a bearing; the end of the rotating shaft (15) located inside the column (2) is connected to a turntable (16), and the end of the rotating shaft (15) located outside the column (2) is fixedly connected to a second rocker arm (17), and the two ends of the connecting rod (18) are connected to the outer wall of the slider (12) and the turntable (16) through a bearing sleeve.
2. The biopathological analysis slide sampling tool for triple-negative breast cancer according to claim 1, characterized in that: The nut block (6) is inserted into the inner wall of the slide groove (3) as a sliding device, and the outer wall of the nut block (6) is provided with a threaded hole for cooperating with the lead screw (4).
3. The biopathological analysis slide sampling tool for triple-negative breast cancer according to claim 1, characterized in that: The slide groove (3) has round holes for installing bearings at both ends, and the two ends of the lead screw (4) are connected to the inner walls of the two ends of the slide groove (3) through the bearings to form a rotating device.
4. The biopathological analysis slide sampling tool for triple-negative breast cancer according to claim 1, characterized in that: The slider (12) is inserted into the inner wall of the column (2) as a sliding device.
5. The biopathological analysis slide sampling tool for triple-negative breast cancer according to claim 1, characterized in that: The rotating shaft (15) is connected to the inner wall of the rotating sleeve (14) by a bearing and is a rotating device.
6. The biopathological analysis slide sampling tool for triple-negative breast cancer according to claim 1, characterized in that: Both the turntable (16) and the slider (12) have cylindrical protrusions on their outer walls, and the two ends of the connecting rod (18) are provided with round holes for installing bearings. The two ends of the connecting rod (18) are connected to the outer walls of the slider (12) and the turntable (16) through the bearings to form a rotating device.