Distributing device of chromatographic column

Abstract

The utility model discloses a distribution device of a chromatographic column, which comprises a mounting seat and a guide pipe arranged in the mounting seat in a liftable manner, a cleaning pipeline is arranged on the mounting seat, a pull rod is arranged in the guide pipe in a penetrating manner, one end of the pull rod is detachably connected with a connecting piece, the peripheral side of the connecting piece is connected with a screen, a liquid outlet is arranged at the bottom of the connecting piece, and the liquid outlet is communicated with the cleaning pipeline. A sealing piece is arranged at the bottom of the guide pipe, and when the sealing piece seals the liquid outlet, a backflow channel is formed between the cleaning pipeline and the guide pipe. The utility model has the advantages that the structure is simple, and the connecting piece and the screen are convenient to disassemble and maintain.

Description

TECHNICAL FIELD

[0001] The utility model relates to food, medicine packing technical field, concretely relates to a distribution device of chromatographic column. BACKGROUND

[0002] In the chromatographic separation technology, the distribution device is one of the key components of the chromatographic column, which is used to distribute the sample evenly to the filler of the chromatographic column. For the chromatographic column with small inner diameter, the connecting piece of the distribution device is usually fixed with the screen mesh in the form of screw thread installation. This design is simple and reliable, and easy to be disassembled and maintained by the operator. However, for the chromatographic column with large inner diameter, the arm of the operator cannot screw the connecting piece from the side due to the limited operation space, and the screen mesh needs to be replaced frequently after a long time of use, which makes the disassembly and maintenance very inconvenient and affects the process efficiency. SUMMARY

[0003] The technical problem to be solved by the utility model is to overcome the deficiencies of the prior art, and provide a distribution device of chromatographic column which is simple in structure and convenient for disassembly and maintenance of the connecting piece and the screen mesh.

[0004] To solve the above technical problems, the utility model adopts the following technical scheme:

[0005] A distribution device of chromatographic column, comprising a mounting seat and a guide pipe which is arranged in the mounting seat in a liftable manner, a cleaning pipeline is arranged on the mounting seat, a pull rod is arranged in the guide pipe, one end of the pull rod is detachably connected with a connecting piece, the connecting piece is connected with a screen mesh on the side, a liquid outlet is arranged at the bottom of the connecting piece, a sealing element is arranged at the bottom of the guide pipe, and a backflow channel is formed between the cleaning pipeline and the guide pipe when the sealing element seals the liquid outlet.

[0006] As a further improvement of the above technical scheme:

[0007] A secondary pipeline is arranged outside the guide pipe, a first cavity and a second cavity are arranged in the mounting seat, the diameter of the first cavity is larger than that of the second cavity, the first cavity is communicated with the cleaning pipeline, the secondary pipeline is arranged in the first cavity and the second cavity in a liftable manner, the backflow channel comprises a cleaning channel and an inlet-outlet liquid channel, the cleaning channel is arranged between the guide pipe and the secondary pipeline, the inlet-outlet liquid channel is arranged between the guide pipe and the pull rod, and a plurality of through holes are arranged on the side of the guide pipe in a spaced manner.

[0008] A first sealing ring for sealing the first cavity is arranged at the top of the secondary pipeline.

[0009] A second sealing ring for sealing the second cavity is arranged on the side of the secondary pipeline.

[0010] A reverse tapered groove is arranged on the connecting piece, the sealing element is cylindrical, and a gap is left between the reverse tapered groove and the cylindrical sealing element.

[0011] The installation seat is internally provided with an air cavity, the catheter is externally provided with a pushing seat, the air cavity is communicated with an air hole, and the air hole is connected with an air pump to drive the pushing seat to descend in the air cavity.

[0012] The installation seat is internally provided with a reset cavity, the reset cavity is internally provided with a reset spring, the catheter is externally provided with a limiting seat, and the reset spring is located between the limiting seat and the pushing seat.

[0013] The installation seat is internally provided with a chromatography channel, one end of the chromatography channel is communicated with a chromatography pipeline, and one end of the chromatography channel is communicated with a screen.

[0014] The other end of the pull rod is detachably connected with the installation seat through a locking piece.

[0015] The sealing piece is provided with a sealing gasket at the bottom.

[0016] Compared with the prior art, the advantages of the utility model lie in that:

[0017] The distribution device of the chromatography column disclosed by the utility model is detachably connected with the connecting piece through the pull rod penetrating in the catheter, the disassembly and assembly of the connecting piece and the pull rod top are realized, the connecting piece does not need to be screwed from the side, the problem that the operation is limited due to the too large inner diameter of the chromatography column is solved, and the disassembly and assembly maintenance of the connecting piece and the screen are facilitated. In addition, the distribution device can also realize cleaning without disassembling the pipe, the catheter is lowered, the sealing piece seals the liquid outlet at the bottom of the connecting piece, after the cleaning pipeline is filled with cleaning liquid, the catheter interior is cleaned through the backflow channel, the catheter is raised, the sealing piece releases the sealing of the connecting piece, and the catheter seals the cleaning pipeline at this time, the cleaning liquid is filled from the catheter top, sequentially flows through the catheter and the connecting piece, and finally flows out from the liquid outlet at the bottom of the connecting piece, so that the catheter and the connecting piece are cleaned. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a cross-sectional structure schematic view of the distribution device of the chromatography column.

[0019] Figure 2 It is a flow direction schematic view of the cleaning liquid when reverse cleaning.

[0020] Figure 3 It is a flow direction schematic view of the cleaning liquid when forward cleaning.

[0021] Figure 4 It is a flow direction schematic view of the process liquid when chromatography.

[0022] The numbers in the figure represent: 1, mounting seat; 11, chromatography channel; 12, first cavity; 13, second cavity; 14, air cavity; 15, reset cavity; 16, reset spring; 2, catheter; 21, cleaning channel; 22, sealing element; 221, sealing pad; 23, auxiliary pipeline; 231, first sealing ring; 232, second sealing ring; 24, through hole; 25, pushing seat; 26, limiting seat; 3, cleaning pipeline; 4, chromatography pipeline; 5, connecting piece; 51, inverted conical groove; 6, screen; 7, pull rod; 8, locking piece; 9, inlet and outlet liquid channel. DETAILED DESCRIPTION

[0023] The utility model will be explained in further detail below in combination with the drawings and specific embodiments.

[0024] In the description of the utility model, it is understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the utility model and simplifying the description, and do not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the utility model.

[0025] In addition, the terms "first" and "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the utility model, the meaning of "multiple" is two or more, unless otherwise specifically limited.

[0026] In the utility model, unless otherwise specifically defined and limited, the terms "assembly", "connection", "connection", "fixing" and the like should be understood broadly, for example, can be fixedly connected, or can be detachably connected, or can be integrated; can be mechanically connected, or can be electrically connected; can be directly connected, or can be indirectly connected through an intermediate medium; can be the communication or interaction relationship between two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0027] Figures 1 to 4An embodiment of the distribution device of the chromatography column is shown, the distribution device of the chromatography column of the embodiment comprises a mounting seat 1 and a guide pipe 2 arranged in the mounting seat 1 in a liftable manner, a cleaning pipe 3 is arranged on the mounting seat 1, a pull rod 7 is arranged in the guide pipe 2, one end of the pull rod 7 is detachably connected with a connecting piece 5, the connecting piece 5 is connected with a screen 6 in a peripheral side, a liquid outlet is arranged at the bottom of the connecting piece 5, a sealing piece 22 is arranged at the bottom of the guide pipe 2, when the sealing piece 22 seals the liquid outlet, a backflow channel is formed between the cleaning pipe 3 and the guide pipe 2.

[0028] The distribution device of the chromatography column is detachably connected with the connecting piece 5 through the pull rod 7 arranged in the guide pipe 2, the disassembly and assembly of the connecting piece 5 and the screen 6 are realized by operating the top of the pull rod 7, the connecting piece 5 does not need to be screwed from the side, the problem that the operation is limited due to the too large inner diameter of the chromatography column is solved, and the disassembly and assembly maintenance of the connecting piece 5 and the screen 6 are facilitated. Figure 2 A reverse cleaning path is shown, at this time, the guide pipe 2 is lowered, the sealing piece 22 seals the liquid outlet at the bottom of the connecting piece 5, after the cleaning pipe 3 is filled with cleaning liquid, the inside of the guide pipe 2 is cleaned through the backflow channel; Figure 3 A forward cleaning path is shown, the guide pipe 2 is raised, the sealing piece 22 releases the sealing of the connecting piece 5, and at this time, the guide pipe 2 seals the cleaning pipe 3, the cleaning liquid is filled into the guide pipe 2 from the top, and the cleaning liquid flows through the guide pipe 2 and the connecting piece 5 in turn, and finally flows out from the liquid outlet at the bottom of the connecting piece 5, thereby realizing the cleaning of the guide pipe 2 and the connecting piece 5.

[0029] Further, as shown in Figure 2 and Figure 3 , in the embodiment, a secondary pipe 23 is arranged outside the guide pipe 2, a first cavity 12 and a second cavity 13 are arranged in the mounting seat 1, the diameter of the first cavity 12 is larger than that of the second cavity 13, the first cavity 12 is in communication with the cleaning pipe 3, the secondary pipe 23 is arranged in the first cavity 12 and the second cavity 13 in a liftable manner, the backflow channel comprises a cleaning channel 21 and an inlet and outlet liquid channel 9, the cleaning channel 21 is located between the guide pipe 2 and the secondary pipe 23, the inlet and outlet liquid channel 9 is located between the guide pipe 2 and the pull rod 7, and a plurality of through holes 24 are arranged at intervals in the peripheral side of the guide pipe 2. When the guide pipe 2 is lowered, there is a gap between the secondary pipe 23 and the top of the first cavity 12, the cleaning liquid passes through the cleaning pipe 3, the gap between the secondary pipe 23 and the top of the first cavity 12, the cleaning channel 21, the through holes 24 and the inlet and outlet liquid channel 9 in turn, and reverse cleaning is realized; when the guide pipe 2 is raised, the secondary pipe 23 abuts and seals the top of the first cavity 12, the cleaning liquid flows out from the liquid outlet at the bottom of the connecting piece 5 from the top through the inlet and outlet liquid channel 9 and the through holes 24, and forward cleaning is realized.

[0030] Further, as shown in Figure 2As shown in the drawings, in this embodiment, the top of the sub-pipe 23 is provided with a first sealing ring 231 for sealing with the first cavity 12. Further improve the sealing of the sub-pipe 23 with the top of the first cavity 12 when the catheter 2 rises.

[0031] Further, as shown in the drawings, Figure 2 As shown in the drawings, in this embodiment, the side of the sub-pipe 23 is provided with a second sealing ring 232 for sealing with the second cavity 13. Further improve the sealing between the sub-pipe 23 and the second cavity 13.

[0032] Further, as shown in the drawings, Figure 2 As shown in the drawings, in this embodiment, the connecting piece 5 is provided with an inverted tapered groove 51, and the sealing piece 22 is cylindrical. The gap between the inverted tapered groove 51 and the cylindrical sealing piece 22. Shorten the rising displacement required for the catheter 2 to unseal. Preferably, the bottom of the sealing piece 22 is provided with a sealing pad 221, which further improves the sealing effect.

[0033] Further, as shown in the drawings, Figure 1 As shown in the drawings, in this embodiment, the mounting seat 1 is provided with an air cavity 14, and the catheter 2 is provided with a pushing seat 25. The air cavity 14 is connected with an air hole, and the air hole is connected with an air pump to drive the pushing seat 25 to descend in the air cavity 14. The air pump drives the pushing seat 25 to descend by feeding air into the air cavity 14, and the pushing seat 25 is arranged outside the catheter 2, so it can drive the catheter 2 to descend, and the structure is simple.

[0034] Further, as shown in the drawings, Figure 1 As shown in the drawings, in this embodiment, the mounting seat 1 is provided with a reset cavity 15, and the reset cavity 15 is provided with a reset spring 16. The catheter 2 is provided with a limiting seat 26, and the reset spring 16 is located between the limiting seat 26 and the pushing seat 25. When the pushing seat 25 descends, a pressure is applied to the reset spring 16. After the reverse cleaning is completed, the air pump is closed, and the reset spring 16 can drive the pushing seat 25 and the catheter 2 to rise and reset.

[0035] Further, as shown in the drawings, Figure 4 As shown in the drawings, in this embodiment, the mounting seat 1 is provided with a chromatography channel 11, and one end of the chromatography channel 11 is communicated with the chromatography pipe 4 and the other end is communicated with the screen 6. The chromatography liquid is input from the chromatography pipe 4, passes through the chromatography channel 11 to the screen 6, and uniformly enters the lower filler for chromatography under the distribution of the screen 6.

[0036] Further, as shown in the drawings, Figure 1 As shown in the drawings, in this embodiment, the other end of the pull rod 7 is detachably connected with the mounting seat 1 through the locking piece 8. The locking piece 8 can be disassembled to realize the fixing and screwing operation of the pull rod 7, and the structure is simple.

[0037] Although the utility model has disclosed as above with preferable embodiments, however, is not used to limit the utility model. Any skilled person in the art, without departing from the utility model technical scheme range, can utilize the above disclosed technical content to make many possible changes and modifications to the utility model technical scheme, or modify as equivalent variation equivalent embodiment. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the utility model, which does not deviate from the content of the utility model technical scheme, should fall within the scope of protection of the utility model technical scheme.

Claims

1. A distribution device for a chromatography column, characterized by: The utility model provides a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

2. A distribution device for chromatography columns according to claim 1, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

3. A distribution device for chromatography columns according to claim 2, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

4. A distribution device for chromatography columns according to claim 3, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

5. The distribution device for chromatography columns of claim 1, wherein: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

6. A distribution device for chromatography columns according to any one of claims 1 to 5, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

7. A distribution device for chromatography columns according to claim 6, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

8. The distribution device of a chromatography column according to any one of claims 1 to 5, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

9. The distribution device of a chromatography column according to any one of claims 1 to 5, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

10. The distribution device of a chromatography column according to any one of claims 1 to 5, characterized in that: The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel. The utility model discloses a cleaning device, including mounting seat (1) and the guide pipe (2) of liftable in mounting seat (1) inside, be equipped with the cleaning pipeline (3) on mounting seat (1), be equipped with pull rod (7) in the guide pipe (2) inside, pull rod (7) one end with connecting piece (5) detachable connection, connecting piece (5) week side connects screen (6), connecting piece (5) bottom is equipped with liquid outlet, the guide pipe (2) bottom is equipped with sealing element (22), when sealing element (22) seals liquid outlet, the cleaning pipeline (3) with guide pipe (2) between form backflow channel.

Images